KEGG   Homo sapiens (human): 116379
Entry
116379            CDS       T01001                                 
Symbol
IL22RA2, CRF2-10, CRF2-S1, CRF2X, IL-22BP, IL-22R-alpha-2, IL-22RA2, ZCYTOR16
Name
(RefSeq) interleukin 22 receptor subunit alpha 2
  KO
K05139  interleukin 22 receptor alpha 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04630  JAK-STAT signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    116379 (IL22RA2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    116379 (IL22RA2)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  IL10/28 receptor family
   116379 (IL22RA2)
SSDB
Motif
Pfam: Tissue_fac Interfer-bind Receptor_2B4
Other DBs
NCBI-GeneID: 116379
NCBI-ProteinID: NP_443194
OMIM: 606648
HGNC: 14901
Ensembl: ENSG00000164485
Pharos: Q969J5(Tbio)
UniProt: Q969J5
Structure
LinkDB
Position
6:complement(137143820..137173644)
AA seq 263 aa
MMPKHCFLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNSSVY
FVQYKIMFSCSMKSSHQKPSGCWQHISCNFPGCRTLAKYGQRQWKNKEDCWGTQELSCDL
TSETSDIQEPYYGRVRAASAGSYSEWSMTPRFTPWWETKIDPPVMNITQVNGSLLVILHA
PNLPYRYQKEKNVSIEDYYELLYRVFIINNSLEKEQKVYEGAHRAVEIEALTPHSSYCVV
AEIYQPMLDRRSQRSEERCVEIP
NT seq 792 nt   +upstreamnt  +downstreamnt
atgatgcctaaacattgctttctaggcttcctcatcagtttcttccttactggtgtagca
ggaactcagtcaacgcatgagtctctgaagcctcagagggtacaatttcagtcccgaaat
tttcacaacattttgcaatggcagcctgggagggcacttactggcaacagcagtgtctat
tttgtgcagtacaaaatcatgttctcatgcagcatgaaaagctctcaccagaagccaagt
ggatgctggcagcacatttcttgtaacttcccaggctgcagaacattggctaaatatgga
cagagacaatggaaaaataaagaagactgttggggtactcaagaactctcttgtgacctt
accagtgaaacctcagacatacaggaaccttattacgggagggtgagggcggcctcggct
gggagctactcagaatggagcatgacgccgcggttcactccctggtgggaaacaaaaata
gatcctccagtcatgaatataacccaagtcaatggctctttgttggtaattctccatgct
ccaaatttaccatatagataccaaaaggaaaaaaatgtatctatagaagattactatgaa
ctactataccgagtttttataattaacaattcactagaaaaggagcaaaaggtttatgaa
ggggctcacagagcggttgaaattgaagctctaacaccacactccagctactgtgtagtg
gctgaaatatatcagcccatgttagacagaagaagtcagagaagtgaagagagatgtgtg
gaaattccatga

KEGG   Homo sapiens (human): 1271
Entry
1271              CDS       T01001                                 
Symbol
CNTFR
Name
(RefSeq) ciliary neurotrophic factor receptor
  KO
K05059  ciliary neurotrophic factor receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Drug target
Dapiclermin: D03647
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    1271 (CNTFR)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    1271 (CNTFR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    1271 (CNTFR)
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
    1271 (CNTFR)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  IL6/12 receptor family
   1271 (CNTFR)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
 Receptors
  1271 (CNTFR)
SSDB
Motif
Pfam: fn3 Ig_3 Ig_2 Ig_5 MAGI_u5
Other DBs
NCBI-GeneID: 1271
NCBI-ProteinID: NP_001193940
OMIM: 118946
HGNC: 2170
Ensembl: ENSG00000122756
Pharos: P26992(Tbio)
UniProt: P26992
Structure
LinkDB
Position
9:complement(34551433..34590852)
AA seq 372 aa
MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN
GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT
YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS
ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL
KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT
PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL
AAAAATASSLLI
NT seq 1119 nt   +upstreamnt  +downstreamnt
atggctgctcctgtcccgtgggcctgctgtgctgtgcttgccgccgccgccgcagttgtc
tacgcccagagacacagtccacaggaggcaccccatgtgcagtacgagcgcctgggctct
gacgtgacactgccatgtgggacagcaaactgggatgctgcggtgacgtggcgggtaaat
gggacagacctggcccctgacctgctcaacggctctcagctggtgctccatggcctggaa
ctgggccacagtggcctctacgcctgcttccaccgtgactcctggcacctgcgccaccaa
gtcctgctgcatgtgggcttgccgccgcgggagcctgtgctcagctgccgctccaacact
taccccaagggcttctactgcagctggcatctgcccacccccacctacattcccaacacc
ttcaatgtgactgtgctgcatggctccaaaattatggtctgtgagaaggacccagccctc
aagaaccgctgccacattcgctacatgcacctgttctccaccatcaagtacaaggtctcc
ataagtgtcagcaatgccctgggccacaatgccacagctatcacctttgacgagttcacc
attgtgaagcctgatcctccagaaaatgtggtagcccggccagtgcccagcaaccctcgc
cggctggaggtgacgtggcagaccccctcgacctggcctgaccctgagtcttttcctctc
aagttctttctgcgctaccgacccctcatcctggaccagtggcagcatgtggagctgtcc
gacggcacagcacacaccatcacagatgcctacgccgggaaggagtacattatccaggtg
gcagccaaggacaatgagattgggacatggagtgactggagcgtagccgcccacgctacg
ccctggactgaggaaccgcgacacctcaccacggaggcccaggctgcggagaccacgacc
agcaccaccagctccctggcacccccacctaccacgaagatctgtgaccctggggagctg
ggcagcggcgggggaccctcggcacccttcttggtcagcgtccccatcactctggccctg
gctgccgctgccgccactgccagcagtctcttgatctga

KEGG   Homo sapiens (human): 1438
Entry
1438              CDS       T01001                                 
Symbol
CSF2RA, CD116, CDw116, CSF2R, CSF2RAX, CSF2RAY, CSF2RX, CSF2RY, GM-CSF-R-alpha, GMCSFR, GMCSFR-alpha, GMR, GMR-alpha, SMDP4, alphaGMR
Name
(RefSeq) colony stimulating factor 2 receptor subunit alpha
  KO
K05066  granulocyte-macrophage colony-stimulating factor receptor alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
hsa05200  Pathways in cancer
Disease
H01122  Congenital pulmonary alveolar proteinosis
Drug target
Mavrilimumab: D09930
Molgramostim: D05066
Regramostim: D05712
Sargramostim: D05803<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    1438 (CSF2RA)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    1438 (CSF2RA)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    1438 (CSF2RA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1438 (CSF2RA)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    1438 (CSF2RA)
   04090 CD molecules [BR:hsa04090]
    1438 (CSF2RA)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  IL3 receptor family
   1438 (CSF2RA)
CD molecules [BR:hsa04090]
 Proteins
  1438 (CSF2RA)
SSDB
Motif
Pfam: IL3Ra_N IL6Ra-bind
Other DBs
NCBI-GeneID: 1438
NCBI-ProteinID: NP_001155001
OMIM: 306250 425000
HGNC: 2435
Ensembl: ENSG00000198223
Pharos: P15509(Tclin)
UniProt: P15509
Structure
LinkDB
Position
X:1268814..1325218, Y:1268814..1325218
AA seq 400 aa
MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKC
FLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTA
AQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHL
DNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLVRWKQP
RTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVKIRAAD
VRILNWSSWSEAIEFGSDDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRFLRIQRLFPPVP
QIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgcttctcctggtgacaagccttctgctctgtgagttaccacacccagcattcctcctg
atcccagagaaatcggatctgcgaacagtggcaccagcctctagtctcaatgtgaggttt
gactccaggacgatgaatttaagctgggactgccaagaaaacacaaccttcagcaagtgt
ttcttaactgacaagaagaacagagtcgtggaacccaggctcagtaacaacgaatgttcg
tgcacatttcgtgaaatttgtctgcatgaaggagtcacatttgaggttcacgtgaatact
agtcaaagaggatttcaacagaaactgctttatccaaattcaggaagggagggtaccgct
gctcagaatttctcctgtttcatctacaatgcggatttaatgaactgtacctgggcgagg
ggtccgacggccccccgtgacgtccagtattttttgtacatacgaaactcaaagagaagg
agggagatccggtgtccttattacatacaagactcaggaacccatgtgggatgtcacctg
gataacctgtcaggattaacgtctcgcaattactttctggttaacggaaccagccgagaa
attggcatccaattctttgattcacttttggacacaaagaaaatagaacgattcaaccct
cccagcaatgtcaccgtacgttgcaacacgacgcactgcctcgtacggtggaaacagccc
aggacctatcagaagctgtcgtacctggactttcagtaccagctggacgtccacagaaag
aatacccagcctggcacggaaaacctactgattaatgtttctggtgatttggaaaataga
tacaactttccaagctctgagcccagagcaaaacacagtgtgaagatcagagctgcagac
gtccgcatcttgaattggagctcctggagtgaagccattgaatttggttctgacgacggg
aacctcggctctgtgtacatttatgtgctcctaatcgtgggaacccttgtctgtggcatc
gtcctcggcttcctctttaaaaggttccttaggatacagcggctgttcccgccagttcca
cagatcaaagacaaactgaatgataaccatgaggtggaagacgagatcatctgggaggaa
ttcaccccagaggaagggaaaggctaccgcgaagaggtcttgaccgtgaaggaaattacc
tga

KEGG   Homo sapiens (human): 1439
Entry
1439              CDS       T01001                                 
Symbol
CSF2RB, CD131, CDw131, IL3RB, IL5RB, SMDP5, betaGMR
Name
(RefSeq) colony stimulating factor 2 receptor subunit beta
  KO
K04738  cytokine receptor common subunit beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04210  Apoptosis
hsa04630  JAK-STAT signaling pathway
hsa05200  Pathways in cancer
Network
nt06119  JAK-STAT signaling (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
  Element
N00053  Cytokine-Jak-STAT signaling pathway
Disease
H01122  Congenital pulmonary alveolar proteinosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    1439 (CSF2RB)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    1439 (CSF2RB)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    1439 (CSF2RB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1439 (CSF2RB)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    1439 (CSF2RB)
   04090 CD molecules [BR:hsa04090]
    1439 (CSF2RB)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  IL3 receptor family
   1439 (CSF2RB)
CD molecules [BR:hsa04090]
 Proteins
  1439 (CSF2RB)
SSDB
Motif
Pfam: fn3 IL6Ra-bind IL4Ra_N EpoR_lig-bind Tissue_fac IL2RB_N1 Interfer-bind Pur_ac_phosph_N
Other DBs
NCBI-GeneID: 1439
NCBI-ProteinID: NP_000386
OMIM: 138981
HGNC: 2436
Ensembl: ENSG00000100368
Pharos: P32927(Tclin)
UniProt: P32927 Q6NSJ8
Structure
LinkDB
Position
22:36913628..36940439
AA seq 897 aa
MVLAQGLLSMALLALCWERSLAGAEETIPLQTLRCYNDYTSHITCRWADTQDAQRLVNVT
LIRRVNEDLLEPVSCDLSDDMPWSACPHPRCVPRRCVIPCQSFVVTDVDYFSFQPDRPLG
TRLTVTLTQHVQPPEPRDLQISTDQDHFLLTWSVALGSPQSHWLSPGDLEFEVVYKRLQD
SWEDAAILLSNTSQATLGPEHLMPSSTYVARVRTRLAPGSRLSGRPSKWSPEVCWDSQPG
DEAQPQNLECFFDGAAVLSCSWEVRKEVASSVSFGLFYKPSPDAGEEECSPVLREGLGSL
HTRHHCQIPVPDPATHGQYIVSVQPRRAEKHIKSSVNIQMAPPSLNVTKDGDSYSLRWET
MKMRYEHIDHTFEIQYRKDTATWKDSKTETLQNAHSMALPALEPSTRYWARVRVRTSRTG
YNGIWSEWSEARSWDTESVLPMWVLALIVIFLTIAVLLALRFCGIYGYRLRRKWEEKIPN
PSKSHLFQNGSAELWPPGSMSAFTSGSPPHQGPWGSRFPELEGVFPVGFGDSEVSPLTIE
DPKHVCDPPSGPDTTPAASDLPTEQPPSPQPGPPAASHTPEKQASSFDFNGPYLGPPHSR
SLPDILGQPEPPQEGGSQKSPPPGSLEYLCLPAGGQVQLVPLAQAMGPGQAVEVERRPSQ
GAAGSPSLESGGGPAPPALGPRVGGQDQKDSPVAIPMSSGDTEDPGVASGYVSSADLVFT
PNSGASSVSLVPSLGLPSDQTPSLCPGLASGPPGAPGPVKSGFEGYVELPPIEGRSPRSP
RNNPVPPEAKSPVLNPGERPADVSPTSPQPEGLLVLQQVGDYCFLPGLGPGPLSLRSKPS
SPGPGPEIKNLDQAFQVKKPPGQAVPQVPVIQLFKALKQQDYLSLPPWEVNKPGEVC
NT seq 2694 nt   +upstreamnt  +downstreamnt
atggtgctggcccaggggctgctctccatggccctgctggccctgtgctgggagcgcagc
ctggcaggggcagaagaaaccatcccgctgcagaccctgcgctgctacaacgactacacc
agccacatcacctgcaggtgggcagacacccaggatgcccagcggctcgtcaacgtgacc
ctcattcgccgggtgaatgaggacctcctggagccagtgtcctgtgacctcagtgatgac
atgccctggtcagcctgcccccatccccgctgcgtgcccaggagatgtgtcattccctgc
cagagttttgtcgtcactgacgttgactacttctcattccaaccagacaggcctctgggc
acccggctcaccgtcactctgacccagcatgtccagcctcctgagcccagggacctgcag
atcagcaccgaccaggaccacttcctgctgacctggagtgtggcccttgggagtccccag
agccactggttgtccccaggggatctggagtttgaggtggtctacaagcggcttcaggac
tcttgggaggacgcagccatcctcctctccaacacctcccaggccaccctggggccagag
cacctcatgcccagcagcacctacgtggcccgagtacggacccgcctggccccaggttct
cggctctcaggacgtcccagcaagtggagcccagaggtttgctgggactcccagccaggg
gatgaggcccagccccagaacctggagtgcttctttgacggggccgccgtgctcagctgc
tcctgggaggtgaggaaggaggtggccagctcggtctcctttggcctattctacaagccc
agcccagatgcaggggaggaagagtgctccccagtgctgagggaggggctcggcagcctc
cacaccaggcaccactgccagattcccgtgcccgaccccgcgacccacggccaatacatc
gtctctgttcagccaaggagggcagagaaacacataaagagctcagtgaacatccagatg
gcccctccatccctcaacgtgaccaaggatggagacagctacagcctgcgctgggaaaca
atgaaaatgcgatacgaacacatagaccacacatttgagatccagtacaggaaagacacg
gccacgtggaaggacagcaagaccgagaccctccagaacgcccacagcatggccctgcca
gccctggagccctccaccaggtactgggccagggtgagggtcaggacctcccgcaccggc
tacaacgggatctggagcgagtggagtgaggcgcgctcctgggacaccgagtcggtgctg
cctatgtgggtgctggccctcatcgtgatcttcctcaccatcgctgtgctcctggccctc
cgcttctgtggcatctacgggtacaggctgcgcagaaagtgggaggagaagatccccaac
cccagcaagagccacctgttccagaacgggagcgcagagctttggcccccaggcagcatg
tcggccttcactagcgggagtcccccacaccaggggccgtggggcagccgcttccctgag
ctggagggggtgttccctgtaggattcggggacagcgaggtgtcacctctcaccatagag
gaccccaagcatgtctgtgatccaccatctgggcctgacacgactccagctgcctcagat
ctacccacagagcagccccccagcccccagccaggcccgcctgccgcctcccacacacct
gagaaacaggcttccagctttgacttcaatgggccctacctggggccgccccacagccgc
tccctacctgacatcctgggccagccggagcccccacaggagggtgggagccagaagtcc
ccacctccagggtccctggagtacctgtgtctgcctgctggggggcaggtgcaactggtc
cctctggcccaggcgatgggaccaggacaggccgtggaagtggagagaaggccgagccag
ggggctgcagggagtccctccctggagtccgggggaggccctgcccctcctgctcttggg
ccaagggtgggaggacaggaccaaaaggacagccctgtggctatacccatgagctctggg
gacactgaggaccctggagtggcctctggttatgtctcctctgcagacctggtattcacc
ccaaactcaggggcctcgtctgtctccctagttccctctctgggcctcccctcagaccag
acccccagcttatgtcctgggctggccagtggaccccctggagccccaggccctgtgaag
tcagggtttgagggctatgtggagctccctccaattgagggccggtcccccaggtcacca
aggaacaatcctgtcccccctgaggccaaaagccctgtcctgaacccaggggaacgcccg
gcagatgtgtccccaacatccccacagcccgagggcctccttgtcctgcagcaagtgggc
gactattgcttcctccccggcctggggcccggccctctctcgctccggagtaaaccttct
tccccgggacccggtcctgagatcaagaacctagaccaggcttttcaagtcaagaagccc
ccaggccaggctgtgccccaggtgcccgtcattcagctcttcaaagccctgaagcagcag
gactacctgtctctgcccccttgggaggtcaacaagcctggggaggtgtgttga

KEGG   Homo sapiens (human): 1441
Entry
1441              CDS       T01001                                 
Symbol
CSF3R, CD114, GCSFR, SCN7
Name
(RefSeq) colony stimulating factor 3 receptor
  KO
K05061  granulocyte colony-stimulating factor receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
hsa05200  Pathways in cancer
Disease
H00100  Neutropenic disorders
H02410  Myelodysplastic/myeloproliferative neoplasms
H02412  Atypical chronic myeloid leukemia
Drug target
Balugrastim: D10310
Efbemalenograstim alfa: D11986
Filgrastim: D03235<JP/US>
Lenograstim: D03247<JP>
Leridistim: D04695
Lipegfilgrastim: D10242
Milodistim: D05036
Nartograstim: D03245
Pegfilgrastim: D06889<JP/US>
Pegnartograstim: D05389
Pegteograstim: D11026
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    1441 (CSF3R)
   04151 PI3K-Akt signaling pathway
    1441 (CSF3R)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    1441 (CSF3R)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    1441 (CSF3R)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1441 (CSF3R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    1441 (CSF3R)
   04090 CD molecules [BR:hsa04090]
    1441 (CSF3R)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  Prolactin receptor family
   1441 (CSF3R)
CD molecules [BR:hsa04090]
 Proteins
  1441 (CSF3R)
SSDB
Motif
Pfam: Lep_receptor_Ig fn3 EpoR_lig-bind fn3_2 IL6Ra-bind ObR_Ig
Other DBs
NCBI-GeneID: 1441
NCBI-ProteinID: NP_000751
OMIM: 138971
HGNC: 2439
Ensembl: ENSG00000119535
Pharos: Q99062(Tclin)
UniProt: Q99062
Structure
LinkDB
Position
1:complement(36466043..36483314)
AA seq 836 aa
MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ
ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAG
YPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPK
DGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPE
AAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPA
TAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVP
LEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT
PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRME
QNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGK
TWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHL
MAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPNRKNPLWP
SVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLEEDEKKPVPWESHNSSETCGL
PTLVQTYVLQGDPRAVSTQPQSQSGTSDQVLYGQLLGSPTSPGPGHYLRCDSTQPLLAGL
TPSPKSYENLWFQASPLGTLVTPAPSQEDDCVFGPLLNFPLLQGIRVHGMEALGSF
NT seq 2511 nt   +upstreamnt  +downstreamnt
atggcaaggctgggaaactgcagcctgacttgggctgccctgatcatcctgctgctcccc
ggaagtctggaggagtgcgggcacatcagtgtctcagcccccatcgtccacctgggggat
cccatcacagcctcctgcatcatcaagcagaactgcagccatctggacccggagccacag
attctgtggagactgggagcagagcttcagcccgggggcaggcagcagcgtctgtctgat
gggacccaggaatctatcatcaccctgccccacctcaaccacactcaggcctttctctcc
tgctgcctgaactggggcaacagcctgcagatcctggaccaggttgagctgcgcgcaggc
taccctccagccataccccacaacctctcctgcctcatgaacctcacaaccagcagcctc
atctgccagtgggagccaggacctgagacccacctacccaccagcttcactctgaagagt
ttcaagagccggggcaactgtcagacccaaggggactccatcctggactgcgtgcccaag
gacgggcagagccactgctgcatcccacgcaaacacctgctgttgtaccagaatatgggc
atctgggtgcaggcagagaatgcgctggggaccagcatgtccccacaactgtgtcttgat
cccatggatgttgtgaaactggagccccccatgctgcggaccatggaccccagccctgaa
gcggcccctccccaggcaggctgcctacagctgtgctgggagccatggcagccaggcctg
cacataaatcagaagtgtgagctgcgccacaagccgcagcgtggagaagccagctgggca
ctggtgggccccctccccttggaggcccttcagtatgagctctgcgggctcctcccagcc
acggcctacaccctgcagatacgctgcatccgctggcccctgcctggccactggagcgac
tggagccccagcctggagctgagaactaccgaacgggcccccactgtcagactggacaca
tggtggcggcagaggcagctggaccccaggacagtgcagctgttctggaagccagtgccc
ctggaggaagacagcggacggatccaaggttatgtggtttcttggagaccctcaggccag
gctggggccatcctgcccctctgcaacaccacagagctcagctgcaccttccacctgcct
tcagaagcccaggaggtggcccttgtggcctataactcagccgggacctctcgtcccact
ccggtggtcttctcagaaagcagaggcccagctctgaccagactccatgccatggcccga
gaccctcacagcctctgggtaggctgggagccccccaatccatggcctcagggctatgtg
attgagtggggcctgggcccccccagcgcgagcaatagcaacaagacctggaggatggaa
cagaatgggagagccacggggtttctgctgaaggagaacatcaggccctttcagctctat
gagatcatcgtgactcccttgtaccaggacaccatgggaccctcccagcatgtctatgcc
tactctcaagaaatggctccctcccatgccccagagctgcatctaaagcacattggcaag
acctgggcacagctggagtgggtgcctgagccccctgagctggggaagagcccccttacc
cactacaccatcttctggaccaacgctcagaaccagtccttctccgccatcctgaatgcc
tcctcccgtggctttgtcctccatggcctggagcccgccagtctgtatcacatccacctc
atggctgccagccaggctggggccaccaacagtacagtcctcaccctgatgaccttgacc
ccagaggggtcggagctacacatcatcctgggcctgttcggcctcctgctgttgctcacc
tgcctctgtggaactgcctggctctgttgcagccccaacaggaagaatcccctctggcca
agtgtcccagacccagctcacagcagcctgggctcctgggtgcccacaatcatggaggag
gatgccttccagctgcccggccttggcacgccacccatcaccaagctcacagtgctggag
gaggatgaaaagaagccggtgccctgggagtcccataacagctcagagacctgtggcctc
cccactctggtccagacctatgtgctccagggggacccaagagcagtttccacccagccc
caatcccagtctggcaccagcgatcaggtcctttatgggcagctgctgggcagccccaca
agcccagggccagggcactatctccgctgtgactccactcagcccctcttggcgggcctc
acccccagccccaagtcctatgagaacctctggttccaggccagccccttggggaccctg
gtaaccccagccccaagccaggaggacgactgtgtctttgggccactgctcaacttcccc
ctcctgcaggggatccgggtccatgggatggaggcgctggggagcttctag

KEGG   Homo sapiens (human): 149233
Entry
149233            CDS       T01001                                 
Symbol
IL23R
Name
(RefSeq) interleukin 23 receptor
  KO
K05065  interleukin 23 receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
hsa04659  Th17 cell differentiation
hsa05200  Pathways in cancer
hsa05321  Inflammatory bowel disease
Network
nt06119  JAK-STAT signaling (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
  Element
N00053  Cytokine-Jak-STAT signaling pathway
Disease
H00286  Crohn disease
H01227  Inflammatory bowel disease (IBD)
H01466  Ulcerative colitis
H01476  Behcet disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    149233 (IL23R)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    149233 (IL23R)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    149233 (IL23R)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    149233 (IL23R)
  09163 Immune disease
   05321 Inflammatory bowel disease
    149233 (IL23R)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    149233 (IL23R)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  IL6/12 receptor family
   149233 (IL23R)
SSDB
Motif
Pfam: IL12p40_C IL6Ra-bind fn3 Lep_receptor_Ig
Other DBs
NCBI-GeneID: 149233
NCBI-ProteinID: NP_653302
OMIM: 607562
HGNC: 19100
Ensembl: ENSG00000162594
Pharos: Q5VWK5(Tbio)
UniProt: Q5VWK5
Structure
LinkDB
Position
1:67138637..67265903
AA seq 629 aa
MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQ
PRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDIS
SGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYIN
ISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTII
YWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETG
KRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGM
IVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMN
NNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDL
NTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSL
SNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGI
VNEELPSINTYFPQNILESHFNRISLLEK
NT seq 1890 nt   +upstreamnt  +downstreamnt
atgaatcaggtcactattcaatgggatgcagtaatagccctttacatactcttcagctgg
tgtcatggaggaattacaaatataaactgctctggccacatctgggtagaaccagccaca
atttttaagatgggtatgaatatctctatatattgccaagcagcaattaagaactgccaa
ccaaggaaacttcatttttataaaaatggcatcaaagaaagatttcaaatcacaaggatt
aataaaacaacagctcggctttggtataaaaactttctggaaccacatgcttctatgtac
tgcactgctgaatgtcccaaacattttcaagagacactgatatgtggaaaagacatttct
tctggatatccgccagatattcctgatgaagtaacctgtgtcatttatgaatattcaggc
aacatgacttgcacctggaatgctgggaagctcacctacatagacacaaaatacgtggta
catgtgaagagtttagagacagaagaagagcaacagtatctcacctcaagctatattaac
atctccactgattcattacaaggtggcaagaagtacttggtttgggtccaagcagcaaac
gcactaggcatggaagagtcaaaacaactgcaaattcacctggatgatatagtgatacct
tctgcagccgtcatttccagggctgagactataaatgctacagtgcccaagaccataatt
tattgggatagtcaaacaacaattgaaaaggtttcctgtgaaatgagatacaaggctaca
acaaaccaaacttggaatgttaaagaatttgacaccaattttacatatgtgcaacagtca
gaattctacttggagccaaacattaagtacgtatttcaagtgagatgtcaagaaacaggc
aaaaggtactggcagccttggagttcactgttttttcataaaacacctgaaacagttccc
caggtcacatcaaaagcattccaacatgacacatggaattctgggctaacagttgcttcc
atctctacagggcaccttacttctgacaacagaggagacattggacttttattgggaatg
atcgtctttgctgttatgttgtcaattctttctttgattgggatatttaacagatcattc
cgaactgggattaaaagaaggatcttattgttaataccaaagtggctttatgaagatatt
cctaatatgaaaaacagcaatgttgtgaaaatgctacaggaaaatagtgaacttatgaat
aataattccagtgagcaggtcctatatgttgatcccatgattacagagataaaagaaatc
ttcatcccagaacacaagcctacagactacaagaaggagaatacaggacccctggagaca
agagactacccgcaaaactcgctattcgacaatactacagttgtatatattcctgatctc
aacactggatataaaccccaaatttcaaattttctgcctgagggaagccatctcagcaat
aataatgaaattacttccttaacacttaaaccaccagttgattccttagactcaggaaat
aatcccaggttacaaaagcatcctaattttgctttttctgtttcaagtgtgaattcacta
agcaacacaatatttcttggagaattaagcctcatattaaatcaaggagaatgcagttct
cctgacatacaaaactcagtagaggaggaaaccaccatgcttttggaaaatgattcaccc
agtgaaactattccagaacagaccctgcttcctgatgaatttgtctcctgtttggggatc
gtgaatgaggagttgccatctattaatacttattttccacaaaatattttggaaagccac
ttcaataggatttcactcttggaaaagtag

KEGG   Homo sapiens (human): 163702
Entry
163702            CDS       T01001                                 
Symbol
IFNLR1, CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2
Name
(RefSeq) interferon lambda receptor 1
  KO
K05140  interferon lambda receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Disease
H01360  Allergic rhinitis
Drug target
Peginterferon lambda-1a: D10078
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    163702 (IFNLR1)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    163702 (IFNLR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    163702 (IFNLR1)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  IL10/28 receptor family
   163702 (IFNLR1)
SSDB
Motif
Pfam: Tissue_fac
Other DBs
NCBI-GeneID: 163702
NCBI-ProteinID: NP_734464
OMIM: 607404
HGNC: 18584
Ensembl: ENSG00000185436
Pharos: Q8IU57(Tbio)
UniProt: Q8IU57
Structure
LinkDB
Position
1:complement(24154168..24187289)
AA seq 520 aa
MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQ
SSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYL
FEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQ
PVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLPSLLILLL
VIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLCPQKELTR
GVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQEHQAPGHS
EAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPGQGPGGDG
HQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLTFCWESSP
EEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR
NT seq 1563 nt   +upstreamnt  +downstreamnt
atggcggggcccgagcgctggggccccctgctcctgtgcctgctgcaggccgctccaggg
aggccccgtctggcccctccccagaatgtgacgctgctctcccagaacttcagcgtgtac
ctgacatggctcccagggcttggcaacccccaggatgtgacctattttgtggcctatcag
agctctcccacccgtagacggtggcgcgaagtggaagagtgtgcgggaaccaaggagctg
ctatgttctatgatgtgcctgaagaaacaggacctgtacaacaagttcaagggacgcgtg
cggacggtttctcccagctccaagtccccctgggtggagtccgaatacctggattacctt
tttgaagtggagccggccccacctgtcctggtgctcacccagacggaggagatcctgagt
gccaatgccacgtaccagctgcccccctgcatgcccccactggatctgaagtatgaggtg
gcattctggaaggagggggccggaaacaagaccctatttccagtcactccccatggccag
ccagtccagatcactctccagccagctgccagcgaacaccactgcctcagtgccagaacc
atctacacgttcagtgtcccgaaatacagcaagttctctaagcccacctgcttcttgctg
gaggtcccagaagccaactgggctttcctggtgctgccatcgcttctgatactgctgtta
gtaattgccgcagggggtgtgatctggaagaccctcatggggaacccctggtttcagcgg
gcaaagatgccacgggccctggacttttctggacacacacaccctgtggcaacctttcag
cccagcagaccagagtccgtgaatgacttgttcctctgtccccaaaaggaactgaccaga
ggggtcaggccgacgcctcgagtcagggccccagccacccaacagacaagatggaagaag
gaccttgcagaggacgaagaggaggaggatgaggaggacacagaagatggcgtcagcttc
cagccctacattgaaccaccttctttcctggggcaagagcaccaggctccagggcactcg
gaggctggtggggtggactcagggaggcccagggctcctctggtcccaagcgaaggctcc
tctgcttgggattcttcagacagaagctgggccagcactgtggactcctcctgggacagg
gctgggtcctctggctatttggctgagaaggggccaggccaagggccgggtggggatggg
caccaagaatctctcccaccacctgaattctccaaggactcgggtttcctggaagagctc
ccagaagataacctctcctcctgggccacctggggcaccttaccaccggagccgaatctg
gtccctgggggacccccagtttctcttcagacactgaccttctgctgggaaagcagccct
gaggaggaagaggaggcgagggaatcagaaattgaggacagcgatgcgggcagctggggg
gctgagagcacccagaggaccgaggacaggggccggacattggggcattacatggccagg
tga

KEGG   Homo sapiens (human): 1956
Entry
1956              CDS       T01001                                 
Symbol
EGFR, ERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA
Name
(RefSeq) epidermal growth factor receptor
  KO
K04361  epidermal growth factor receptor [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04144  Endocytosis
hsa04151  PI3K-Akt signaling pathway
hsa04510  Focal adhesion
hsa04520  Adherens junction
hsa04540  Gap junction
hsa04630  JAK-STAT signaling pathway
hsa04810  Regulation of actin cytoskeleton
hsa04912  GnRH signaling pathway
hsa04915  Estrogen signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04934  Cushing syndrome
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa05131  Shigellosis
hsa05160  Hepatitis C
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06110  MAPK signaling (viruses and bacteria)
nt06114  PI3K signaling (viruses)
nt06120  Calcium signaling (viruses and bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06210  ERK signaling
nt06213  Other RAS signaling
nt06214  PI3K signaling
nt06219  JAK-STAT signaling
nt06220  Calcium signaling
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06273  Glioma
nt06274  Thyroid cancer
nt06276  Chronic myeloid leukemia
nt06310  CRH-ACTH-cortisol signaling
nt06360  Cushing syndrome
  Element
N00001  EGF-EGFR-RAS-ERK signaling pathway
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00021  EGF-ERBB2-RAS-ERK signaling pathway
N00022  ERBB2-overexpression to RAS-ERK signaling pathway
N00023  EGF-EGFR-PLCG-ERK signaling pathway
N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
N00026  EGF-EGFR-PLCG-CAMK signaling pathway
N00027  Amplified EGFR to PLCG-CAMK signaling pathway
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00033  EGF-EGFR-PI3K signaling pathway
N00034  ERBB2-overexpression to PI3K signaling pathway
N00035  Amplified EGFR to PI3K signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N00041  EGFR-overexpression to RAS-ERK signaling pathway
N00042  EGFR-overexpression to PI3K signaling pathway
N00094  EGF-Jak-STAT signaling pathway
N00095  ERBB2-overexpression to EGF-Jak-STAT signaling pathway
N00096  EGF-EGFR-RAS-RASSF1 signaling pathway
N00103  EGF-EGFR-RAS-RalGDS signaling pathway
N00147  EGF-EGFR-PLCG-calcineurin signaling pathway
N00227  TGFA-EGFR-PLCG-PKC signaling pathway
N00228  TGFA-overexpression to PLCG-PKC signaling pathway
N00229  TGFA-EGFR-RAS-ERK signaling pathway
N00230  TGFA-overexpression to RAS-ERK signaling pathway
N00231  TGFA-EGFR-PI3K signaling pathway
N00232  TGFA-overexpression to PI3K signaling pathway
N00252  Amplified ERBB2 to RAS-ERK signaling pathway
N00253  Amplified ERBB2 to PI3K signaling pathway
N00276  EGF-overexpression to RAS-ERK signaling pathway
N00277  EREG-EGFR-RAS-ERK signaling pathway
N00278  EREG-overexpression to RAS-ERK signaling pathway
N00279  AREG-EGFR-RAS-ERK signaling pathway
N00280  AREG-overexpression to RAS-ERK signaling pathway
N00281  EGF-overexpression to PI3K signaling pathway
N00282  EREG-EGFR-PI3K signaling pathway
N00283  EREG-overexpression to PI3K signaling pathway
N00284  AREG-EGFR-PI3K signaling pathway
N00285  AREG-overexpression to PI3K signaling pathway
N00318  EGFR-ERK-ACTH signaling pathway
N00319  Mutation-activated USP8 to EGFR-ERK-ACTH signaling pathway
N00366  HPV E5 to EGFR-PI3K signaling pathway
N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
N00390  EGF-EGFR-PI3K-NFKB signaling pathway
N00391  HCMV gB to EGFR-PI3K-NFKB signaling pathway
N00392  HCMV gB to EGFR-RAS-ERK signaling pathway
N00513  Mutation-activated EGFR to RAS-ERK signaling pathway
N00514  Mutation-activated EGFR to PI3K signaling pathway
N00542  EGF-EGFR-RAS-JNK signaling pathway
N01078  EGF-EGFR-Actin signaling pathway
N01354  BPA to RAS-ERK signaling pathway
N01355  Arsenic to PI3K signaling pathway
N10005  First/second-generation tyrosine kinase inhibitor to EGFR mutation
N10006  Third-generation tyrosine kinase inhibitor to EGFR mutation
Disease
H00014  Non-small cell lung cancer
H00016  Oral cancer
H00017  Esophageal cancer
H00022  Bladder cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00031  Breast cancer
H00042  Glioma
H00055  Laryngeal cancer
H01508  Salivary gland cancer
H01559  Oropharyngeal cancer
H02467  Neonatal inflammatory skin and bowel disease
Drug target
Afatinib (DG00717): D09724 D09733<JP/US>
Amivantamab: D11894<US> D11894<US>
Aumolertinib (DG03209): D12258 D12259
Canertinib dihydrochloride: D03350
Cetuximab: D03455<JP/US>
Cetuximab sarotalocan: D11803
Cetuximab sarotalocan sodium: D11805<JP>
Dacomitinib (DG01793): D09883 D10514<JP/US>
Duligotuzumab: D11750
Erlotinib (DG00711): D04023<JP/US> D07907
Gefitinib: D01977<JP/US>
Icotinib: D11251
Imgatuzumab: D10439
Lapatinib (DG00715): D04024<JP/US> D08108
Lazertinib (DG03205): D11980 D12245
Lifirafenib (DG03009): D11410 D11411
Masoprocol: D04862
Mavelertinib: D11368
Mobocertinib (DG03148): D11969<US> D12001
Modotuximab: D11125
Naquotinib (DG03112): D10886 D10958
Nazartinib (DG03015): D11430 D11434
Necitumumab: D10018<JP/US>
Neratinib (DG02303): D08950 D10898<US>
Olmutinib (DG02916): D10859 D11115
Osimertinib: D10766<JP/US>
Panitumumab: D05350<JP/US>
Pelitinib: D05399
Petosemtamab: D12416
Poziotinib (DG03196): D12229 D12230
Rindopepimut: D09660
Rociletinib: D10858
Serclutamab: D11872
Serclutamab talirine: D11874
Tesevatinib (DG03101): D11772 D11773
Vandetanib: D06407<JP/US>
Varlitinib (DG01357): D09689 D09690
Zalutumumab: D10031
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    1956 (EGFR)
   04012 ErbB signaling pathway
    1956 (EGFR)
   04014 Ras signaling pathway
    1956 (EGFR)
   04015 Rap1 signaling pathway
    1956 (EGFR)
   04630 JAK-STAT signaling pathway
    1956 (EGFR)
   04066 HIF-1 signaling pathway
    1956 (EGFR)
   04068 FoxO signaling pathway
    1956 (EGFR)
   04020 Calcium signaling pathway
    1956 (EGFR)
   04072 Phospholipase D signaling pathway
    1956 (EGFR)
   04151 PI3K-Akt signaling pathway
    1956 (EGFR)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    1956 (EGFR)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    1956 (EGFR)
   04520 Adherens junction
    1956 (EGFR)
   04540 Gap junction
    1956 (EGFR)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1956 (EGFR)
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    1956 (EGFR)
   04915 Estrogen signaling pathway
    1956 (EGFR)
   04921 Oxytocin signaling pathway
    1956 (EGFR)
   04926 Relaxin signaling pathway
    1956 (EGFR)
   04928 Parathyroid hormone synthesis, secretion and action
    1956 (EGFR)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1956 (EGFR)
   05206 MicroRNAs in cancer
    1956 (EGFR)
   05205 Proteoglycans in cancer
    1956 (EGFR)
   05207 Chemical carcinogenesis - receptor activation
    1956 (EGFR)
   05208 Chemical carcinogenesis - reactive oxygen species
    1956 (EGFR)
   05230 Central carbon metabolism in cancer
    1956 (EGFR)
   05231 Choline metabolism in cancer
    1956 (EGFR)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    1956 (EGFR)
  09162 Cancer: specific types
   05210 Colorectal cancer
    1956 (EGFR)
   05212 Pancreatic cancer
    1956 (EGFR)
   05225 Hepatocellular carcinoma
    1956 (EGFR)
   05226 Gastric cancer
    1956 (EGFR)
   05214 Glioma
    1956 (EGFR)
   05218 Melanoma
    1956 (EGFR)
   05219 Bladder cancer
    1956 (EGFR)
   05215 Prostate cancer
    1956 (EGFR)
   05213 Endometrial cancer
    1956 (EGFR)
   05224 Breast cancer
    1956 (EGFR)
   05223 Non-small cell lung cancer
    1956 (EGFR)
  09172 Infectious disease: viral
   05160 Hepatitis C
    1956 (EGFR)
   05171 Coronavirus disease - COVID-19
    1956 (EGFR)
   05163 Human cytomegalovirus infection
    1956 (EGFR)
   05165 Human papillomavirus infection
    1956 (EGFR)
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    1956 (EGFR)
   05131 Shigellosis
    1956 (EGFR)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1956 (EGFR)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    1956 (EGFR)
   01522 Endocrine resistance
    1956 (EGFR)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1956 (EGFR)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    1956 (EGFR)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     1956 (EGFR)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   1956 (EGFR)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   1956 (EGFR)
  Exosomal proteins of pancreatic cancer cells
   1956 (EGFR)
  Exosomal proteins of bladder cancer cells
   1956 (EGFR)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like Kinase-like APH GAPT ABC1 Kdo
Other DBs
NCBI-GeneID: 1956
NCBI-ProteinID: NP_005219
OMIM: 131550
HGNC: 3236
Ensembl: ENSG00000146648
Pharos: P00533(Tclin)
UniProt: P00533 Q504U8 F2YGG7
Structure
LinkDB
Position
7:55019017..55211628
AA seq 1210 aa
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA
NT seq 3633 nt   +upstreamnt  +downstreamnt
atgcgaccctccgggacggccggggcagcgctcctggcgctgctggctgcgctctgcccg
gcgagtcgggctctggaggaaaagaaagtttgccaaggcacgagtaacaagctcacgcag
ttgggcacttttgaagatcattttctcagcctccagaggatgttcaataactgtgaggtg
gtccttgggaatttggaaattacctatgtgcagaggaattatgatctttccttcttaaag
accatccaggaggtggctggttatgtcctcattgccctcaacacagtggagcgaattcct
ttggaaaacctgcagatcatcagaggaaatatgtactacgaaaattcctatgccttagca
gtcttatctaactatgatgcaaataaaaccggactgaaggagctgcccatgagaaattta
caggaaatcctgcatggcgccgtgcggttcagcaacaaccctgccctgtgcaacgtggag
agcatccagtggcgggacatagtcagcagtgactttctcagcaacatgtcgatggacttc
cagaaccacctgggcagctgccaaaagtgtgatccaagctgtcccaatgggagctgctgg
ggtgcaggagaggagaactgccagaaactgaccaaaatcatctgtgcccagcagtgctcc
gggcgctgccgtggcaagtcccccagtgactgctgccacaaccagtgtgctgcaggctgc
acaggcccccgggagagcgactgcctggtctgccgcaaattccgagacgaagccacgtgc
aaggacacctgccccccactcatgctctacaaccccaccacgtaccagatggatgtgaac
cccgagggcaaatacagctttggtgccacctgcgtgaagaagtgtccccgtaattatgtg
gtgacagatcacggctcgtgcgtccgagcctgtggggccgacagctatgagatggaggaa
gacggcgtccgcaagtgtaagaagtgcgaagggccttgccgcaaagtgtgtaacggaata
ggtattggtgaatttaaagactcactctccataaatgctacgaatattaaacacttcaaa
aactgcacctccatcagtggcgatctccacatcctgccggtggcatttaggggtgactcc
ttcacacatactcctcctctggatccacaggaactggatattctgaaaaccgtaaaggaa
atcacagggtttttgctgattcaggcttggcctgaaaacaggacggacctccatgccttt
gagaacctagaaatcatacgcggcaggaccaagcaacatggtcagttttctcttgcagtc
gtcagcctgaacataacatccttgggattacgctccctcaaggagataagtgatggagat
gtgataatttcaggaaacaaaaatttgtgctatgcaaatacaataaactggaaaaaactg
tttgggacctccggtcagaaaaccaaaattataagcaacagaggtgaaaacagctgcaag
gccacaggccaggtctgccatgccttgtgctcccccgagggctgctggggcccggagccc
agggactgcgtctcttgccggaatgtcagccgaggcagggaatgcgtggacaagtgcaac
cttctggagggtgagccaagggagtttgtggagaactctgagtgcatacagtgccaccca
gagtgcctgcctcaggccatgaacatcacctgcacaggacggggaccagacaactgtatc
cagtgtgcccactacattgacggcccccactgcgtcaagacctgcccggcaggagtcatg
ggagaaaacaacaccctggtctggaagtacgcagacgccggccatgtgtgccacctgtgc
catccaaactgcacctacggatgcactgggccaggtcttgaaggctgtccaacgaatggg
cctaagatcccgtccatcgccactgggatggtgggggccctcctcttgctgctggtggtg
gccctggggatcggcctcttcatgcgaaggcgccacatcgttcggaagcgcacgctgcgg
aggctgctgcaggagagggagcttgtggagcctcttacacccagtggagaagctcccaac
caagctctcttgaggatcttgaaggaaactgaattcaaaaagatcaaagtgctgggctcc
ggtgcgttcggcacggtgtataagggactctggatcccagaaggtgagaaagttaaaatt
cccgtcgctatcaaggaattaagagaagcaacatctccgaaagccaacaaggaaatcctc
gatgaagcctacgtgatggccagcgtggacaacccccacgtgtgccgcctgctgggcatc
tgcctcacctccaccgtgcagctcatcacgcagctcatgcccttcggctgcctcctggac
tatgtccgggaacacaaagacaatattggctcccagtacctgctcaactggtgtgtgcag
atcgcaaagggcatgaactacttggaggaccgtcgcttggtgcaccgcgacctggcagcc
aggaacgtactggtgaaaacaccgcagcatgtcaagatcacagattttgggctggccaaa
ctgctgggtgcggaagagaaagaataccatgcagaaggaggcaaagtgcctatcaagtgg
atggcattggaatcaattttacacagaatctatacccaccagagtgatgtctggagctac
ggggtgactgtttgggagttgatgacctttggatccaagccatatgacggaatccctgcc
agcgagatctcctccatcctggagaaaggagaacgcctccctcagccacccatatgtacc
atcgatgtctacatgatcatggtcaagtgctggatgatagacgcagatagtcgcccaaag
ttccgtgagttgatcatcgaattctccaaaatggcccgagacccccagcgctaccttgtc
attcagggggatgaaagaatgcatttgccaagtcctacagactccaacttctaccgtgcc
ctgatggatgaagaagacatggacgacgtggtggatgccgacgagtacctcatcccacag
cagggcttcttcagcagcccctccacgtcacggactcccctcctgagctctctgagtgca
accagcaacaattccaccgtggcttgcattgatagaaatgggctgcaaagctgtcccatc
aaggaagacagcttcttgcagcgatacagctcagaccccacaggcgccttgactgaggac
agcatagacgacaccttcctcccagtgcctgaatacataaaccagtccgttcccaaaagg
cccgctggctctgtgcagaatcctgtctatcacaatcagcctctgaaccccgcgcccagc
agagacccacactaccaggacccccacagcactgcagtgggcaaccccgagtatctcaac
actgtccagcccacctgtgtcaacagcacattcgacagccctgcccactgggcccagaaa
ggcagccaccaaattagcctggacaaccctgactaccagcaggacttctttcccaaggaa
gccaagccaaatggcatctttaagggctccacagctgaaaatgcagaatacctaagggtc
gcgccacaaagcagtgaatttattggagcatga

KEGG   Homo sapiens (human): 2057
Entry
2057              CDS       T01001                                 
Symbol
EPOR, EPO-R
Name
(RefSeq) erythropoietin receptor
  KO
K05079  erythropoietin receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
hsa05200  Pathways in cancer
Network
nt06119  JAK-STAT signaling (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
  Element
N00053  Cytokine-Jak-STAT signaling pathway
Disease
H00236  Congenital polycythemia
Drug target
Darbepoetin alfa: D03651<JP/US>
Erythropoietin (DG00177): D03231<JP/US> D03232<JP> D04032 D10000 D10846 D10847
Methoxy polyethylene glycol-epoetin beta: D09998<JP/US>
Peginesatide (DG00178): D09946 D09947
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    2057 (EPOR)
   04151 PI3K-Akt signaling pathway
    2057 (EPOR)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    2057 (EPOR)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    2057 (EPOR)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2057 (EPOR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    2057 (EPOR)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  Prolactin receptor family
   2057 (EPOR)
SSDB
Motif
Pfam: EpoR_lig-bind fn3
Other DBs
NCBI-GeneID: 2057
NCBI-ProteinID: NP_000112
OMIM: 133171
HGNC: 3416
Ensembl: ENSG00000187266
Pharos: P19235(Tclin)
UniProt: P19235
Structure
LinkDB
Position
19:complement(11377207..11384314)
AA seq 508 aa
MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDL
VCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPL
ELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRY
EVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPV
SLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTH
KGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVG
SEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGAS
AASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGL
SDGPYSNPYENSLIPAAEPLPPSYVACS
NT seq 1527 nt   +upstreamnt  +downstreamnt
atggaccacctcggggcgtccctctggccccaggtcggctccctttgtctcctgctcgct
ggggccgcctgggcgcccccgcctaacctcccggaccccaagttcgagagcaaagcggcc
ttgctggcggcccgggggcccgaagagcttctgtgcttcaccgagcggttggaggacttg
gtgtgtttctgggaggaagcggcgagcgctggggtgggcccgggcaactacagcttctcc
taccagctcgaggatgagccatggaagctgtgtcgcctgcaccaggctcccacggctcgt
ggtgcggtgcgcttctggtgttcgctgcctacagccgacacgtcgagcttcgtgccccta
gagttgcgcgtcacagcagcctccggcgctccgcgatatcaccgtgtcatccacatcaat
gaagtagtgctcctagacgcccccgtggggctggtggcgcggttggctgacgagagcggc
cacgtagtgttgcgctggctcccgccgcctgagacacccatgacgtctcacatccgctac
gaggtggacgtctcggccggcaacggcgcagggagcgtacagagggtggagatcctggag
ggccgcaccgagtgtgtgctgagcaacctgcggggccggacgcgctacaccttcgccgtc
cgcgcgcgtatggctgagccgagcttcggcggcttctggagcgcctggtcggagcctgtg
tcgctgctgacgcctagcgacctggaccccctcatcctgacgctctccctcatcctcgtg
gtcatcctggtgctgctgaccgtgctcgcgctgctctcccaccgccgggctctgaagcag
aagatctggcctggcatcccgagcccagagagcgagtttgaaggcctcttcaccacccac
aagggtaacttccagctgtggctgtaccagaatgatggctgcctgtggtggagcccctgc
acccccttcacggaggacccacctgcttccctggaagtcctctcagagcgctgctggggg
acgatgcaggcagtggagccggggacagatgatgagggccccctgctggagccagtgggc
agtgagcatgcccaggatacctatctggtgctggacaaatggttgctgccccggaacccg
cccagtgaggacctcccagggcctggtggcagtgtggacatagtggccatggatgaaggc
tcagaagcatcctcctgctcatctgctttggcctcgaagcccagcccagagggagcctct
gctgccagctttgagtacactatcctggaccccagctcccagctcttgcgtccatggaca
ctgtgccctgagctgccccctaccccaccccacctaaagtacctgtaccttgtggtatct
gactctggcatctcaactgactacagctcaggggactcccagggagcccaagggggctta
tccgatggcccctactccaacccttatgagaacagccttatcccagccgctgagcctctg
ccccccagctatgtggcttgctcttag

KEGG   Homo sapiens (human): 2690
Entry
2690              CDS       T01001                                 
Symbol
GHR, GHBP, GHIP
Name
(RefSeq) growth hormone receptor
  KO
K05080  growth hormone receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04080  Neuroactive ligand-receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04935  Growth hormone synthesis, secretion and action
Network
nt06324  GHRH-GH-IGF signaling
  Element
N00907  GH-Jak-STAT signaling pathway
N00908  Mutation-inactivated GH to GH-Jak-STAT signaling pathway
N00909  Mutation-inactivated GHR to GH-Jak-STAT signaling pathway
Disease
H00155  Familial hypercholesterolemia
H00254  Growth hormone deficiency
H02037  Laron syndrome
Drug target
Atesidorsen: D11161
Atesidorsen sodium: D11162
Lonapegsomatropin: D11486<US>
Mecasermin: D03297<JP/US>
Mecasermin rinfabate: D04870
Pegvisomant: D05394<JP/US>
Somapacitan: D11194<JP>
Somatrem: D05884
Somatropin: D02691<JP/US>
Somavaratan: D11193
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    2690 (GHR)
   04151 PI3K-Akt signaling pathway
    2690 (GHR)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2690 (GHR)
   04060 Cytokine-cytokine receptor interaction
    2690 (GHR)
 09150 Organismal Systems
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    2690 (GHR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    2690 (GHR)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  Prolactin receptor family
   2690 (GHR)
SSDB
Motif
Pfam: GHBP EpoR_lig-bind fn3
Other DBs
NCBI-GeneID: 2690
NCBI-ProteinID: NP_000154
OMIM: 600946
HGNC: 4263
Ensembl: ENSG00000112964
Pharos: P10912(Tclin)
UniProt: P10912
Structure
LinkDB
Position
5:42423439..42721878
AA seq 638 aa
MDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPE
RETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTS
IWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRN
ADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNY
GEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTVMLFVFLFSKQQRIKMLILPP
VPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDIDEPDEKTEES
DTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGE
ADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSS
LSNIDFYAQVSDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADA
KKCIPVAPHIKVESHIQPSLNQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHI
VQSPQGLILNATALPLPDKEFLSSCGYVSTDQLNKIMP
NT seq 1917 nt   +upstreamnt  +downstreamnt
atggatctctggcagctgctgttgaccttggcactggcaggatcaagtgatgctttttct
ggaagtgaggccacagcagctatccttagcagagcaccctggagtctgcaaagtgttaat
ccaggcctaaagacaaattcttctaaggagcctaaattcaccaagtgccgttcacctgag
cgagagactttttcatgccactggacagatgaggttcatcatggtacaaagaacctagga
cccatacagctgttctataccagaaggaacactcaagaatggactcaagaatggaaagaa
tgccctgattatgtttctgctggggaaaacagctgttactttaattcatcgtttacctcc
atctggataccttattgtatcaagctaactagcaatggtggtacagtggatgaaaagtgt
ttctctgttgatgaaatagtgcaaccagatccacccattgccctcaactggactttactg
aacgtcagtttaactgggattcatgcagatatccaagtgagatgggaagcaccacgcaat
gcagatattcagaaaggatggatggttctggagtatgaacttcaatacaaagaagtaaat
gaaactaaatggaaaatgatggaccctatattgacaacatcagttccagtgtactcattg
aaagtggataaggaatatgaagtgcgtgtgagatccaaacaacgaaactctggaaattat
ggcgagttcagtgaggtgctctatgtaacacttcctcagatgagccaatttacatgtgaa
gaagatttctactttccatggctcttaattattatctttggaatatttgggctaacagtg
atgctatttgtattcttattttctaaacagcaaaggattaaaatgctgattctgccccca
gttccagttccaaagattaaaggaatcgatccagatctcctcaaggaaggaaaattagag
gaggtgaacacaatcttagccattcatgatagctataaacccgaattccacagtgatgac
tcttgggttgaatttattgagctagatattgatgagccagatgaaaagactgaggaatca
gacacagacagacttctaagcagtgaccatgagaaatcacatagtaacctaggggtgaag
gatggcgactctggacgtaccagctgttgtgaacctgacattctggagactgatttcaat
gccaatgacatacatgagggtacctcagaggttgctcagccacagaggttaaaaggggaa
gcagatctcttatgccttgaccagaagaatcaaaataactcaccttatcatgatgcttgc
cctgctactcagcagcccagtgttatccaagcagagaaaaacaaaccacaaccacttcct
actgaaggagctgagtcaactcaccaagctgcccatattcagctaagcaatccaagttca
ctgtcaaacatcgacttttatgcccaggtgagcgacattacaccagcaggtagtgtggtc
ctttccccgggccaaaagaataaggcagggatgtcccaatgtgacatgcacccggaaatg
gtctcactctgccaagaaaacttccttatggacaatgcctacttctgtgaggcagatgcc
aaaaagtgcatccctgtggctcctcacatcaaggttgaatcacacatacagccaagctta
aaccaagaggacatttacatcaccacagaaagccttaccactgctgctgggaggcctggg
acaggagaacatgttccaggttctgagatgcctgtcccagactatacctccattcatata
gtacagtccccacagggcctcatactcaatgcgactgccttgcccttgcctgacaaagag
tttctctcatcatgtggctatgtgagcacagaccaactgaacaaaatcatgccttag

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