Homo sapiens (human): 1508 Help Entry 1508              CDS       T01001                                  Symbol CTSB, APPS, CPSB, KWE, RECEUP Name (RefSeq) cathepsin B   KO K01363   cathepsin B [EC:3.4.22.1] Organism hsa  Homo sapiens (human) Pathway hsa04140   Autophagy - animal hsa04142   Lysosome hsa04210   Apoptosis hsa04612   Antigen processing and presentation hsa04621   NOD-like receptor signaling pathway hsa04924   Renin secretion Disease H00932   Tropical calcific pancreatitis Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09141 Transport and catabolism    04142 Lysosome     1508 (CTSB)    04140 Autophagy - animal     1508 (CTSB)   09143 Cell growth and death    04210 Apoptosis     1508 (CTSB)  09150 Organismal Systems   09151 Immune system    04621 NOD-like receptor signaling pathway     1508 (CTSB)    04612 Antigen processing and presentation     1508 (CTSB)   09152 Endocrine system    04924 Renin secretion     1508 (CTSB)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     1508 (CTSB)   09182 Protein families: genetic information processing    03110 Chaperones and folding catalysts [BR:hsa03110]     1508 (CTSB)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     1508 (CTSB)    00536 Glycosaminoglycan binding proteins [BR:hsa00536]     1508 (CTSB) Enzymes [BR:hsa01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.22  Cysteine endopeptidases     3.4.22.1  cathepsin B      1508 (CTSB) Peptidases and inhibitors [BR:hsa01002]  Cysteine peptidases   Family C1: papain family    1508 (CTSB) Chaperones and folding catalysts [BR:hsa03110]  Intramolecular chaperones   Papain family    1508 (CTSB) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of microglial cells    1508 (CTSB) Glycosaminoglycan binding proteins [BR:hsa00536]  Heparan sulfate / Heparin   Others    1508 (CTSB) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Peptidase_C1 Propeptide_C1 Peptidase_C1_2 Motif Other DBs NCBI-GeneID:  1508 NCBI-ProteinID:  NP_001899 OMIM:  116810 HGNC:  2527 Ensembl:  ENSG00000164733 Pharos:  P07858(Tchem) UniProt:  P07858 A0A024R374 Structure PDBPDBj LinkDB All DBs Position 8:complement(11842524..11868087) Genome browser AA seq 339 aa AA seqDB search MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI NT seq 1020 nt NT seq  +upstreamnt  +downstreamnt atgtggcagctctgggcctccctctgctgcctgctggtgttggccaatgcccggagcagg ccctctttccatcccctgtcggatgagctggtcaactatgtcaacaaacggaataccacg tggcaggccgggcacaacttctacaacgtggacatgagctacttgaagaggctatgtggt accttcctgggtgggcccaagccaccccagagagttatgtttaccgaggacctgaagctg cctgcaagcttcgatgcacgggaacaatggccacagtgtcccaccatcaaagagatcaga gaccagggctcctgtggctcctgctgggccttcggggctgtggaagccatctctgaccgg atctgcatccacaccaatgcgcacgtcagcgtggaggtgtcggcggaggacctgctcaca tgctgtggcagcatgtgtggggacggctgtaatggtggctatcctgctgaagcttggaac ttctggacaagaaaaggcctggtttctggtggcctctatgaatcccatgtagggtgcaga ccgtactccatccctccctgtgagcaccacgtcaacggctcccggcccccatgcacgggg gagggagatacccccaagtgtagcaagatctgtgagcctggctacagcccgacctacaaa caggacaagcactacggatacaattcctacagcgtctccaatagcgagaaggacatcatg gccgagatctacaaaaacggccccgtggagggagctttctctgtgtattcggacttcctg ctctacaagtcaggagtgtaccaacacgtcaccggagagatgatgggtggccatgccatc cgcatcctgggctggggagtggagaatggcacaccctactggctggttgccaactcctgg aacactgactggggtgacaatggcttctttaaaatactcagaggacaggatcactgtgga atcgaatcagaagtggtggctggaattccacgcaccgatcagtactgggaaaagatctaa

Homo sapiens (human): 1514 Help Entry 1514              CDS       T01001                                  Symbol CTSL, CATL, CTSL1, MEP Name (RefSeq) cathepsin L   KO K01365   cathepsin L [EC:3.4.22.15] Organism hsa  Homo sapiens (human) Pathway hsa04140   Autophagy - animal hsa04142   Lysosome hsa04145   Phagosome hsa04210   Apoptosis hsa04612   Antigen processing and presentation hsa05205   Proteoglycans in cancer hsa05323   Rheumatoid arthritis hsa05418   Fluid shear stress and atherosclerosis Drug target Olgotrelvir (DG03293):  D12777 D12778 Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     1514 (CTSL)    04142 Lysosome     1514 (CTSL)    04140 Autophagy - animal     1514 (CTSL)   09143 Cell growth and death    04210 Apoptosis     1514 (CTSL)  09150 Organismal Systems   09151 Immune system    04612 Antigen processing and presentation     1514 (CTSL)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     1514 (CTSL)   09163 Immune disease    05323 Rheumatoid arthritis     1514 (CTSL)   09166 Cardiovascular disease    05418 Fluid shear stress and atherosclerosis     1514 (CTSL)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     1514 (CTSL)   09182 Protein families: genetic information processing    03110 Chaperones and folding catalysts [BR:hsa03110]     1514 (CTSL)   09183 Protein families: signaling and cellular processes    00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]     1514 (CTSL) Enzymes [BR:hsa01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.22  Cysteine endopeptidases     3.4.22.15  cathepsin L      1514 (CTSL) Peptidases and inhibitors [BR:hsa01002]  Cysteine peptidases   Family C1: papain family    1514 (CTSL) Chaperones and folding catalysts [BR:hsa03110]  Intramolecular chaperones   Papain family    1514 (CTSL) Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]  Others   1514 (CTSL) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Peptidase_C1 Inhibitor_I29 Peptidase_C1_2 Styelin Motif Other DBs NCBI-GeneID:  1514 NCBI-ProteinID:  NP_001244900 OMIM:  116880 HGNC:  2537 Ensembl:  ENSG00000135047 Pharos:  P07711(Tchem) UniProt:  P07711 Structure PDBPDBj LinkDB All DBs Position 9:87726119..87731469 Genome browser AA seq 333 aa AA seqDB search MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV NT seq 1002 nt NT seq  +upstreamnt  +downstreamnt atgaatcctacactcatccttgctgccttttgcctgggaattgcctcagctactctaaca tttgatcacagtttagaggcacagtggaccaagtggaaggcgatgcacaacagattatac ggcatgaatgaagaaggatggaggagagcagtgtgggagaagaacatgaagatgattgaa ctgcacaatcaggaatacagggaagggaaacacagcttcacaatggccatgaacgccttt ggagacatgaccagtgaagaattcaggcaggtgatgaatggctttcaaaaccgtaagccc aggaaggggaaagtgttccaggaacctctgttttatgaggcccccagatctgtggattgg agagagaaaggctacgtgactcctgtgaagaatcagggtcagtgtggttcttgttgggct tttagtgctactggtgctcttgaaggacagatgttccggaaaactgggaggcttatctca ctgagtgagcagaatctggtagactgctctgggcctcaaggcaatgaaggctgcaatggt ggcctaatggattatgctttccagtatgttcaggataatggaggcctggactctgaggaa tcctatccatatgaggcaacagaagaatcctgtaagtacaatcccaagtattctgttgct aatgacaccggctttgtggacatccctaagcaggagaaggccctgatgaaggcagttgca actgtggggcccatttctgttgctattgatgcaggtcatgagtccttcctgttctataaa gaaggcatttattttgagccagactgtagcagtgaagacatggatcatggtgtgctggtg gttggctacggatttgaaagcacagaatcagataacaataaatattggctggtgaagaac agctggggtgaagaatggggcatgggtggctacgtaaagatggccaaagaccggagaaac cattgtggaattgcctcagcagccagctaccccactgtgtga

Homo sapiens (human): 1520 Help Entry 1520              CDS       T01001                                  Symbol CTSS Name (RefSeq) cathepsin S   KO K01368   cathepsin S [EC:3.4.22.27] Organism hsa  Homo sapiens (human) Pathway hsa04142   Lysosome hsa04145   Phagosome hsa04210   Apoptosis hsa04612   Antigen processing and presentation hsa05152   Tuberculosis Drug target Petesicatib:  D11376 Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     1520 (CTSS)    04142 Lysosome     1520 (CTSS)   09143 Cell growth and death    04210 Apoptosis     1520 (CTSS)  09150 Organismal Systems   09151 Immune system    04612 Antigen processing and presentation     1520 (CTSS)  09160 Human Diseases   09171 Infectious disease: bacterial    05152 Tuberculosis     1520 (CTSS)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     1520 (CTSS)   09182 Protein families: genetic information processing    03110 Chaperones and folding catalysts [BR:hsa03110]     1520 (CTSS) Enzymes [BR:hsa01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.22  Cysteine endopeptidases     3.4.22.27  cathepsin S      1520 (CTSS) Peptidases and inhibitors [BR:hsa01002]  Cysteine peptidases   Family C1: papain family    1520 (CTSS) Chaperones and folding catalysts [BR:hsa03110]  Intramolecular chaperones   Papain family    1520 (CTSS) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Peptidase_C1 Inhibitor_I29 Peptidase_C1_2 Motif Other DBs NCBI-GeneID:  1520 NCBI-ProteinID:  NP_004070 OMIM:  116845 HGNC:  2545 Ensembl:  ENSG00000163131 Pharos:  P25774(Tchem) UniProt:  P25774 Structure PDBPDBj LinkDB All DBs Position 1:complement(150730188..150765778) Genome browser AA seq 331 aa AA seqDB search MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW GHNFGEEGYIRMARNKGNHCGIASFPSYPEI NT seq 996 nt NT seq  +upstreamnt  +downstreamnt atgaaacggctggtttgtgtgctcttggtgtgctcctctgcagtggcacagttgcataaa gatcctaccctggatcaccactggcatctctggaagaaaacctatggcaaacaatacaag gaaaagaatgaagaagcagtacgacgtctcatctgggaaaagaatctaaagtttgtgatg cttcacaacctggagcattcaatgggaatgcactcatacgatctgggcatgaaccacctg ggagacatgaccagtgaagaagtgatgtctttgatgagttccctgagagttcccagccag tggcagagaaatatcacatataagtcaaaccctaatcggatattgcctgattctgtggac tggagagagaaagggtgtgttactgaagtgaaatatcaaggttcttgtggtgcttgctgg gctttcagtgctgtgggggccctggaagcacagctgaagctgaaaacaggaaagctggtg tctctcagtgcccagaacctggtggattgctcaactgaaaaatatggaaacaaaggctgc aatggtggcttcatgacaacggctttccagtacatcattgataacaagggcatcgactca gacgcttcctatccctacaaagccatggatcagaaatgtcaatatgactcaaaatatcgt gctgccacatgttcaaagtacactgaacttccttatggcagagaagatgtcctgaaagaa gctgtggccaataaaggcccagtgtctgttggtgtagatgcgcgtcatccttctttcttc ctctacagaagtggtgtctactatgaaccatcctgtactcagaatgtgaatcatggtgta cttgtggttggctatggtgatcttaatgggaaagaatactggcttgtgaaaaacagctgg ggccacaactttggtgaagaaggatatattcggatggcaagaaataaaggaaatcattgt gggattgctagctttccctcttacccagaaatctag

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