KEGG   Homo sapiens (human): 131890
Entry
131890            CDS       T01001                                 

Gene name
GRK7, GPRK7
Definition
(RefSeq) G protein-coupled receptor kinase 7
  KO
K00909  rhodopsin kinase [EC:2.7.11.14]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
hsa04744  Phototransduction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    131890 (GRK7)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    131890 (GRK7)
  09157 Sensory system
   04744 Phototransduction
    131890 (GRK7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    131890 (GRK7)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.14  rhodopsin kinase
     131890 (GRK7)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  GRK family [OT]
   131890 (GRK7)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RGS Kinase-like
Other DBs
NCBI-GeneID: 131890
NCBI-ProteinID: NP_631948
OMIM: 606987
HGNC: 17031
Ensembl: ENSG00000114124
Vega: OTTHUMG00000159068
Pharos: Q8WTQ7(Tchem)
UniProt: Q8WTQ7
LinkDB
Position
3q23
AA seq 553 aa
MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLC
EQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPG
NPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKL
FEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEK
EILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQI
ACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPE
ILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFT
EEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYA
KDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCE
EGNSSKSGVCLLL
NT seq 1662 nt   +upstreamnt  +downstreamnt
atggtggacatgggggccctggacaacctgatcgccaacaccgcctacctgcaggcccgg
aagccctcggactgcgacagcaaagagctgcagcggcggcggcgtagcctggccctgccc
gggctgcagggctgcgcggagctccgccagaagctgtccctgaacttccacagcctgtgt
gagcagcagcccatcggtcgccgcctcttccgtgacttcctagccacagtgcccacgttc
cgcaaggcggcaaccttcctagaggacgtgcagaactgggagctggccgaggagggaccc
accaaagacagcgcgctgcaggggctggtggccacttgtgcgagtgcccctgccccgggg
aacccgcaacccttcctcagccaggccgtggccaccaagtgccaagcagccaccactgag
gaagagcgagtggctgcagtgacgctggccaaggctgaggccatggctttcttgcaagag
cagccctttaaggatttcgtgaccagcgccttctacgacaagtttctgcagtggaaactc
ttcgagatgcaaccagtgtcagacaagtacttcactgagttcagagtgctggggaaaggt
ggttttggggaggtatgtgccgtccaggtgaaaaacactgggaagatgtatgcctgtaag
aaactggacaagaagcggctgaagaagaaaggtggcgagaagatggctctcttggaaaag
gaaatcttggagaaggtcagcagccctttcattgtctctctggcctatgcctttgagagc
aagacccatctctgccttgtcatgagcctgatgaatgggggagacctcaagttccacatc
tacaacgtgggcacgcgtggcctggacatgagccgggtgatcttttactcggcccagata
gcctgtgggatgctgcacctccatgaactcggcatcgtctatcgggacatgaagcctgag
aatgtgcttctggatgacctcggcaactgcaggttatctgacctggggctggccgtggag
atgaagggtggcaagcccatcacccagagggctggaaccaatggttacatggctcctgag
atcctaatggaaaaggtaagttattcctatcctgtggactggtttgccatgggatgcagc
atttatgaaatggttgctggacgaacaccattcaaagattacaaggaaaaggtcagtaaa
gaggatctgaagcaaagaactctgcaagacgaggtcaaattccagcatgataacttcaca
gaggaagcaaaagatatttgcaggctcttcttggctaagaaaccagagcaacgcttagga
agcagagaaaagtctgatgatcccaggaaacatcatttctttaaaacgatcaactttcct
cgcctggaagctggcctaattgaacccccatttgtgccagacccttcagtggtttatgcc
aaagacatcgctgaaattgatgatttctctgaggttcggggggtggaatttgatgacaaa
gataagcagttcttcaaaaactttgcgacaggtgctgttcctatagcatggcaggaagaa
attatagaaacgggactgtttgaggaactgaatgaccccaacagacctacgggttgtgag
gagggtaattcatccaagtctggcgtgtgtttgttattgtaa

KEGG   Homo sapiens (human): 6011
Entry
6011              CDS       T01001                                 

Gene name
GRK1, GPRK1, RHOK, RK
Definition
(RefSeq) G protein-coupled receptor kinase 1
  KO
K00909  rhodopsin kinase [EC:2.7.11.14]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
hsa04744  Phototransduction
Disease
H00787  Congenital stationary night blindness
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    6011 (GRK1)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    6011 (GRK1)
  09157 Sensory system
   04744 Phototransduction
    6011 (GRK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    6011 (GRK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.14  rhodopsin kinase
     6011 (GRK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  GRK family [OT]
   6011 (GRK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RGS Pkinase_fungal Kinase-like
Other DBs
NCBI-GeneID: 6011
NCBI-ProteinID: NP_002920
OMIM: 180381
HGNC: 10013
Ensembl: ENSG00000185974
Vega: OTTHUMG00000185528
Pharos: Q15835(Tchem)
UniProt: Q15835
LinkDB
Structure
PDB: 
5AFP

Position
13q34
AA seq 563 aa
MDFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFES
VCLEQPIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAK
LFCSFLDEGIVAKFKEGPVEIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWL
EAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKK
ILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQ
IICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMA
PELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFS
QASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVY
AKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQM
PDDMKGISGGSSSSSKSGMCLVS
NT seq 1692 nt   +upstreamnt  +downstreamnt
atggatttcgggtctttggagaccgtggtggccaactctgccttcatcgccgcccgaggc
agctttgacggcagcagctcccaaccctcccgggacaagaagtacctggccaagctcaag
ctgcccccgctgtccaagtgtgagtccctccgcgacagcctcagcctggagtttgagagt
gtgtgcttggagcagcccatcggcaagaagctctttcagcagttcctacaatcggcagag
aagcacctgccggccctggagctctggaaagacatcgaggactatgacacggcagacaat
gacctccagccacagaaggcccagaccatcctggcccagtacctggacccccaggccaaa
ctcttctgcagcttcctggatgaggggatagtggcgaagtttaaggaggggcctgtggag
atccaggacgggctcttccagcccctgctgcaggccaccctggcacacctgggccaagcc
cccttccaggagtacctgggcagcctgtacttcctgaggttcctgcagtggaagtggctg
gaagcccagcccatgggggaggactggttcctggacttcagggtcctagggaaagggggc
ttcggggaggtgtcggcctgccagatgaaggcgaccggcaagctgtatgcctgcaagaag
ctgaacaagaagcggctgaagaagaggaagggctaccagggtgctatggtggagaagaag
attctgatgaaagtacacagcaggttcatcgtgtctctggcctatgcgtttgaaaccaaa
gccgacctctgtctggtgatgaccatcatgaacggaggtgacatcaggtaccacatctac
aacgtgaatgaggagaaccctggcttcccggagccgcgcgccctcttctacacggcgcag
atcatctgcggcctggagcacctgcaccagaggcggatcgtctaccgcgacctcaagccc
gagaacgtgctgctggacaatgacggcaatgtccggatctctgaccttgggctggccgtg
gagctgctggacggacagagcaagaccaagggctacgcagggaccccaggtttcatggcc
cccgagctcctgcagggcgaggagtacgacttctccgtggactactttgccctgggggtc
accctgtatgagatgattgcggccagaggacccttccgagcccgtggagagaaggtggag
aacaaggagctgaagcaccggatcatctcagagcccgtgaagtaccctgataagttcagc
caggccagcaaggacttctgcgaggcgctgctggagaaggacccggagaagcgcctgggg
ttcagagatgagacctgcgacaagctccgtgcccaccccctcttcaaggaccttaactgg
aggcagctggaggctgggatgctgatgccccctttcatcccagactccaaaactgtctac
gcaaaggatattcaggacgtgggtgccttttccaccgtcaaaggtgtggcctttgacaaa
acagacacagaattctttcaggaatttgccactggcaactgccccatcccctggcaggag
gagatgatcgagacgggcatctttggcgagctgaacgtgtggcgctcggacggtcagatg
ccggacgacatgaagggcatctccgggggctccagctcctcgtccaagtcagggatgtgt
ctggtttcctag

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