KEGG   Homo sapiens (human): 1536
Entry
1536              CDS       T01001                                 
Symbol
CYBB, AMCBX2, CGD, CGDX, GP91-1, GP91-PHOX, GP91PHOX, IMD34, NOX2, p91-PHOX
Name
(RefSeq) cytochrome b-245 beta chain
  KO
K21421  NADPH oxidase 2 [EC:1.-.-.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04066  HIF-1 signaling pathway
hsa04145  Phagosome
hsa04216  Ferroptosis
hsa04217  Necroptosis
hsa04613  Neutrophil extracellular trap formation
hsa04621  NOD-like receptor signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05010  Alzheimer disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05140  Leishmaniasis
hsa05171  Coronavirus disease - COVID-19
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06465  Prion disease
  Element
N01204  PRNP-PI3K-NOX2 signaling pathway
N01205  Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway
N01306  AngII-AT1R-NOX2 signaling pathway
N01307  SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
Disease
H00089  IFN-gamma/IL-12 axis
H00098  Chronic granulomatous disease
H01167  Granulibacter infection
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    1536 (CYBB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    1536 (CYBB)
  09143 Cell growth and death
   04216 Ferroptosis
    1536 (CYBB)
   04217 Necroptosis
    1536 (CYBB)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    1536 (CYBB)
   04621 NOD-like receptor signaling pathway
    1536 (CYBB)
   04670 Leukocyte transendothelial migration
    1536 (CYBB)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    1536 (CYBB)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    1536 (CYBB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1536 (CYBB)
   05020 Prion disease
    1536 (CYBB)
   05022 Pathways of neurodegeneration - multiple diseases
    1536 (CYBB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    1536 (CYBB)
   05415 Diabetic cardiomyopathy
    1536 (CYBB)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    1536 (CYBB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    1536 (CYBB)
Membrane trafficking [BR:hsa04131]
 Others
  NADPH oxidases (Nox) and associated proteins
   NADPH oxidases
    1536 (CYBB)
SSDB
Motif
Pfam: NAD_binding_6 FAD_binding_8 Ferric_reduct FAD_binding_6 NAD_binding_1
Other DBs
NCBI-GeneID: 1536
NCBI-ProteinID: NP_000388
OMIM: 300481
HGNC: 2578
Ensembl: ENSG00000165168
UniProt: P04839 A0A0S2Z3S6
Structure
LinkDB
Position
X:37780059..37813461
AA seq 570 aa
MGNWAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACL
NFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNLTFHKMVAWMIALHSAIHTIAHL
FNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGV
VITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHN
ITVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKV
VTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGD
WTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASIL
KSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYL
TGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPE
ALAETLSKQSISNSESGPRGVHFIFNKENF
NT seq 1713 nt   +upstreamnt  +downstreamnt
atggggaactgggctgtgaatgaggggctctccatttttgtcattctggtttggctgggg
ttgaacgtcttcctctttgtctggtattaccgggtttatgatattccacctaagttcttt
tacacaagaaaacttcttgggtcagcactggcactggccagggcccctgcagcctgcctg
aatttcaactgcatgctgattctcttgccagtctgtcgaaatctgctgtccttcctcagg
ggttccagtgcgtgctgctcaacaagagttcgaagacaactggacaggaatctcaccttt
cataaaatggtggcatggatgattgcacttcactctgcgattcacaccattgcacatcta
tttaatgtggaatggtgtgtgaatgcccgagtcaataattctgatccttattcagtagca
ctctctgaacttggagacaggcaaaatgaaagttatctcaattttgctcgaaagagaata
aagaaccctgaaggaggcctgtacctggctgtgaccctgttggcaggcatcactggagtt
gtcatcacgctgtgcctcatattaattatcacttcctccaccaaaaccatccggaggtct
tactttgaagtcttttggtacacacatcatctctttgtgatcttcttcattggccttgcc
atccatggagctgaacgaattgtacgtgggcagaccgcagagagtttggctgtgcataat
ataacagtttgtgaacaaaaaatctcagaatggggaaaaataaaggaatgcccaatccct
cagtttgctggaaaccctcctatgacttggaaatggatagtgggtcccatgtttctgtat
ctctgtgagaggttggtgcggttttggcgatctcaacagaaggtggtcatcaccaaggtg
gtcactcaccctttcaaaaccatcgagctacagatgaagaagaaggggttcaaaatggaa
gtgggacaatacatttttgtcaagtgcccaaaggtgtccaagctggagtggcaccctttt
acactgacatccgcccctgaggaagacttctttagtatccatatccgcatcgttggggac
tggacagaggggctgttcaatgcttgtggctgtgataagcaggagtttcaagatgcgtgg
aaactacctaagatagcggttgatgggccctttggcactgccagtgaagatgtgttcagc
tatgaggtggtgatgttagtgggagcagggattggggtcacacccttcgcatccattctc
aagtcagtctggtacaaatattgcaataacgccaccaatctgaagctcaaaaagatctac
ttctactggctgtgccgggacacacatgcctttgagtggtttgcagatctgctgcaactg
ctggagagccagatgcaggaaaggaacaatgccggcttcctcagctacaacatctacctc
actggctgggatgagtctcaggccaatcactttgctgtgcaccatgatgaggagaaagat
gtgatcacaggcctgaaacaaaagactttgtatggacggcccaactgggataatgaattc
aagacaattgcaagtcaacaccctaataccagaataggagttttcctctgtggacctgaa
gccttggctgaaaccctgagtaaacaaagcatctccaactctgagtctggccctcgggga
gtgcatttcattttcaacaaggaaaacttctaa

KEGG   Homo sapiens (human): 27035
Entry
27035             CDS       T01001                                 
Symbol
NOX1, GP91-2, MOX1, NOH-1, NOH-1L, NOH1
Name
(RefSeq) NADPH oxidase 1
  KO
K08008  NADPH oxidase 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04380  Osteoclast differentiation
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04380 Osteoclast differentiation
    27035 (NOX1)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    27035 (NOX1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    27035 (NOX1)
   05022 Pathways of neurodegeneration - multiple diseases
    27035 (NOX1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    27035 (NOX1)
   05418 Fluid shear stress and atherosclerosis
    27035 (NOX1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    27035 (NOX1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    27035 (NOX1)
Membrane trafficking [BR:hsa04131]
 Others
  NADPH oxidases (Nox) and associated proteins
   NADPH oxidases
    27035 (NOX1)
SSDB
Motif
Pfam: NAD_binding_6 FAD_binding_8 Ferric_reduct NAD_binding_1 FAD_binding_6
Other DBs
NCBI-GeneID: 27035
NCBI-ProteinID: NP_008983
OMIM: 300225
HGNC: 7889
Ensembl: ENSG00000007952
UniProt: Q9Y5S8
LinkDB
Position
X:complement(100843324..100874359)
AA seq 564 aa
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCL
NFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHL
FNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVI
MTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHP
RKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKV
VMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGD
WTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYK
FQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSN
IVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSL
RKCCHRYSSLDPRKVQFYFNKENF
NT seq 1695 nt   +upstreamnt  +downstreamnt
atgggaaactgggtggttaaccactggttttcagttttgtttctggttgtttggttaggg
ctgaatgttttcctgtttgtggatgccttcctgaaatatgagaaggccgacaaatactac
tacacaagaaaaatccttgggtcaacattggcctgtgcccgagcgtctgctctctgcttg
aattttaacagcacgctgatcctgcttcctgtgtgtcgcaatctgctgtccttcctgagg
ggcacctgctcattttgcagccgcacactgagaaagcaattggatcacaacctcaccttc
cacaagctggtggcctatatgatctgcctacatacagctattcacatcattgcacacctg
tttaactttgactgctatagcagaagccgacaggccacagatggctcccttgcctccatt
ctctccagcctatctcatgatgagaaaaaggggggttcttggctaaatcccatccagtcc
cgaaacacgacagtggagtatgtgacattcaccagcattgctggtctcactggagtgatc
atgacaatagccttgattctcatggtaacttcagctactgagttcatccggaggagttat
tttgaagtcttctggtatactcaccacctttttatcttctatatccttggcttagggatt
cacggcattggtggaattgtccggggtcaaacagaggagagcatgaatgagagtcatcct
cgcaagtgtgcagagtcttttgagatgtgggatgatcgtgactcccactgtaggcgccct
aagtttgaagggcatccccctgagtcttggaagtggatccttgcaccggtcattctttat
atctgtgaaaggatcctccggttttaccgctcccagcagaaggttgtgattaccaaggtt
gttatgcacccatccaaagttttggaattgcagatgaacaagcgtggcttcagcatggaa
gtggggcagtatatctttgttaattgcccctcaatctctctcctggaatggcatcctttt
actttgacctctgctccagaggaagatttcttctccattcatatccgagcagcaggggac
tggacagaaaatctcataagggctttcgaacaacaatattcaccaattcccaggattgaa
gtggatggtccctttggcacagccagtgaggatgttttccagtatgaagtggctgtgctg
gttggagcaggaattggggtcaccccctttgcttctatcttgaaatccatctggtacaaa
ttccagtgtgcagaccacaacctcaaaacaaaaaagatctatttctactggatctgcagg
gagacaggtgccttttcctggttcaacaacctgttgacttccctggaacaggagatggag
gaattaggcaaagtgggttttctaaactaccgtctcttcctcaccggatgggacagcaat
attgttggtcatgcagcattaaactttgacaaggccactgacatcgtgacaggtctgaaa
cagaaaacctcctttgggagaccaatgtgggacaatgagttttctacaatagctacctcc
caccccaagtctgtagtgggagttttcttatgtggccctcggactttggcaaagagcctg
cgcaaatgctgtcaccgatattccagtctggatcctagaaaggttcaattctacttcaac
aaagaaaatttttga

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