Homo sapiens (human): 134 Help Entry 134               CDS       T01001                                  Symbol ADORA1, RDC7 Name (RefSeq) adenosine A1 receptor   KO K04265   adenosine receptor A1 Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04024   cAMP signaling pathway hsa04071   Sphingolipid signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04923   Regulation of lipolysis in adipocytes hsa04924   Renin secretion hsa05032   Morphine addiction Drug target Adenosine (DG00243):  D00045<JP/US> D02300<JP> D02769 D08646 D08647 Aminophylline (DG01062):  D00227 D05429<JP> D11630<US> Apaxifylline:  D02964 Bamifylline (DG01064):  D03051 D07491 Caffeine (DG00974):  D00528<JP> D01453<JP> D07603<US> Choline theophyllinate:  D02017 Diprophylline:  D00691<JP> Enprofylline:  D04006 Naxifylline:  D05125 Proxyphylline:  D01771<JP> Rolofylline:  D08989 Selodenoson:  D05818 Tecadenoson:  D06019 Theophylline (DG01061):  D00371<JP/US> D01712 D06103 D06104 Tonapofylline:  D09684 Trabodenoson:  D10493 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04071 Sphingolipid signaling pathway     134 (ADORA1)    04024 cAMP signaling pathway     134 (ADORA1)    04022 cGMP-PKG signaling pathway     134 (ADORA1)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     134 (ADORA1)  09150 Organismal Systems   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     134 (ADORA1)    04924 Renin secretion     134 (ADORA1)  09160 Human Diseases   09165 Substance dependence    05032 Morphine addiction     134 (ADORA1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     134 (ADORA1) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Base and nucleoside    Adenosine     134 (ADORA1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx Motif Other DBs NCBI-GeneID:  134 NCBI-ProteinID:  NP_000665 OMIM:  102775 HGNC:  262 Ensembl:  ENSG00000163485 Pharos:  P30542(Tclin) UniProt:  P30542 Structure PDB LinkDB All DBs Position 1:203127726..203167405 Genome browser AA seq 326 aa AA seqDB search MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL KIWNDHFRCQPAPPIDEDLPEERPDD NT seq 981 nt NT seq  +upstreamnt  +downstreamnt atgccgccctccatctcagctttccaggccgcctacatcggcatcgaggtgctcatcgcc ctggtctctgtgcccgggaacgtgctggtgatctgggcggtgaaggtgaaccaggcgctg cgggatgccaccttctgcttcatcgtgtcgctggcggtggctgatgtggccgtgggtgcc ctggtcatccccctcgccatcctcatcaacattgggccacagacctacttccacacctgc ctcatggttgcctgtccggtcctcatcctcacccagagctccatcctggccctgctggca attgctgtggaccgctacctccgggtcaagatccctctccggtacaagatggtggtgacc ccccggagggcggcggtggccatagccggctgctggatcctctccttcgtggtgggactg acccctatgtttggctggaacaatctgagtgcggtggagcgggcctgggcagccaacggc agcatgggggagcccgtgatcaagtgcgagttcgagaaggtcatcagcatggagtacatg gtctacttcaacttctttgtgtgggtgctgcccccgcttctcctcatggtcctcatctac ctggaggtcttctacctaatccgcaagcagctcaacaagaaggtgtcggcctcctccggc gacccgcagaagtactatgggaaggagctgaagatcgccaagtcgctggccctcatcctc ttcctctttgccctcagctggctgcctttgcacatcctcaactgcatcaccctcttctgc ccgtcctgccacaagcccagcatccttacctacattgccatcttcctcacgcacggcaac tcggccatgaaccccattgtctatgccttccgcatccagaagttccgcgtcaccttcctt aagatttggaatgaccatttccgctgccagcctgcacctcccattgacgaggatctccca gaagagaggcctgatgactag

Homo sapiens (human): 140 Help Entry 140               CDS       T01001                                  Symbol ADORA3, A3AR Name (RefSeq) adenosine A3 receptor   KO K04268   adenosine receptor A3 Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04071   Sphingolipid signaling pathway hsa04080   Neuroactive ligand-receptor interaction Drug target Adenosine (DG00243):  D00045<JP/US> D02300<JP> D02769 D08646 D08647 Namodenoson:  D11128 Piclidenoson:  D10971 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04071 Sphingolipid signaling pathway     140 (ADORA3)    04022 cGMP-PKG signaling pathway     140 (ADORA3)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     140 (ADORA3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     140 (ADORA3) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Base and nucleoside    Adenosine     140 (ADORA3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7tm_4 7TM_GPCR_Srsx PapG_N Motif Other DBs NCBI-GeneID:  140 NCBI-ProteinID:  NP_000668 OMIM:  600445 HGNC:  268 Ensembl:  ENSG00000282608 Pharos:  P0DMS8(Tchem) UniProt:  P0DMS8 LinkDB All DBs Position 1:complement(111499429..111503633) Genome browser AA seq 318 aa AA seqDB search MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC VVCHPSDSLDTSIEKNSE NT seq 957 nt NT seq  +upstreamnt  +downstreamnt atgcccaacaacagcactgctctgtcattggccaatgttacctacatcaccatggaaatt ttcattggactctgcgccatagtgggcaacgtgctggtcatctgcgtggtcaagctgaac cccagcctgcagaccaccaccttctatttcattgtctctctagccctggctgacattgct gttggggtgctggtcatgcctttggccattgttgtcagcctgggcatcacaatccacttc tacagctgcctttttatgacttgcctactgcttatctttacccacgcctccatcatgtcc ttgctggccatcgctgtggaccgatacttgcgggtcaagcttaccgtcagatacaagagg gtcaccactcacagaagaatatggctggccctgggcctttgctggctggtgtcattcctg gtgggattgacccccatgtttggctggaacatgaaactgacctcagagtaccacagaaat gtcaccttcctttcatgccaatttgtttccgtcatgagaatggactacatggtatacttc agcttcctcacctggattttcatccccctggttgtcatgtgcgccatctatcttgacatc ttttacatcattcggaacaaactcagtctgaacttatctaactccaaagagacaggtgca ttttatggacgggagttcaagacggctaagtccttgtttctggttcttttcttgtttgct ctgtcatggctgcctttatctatcatcaactgcatcatctactttaatggtgaggtacca cagcttgtgctgtacatgggcatcctgctgtcccatgccaactccatgatgaaccctatc gtctatgcctataaaataaagaagttcaaggaaacctaccttttgatcctcaaagcttgt gtggtctgccatccctctgattctttggacacaagcattgagaagaattctgagtag

Homo sapiens (human): 4985 Help Entry 4985              CDS       T01001                                  Symbol OPRD1, DOP, DOR, DOR1, OPRD Name (RefSeq) opioid receptor delta 1   KO K04213   delta-type opioid receptor Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04071   Sphingolipid signaling pathway hsa04080   Neuroactive ligand-receptor interaction Disease H01703   Eating Disorders Drug target Eluxadoline:  D10403<US> Etorphine:  D07937 Ketobemidone (DG00815):  D08100 D08101 Levallorphan tartrate:  D02238<JP> Loperamide (DG00092):  D00729<JP/US> D08144 Loperamide oxide (DG00092):  D07113 Metkephamid acetate:  D05007 Nalbuphine (DG00822):  D00843<US> D08246 Nalmefene (DG00998):  D02104<US> D05111 D10812<JP> Naloxone (DG01155):  D01340<JP/US> D08249 D11620<US> Naltrexone (DG00997):  D02095<US> D05113<US> Oxycodone (DG00813):  D00847<US> D03783 D05312<US> D05462<JP> Quadazocine mesylate:  D05667 Tonazocine mesylate:  D06189 Xorphanol mesylate:  D06342 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04071 Sphingolipid signaling pathway     4985 (OPRD1)    04022 cGMP-PKG signaling pathway     4985 (OPRD1)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     4985 (OPRD1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     4985 (OPRD1) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Peptide    Opioid     4985 (OPRD1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7TM_GPCR_Srv 7tm_4 Motif Other DBs NCBI-GeneID:  4985 NCBI-ProteinID:  NP_000902 OMIM:  165195 HGNC:  8153 Ensembl:  ENSG00000116329 Pharos:  P41143(Tclin) UniProt:  P41143 Structure PDB LinkDB All DBs Position 1:28812170..28871267 Genome browser AA seq 372 aa AA seqDB search MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC TPSDGPGGGAAA NT seq 1119 nt NT seq  +upstreamnt  +downstreamnt atggaaccggccccctccgccggcgccgagctgcagcccccgctcttcgccaacgcctcg gacgcctaccctagcgcctgccccagcgctggcgccaatgcgtcggggccgccaggcgcg cggagcgcctcgtccctcgccctggcaatcgccatcaccgcgctctactcggccgtgtgc gccgtggggctgctgggcaacgtgcttgtcatgttcggcatcgtccggtacactaagatg aagacggccaccaacatctacatcttcaacctggccttagccgatgcgctggccaccagc acgctgcctttccagagtgccaagtacctgatggagacgtggcccttcggcgagctgctc tgcaaggctgtgctctccatcgactactacaatatgttcaccagcatcttcacgctcacc atgatgagtgttgaccgctacatcgctgtctgccaccctgtcaaggccctggacttccgc acgcctgccaaggccaagctgatcaacatctgtatctgggtcctggcctcaggcgttggc gtgcccatcatggtcatggctgtgacccgtccccgggacggggcagtggtgtgcatgctc cagttccccagccccagctggtactgggacacggtgaccaagatctgcgtgttcctcttc gccttcgtggtgcccatcctcatcatcaccgtgtgctatggcctcatgctgctgcgcctg cgcagtgtgcgcctgctgtcgggctccaaggagaaggaccgcagcctgcggcgcatcacg cgcatggtgctggtggttgtgggcgccttcgtggtgtgttgggcgcccatccacatcttc gtcatcgtctggacgctggtggacatcgaccggcgcgacccgctggtggtggctgcgctg cacctgtgcatcgcgctgggctacgccaatagcagcctcaaccccgtgctctacgctttc ctcgacgagaacttcaagcgctgcttccgccagctctgccgcaagccctgcggccgccca gaccccagcagcttcagccgcgcccgcgaagccacggcccgcgagcgtgtcaccgcctgc accccgtccgatggtcccggcggtggcgctgccgcctga

Homo sapiens (human): 624 Help Entry 624               CDS       T01001                                  Symbol BDKRB2, B2R, BK-2, BK2, BKR2, BRB2 Name (RefSeq) bradykinin receptor B2   KO K03916   bradykinin receptor B2 Organism hsa  Homo sapiens (human) Pathway hsa04020   Calcium signaling pathway hsa04022   cGMP-PKG signaling pathway hsa04071   Sphingolipid signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04610   Complement and coagulation cascades hsa04750   Inflammatory mediator regulation of TRP channels hsa04810   Regulation of actin cytoskeleton hsa04961   Endocrine and other factor-regulated calcium reabsorption hsa05142   Chagas disease hsa05200   Pathways in cancer Network nt06514  Coagulation cascade   Element N01517   Kallikrein-kinin system, HMWK to bradykinin Drug target Deltibant:  D03677 Icatibant:  D04492<JP/US> Labradimil:  D08937 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04020 Calcium signaling pathway     624 (BDKRB2)    04071 Sphingolipid signaling pathway     624 (BDKRB2)    04022 cGMP-PKG signaling pathway     624 (BDKRB2)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     624 (BDKRB2)  09140 Cellular Processes   09142 Cell motility    04810 Regulation of actin cytoskeleton     624 (BDKRB2)  09150 Organismal Systems   09151 Immune system    04610 Complement and coagulation cascades     624 (BDKRB2)   09155 Excretory system    04961 Endocrine and other factor-regulated calcium reabsorption     624 (BDKRB2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     624 (BDKRB2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     624 (BDKRB2)   09174 Infectious disease: parasitic    05142 Chagas disease     624 (BDKRB2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     624 (BDKRB2) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Peptide    Bradykinin     624 (BDKRB2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 Motif Other DBs NCBI-GeneID:  624 NCBI-ProteinID:  NP_000614 OMIM:  113503 HGNC:  1030 Ensembl:  ENSG00000168398 Pharos:  P30411(Tclin) UniProt:  P30411 Structure PDB LinkDB All DBs Position 14:96204839..96244164 Genome browser AA seq 391 aa AA seqDB search MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQ PPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNN FDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLV IWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVI TFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGI LSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEP IQMENSMGTLRTSISVERQIHKLQDWAGSRQ NT seq 1176 nt NT seq  +upstreamnt  +downstreamnt atgttctctccctggaagatatcaatgtttctgtctgttcgtgaggactccgtgcccacc acggcctctttcagcgccgacatgctcaatgtcaccttgcaagggcccactcttaacggg acctttgcccagagcaaatgcccccaagtggagtggctgggctggctcaacaccatccag ccccccttcctctgggtgctgttcgtgctggccaccctagagaacatctttgtcctcagc gtcttctgcctgcacaagagcagctgcacggtggcagagatctacctggggaacctggcc gcagcagacctgatcctggcctgcgggctgcccttctgggccatcaccatctccaacaac ttcgactggctctttggggagacgctctgccgcgtggtgaatgccattatctccatgaac ctgtacagcagcatctgtttcctgatgctggtgagcatcgaccgctacctggccctggtg aaaaccatgtccatgggccggatgcgcggcgtgcgctgggccaagctctacagcttggtg atctgggggtgtacgctgctcctgagctcacccatgctggtgttccggaccatgaaggag tacagcgatgagggccacaacgtcaccgcttgtgtcatcagctacccatccctcatctgg gaagtgttcaccaacatgctcctgaatgtcgtgggcttcctgctgcccctgagtgtcatc accttctgcacgatgcagatcatgcaggtgctgcggaacaacgagatgcagaagttcaag gagatccagacagagaggagggccacggtgctagtcctggttgtgctgctgctattcatc atctgctggctgcccttccagatcagcaccttcctggatacgctgcatcgcctcggcatc ctctccagctgccaggacgagcgcatcatcgatgtaatcacacagatcgcctccttcatg gcctacagcaacagctgcctcaacccactggtgtacgtgatcgtgggcaagcgcttccga aagaagtcttgggaggtgtaccagggagtgtgccagaaagggggctgcaggtcagaaccc attcagatggagaactccatgggcacactgcggacctccatctccgtggaacgccagatt cacaaactgcaggactgggcagggagcagacagtga

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