KEGG   Homo sapiens (human): 133
Entry
133               CDS       T01001                                 
Symbol
ADM, AM, PAMP
Name
(RefSeq) adrenomedullin
  KO
K12333  adrenomedullin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    133 (ADM)
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    133 (ADM)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    133 (ADM)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  GPCR binding
   133 (ADM)
SSDB
Motif
Pfam: Calc_CGRP_IAPP Fibrinogen_C ASPRs
Other DBs
NCBI-GeneID: 133
NCBI-ProteinID: NP_001115
OMIM: 103275
HGNC: 259
Ensembl: ENSG00000148926
CPD: C16127 C18198
UniProt: P35318
Structure
LinkDB
Position
11:10305073..10307397
AA seq 185 aa
MKLVSVALMYLGSLAFLGADTARLDVASEFRKKWNKWALSRGKRELRMSSSYPTGLADVK
AGPAQTLIRPQDMKGASRSPEDSSPDAARIRVKRYRQSMNNFQGLRSFGCRFGTCTVQKL
AHQIYQFTDKDKDNVAPRSKISPQGYGRRRRRSLPEAGPGRTLVSSKPQAHGAPAPPSGS
APHFL
NT seq 558 nt   +upstreamnt  +downstreamnt
atgaagctggtttccgtcgccctgatgtacctgggttcgctcgccttcctaggcgctgac
accgctcggttggatgtcgcgtcggagtttcgaaagaagtggaataagtgggctctgagt
cgtgggaagagggaactgcggatgtccagcagctaccccaccgggctcgctgacgtgaag
gccgggcctgcccagacccttattcggccccaggacatgaagggtgcctctcgaagcccc
gaagacagcagtccggatgccgcccgcatccgagtcaagcgctaccgccagagcatgaac
aacttccagggcctccggagctttggctgccgcttcgggacgtgcacggtgcagaagctg
gcacaccagatctaccagttcacagataaggacaaggacaacgtcgcccccaggagcaag
atcagcccccagggctacggccgccggcgccggcgctccctgcccgaggccggcccgggt
cggactctggtgtcttctaagccacaagcacacggggctccagcccccccgagtggaagt
gctccccactttctttag

KEGG   Homo sapiens (human): 3375
Entry
3375              CDS       T01001                                 
Symbol
IAPP, DAP, IAP
Name
(RefSeq) islet amyloid polypeptide
  KO
K08039  islet amyloid polypeptide
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04950  Maturity onset diabetes of the young
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3375 (IAPP)
   04081 Hormone signaling
    3375 (IAPP)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04950 Maturity onset diabetes of the young
    3375 (IAPP)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3375 (IAPP)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  GPCR binding
   3375 (IAPP)
SSDB
Motif
Pfam: Calc_CGRP_IAPP L-fibroin SPV1_VP4
Other DBs
NCBI-GeneID: 3375
NCBI-ProteinID: NP_000406
OMIM: 147940
HGNC: 5329
Ensembl: ENSG00000121351
CPD: C16130
UniProt: P10997
Structure
LinkDB
Position
12:21354959..21379980
AA seq 89 aa
MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAIL
SSTNVGSNTYGKRNAVEVLKREPLNYLPL
NT seq 270 nt   +upstreamnt  +downstreamnt
atgggcatcctgaagctgcaagtatttctcattgtgctctctgttgcattgaaccatctg
aaagctacacccattgaaagtcatcaggtggaaaagcggaaatgcaacactgccacatgt
gcaacgcagcgcctggcaaattttttagttcattccagcaacaactttggtgccattctc
tcatctaccaacgtgggatccaatacatatggcaagaggaatgcagtagaggttttaaag
agagagccactgaattacttgcccctttag

KEGG   Homo sapiens (human): 796
Entry
796               CDS       T01001                                 
Symbol
CALCA, CALC1, CGRP, CGRP-I, CGRP-alpha, CGRP1, CT, KC, PCT
Name
(RefSeq) calcitonin related polypeptide alpha
  KO
K12332  calcitonin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04270  Vascular smooth muscle contraction
Drug target
Eptinezumab: D11303<US>
Fremanezumab: D11055<JP/US>
Galcanezumab: D10936<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    796 (CALCA)
   04081 Hormone signaling
    796 (CALCA)
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    796 (CALCA)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    796 (CALCA)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  GPCR binding
   796 (CALCA)
SSDB
Motif
Pfam: Calc_CGRP_IAPP
Other DBs
NCBI-GeneID: 796
NCBI-ProteinID: NP_001029124
OMIM: 114130
HGNC: 1437
Ensembl: ENSG00000110680
CPD: C15876 C16125
UniProt: P01258
Structure
LinkDB
Position
11:complement(14966668..14972351)
AA seq 141 aa
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQ
MKASELEQEQEREGSSLDSPRSKRCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPGKKR
DMSSDLERDHRPHVSMPQNAN
NT seq 426 nt   +upstreamnt  +downstreamnt
atgggcttccaaaagttctcccccttcctggctctcagcatcttggtcctgttgcaggca
ggcagcctccatgcagcaccattcaggtctgccctggagagcagcccagcagacccggcc
acgctcagtgaggacgaagcgcgcctcctgctggctgcactggtgcaggactatgtgcag
atgaaggccagtgagctggagcaggagcaagagagagagggctccagcctggacagcccc
agatctaagcggtgcggtaatctgagtacttgcatgctgggcacatacacgcaggacttc
aacaagtttcacacgttcccccaaactgcaattggggttggagcacctggaaagaaaagg
gatatgtccagcgacttggagagagaccatcgccctcatgttagcatgccccagaatgcc
aactaa

KEGG   Homo sapiens (human): 797
Entry
797               CDS       T01001                                 
Symbol
CALCB, CALC2, CGRP-II, CGRP2
Name
(RefSeq) calcitonin related polypeptide beta
  KO
K12332  calcitonin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04270  Vascular smooth muscle contraction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    797 (CALCB)
   04081 Hormone signaling
    797 (CALCB)
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    797 (CALCB)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    797 (CALCB)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  GPCR binding
   797 (CALCB)
SSDB
Motif
Pfam: Calc_CGRP_IAPP
Other DBs
NCBI-GeneID: 797
NCBI-ProteinID: NP_000719
OMIM: 114160
HGNC: 1438
Ensembl: ENSG00000175868
CPD: C16126
UniProt: P10092
LinkDB
Position
11:15073593..15078637
AA seq 127 aa
MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARLLLAALVQDYVQM
KASELKQEQETQGSSSAAQKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGR
RRRDLQA
NT seq 384 nt   +upstreamnt  +downstreamnt
atgggtttccggaagttctcccccttcctggctctcagtatcttggtcctgtaccaggcg
ggcagcctccaggcggcgccattcaggtctgccctggagagcagcccagacccggccaca
ctcagtaaagaggacgcgcgcctcctgctggctgcactggtgcaggactatgtgcagatg
aaggccagtgagctgaagcaggagcaggagacacagggctccagctccgctgcccagaag
agagcctgcaacactgccacctgtgtgactcatcggctggcaggcttgctgagcagatca
gggggcatggtgaagagcaacttcgtgcccaccaatgtgggttccaaagcctttggcagg
cgccgcagggaccttcaagcctga

KEGG   Homo sapiens (human): 79924
Entry
79924             CDS       T01001                                 
Symbol
ADM2, AM2, dJ579N16.4
Name
(RefSeq) adrenomedullin 2
  KO
K25343  adrenomedullin-2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    79924 (ADM2)
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    79924 (ADM2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    79924 (ADM2)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  GPCR binding
   79924 (ADM2)
SSDB
Motif
Pfam: Calc_CGRP_IAPP CLE_peptide
Other DBs
NCBI-GeneID: 79924
NCBI-ProteinID: NP_001240774
OMIM: 608682
HGNC: 28898
Ensembl: ENSG00000128165
CPD: C16128
UniProt: Q7Z4H4
Structure
LinkDB
Position
22:50481543..50486437
AA seq 148 aa
MARIPTAALGCISLLCLQLPGSLSRSLGGDPRPVKPREPPARSPSSSLQPRHPAPRPVVW
KLHRALQAQRGAGLAPVMGQPLRDGGRQHSGPRRHSGPRRTQAQLLRVGCVLGTCQVQNL
SHRLWQLMGPAGRQDSAPVDPSSPHSYG
NT seq 447 nt   +upstreamnt  +downstreamnt
atggcccggatcccgacggccgccctgggttgcatcagcctcctctgcctgcagctccct
ggctcgctgtcccgcagcctgggcggggacccgcgacccgtcaaacccagggagccccca
gcccggagcccttccagcagcctgcagcccaggcaccccgcaccccgacctgtggtctgg
aagcttcaccgggccctccaggcacagaggggtgccggcctggcccctgttatgggtcag
cctctccgggatggtggccgccaacactcgggcccccgaagacactcgggcccccgcagg
acccaagcccagctcctgcgagtgggctgtgtgctgggcacctgccaggtgcagaatctc
agccaccgcctgtggcaactcatgggaccggccggccggcaggactcagctcctgtggac
cccagcagcccccacagctatggctga

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