Homo sapiens (human): 125981 Help Entry 125981            CDS       T01001                                  Symbol ACER1, ALKCDase1, ASAH3 Name (RefSeq) alkaline ceramidase 1   KO K01441   alkaline ceramidase [EC:3.5.1.23] Organism hsa  Homo sapiens (human) Pathway hsa00600   Sphingolipid metabolism hsa01100   Metabolic pathways hsa04071   Sphingolipid signaling pathway Module hsa_M00099   Sphingosine biosynthesis Network nt06014  Sphingolipid degradation   Element N00649   Hydrolysis of sphingomyelin Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00600 Sphingolipid metabolism     125981 (ACER1)  09130 Environmental Information Processing   09132 Signal transduction    04071 Sphingolipid signaling pathway     125981 (ACER1) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.1  In linear amides     3.5.1.23  ceramidase      125981 (ACER1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Ceramidase Motif Other DBs NCBI-GeneID:  125981 NCBI-ProteinID:  NP_597999 OMIM:  613491 HGNC:  18356 Ensembl:  ENSG00000167769 Pharos:  Q8TDN7(Tbio) UniProt:  Q8TDN7 LinkDB All DBs Position 19:complement(6306142..6360368) Genome browser AA seq 264 aa AA seqDB search MPSIFAYQSSEVDWCESNFQYSELVAEFYNTFSNIPFFIFGPLMMLLMHPYAQKRSRYIY VVWVLFMIIGLFSMYFHMTLSFLGQLLDEIAILWLLGSGYSIWMPRCYFPSFLGGNRSQF IRLVFITTVVSTLLSFLRPTVNAYALNSIALHILYIVCQEYRKTSNKELRHLIEVSVVLW AVALTSWISDRLLCSFWQRIHFFYLHSIWHVLISITFPYGMVTMALVDANYEMPGETLKV RYWPRDSWPVGLPYVEIRGDDKDC NT seq 795 nt NT seq  +upstreamnt  +downstreamnt atgcctagcatcttcgcctatcagagctccgaggtggactggtgtgagagcaacttccag tactcggagctggtggccgagttctacaacacgttctccaatatccccttcttcatcttc gggccactgatgatgctcctgatgcacccgtatgcccagaagcgctcccgctacatttac gttgtctgggtcctcttcatgatcataggcctgttctccatgtatttccacatgacgctc agcttcctgggccagctgctggacgagatcgccatcctgtggctcctgggcagtggctat agcatatggatgccccgctgctatttcccctccttccttggggggaacaggtcccagttc atccgcctggtcttcatcaccactgtggtcagcacccttctgtccttcctgcggcccacg gtcaacgcctacgccctcaacagcattgccctgcacattctctacatcgtgtgccaggag tacaggaagaccagcaataaggagcttcggcacctgattgaggtctccgtggttttatgg gctgttgctctgaccagctggatcagtgaccgtctgctttgcagcttctggcagaggatt catttcttctatctgcacagcatctggcatgtgctcatcagcatcaccttcccttatggc atggtcaccatggccttggtggatgccaactatgagatgccaggtgaaaccctcaaagtc cgctactggcctcgggacagttggcccgtggggctgccctacgtggaaatccggggtgat gacaaggactgctga

Homo sapiens (human): 340485 Help Entry 340485            CDS       T01001                                  Symbol ACER2, ALKCDase2, ASAH3L Name (RefSeq) alkaline ceramidase 2   KO K01441   alkaline ceramidase [EC:3.5.1.23] Organism hsa  Homo sapiens (human) Pathway hsa00600   Sphingolipid metabolism hsa01100   Metabolic pathways hsa04071   Sphingolipid signaling pathway Module hsa_M00099   Sphingosine biosynthesis Network nt06014  Sphingolipid degradation   Element N00649   Hydrolysis of sphingomyelin Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00600 Sphingolipid metabolism     340485 (ACER2)  09130 Environmental Information Processing   09132 Signal transduction    04071 Sphingolipid signaling pathway     340485 (ACER2) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.1  In linear amides     3.5.1.23  ceramidase      340485 (ACER2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Ceramidase Motif Other DBs NCBI-GeneID:  340485 NCBI-ProteinID:  NP_001010887 OMIM:  613492 HGNC:  23675 Ensembl:  ENSG00000177076 Pharos:  Q5QJU3(Tchem) UniProt:  Q5QJU3 B3KVV5 LinkDB All DBs Position 9:19409009..19452505 Genome browser AA seq 275 aa AA seqDB search MGAPHWWDQLQAGSSEVDWCEDNYTIVPAIAEFYNTISNVLFFILPPICMCLFRQYATCF NSGIYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAVLWVLMCALAMWFPRRYLPKIFRN DRGRFKVVVSVLSAVTTCLAFVKPAINNISLMTLGVPCTALLIAELKRCDNMRVFKLGLF SGLWWTLALFCWISDRAFCELLSSFNFPYLHCMWHILICLAAYLGCVCFAYFDAASEIPE QGPVIKFWPNEKWAFIGVPYVSLLCANKKSSVKIT NT seq 828 nt NT seq  +upstreamnt  +downstreamnt atgggcgccccgcactggtgggaccagctgcaggctggtagctcggaggtggactggtgc gaggacaactacaccatcgtgcctgctatcgccgagttctacaacacgatcagcaatgtc ttatttttcattttaccgcccatctgcatgtgcttgtttcgtcagtatgcaacatgcttc aacagtggcatctacttaatctggactcttttggttgtagtgggaattggatccgtctac ttccatgcaacccttagtttcttgggtcagatgcttgatgaacttgcagtcctttgggtt ctgatgtgtgctttggccatgtggttccccagaaggtatctaccaaagatctttcggaat gaccggggtaggttcaaggtggtggtcagtgtcctgtctgcggttacgacgtgcctggca tttgtcaagcctgccatcaacaacatctctctgatgaccctgggagttccttgcactgca ctgctcatcgcagagctaaagaggtgtgacaacatgcgtgtgtttaagctgggcctcttc tcgggcctctggtggaccctggccctgttctgctggatcagtgaccgagctttctgcgag ctgctgtcatccttcaacttcccctacctgcactgcatgtggcacatcctcatctgcctt gctgcctacctgggctgtgtatgctttgcctactttgatgctgcctcagagattcctgag caaggccctgtcatcaagttctggcccaatgagaaatgggccttcattggtgtcccctat gtgtccctcctgtgtgccaacaagaaatcatcagtcaagatcacgtga

Homo sapiens (human): 427 Help Entry 427               CDS       T01001                                  Symbol ASAH1, AC, ACDase, ASAH, PHP, PHP32, SMAPME Name (RefSeq) N-acylsphingosine amidohydrolase 1   KO K12348   acid ceramidase [EC:3.5.1.23] Organism hsa  Homo sapiens (human) Pathway hsa00600   Sphingolipid metabolism hsa01100   Metabolic pathways hsa04071   Sphingolipid signaling pathway hsa04142   Lysosome Module hsa_M00099   Sphingosine biosynthesis Network nt06014  Sphingolipid degradation   Element N00649   Hydrolysis of sphingomyelin Disease H00138   Farber lipogranulomatosis H00423   Sphingolipidosis H00424   Defects in the degradation of sphingomyelin Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00600 Sphingolipid metabolism     427 (ASAH1)  09130 Environmental Information Processing   09132 Signal transduction    04071 Sphingolipid signaling pathway     427 (ASAH1)  09140 Cellular Processes   09141 Transport and catabolism    04142 Lysosome     427 (ASAH1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     427 (ASAH1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     427 (ASAH1) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.1  In linear amides     3.5.1.23  ceramidase      427 (ASAH1) Peptidases and inhibitors [BR:hsa01002]  Cysteine peptidases   Family C89    427 (ASAH1) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    427 (ASAH1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  CBAH NAAA-beta AAT DUF502 HP_OMP Motif Other DBs NCBI-GeneID:  427 NCBI-ProteinID:  NP_808592 OMIM:  613468 HGNC:  735 Ensembl:  ENSG00000104763 Pharos:  Q13510(Tchem) UniProt:  Q13510 Q53H01 A8K0B6 Structure PDBPDBj LinkDB All DBs Position 8:complement(18055992..18084961) Genome browser AA seq 395 aa AA seqDB search MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYK RWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIA AVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITE QLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWI LGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKE SLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLST KPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW NT seq 1188 nt NT seq  +upstreamnt  +downstreamnt atgccgggccggagttgcgtcgccttagtcctcctggctgccgccgtcagctgtgccgtc gcgcagcacgcgccgccgtggacagaggactgcagaaaatcaacctatcctccttcagga ccaacgtacagaggtgcagttccatggtacaccataaatcttgacttaccaccctacaaa agatggcatgaattgatgcttgacaaggcaccagtgctaaaggttatagtgaattctctg aagaatatgataaatacattcgtgccaagtggaaaaattatgcaggtggtggatgaaaaa ttgcctggcctacttggcaactttcctggcccttttgaagaggaaatgaagggtattgcc gctgttactgatatacctttaggagagattatttcattcaatattttttatgaattattt accatttgtacttcaatagtagcagaagacaaaaaaggtcatctaatacatgggagaaac atggattttggagtatttcttgggtggaacataaataatgatacctgggtcataactgag caactaaaacctttaacagtgaatttggatttccaaagaaacaacaaaactgtcttcaag gcttcaagctttgctggctatgtgggcatgttaacaggattcaaaccaggactgttcagt cttacactgaatgaacgtttcagtataaatggtggttatctgggtattctagaatggatt ctgggaaagaaagatgtcatgtggatagggttcctcactagaacagttctggaaaatagc acaagttatgaagaagccaagaatttattgaccaagaccaagatattggccccagcctac tttatcctgggaggcaaccagtctggggaaggttgtgtgattacacgagacagaaaggaa tcattggatgtatatgaactcgatgctaagcagggtagatggtatgtggtacaaacaaat tatgaccgttggaaacatcccttcttccttgatgatcgcagaacgcctgcaaagatgtgt ctgaaccgcaccagccaagagaatatctcatttgaaaccatgtatgatgtcctgtcaaca aaacctgtcctcaacaagctgaccgtatacacaaccttgatagatgttaccaaaggtcaa ttcgaaacttacctgcgggactgccctgacccttgtataggttggtga

Homo sapiens (human): 56624 Help Entry 56624             CDS       T01001                                  Symbol ASAH2, BCDase, HNAC1, LCDase, N-CDase, NCDase Name (RefSeq) N-acylsphingosine amidohydrolase 2   KO K12349   neutral ceramidase [EC:3.5.1.23] Organism hsa  Homo sapiens (human) Pathway hsa00600   Sphingolipid metabolism hsa01100   Metabolic pathways hsa04071   Sphingolipid signaling pathway Module hsa_M00099   Sphingosine biosynthesis Network nt06014  Sphingolipid degradation   Element N00649   Hydrolysis of sphingomyelin Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00600 Sphingolipid metabolism     56624 (ASAH2)  09130 Environmental Information Processing   09132 Signal transduction    04071 Sphingolipid signaling pathway     56624 (ASAH2) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.1  In linear amides     3.5.1.23  ceramidase      56624 (ASAH2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Ceramidase_alk Ceramidse_alk_C Pga1 Motif Other DBs NCBI-GeneID:  56624 NCBI-ProteinID:  NP_063946 OMIM:  611202 HGNC:  18860 Ensembl:  ENSG00000188611 Pharos:  Q9NR71(Tbio) UniProt:  Q9NR71 Structure PDBPDBj LinkDB All DBs Position 10:complement(50184861..50251516) Genome browser AA seq 780 aa AA seqDB search MAKRTFSNLETFLIFLLVMMSAITVALLSLLFITSGTIENHKDLGGHFFSTTQSPPATQG STAAQRSTATQHSTATQSSTATQTSPVPLTPESPLFQNFSGYHIGVGRADCTGQVADINL MGYGKSGQNAQGILTRLYSRAFIMAEPDGSNRTVFVSIDIGMVSQRLRLEVLNRLQSKYG SLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHMVTGILKSIDIAHTNMKP GKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIVLKMVDLNGDDLGLISWF AIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQGPFVAAFASSNLGDVSPNILGP RCINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQIIGRAMYQRAKELYASASQEVT GPLASAHQWVDMTDVTVWLNSTHASKTCKPALGYSFAAGTIDGVGGLNFTQGKTEGDPFW DTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWHPDIVDVQIITLGSLAITAIPGE FTTMSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTHYITTYEEYQAQRYEAASTIYGP HTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLIVPLIPSIVDRAPKGRTFGDVLQ PAKPEYRVGEVAEVIFVGANPKNSVQNQTHQTFLTVEKYEATSTSWQIVCNDASWETRFY WHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQDILKPAVILSFEGTSPAFEVVTI NT seq 2343 nt NT seq  +upstreamnt  +downstreamnt atggccaaacgcaccttctctaacttggagacattcctgattttcctccttgtaatgatg agtgccatcacagtggcccttctcagcctcttgtttatcaccagtgggaccattgaaaac cacaaagatttaggaggccattttttttcaaccacccaaagccctccagccacccagggc tccacagctgcccaacgctccacagccacccagcattccacagccacccagagctccaca gccactcaaacttctccagtgcctttaaccccagagtctcctctatttcagaacttcagt ggctaccatattggtgttggacgagctgactgcacaggacaagtagcagatatcaatttg atgggctatggcaaatccggccagaatgcacagggcatcctcaccaggctatacagtcgt gccttcatcatggcagaacctgatgggtccaatcgaacagtgtttgtcagcatcgacata ggcatggtatcacaaaggctcaggctggaggtcctgaacagactgcagagtaaatatggc tccctgtacagaagagataatgtcatcctgagtggcactcacactcattcaggtcctgca ggatatttccagtataccgtgtttgtaattgccagtgaaggatttagcaatcaaactttt cagcacatggtcactggtatcttgaagagcattgacatagcacacacaaatatgaaacca ggcaaaatcttcatcaataaaggaaatgtggatggtgtgcagatcaacagaagtccgtat tcttaccttcaaaatccgcagtcagagagagcaaggtattcttcaaatacagacaaggaa atgatagttttgaaaatggtagatttgaatggagatgacttgggccttatcagctggttt gccatccacccggtcagcatgaacaacagtaaccatcttgtaaacagtgacaatgtgggc tatgcatcttacctgcttgagcaagagaagaacaaaggatatctacctggacaggggcca tttgtagcagcctttgcttcatcaaacctaggagatgtgtcccccaacattcttggacca cgttgcatcaacacaggagagtcctgtgataacgccaatagcacttgtcccattggtggg cctagcatgtgcattgctaagggacctggacaggatatgtttgacagcacacaaattata ggacgggccatgtatcagagagcaaaggaactctatgcctctgcctcccaggaggtaaca ggaccactggcttcagcacaccagtgggtggatatgacagatgtgactgtctggctcaat tccacacatgcatcaaaaacatgtaaaccagcattgggctacagttttgcagctggcact attgatggagttggaggcctcaattttacacaggggaaaacagaaggggatccattttgg gacaccattcgggaccagatcctgggaaagccatctgaagaaattaaagaatgtcataaa ccaaagcccatccttcttcacaccggagaactatcaaaacctcacccctggcatccagac attgttgatgttcagattattacccttgggtccttggccataactgccatccccggggag tttacgaccatgtctggacgaagacttcgagaggcagttcaagcagaatttgcatctcat gggatgcagaacatgactgttgttatttcaggtctatgcaacgtctatacacattacatt accacttatgaagaataccaggctcagcgatatgaggcagcatcgacaatttatggaccg cacacattatctgcttacattcagctcttcagaaaccttgctaaggctattgctacggac acggtagccaacctgagcagaggtccagaacctccctttttcaaacaattaatagttcca ttaattcctagtattgtggatagagcaccaaaaggcagaactttcggggatgtcctgcag ccagcaaaacctgaatacagagtgggggaagttgctgaagttatatttgtaggtgctaac ccgaagaattcagtacaaaaccagacccatcagaccttcctcactgtggagaaatatgag gctacttcaacatcgtggcagatagtgtgtaatgatgcctcctgggagactcgtttttat tggcacaagggactcctgggtctgagtaatgcaacagtggaatggcatattccagacact gcccagcctggaatctacagaataagatattttggacacaatcggaagcaggacattctg aagcctgctgtcatactttcatttgaaggcacttccccggcttttgaagttgtaactatt tag

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