KEGG   Homo sapiens (human): 1327
Entry
1327              CDS       T01001                                 
Symbol
COX4I1, COX_IV-1, COX4, COX4-1, COXIV, COXIV-1, MC4DN16
Name
(RefSeq) cytochrome c oxidase subunit 4I1
  KO
K02263  cytochrome c oxidase subunit 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06252  Mitochondrial ROS formation (cancer)
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06529  Thermogenesis
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
N01394  Arsenic to electron transfer in complex IV
N01691  mitochondrial complex - UCP1 in Thermogenesis
Disease
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1327 (COX4I1)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1327 (COX4I1)
  09159 Environmental adaptation
   04714 Thermogenesis
    1327 (COX4I1)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    1327 (COX4I1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1327 (COX4I1)
   05012 Parkinson disease
    1327 (COX4I1)
   05014 Amyotrophic lateral sclerosis
    1327 (COX4I1)
   05016 Huntington disease
    1327 (COX4I1)
   05020 Prion disease
    1327 (COX4I1)
   05022 Pathways of neurodegeneration - multiple diseases
    1327 (COX4I1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    1327 (COX4I1)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    1327 (COX4I1)
SSDB
Motif
Pfam: COX4
Other DBs
NCBI-GeneID: 1327
NCBI-ProteinID: NP_001305715
OMIM: 123864
HGNC: 2265
Ensembl: ENSG00000131143
Pharos: P13073(Tbio)
UniProt: P13073 Q86WV2
Structure
LinkDB
Position
16:85799695..85807068
AA seq 169 aa
MLATRVFSLVGKRAISTSVCVRAHESVVKSEDFSLPAYMDRRDHPLPEVAHVKHLSASQK
ALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMW
QKHYVYGPLPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWKK
NT seq 510 nt   +upstreamnt  +downstreamnt
atgttggctaccagggtatttagcctagttggcaagcgagcaatttccacctctgtgtgt
gtacgagctcatgaaagtgttgtgaagagcgaagacttttcgctcccagcttatatggat
cggcgtgaccaccccttgccggaggtggcccatgtcaagcacctgtctgccagccagaag
gcattgaaggagaaggagaaggcctcctggagcagcctctccatggatgagaaagtcgag
ttgtatcgcattaagttcaaggagagctttgctgagatgaacaggggctcgaacgagtgg
aagacggttgtgggcggtgccatgttcttcatcggtttcaccgcgctcgttatcatgtgg
cagaagcactatgtgtacggccccctcccgcaaagctttgacaaagagtgggtggccaag
cagaccaagaggatgctggacatgaaggtgaaccccatccagggcttagcctccaagtgg
gactacgaaaagaacgagtggaagaagtga

KEGG   Homo sapiens (human): 9377
Entry
9377              CDS       T01001                                 
Symbol
COX5A, COX, COX-VA, MC4DN20, VA
Name
(RefSeq) cytochrome c oxidase subunit 5A
  KO
K02264  cytochrome c oxidase subunit 5a
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06252  Mitochondrial ROS formation (cancer)
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06529  Thermogenesis
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
N01394  Arsenic to electron transfer in complex IV
N01691  mitochondrial complex - UCP1 in Thermogenesis
Disease
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    9377 (COX5A)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    9377 (COX5A)
  09159 Environmental adaptation
   04714 Thermogenesis
    9377 (COX5A)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    9377 (COX5A)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    9377 (COX5A)
   05012 Parkinson disease
    9377 (COX5A)
   05014 Amyotrophic lateral sclerosis
    9377 (COX5A)
   05016 Huntington disease
    9377 (COX5A)
   05020 Prion disease
    9377 (COX5A)
   05022 Pathways of neurodegeneration - multiple diseases
    9377 (COX5A)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    9377 (COX5A)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    9377 (COX5A)
SSDB
Motif
Pfam: COX5A Anticodon_3
Other DBs
NCBI-GeneID: 9377
NCBI-ProteinID: NP_004246
OMIM: 603773
HGNC: 2267
Ensembl: ENSG00000178741
Pharos: P20674(Tbio)
UniProt: P20674
Structure
LinkDB
Position
15:complement(74919791..74938073)
AA seq 150 aa
MLGAALRRCAVAATTRADPRGLLHSARTPGPAVAIQSVRCYSHGSQETDEEFDARWVTYF
NKPDIDAWELRKGINTLVTYDMVPEPKIIDAALRACRRLNDFASTVRILEVVKDKAGPHK
EIYPYVIQELRPTLNELGISTPEELGLDKV
NT seq 453 nt   +upstreamnt  +downstreamnt
atgctgggcgccgctctccgccgctgcgctgtggccgcaaccacccgggccgaccctcga
ggcctcctgcactccgcccggacccccggccccgccgtggctatccagtcagttcgctgc
tattcccatgggtcacaggagacagatgaggagtttgatgctcgctgggtaacatacttc
aacaagccagatatagatgcctgggaattgcgtaaagggataaacacacttgttacctat
gatatggttccagagcccaaaatcattgatgctgctttgcgggcatgcagacggttaaat
gattttgctagtacagttcgtatcctagaggttgttaaggacaaagcaggacctcataag
gaaatctacccctatgtcatccaggaacttagaccaactttaaatgaactgggaatctcc
actccggaggaactgggccttgacaaagtgtaa

KEGG   Homo sapiens (human): 1339
Entry
1339              CDS       T01001                                 
Symbol
COX6A2, COX6AH, COXVIAH, COXVIa-M, MC4DN18
Name
(RefSeq) cytochrome c oxidase subunit 6A2
  KO
K02266  cytochrome c oxidase subunit 6a
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06252  Mitochondrial ROS formation (cancer)
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06529  Thermogenesis
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
N01394  Arsenic to electron transfer in complex IV
N01691  mitochondrial complex - UCP1 in Thermogenesis
Disease
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1339 (COX6A2)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1339 (COX6A2)
  09159 Environmental adaptation
   04714 Thermogenesis
    1339 (COX6A2)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    1339 (COX6A2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1339 (COX6A2)
   05012 Parkinson disease
    1339 (COX6A2)
   05014 Amyotrophic lateral sclerosis
    1339 (COX6A2)
   05016 Huntington disease
    1339 (COX6A2)
   05020 Prion disease
    1339 (COX6A2)
   05022 Pathways of neurodegeneration - multiple diseases
    1339 (COX6A2)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    1339 (COX6A2)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    1339 (COX6A2)
SSDB
Motif
Pfam: COX6A
Other DBs
NCBI-GeneID: 1339
NCBI-ProteinID: NP_005196
OMIM: 602009
HGNC: 2279
Ensembl: ENSG00000156885
Pharos: Q02221(Tbio)
UniProt: Q02221
LinkDB
Position
16:complement(31427731..31428360)
AA seq 97 aa
MALPLRPLTRGLASAAKGGHGGAGARTWRLLTFVLALPSVALCTFNSYLHSGHRPRPEFR
PYQHLRIRTKPYPWGDGNHTLFHNSHVNPLPTGYEHP
NT seq 294 nt   +upstreamnt  +downstreamnt
atggctttgcctctgaggcccctgacccggggcttggccagcgctgccaaaggaggccac
ggaggagcaggagctcgtacctggcgtctgctgaccttcgtgctggcgctgcccagcgtg
gccctctgcaccttcaactcctatctccactcgggccaccgcccgcgccccgagttccgt
ccctaccaacacctccgcatccgcaccaagccctacccctggggggacggcaaccacact
ctgttccacaatagccacgtgaaccctctgcccacgggctacgaacacccctga

KEGG   Homo sapiens (human): 1340
Entry
1340              CDS       T01001                                 
Symbol
COX6B1, COX6B, COXG, COXVIb1, MC4DN7
Name
(RefSeq) cytochrome c oxidase subunit 6B1
  KO
K02267  cytochrome c oxidase subunit 6b
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06252  Mitochondrial ROS formation (cancer)
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06529  Thermogenesis
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
N01394  Arsenic to electron transfer in complex IV
N01691  mitochondrial complex - UCP1 in Thermogenesis
Disease
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1340 (COX6B1)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1340 (COX6B1)
  09159 Environmental adaptation
   04714 Thermogenesis
    1340 (COX6B1)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    1340 (COX6B1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1340 (COX6B1)
   05012 Parkinson disease
    1340 (COX6B1)
   05014 Amyotrophic lateral sclerosis
    1340 (COX6B1)
   05016 Huntington disease
    1340 (COX6B1)
   05020 Prion disease
    1340 (COX6B1)
   05022 Pathways of neurodegeneration - multiple diseases
    1340 (COX6B1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    1340 (COX6B1)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    1340 (COX6B1)
SSDB
Motif
Pfam: COX6B YozE_SAM_like
Other DBs
NCBI-GeneID: 1340
NCBI-ProteinID: NP_001854
OMIM: 124089
HGNC: 2280
Ensembl: ENSG00000126267
Pharos: P14854(Tbio)
UniProt: P14854
Structure
LinkDB
Position
19:35648323..35658782
AA seq 86 aa
MAEDMETKIKNYKTAPFDSRFPNQNQTRNCWQNYLDFHRCQKAMTAKGGDISVCEWYQRV
YQSLCPTSWVTDWDEQRAEGTFPGKI
NT seq 261 nt   +upstreamnt  +downstreamnt
atggcggaagacatggagaccaaaatcaagaactacaagaccgccccttttgacagccgc
ttccccaaccagaaccagactagaaactgctggcagaactacctggacttccaccgctgt
cagaaggcaatgaccgctaaaggaggcgatatctctgtgtgcgaatggtaccagcgtgtg
taccagtccctctgccccacatcctgggtcacagactgggatgagcaacgggctgaaggc
acgtttcccgggaagatctga

KEGG   Homo sapiens (human): 1351
Entry
1351              CDS       T01001                                 
Symbol
COX8A, COX, COX8, COX8-2, COX8L, MC4DN15, VIII, VIII-L
Name
(RefSeq) cytochrome c oxidase subunit 8A
  KO
K02273  cytochrome c oxidase subunit 8
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06252  Mitochondrial ROS formation (cancer)
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06529  Thermogenesis
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
N01394  Arsenic to electron transfer in complex IV
N01691  mitochondrial complex - UCP1 in Thermogenesis
Disease
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1351 (COX8A)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1351 (COX8A)
  09159 Environmental adaptation
   04714 Thermogenesis
    1351 (COX8A)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    1351 (COX8A)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1351 (COX8A)
   05012 Parkinson disease
    1351 (COX8A)
   05014 Amyotrophic lateral sclerosis
    1351 (COX8A)
   05016 Huntington disease
    1351 (COX8A)
   05020 Prion disease
    1351 (COX8A)
   05022 Pathways of neurodegeneration - multiple diseases
    1351 (COX8A)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    1351 (COX8A)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    1351 (COX8A)
SSDB
Motif
Pfam: COX8
Other DBs
NCBI-GeneID: 1351
NCBI-ProteinID: NP_004065
OMIM: 123870
HGNC: 2294
Ensembl: ENSG00000176340
Pharos: P10176(Tbio)
UniProt: P10176 Q53XN1
Structure
LinkDB
Position
11:63974620..63976543
AA seq 69 aa
MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVTFLLPAGWILS
HLETYRRPE
NT seq 210 nt   +upstreamnt  +downstreamnt
atgtccgtcctgacgccgctgctgctgcggggcttgacaggctcggcccggcggctccca
gtgccgcgcgccaagatccattcgttgccgccggaggggaagcttgggatcatggaattg
gccgttgggcttacctcctgcttcgtgaccttcctcctgccagcgggctggatcctgtca
cacctggagacctacaggaggccagagtga

KEGG   Homo sapiens (human): 1352
Entry
1352              CDS       T01001                                 
Symbol
COX10, MC4DN3
Name
(RefSeq) cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
  KO
K02257  heme o synthase [EC:2.5.1.141]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa00860  Porphyrin metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa04714  Thermogenesis
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06529  Thermogenesis
  Element
N01691  mitochondrial complex - UCP1 in Thermogenesis
Disease
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1352 (COX10)
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    1352 (COX10)
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    1352 (COX10)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases [BR:hsa01006]
    1352 (COX10)
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    1352 (COX10)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.141  heme o synthase
     1352 (COX10)
Prenyltransferases [BR:hsa01006]
 Compound prenylation
  Protoheme farnesyltransferase
   1352 (COX10)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitochondrial respiratory chain complex assembly factors
   Complex-IV assembly factors
    1352 (COX10)
SSDB
Motif
Pfam: UbiA
Other DBs
NCBI-GeneID: 1352
NCBI-ProteinID: NP_001294
OMIM: 602125
HGNC: 2260
Ensembl: ENSG00000006695
Pharos: Q12887(Tbio)
UniProt: Q12887
LinkDB
Position
17:14069504..14208677
AA seq 443 aa
MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMY
VTQLNRSHNQQVRPKPEPVASPFLEKTSSGQAKAEIYEMRPLSPPSLSLSRKPNEKELIE
LEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTALVVSTTAAGFALA
PGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFA
TCCAVPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGW
TAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRH
CLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLP
LLLLLMLTCKRPSGGGDAGPPPS
NT seq 1332 nt   +upstreamnt  +downstreamnt
atggccgcatctccgcacactctctcctcacgcctcctgacaggttgcgtaggaggctct
gtctggtatcttgaaagaagaactatacaggactcccctcacaagttcttacatcttctc
aggaatgtcaataagcagtggattacatttcagcactttagcttcctcaaacgcatgtat
gtcacacagctgaacagaagccacaaccagcaagtaagacccaagccagaaccagtagca
tctcctttccttgaaaaaacatcttcaggtcaagccaaagcagaaatatatgagatgaga
cctctctcaccgcccagcctatctttgtccagaaagccaaatgaaaaggaattgatagaa
ctagagccagactcagtaattgaagactcaatagatgtagggaaagagacaaaagaggaa
aagcggtggaaagagatgaagctgcaagtgtatgatttgccaggaattttggctcgacta
tccaaaatcaaactcacagctctggttgtaagtaccactgcagctggatttgcattggct
ccgggcccttttgactggccctgtttcctgcttacttctgttgggacaggccttgcatcc
tgtgctgccaactccatcaatcagttttttgaggtgccatttgactcaaacatgaatagg
acaaagaacagaccgctggttcgtggacagatcagcccattgctagctgtgtcctttgcc
acttgttgtgctgttccgggagttgccattctgaccttgggggtgaatccactcacagga
gccctggggctcttcaacattttcctgtatacctgctgctacacaccactgaaaaggatc
agcattgccaacacatgggtcggagctgtggttggggccatcccgcctgtcatgggctgg
acagcggccacgggcagcctcgatgctggcgcatttctcctgggaggaatcctctactcc
tggcagtttcctcatttcaacgccctgagctggggcctccgtgaagactactcccggggc
ggctactgcatgatgtcggtcacccacccgggcctgtgccggcgcgtggcgctgcgccac
tgcctggccctgctcgtgctgtccgcagcagcccctgtgctggacatcaccacatggacc
ttccccatcatggcccttcccatcaatgcgtacatctcctacctcggcttccgcttctac
gtggacgcagaccgcaggagctcgcggagactgttcttctgcagcctgtggcacctgccg
ctgctgctgctgctcatgctcacctgcaagcggccgagcggaggcggggacgcagggccc
cctcccagctga

KEGG   Homo sapiens (human): 84987
Entry
84987             CDS       T01001                                 
Symbol
COX14, C12orf62, MC4DN10, PCAG1
Name
(RefSeq) cytochrome c oxidase assembly factor COX14
  KO
K18181  cytochrome c oxidase assembly factor 14
Organism
hsa  Homo sapiens (human)
Pathway
hsa04714  Thermogenesis
Network
nt06529  Thermogenesis
  Element
N01691  mitochondrial complex - UCP1 in Thermogenesis
Disease
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    84987 (COX14)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    84987 (COX14)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitochondrial respiratory chain complex assembly factors
   Complex-IV assembly factors
    84987 (COX14)
SSDB
Motif
Pfam: COX14
Other DBs
NCBI-GeneID: 84987
NCBI-ProteinID: NP_001244062
OMIM: 614478
HGNC: 28216
Ensembl: ENSG00000178449
Pharos: Q96I36(Tbio)
UniProt: Q96I36
LinkDB
Position
12:50112236..50120453
AA seq 57 aa
MPTGKQLADIGYKTFSTSMMLLTVYGGYLCSVRVYHYFQWRRAQRQAAEEQKTSGIM
NT seq 174 nt   +upstreamnt  +downstreamnt
atgccaactggcaagcagctagctgacattggctataagaccttctctacctccatgatg
cttctcactgtgtatggggggtacctctgcagtgtccgagtctaccactatttccagtgg
cgcagggcccagcgccaggccgcagaagaacagaagacctcaggaatcatgtag

KEGG   Homo sapiens (human): 1355
Entry
1355              CDS       T01001                                 
Symbol
COX15, CEMCOX2, HAS, MC4DN6
Name
(RefSeq) cytochrome c oxidase assembly homolog COX15
  KO
K02259  heme a synthase [EC:1.17.99.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa00860  Porphyrin metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa04714  Thermogenesis
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06529  Thermogenesis
  Element
N01691  mitochondrial complex - UCP1 in Thermogenesis
Disease
H01200  Fatal infantile cardioencephalomyopathy
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1355 (COX15)
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    1355 (COX15)
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    1355 (COX15)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    1355 (COX15)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.17  Acting on CH or CH2 groups
   1.17.99  With unknown physiological acceptors
    1.17.99.9  heme a synthase
     1355 (COX15)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitochondrial respiratory chain complex assembly factors
   Complex-IV assembly factors
    1355 (COX15)
SSDB
Motif
Pfam: COX15-CtaA DUF6220 Peptidase_S3
Other DBs
NCBI-GeneID: 1355
NCBI-ProteinID: NP_510870
OMIM: 603646
HGNC: 2263
Ensembl: ENSG00000014919
Pharos: Q7KZN9(Tbio)
UniProt: Q7KZN9
LinkDB
Position
10:complement(99694293..99732127)
AA seq 410 aa
MQRLLFPPLRALKGRQYLPLLAPRAAPRAQCDCIRRPLRPGQYSTISEVALQSGRGTVSL
PSKAAERVVGRWLLVCSGTVAGAVILGGVTRLTESGLSMVDWHLIKEMKPPTSQEEWEAE
FQRYQQFPEFKILNHDMTLTEFKFIWYMEYSHRMWGRLVGLVYILPAAYFWRKGWLSRGM
KGRVLALCGLVCFQGLLGWYMVKSGLEEKSDSHDIPRVSQYRLAAHLGSALVLYCASLWT
SLSLLLPPHKLPETHQLLQLRRFAHGTAGLVFLTALSGAFVAGLDAGLVYNSFPKMGESW
IPEDLFTFSPILRNVFENPTMVQFDHRILGITSVTAITVLYFLSRRIPLPRRTKMAAVTL
LALAYTQVGLGISTLLMYVPTPLAATHQSGSLALLTGALWLMNELRRVPK
NT seq 1233 nt   +upstreamnt  +downstreamnt
atgcagcgattgctctttccgccgttgagggccttgaaggggaggcagtatctgccgctc
ctggctcctagggcagcgcctagagcacagtgtgattgcatcaggcgccctttgaggcca
gggcaatacagcaccatctctgaagtagctttgcaatctggaaggggtacagtgtccctt
ccctcaaaggctgctgagcgggtggtgggccgatggctcctggtctgcagtggaacagtg
gctggagcagttattcttggtggagtaactaggttgacagagtctggcctctcgatggta
gattggcatttaataaaggagatgaagccacctacaagccaagaggaatgggaagcagaa
ttccaaagataccagcaatttccagaatttaaaatcttgaatcatgatatgacactgaca
gaattcaagttcatctggtacatggagtactcacaccgaatgtggggtcgccttgtaggc
cttgtgtacatcctgcctgctgcctacttttggagaaagggctggctcagccgtggcatg
aaaggacgtgttcttgccctctgtggcctcgtctgcttccagggtctgttgggatggtat
atggtgaaaagtggactagaagaaaaatcagactcccatgacatccctcgggtcagtcag
taccgccttgctgcccacctgggatcagccctggttctttattgtgccagcttgtggacc
tcactgtcactgctactccctccgcacaagttgcctgaaacccaccaactcctacagttg
agacgatttgctcatggaacagcaggtctggtgttccttacggccctctcaggggctttt
gtggcagggctagatgctgggcttgtttataactcctttcccaaaatgggagaatcctgg
atcccggaggacctctttaccttctcccccatcctgaggaatgtttttgagaatcccacc
atggtgcagtttgatcaccggattctgggaatcacttcagtcactgccattacagtgctc
tacttcctctctcggagaattccccttcctagaaggaccaagatggcagcagtgactctg
ctggctttggcgtatacacaggtgggcttgggcatcagcacgctgctgatgtatgtccca
actcctctggccgccactcaccagtcaggctccttggctttgctcactggtgctctttgg
ctgatgaatgaactccgaagagtcccaaaatga

KEGG   Homo sapiens (human): 51241
Entry
51241             CDS       T01001                                 
Symbol
COX16, C14orf112, HSPC203, MC4DN22, hCOX16
Name
(RefSeq) cytochrome c oxidase assembly factor COX16
  KO
K18182  cytochrome c oxidase assembly protein subunit 16
Organism
hsa  Homo sapiens (human)
Pathway
hsa04714  Thermogenesis
Network
nt06529  Thermogenesis
  Element
N01691  mitochondrial complex - UCP1 in Thermogenesis
Disease
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    51241 (COX16)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    51241 (COX16)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitochondrial respiratory chain complex assembly factors
   Complex-IV assembly factors
    51241 (COX16)
SSDB
Motif
Pfam: COX16 TubC_N AcrIC5
Other DBs
NCBI-GeneID: 51241
NCBI-ProteinID: NP_057552
OMIM: 618064
HGNC: 20213
Ensembl: ENSG00000133983
Pharos: Q9P0S2(Tdark)
UniProt: Q9P0S2
LinkDB
Position
14:complement(70325081..70359683)
AA seq 106 aa
MFAPAVMRAFRKNKTLGYGVPMLLLIVGGSFGLREFSQIRYDAVKSKMDPELEKKLKENK
ISLESEYEKIKDSKFDDWKNIRGPRPWEDPDLLQGRNPESLKTKTT
NT seq 321 nt   +upstreamnt  +downstreamnt
atgtttgcacccgcggtgatgcgtgcttttcgcaagaacaagactctcggctatggagtc
cccatgttgttgctgattgttggaggttcttttggtcttcgtgagttttctcaaatccga
tatgatgctgtgaagagtaaaatggatcctgagcttgaaaaaaaactgaaagagaataaa
atatctttagagtcggaatatgagaaaatcaaagactccaagtttgatgactggaagaat
attcgaggacccaggccttgggaagatcctgacctcctccaaggaagaaatccagaaagc
cttaagactaagacaacttga

KEGG   Homo sapiens (human): 116228
Entry
116228            CDS       T01001                                 
Symbol
COX20, FAM36A, MC4DN11
Name
(RefSeq) cytochrome c oxidase assembly factor COX20
  KO
K18184  cytochrome c oxidase assembly protein subunit 20
Organism
hsa  Homo sapiens (human)
Pathway
hsa04714  Thermogenesis
Network
nt06529  Thermogenesis
  Element
N01691  mitochondrial complex - UCP1 in Thermogenesis
Disease
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    116228 (COX20)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    116228 (COX20)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitochondrial respiratory chain complex assembly factors
   Complex-IV assembly factors
    116228 (COX20)
SSDB
Motif
Pfam: Cox20 TMIE
Other DBs
NCBI-GeneID: 116228
NCBI-ProteinID: NP_001299800
OMIM: 614698
HGNC: 26970
Ensembl: ENSG00000203667
Pharos: Q5RI15(Tbio)
UniProt: Q5RI15 B3KM21
LinkDB
Position
1:244835306..244845063
AA seq 118 aa
MAAPPEPGEPEERKSLKLLGFLDVENTPCARHSILYGSLGSVVAGFGHFLFTSRIRRSCD
VGVGGFILVTLGCWFHCRYNYAKQRIQERIAREEIKKKILYEGTHLDPERKHNGSSSN
NT seq 357 nt   +upstreamnt  +downstreamnt
atggccgccccgccggagcccggtgagcccgaggagaggaagtcccttaagctcctagga
tttttagatgttgaaaatactccctgcgcccggcattcaatattgtatggttcattagga
tctgttgtggctggctttggacattttttgttcactagtagaattagaagatcatgtgat
gttggagtaggagggtttatcttggtgactttgggatgctggtttcattgtaggtataat
tatgcaaagcaaagaatccaggaaagaattgccagagaagaaattaaaaagaagatatta
tatgaaggtacccacctcgatcctgaaagaaaacacaacggcagcagcagcaattga

DBGET integrated database retrieval system