Homo sapiens (human): 134 Help Entry 134               CDS       T01001                                  Symbol ADORA1, RDC7 Name (RefSeq) adenosine A1 receptor   KO K04265   adenosine receptor A1 Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04024   cAMP signaling pathway hsa04071   Sphingolipid signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04082   Neuroactive ligand signaling hsa04923   Regulation of lipolysis in adipocytes hsa04924   Renin secretion hsa05032   Morphine addiction Drug target Adenosine (DG00243):  D00045<JP/US> D02300<JP> D02769 D08646 D08647 Aminophylline (DG01062):  D00227 D05429<JP> D11630<US> Apaxifylline:  D02964 Bamifylline (DG01064):  D03051 D07491 Caffeine (DG00974):  D00528<JP> D01453<JP> D07603<US> Choline theophyllinate:  D02017 Diprophylline:  D00691<JP> Enprofylline:  D04006 Naxifylline:  D05125 Proxyphylline:  D01771 Rolofylline:  D08989 Selodenoson:  D05818 Tecadenoson:  D06019 Theophylline (DG01061):  D00371<JP/US> D01712 D06103 D06104 Tonapofylline:  D09684 Trabodenoson:  D10493 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04071 Sphingolipid signaling pathway     134 (ADORA1)    04024 cAMP signaling pathway     134 (ADORA1)    04022 cGMP-PKG signaling pathway     134 (ADORA1)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     134 (ADORA1)    04082 Neuroactive ligand signaling     134 (ADORA1)  09150 Organismal Systems   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     134 (ADORA1)    04924 Renin secretion     134 (ADORA1)  09160 Human Diseases   09165 Substance dependence    05032 Morphine addiction     134 (ADORA1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     134 (ADORA1) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Base and nucleoside    Adenosine     134 (ADORA1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx Motif Other DBs NCBI-GeneID:  134 NCBI-ProteinID:  NP_000665 OMIM:  102775 HGNC:  262 Ensembl:  ENSG00000163485 UniProt:  P30542 Structure PDBPDBj LinkDB All DBs Position 1:203127726..203167405 Genome browser AA seq 326 aa AA seqDB search MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL KIWNDHFRCQPAPPIDEDLPEERPDD NT seq 981 nt NT seq  +upstreamnt  +downstreamnt atgccgccctccatctcagctttccaggccgcctacatcggcatcgaggtgctcatcgcc ctggtctctgtgcccgggaacgtgctggtgatctgggcggtgaaggtgaaccaggcgctg cgggatgccaccttctgcttcatcgtgtcgctggcggtggctgatgtggccgtgggtgcc ctggtcatccccctcgccatcctcatcaacattgggccacagacctacttccacacctgc ctcatggttgcctgtccggtcctcatcctcacccagagctccatcctggccctgctggca attgctgtggaccgctacctccgggtcaagatccctctccggtacaagatggtggtgacc ccccggagggcggcggtggccatagccggctgctggatcctctccttcgtggtgggactg acccctatgtttggctggaacaatctgagtgcggtggagcgggcctgggcagccaacggc agcatgggggagcccgtgatcaagtgcgagttcgagaaggtcatcagcatggagtacatg gtctacttcaacttctttgtgtgggtgctgcccccgcttctcctcatggtcctcatctac ctggaggtcttctacctaatccgcaagcagctcaacaagaaggtgtcggcctcctccggc gacccgcagaagtactatgggaaggagctgaagatcgccaagtcgctggccctcatcctc ttcctctttgccctcagctggctgcctttgcacatcctcaactgcatcaccctcttctgc ccgtcctgccacaagcccagcatccttacctacattgccatcttcctcacgcacggcaac tcggccatgaaccccattgtctatgccttccgcatccagaagttccgcgtcaccttcctt aagatttggaatgaccatttccgctgccagcctgcacctcccattgacgaggatctccca gaagagaggcctgatgactag

Homo sapiens (human): 135 Help Entry 135               CDS       T01001                                  Symbol ADORA2A, A2aR, ADORA2, RDC8 Name (RefSeq) adenosine A2a receptor   KO K04266   adenosine receptor A2a Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04020   Calcium signaling pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04082   Neuroactive ligand signaling hsa04270   Vascular smooth muscle contraction hsa05012   Parkinson disease hsa05034   Alcoholism Drug target Adenosine (DG00243):  D00045<JP/US> D02300<JP> D02769 D08646 D08647 Apadenoson:  D03212 Binodenoson:  D03120 Caffeine (DG00974):  D00528<JP> D01453<JP> D07603<US> Choline theophyllinate:  D02017 Ciforadenant:  D11547 Doxofylline:  D03898 Enprofylline:  D04006 Etrumadenant:  D12369 Evodenoson:  D10362 Inupadenant (DG03145):  D11978 D11979 Istradefylline:  D04641<JP/US> Preladenant:  D09717 Proxyphylline:  D01771 Regadenoson (DG03262):  D05711<US> D12568<US> Sonedenoson:  D09003 Tozadenant:  D10174 Vipadenant:  D09991 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     135 (ADORA2A)    04020 Calcium signaling pathway     135 (ADORA2A)    04024 cAMP signaling pathway     135 (ADORA2A)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     135 (ADORA2A)    04082 Neuroactive ligand signaling     135 (ADORA2A)  09150 Organismal Systems   09153 Circulatory system    04270 Vascular smooth muscle contraction     135 (ADORA2A)  09160 Human Diseases   09164 Neurodegenerative disease    05012 Parkinson disease     135 (ADORA2A)   09165 Substance dependence    05034 Alcoholism     135 (ADORA2A)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     135 (ADORA2A) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Base and nucleoside    Adenosine     135 (ADORA2A) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx GPR_Gpa2_C Motif Other DBs NCBI-GeneID:  135 NCBI-ProteinID:  NP_000666 OMIM:  102776 HGNC:  263 Ensembl:  ENSG00000128271 UniProt:  P29274 B3KVQ4 X5DNB4 Structure PDBPDBj LinkDB All DBs Position 22:24423597..24442357 Genome browser AA seq 412 aa AA seqDB search MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS NT seq 1239 nt NT seq  +upstreamnt  +downstreamnt atgcccatcatgggctcctcggtgtacatcacggtggagctggccattgctgtgctggcc atcctgggcaatgtgctggtgtgctgggccgtgtggctcaacagcaacctgcagaacgtc accaactactttgtggtgtcactggcggcggccgacatcgcagtgggtgtgctcgccatc ccctttgccatcaccatcagcaccgggttctgcgctgcctgccacggctgcctcttcatt gcctgcttcgtcctggtcctcacgcagagctccatcttcagtctcctggccatcgccatt gaccgctacattgccatccgcatcccgctccggtacaatggcttggtgaccggcacgagg gctaagggcatcattgccatctgctgggtgctgtcgtttgccatcggcctgactcccatg ctaggttggaacaactgcggtcagccaaaggagggcaagaaccactcccagggctgcggg gagggccaagtggcctgtctctttgaggatgtggtccccatgaactacatggtgtacttc aacttctttgcctgtgtgctggtgcccctgctgctcatgctgggtgtctatttgcggatc ttcctggcggcgcgacgacagctgaagcagatggagagccagcctctgccgggggagcgg gcacggtccacactgcagaaggaggtccatgctgccaagtcactggccatcattgtgggg ctctttgccctctgctggctgcccctacacatcatcaactgcttcactttcttctgcccc gactgcagccacgcccctctctggctcatgtacctggccatcgtcctctcccacaccaat tcggttgtgaatcccttcatctacgcctaccgtatccgcgagttccgccagaccttccgc aagatcattcgcagccacgtcctgaggcagcaagaacctttcaaggcagctggcaccagt gcccgggtcttggcagctcatggcagtgacggagagcaggtcagcctccgtctcaacggc cacccgccaggagtgtgggccaacggcagtgctccccaccctgagcggaggcccaatggc tatgccctggggctggtgagtggagggagtgcccaagagtcccaggggaacacgggcctc ccagacgtggagctccttagccatgagctcaagggagtgtgcccagagccccctggccta gatgaccccctggcccaggatggagcaggagtgtcctga

Homo sapiens (human): 136 Help Entry 136               CDS       T01001                                  Symbol ADORA2B, ADORA2 Name (RefSeq) adenosine A2b receptor   KO K04267   adenosine receptor A2b Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04020   Calcium signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04082   Neuroactive ligand signaling hsa04270   Vascular smooth muscle contraction hsa05034   Alcoholism Drug target Adenosine (DG00243):  D00045<JP/US> D02300<JP> D02769 D08646 D08647 Aminophylline (DG01062):  D00227 D05429<JP> D11630<US> Diprophylline:  D00691<JP> Enprofylline:  D04006 Etrumadenant:  D12369 Proxyphylline:  D01771 Theophylline (DG01061):  D00371<JP/US> D01712 D06103 D06104 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     136 (ADORA2B)    04020 Calcium signaling pathway     136 (ADORA2B)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     136 (ADORA2B)    04082 Neuroactive ligand signaling     136 (ADORA2B)  09150 Organismal Systems   09153 Circulatory system    04270 Vascular smooth muscle contraction     136 (ADORA2B)  09160 Human Diseases   09165 Substance dependence    05034 Alcoholism     136 (ADORA2B)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     136 (ADORA2B) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Base and nucleoside    Adenosine     136 (ADORA2B) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 TMEM116 GPR_Gpa2_C 7TM_GPCR_Srx 7TM_GPCR_Sri Motif Other DBs NCBI-GeneID:  136 NCBI-ProteinID:  NP_000667 OMIM:  600446 HGNC:  264 Ensembl:  ENSG00000170425 UniProt:  P29275 Structure PDBPDBj LinkDB All DBs Position 17:15850362..15975746 Genome browser AA seq 332 aa AA seqDB search MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFA IPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGT RARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT FHKIISRYLLCQADVKSGNGQAGVQPALGVGL NT seq 999 nt NT seq  +upstreamnt  +downstreamnt atgctgctggagacacaggacgcgctgtacgtggcgctggagctggtcatcgccgcgctt tcggtggcgggcaacgtgctggtgtgcgccgcggtgggcacggcgaacactctgcagacg cccaccaactacttcctggtgtccctggctgcggccgacgtggccgtggggctcttcgcc atcccctttgccatcaccatcagcctgggcttctgcactgacttctacggctgcctcttc ctcgcctgcttcgtgctggtgctcacgcagagctccatcttcagccttctggccgtggca gtcgacagatacctggccatctgtgtcccgctcaggtataaaagtttggtcacggggacc cgagcaagaggggtcattgctgtcctctgggtccttgcctttggcatcggattgactcca ttcctggggtggaacagtaaagacagtgccaccaacaactgcacagaaccctgggatgga accacgaatgaaagctgctgccttgtgaagtgtctctttgagaatgtggtccccatgagc tacatggtatatttcaatttctttgggtgtgttctgcccccactgcttataatgctggtg atctacattaagatcttcctggtggcctgcaggcagcttcagcgcactgagctgatggac cactcgaggaccaccctccagcgggagatccatgcagccaagtcactggccatgattgtg gggatttttgccctgtgctggttacctgtgcatgctgttaactgtgtcactcttttccag ccagctcagggtaaaaataagcccaagtgggcaatgaatatggccattcttctgtcacat gccaattcagttgtcaatcccattgtctatgcttaccggaaccgagacttccgctacact tttcacaaaattatctccaggtatcttctctgccaagcagatgtcaagagtgggaatggt caggctggggtacagcctgctctcggtgtgggcctatga

Homo sapiens (human): 140 Help Entry 140               CDS       T01001                                  Symbol ADORA3, A3AR Name (RefSeq) adenosine A3 receptor   KO K04268   adenosine receptor A3 Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04071   Sphingolipid signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04082   Neuroactive ligand signaling Drug target Adenosine (DG00243):  D00045<JP/US> D02300<JP> D02769 D08646 D08647 Namodenoson:  D11128 Piclidenoson:  D10971 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04071 Sphingolipid signaling pathway     140 (ADORA3)    04022 cGMP-PKG signaling pathway     140 (ADORA3)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     140 (ADORA3)    04082 Neuroactive ligand signaling     140 (ADORA3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     140 (ADORA3) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Base and nucleoside    Adenosine     140 (ADORA3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  7tm_1 7tm_4 7TM_GPCR_Srsx PapG_N Motif Other DBs NCBI-GeneID:  140 NCBI-ProteinID:  NP_000668 OMIM:  600445 HGNC:  268 Ensembl:  ENSG00000282608 UniProt:  P0DMS8 Structure PDBPDBj LinkDB All DBs Position 1:complement(111499429..111503633) Genome browser AA seq 318 aa AA seqDB search MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC VVCHPSDSLDTSIEKNSE NT seq 957 nt NT seq  +upstreamnt  +downstreamnt atgcccaacaacagcactgctctgtcattggccaatgttacctacatcaccatggaaatt ttcattggactctgcgccatagtgggcaacgtgctggtcatctgcgtggtcaagctgaac cccagcctgcagaccaccaccttctatttcattgtctctctagccctggctgacattgct gttggggtgctggtcatgcctttggccattgttgtcagcctgggcatcacaatccacttc tacagctgcctttttatgacttgcctactgcttatctttacccacgcctccatcatgtcc ttgctggccatcgctgtggaccgatacttgcgggtcaagcttaccgtcagatacaagagg gtcaccactcacagaagaatatggctggccctgggcctttgctggctggtgtcattcctg gtgggattgacccccatgtttggctggaacatgaaactgacctcagagtaccacagaaat gtcaccttcctttcatgccaatttgtttccgtcatgagaatggactacatggtatacttc agcttcctcacctggattttcatccccctggttgtcatgtgcgccatctatcttgacatc ttttacatcattcggaacaaactcagtctgaacttatctaactccaaagagacaggtgca ttttatggacgggagttcaagacggctaagtccttgtttctggttcttttcttgtttgct ctgtcatggctgcctttatctatcatcaactgcatcatctactttaatggtgaggtacca cagcttgtgctgtacatgggcatcctgctgtcccatgccaactccatgatgaaccctatc gtctatgcctataaaataaagaagttcaaggaaacctaccttttgatcctcaaagcttgt gtggtctgccatccctctgattctttggacacaagcattgagaagaattctgagtag

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