KEGG   Homo sapiens (human): 1543
Entry
1543              CDS       T01001                                 

Symbol
CYP1A1, AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX
Name
(RefSeq) cytochrome P450 family 1 subfamily A member 1
  KO
K07408  cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00380  Tryptophan metabolism
hsa00830  Retinol metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa01100  Metabolic pathways
hsa04913  Ovarian steroidogenesis
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05417  Lipid and atherosclerosis
Network
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06251  CYP-mediated ROS formation
nt06360  Cushing syndrome
  Element
N00317  AhR signaling pathway
N01365  TCDD to Ahr signaling pathway
N01366  BaP to Ahr signaling pathway
N01367  PCB to Ahr signaling pathway
N01368  HCB to Ahr signaling pathway
N01374  BaP to DNA adducts
N01375  DMBA to DNA adducts
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
N01404  17beta-estradiol to CYP-mediated metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    1543 (CYP1A1)
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    1543 (CYP1A1)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    1543 (CYP1A1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1543 (CYP1A1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    1543 (CYP1A1)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    1543 (CYP1A1)
   05207 Chemical carcinogenesis - receptor activation
    1543 (CYP1A1)
   05208 Chemical carcinogenesis - reactive oxygen species
    1543 (CYP1A1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    1543 (CYP1A1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1543 (CYP1A1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1543 (CYP1A1)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP1 family
   1543 (CYP1A1)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1543
NCBI-ProteinID: NP_000490
OMIM: 108330
HGNC: 2595
Ensembl: ENSG00000140465
Vega: OTTHUMG00000142812
Pharos: P04798(Tchem)
UniProt: P04798 A0N0X8
LinkDB
Structure
PDB: 
4I8V 6DWM 6DWN

Position
15q24.1
AA seq 512 aa
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
NT seq 1539 nt   +upstreamnt  +downstreamnt
atgcttttcccaatctccatgtcggccacggagtttcttctggcctctgtcatcttctgt
ctggtattctgggtaatcagggcctcaagacctcaggtccccaaaggcctgaagaatcca
ccagggccatggggctggcctctgattgggcacatgctgaccctgggaaagaacccgcac
ctggcactgtcaaggatgagccagcagtatggggacgtgctgcagatccgaattggctcc
acacccgtggtggtgctgagcggcctggacaccatccggcaggccctggtgcggcagggc
gatgatttcaagggccggcccgacctctacaccttcaccctcatcagtaatggtcagagc
atgtccttcagcccagactctggaccagtgtgggctgcccgccggcgcctggcccagaat
ggcctgaaaagtttctccattgcctctgacccagcctcctcaacctcctgctacctggaa
gagcatgtgagcaaggaggctgaggtcctgataagcacgttgcaggagctgatggcaggg
cctgggcactttaacccctacaggtatgtggtggtatcagtgaccaatgtcatctgtgcc
atttgctttggccggcgctatgaccacaaccaccaagaactgcttagcctagtcaacctg
aataataatttcggggaggtggttggctctggaaacccagctgacttcatccctattctt
cgctacctacccaacccttccctgaatgccttcaaggacctgaatgagaagttctacagc
ttcatgcagaagatggtcaaggagcactacaaaacctttgagaagggccacatccgggac
atcacagacagcctgattgagcactgtcaggagaagcagctggatgagaacgccaatgtc
cagctgtcagatgagaagatcattaacatcgtcttggacctctttggagctgggtttgac
acagtcacaactgctatctcctggagcctcatgtatttggtgatgaaccccagggtacag
agaaagatccaagaggagctagacacagtgattggcaggtcacggcggccccggctctct
gacagatcccatctgccctatatggaggccttcatcctggagaccttccgacactcttcc
ttcgtccccttcaccatcccccacagcacaacaagagacacaagtttgaaaggcttttac
atccccaaggggcgttgtgtctttgtaaaccagtggcagatcaaccatgaccagaagcta
tgggtcaacccatctgagttcctacctgaacggtttctcacccctgatggtgctatcgac
aaggtgttaagtgagaaggtgattatctttggcatgggcaagcggaagtgtatcggtgag
accattgcccgctgggaggtctttctcttcctggctatcctgctgcaacgggtggaattc
agcgtgccactgggcgtgaaggtggacatgacccccatctatgggctaaccatgaagcat
gcctgctgtgagcacttccaaatgcagctgcgctcttag

KEGG   Homo sapiens (human): 1545
Entry
1545              CDS       T01001                                 

Symbol
CYP1B1, ASGD6, CP1B, CYPIB1, GLC3A, P4501B1
Name
(RefSeq) cytochrome P450 family 1 subfamily B member 1
  KO
K07410  cytochrome P450 family 1 subfamily B1 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00380  Tryptophan metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa04913  Ovarian steroidogenesis
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05206  MicroRNAs in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06251  CYP-mediated ROS formation
nt06360  Cushing syndrome
  Element
N00317  AhR signaling pathway
N01365  TCDD to Ahr signaling pathway
N01366  BaP to Ahr signaling pathway
N01367  PCB to Ahr signaling pathway
N01374  BaP to DNA adducts
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
N01405  17beta-estradiol to CYP-mediated metabolism
Disease
H01159  Anterior segment dysgenesis
H01203  Primary congenital glaucoma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    1545 (CYP1B1)
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    1545 (CYP1B1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1545 (CYP1B1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    1545 (CYP1B1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    1545 (CYP1B1)
   05204 Chemical carcinogenesis - DNA adducts
    1545 (CYP1B1)
   05207 Chemical carcinogenesis - receptor activation
    1545 (CYP1B1)
   05208 Chemical carcinogenesis - reactive oxygen species
    1545 (CYP1B1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1545 (CYP1B1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1545 (CYP1B1)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP1 family
   1545 (CYP1B1)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1545
NCBI-ProteinID: NP_000095
OMIM: 601771
HGNC: 2597
Ensembl: ENSG00000138061
Vega: OTTHUMG00000100970
Pharos: Q16678(Tchem)
UniProt: Q16678 Q53TK1
LinkDB
Structure
PDB: 
3PM0 6IQ5

Position
2p22.2
AA seq 543 aa
MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI
GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF
ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL
LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL
VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSA
EKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAEL
DQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVV
FVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL
FLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKE
TCQ
NT seq 1632 nt   +upstreamnt  +downstreamnt
atgggcaccagcctcagcccgaacgacccttggccgctaaacccgctgtccatccagcag
accacgctcctgctactcctgtcggtgctggccactgtgcatgtgggccagcggctgctg
aggcaacggaggcggcagctccggtccgcgcccccgggcccgtttgcgtggccactgatc
ggaaacgcggcggcggtgggccaggcggctcacctctcgttcgctcgcctggcgcggcgc
tacggcgacgttttccagatccgcctgggcagctgccccatagtggtgctgaatggcgag
cgcgccatccaccaggccctggtgcagcagggctcggccttcgccgaccggccggccttc
gcctccttccgtgtggtgtccggcggccgcagcatggctttcggccactactcggagcac
tggaaggtgcagcggcgcgcagcccacagcatgatgcgcaacttcttcacgcgccagccg
cgcagccgccaagtcctcgagggccacgtgctgagcgaggcgcgcgagctggtggcgctg
ctggtgcgcggcagcgcggacggcgccttcctcgacccgaggccgctgaccgtcgtggcc
gtggccaacgtcatgagtgccgtgtgtttcggctgccgctacagccacgacgaccccgag
ttccgtgagctgctcagccacaacgaagagttcgggcgcacggtgggcgcgggcagcctg
gtggacgtgatgccctggctgcagtacttccccaacccggtgcgcaccgttttccgcgaa
ttcgagcagctcaaccgcaacttcagcaacttcatcctggacaagttcttgaggcactgc
gaaagccttcggcccggggccgccccccgcgacatgatggacgcctttatcctctctgcg
gaaaagaaggcggccggggactcgcacggtggtggcgcgcggctggatttggagaacgta
ccggccactatcactgacatcttcggcgccagccaggacaccctgtccaccgcgctgcag
tggctgctcctcctcttcaccaggtatcctgatgtgcagactcgagtgcaggcagaattg
gatcaggtcgtggggagggaccgtctgccttgtatgggtgaccagcccaacctgccctat
gtcctggccttcctttatgaagccatgcgcttctccagctttgtgcctgtcactattcct
catgccaccactgccaacacctctgtcttgggctaccacattcccaaggacactgtggtt
tttgtcaaccagtggtctgtgaatcatgacccactgaagtggcctaacccggagaacttt
gatccagctcgattcttggacaaggatggcctcatcaacaaggacctgaccagcagagtg
atgattttttcagtgggcaaaaggcggtgcattggcgaagaactttctaagatgcagctt
tttctcttcatctccatcctggctcaccagtgcgatttcagggccaacccaaatgagcct
gcgaaaatgaatttcagttatggtctaaccattaaacccaagtcatttaaagtcaatgtc
actctcagagagtccatggagctccttgatagtgctgtccaaaatttacaagccaaggaa
acttgccaataa

KEGG   Homo sapiens (human): 119391
Entry
119391            CDS       T01001                                 

Symbol
GSTO2, GSTO_2-2, bA127L20.1
Name
(RefSeq) glutathione S-transferase omega 2
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    119391 (GSTO2)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    119391 (GSTO2)
   00982 Drug metabolism - cytochrome P450
    119391 (GSTO2)
   00983 Drug metabolism - other enzymes
    119391 (GSTO2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119391 (GSTO2)
   05204 Chemical carcinogenesis - DNA adducts
    119391 (GSTO2)
   05207 Chemical carcinogenesis - receptor activation
    119391 (GSTO2)
   05208 Chemical carcinogenesis - reactive oxygen species
    119391 (GSTO2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    119391 (GSTO2)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    119391 (GSTO2)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    119391 (GSTO2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    119391 (GSTO2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     119391 (GSTO2)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   119391 (GSTO2)
SSDB
Motif
Pfam: GST_N_3 GST_N_2 GST_N GST_C_2 Glutaredoxin GST_C GST_C_3
Other DBs
NCBI-GeneID: 119391
NCBI-ProteinID: NP_899062
OMIM: 612314
HGNC: 23064
Ensembl: ENSG00000065621
Vega: OTTHUMG00000019006
Pharos: Q9H4Y5(Tbio)
UniProt: Q9H4Y5
LinkDB
Structure
PDB: 
3Q18 3Q19 3QAG

Position
10q25.1
AA seq 243 aa
MSGDATRTLGKGSQPPGPVPEGLIRIYSMRFCPYSHRTRLVLKAKDIRHEVVNINLRNKP
EWYYTKHPFGHIPVLETSQCQLIYESVIACEYLDDAYPGRKLFPYDPYERARQKMLLELF
CKVPHLTKECLVALRCGRECTNLKAALRQEFSNLEEILEYQNTTFFGGTCISMIDYLLWP
WFERLDVYGILDCVSHTPALRLWISAMKWDPTVCALLMDKSIFQGFLNLYFQNNPNAFDF
GLC
NT seq 732 nt   +upstreamnt  +downstreamnt
atgtctggggatgcgaccaggaccctggggaaaggaagccagcccccagggccagtcccg
gaggggctgatccgcatctacagcatgaggttctgcccctattctcacaggacccgcctc
gtcctcaaggccaaagacatcagacatgaagtggtcaacattaacctgagaaacaagcct
gaatggtactatacaaagcacccttttggccacattcctgtcctggagaccagccaatgt
caactgatctatgaatctgttattgcttgtgagtacctggatgatgcttatccaggaagg
aagctgtttccatatgacccttatgaacgagctcgccaaaagatgttattggagctattt
tgtaaggtcccacatttgaccaaggagtgcctggtagcgttgagatgtgggagagaatgc
actaatctgaaggcagccctgcgtcaggaattcagcaacctggaagagattcttgagtat
cagaacaccaccttctttggtggaacctgtatatccatgattgattacctcctctggccc
tggtttgagcggctggatgtgtatgggatactggactgtgtgagccacacgccagccctg
cggctctggatatcagccatgaagtgggaccccacagtctgtgctcttctcatggataag
agcattttccagggcttcttgaatctctattttcagaacaaccctaatgcctttgacttt
gggctgtgctga

KEGG   Homo sapiens (human): 221357
Entry
221357            CDS       T01001                                 

Symbol
GSTA5
Name
(RefSeq) glutathione S-transferase alpha 5
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    221357 (GSTA5)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    221357 (GSTA5)
   00982 Drug metabolism - cytochrome P450
    221357 (GSTA5)
   00983 Drug metabolism - other enzymes
    221357 (GSTA5)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    221357 (GSTA5)
   05204 Chemical carcinogenesis - DNA adducts
    221357 (GSTA5)
   05207 Chemical carcinogenesis - receptor activation
    221357 (GSTA5)
   05208 Chemical carcinogenesis - reactive oxygen species
    221357 (GSTA5)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    221357 (GSTA5)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    221357 (GSTA5)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    221357 (GSTA5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    221357 (GSTA5)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     221357 (GSTA5)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   221357 (GSTA5)
SSDB
Motif
Pfam: GST_C_3 GST_C GST_N GST_N_3 GST_C_2
Other DBs
NCBI-GeneID: 221357
NCBI-ProteinID: NP_714543
OMIM: 607605
HGNC: 19662
Ensembl: ENSG00000182793
Vega: OTTHUMG00000014857
Pharos: Q7RTV2(Tdark)
UniProt: Q7RTV2
LinkDB
Position
6p12.2
AA seq 222 aa
MAEKPKLHYSNARGSMESIRWLLAAAGVELEEKFLESAEDLDKLRNDGSLLFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDMKERALIDMYTEGIVDLTEMILLLLICQPEERDAK
TALVKEKIKNRYFPAFEKVLKSHRQDYLVGNKLSWADIHLVELFYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSQRKPPMDEKSLEEARKIFRF
NT seq 669 nt   +upstreamnt  +downstreamnt
atggcagagaagcccaagctccactactccaatgcacggggcagtatggagtccattcgg
tggctcctggctgcagctggagtagagttggaagagaaatttctagaatctgcagaagat
ttggacaagttaagaaatgatgggagtttgctgttccagcaagtaccaatggttgagatt
gacgggatgaagctggtgcagaccagagccattcttaactacattgccagcaaatacaac
ctttatgggaaagacatgaaggagagagccctgattgatatgtacacagaaggtatagta
gatttgactgaaatgatccttcttctgctcatatgtcaaccagaggaaagagatgccaag
actgccttggtcaaagagaaaataaaaaatcgctacttccctgcctttgaaaaagtctta
aagagccacagacaagactaccttgttggcaacaagctgagctgggctgacattcacctg
gtggaacttttctactacgtggaagagcttgactcgagtcttatctccagcttccctctg
ctgaaggccctgaaaaccagaatcagcaacctgcccacggtgaagaagtttctgcagcct
ggcagccagagaaagcctcccatggatgagaaatctttagaagaagcaaggaagattttc
aggttttaa

KEGG   Homo sapiens (human): 2938
Entry
2938              CDS       T01001                                 

Symbol
GSTA1, GST-epsilon, GST2, GSTA1-1, GTH1
Name
(RefSeq) glutathione S-transferase alpha 1
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2938 (GSTA1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2938 (GSTA1)
   00982 Drug metabolism - cytochrome P450
    2938 (GSTA1)
   00983 Drug metabolism - other enzymes
    2938 (GSTA1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2938 (GSTA1)
   05204 Chemical carcinogenesis - DNA adducts
    2938 (GSTA1)
   05207 Chemical carcinogenesis - receptor activation
    2938 (GSTA1)
   05208 Chemical carcinogenesis - reactive oxygen species
    2938 (GSTA1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2938 (GSTA1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2938 (GSTA1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2938 (GSTA1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2938 (GSTA1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2938 (GSTA1)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2938 (GSTA1)
SSDB
Motif
Pfam: GST_N GST_C GST_C_3 GST_N_3
Other DBs
NCBI-GeneID: 2938
NCBI-ProteinID: NP_665683
OMIM: 138359
HGNC: 4626
Ensembl: ENSG00000243955
Vega: OTTHUMG00000014861
Pharos: P08263(Tchem)
UniProt: P08263 A0A140VJK4
LinkDB
Structure
PDB: 

Position
6p12.2
AA seq 222 aa
MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAK
LALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF
NT seq 669 nt   +upstreamnt  +downstreamnt
atggcagagaagcccaagctccactacttcaatgcacggggcagaatggagtccacccgg
tggctcctggctgcagctggagtagagtttgaagagaaatttataaaatctgcagaagat
ttggacaagttaagaaatgatggatatttgatgttccagcaagtgccaatggttgagatt
gatgggatgaagctggtgcagaccagagccattctcaactacattgccagcaaatacaac
ctctatgggaaagacataaaggagagagccctgattgatatgtatatagaaggtatagca
gatttgggtgaaatgatcctccttctgcccgtatgtccacctgaggaaaaagatgccaag
cttgccttgatcaaagagaaaataaaaaatcgctacttccctgcctttgaaaaagtctta
aagagccatggacaagactaccttgttggcaacaagctgagccgggctgacattcatctg
gtggaacttctctactacgtcgaggagcttgactccagtcttatctccagcttccctctg
ctgaaggccctgaaaaccagaatcagcaacctgcccacagtgaagaagtttctacagcct
ggcagcccaaggaagcctcccatggatgagaaatctttagaagaagcaaggaagattttc
aggttttaa

KEGG   Homo sapiens (human): 2939
Entry
2939              CDS       T01001                                 

Symbol
GSTA2, GST2, GSTA2-2, GTA2, GTH2
Name
(RefSeq) glutathione S-transferase alpha 2
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2939 (GSTA2)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2939 (GSTA2)
   00982 Drug metabolism - cytochrome P450
    2939 (GSTA2)
   00983 Drug metabolism - other enzymes
    2939 (GSTA2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2939 (GSTA2)
   05204 Chemical carcinogenesis - DNA adducts
    2939 (GSTA2)
   05207 Chemical carcinogenesis - receptor activation
    2939 (GSTA2)
   05208 Chemical carcinogenesis - reactive oxygen species
    2939 (GSTA2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2939 (GSTA2)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2939 (GSTA2)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2939 (GSTA2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2939 (GSTA2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2939 (GSTA2)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2939 (GSTA2)
SSDB
Motif
Pfam: GST_C_3 GST_C GST_N GST_N_3
Other DBs
NCBI-GeneID: 2939
NCBI-ProteinID: NP_000837
OMIM: 138360
HGNC: 4627
Ensembl: ENSG00000244067
Vega: OTTHUMG00000016263
Pharos: P09210(Tbio)
UniProt: P09210 A0A140VKE2 A8K987
LinkDB
Structure
PDB: 
4ACS 2VCT 2WJU

Position
6p12.2
AA seq 222 aa
MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAK
LALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF
NT seq 669 nt   +upstreamnt  +downstreamnt
atggcagagaagcccaagctccactactccaatatacggggcagaatggagtccatccgg
tggctcctggctgcagctggagtagagtttgaagagaaatttataaaatctgcagaagat
ttggacaagttaagaaatgatggatatttgatgttccagcaagtgccaatggttgagatt
gatgggatgaagctggtgcagaccagagccattctcaactacattgccagcaaatacaac
ctctatgggaaagacataaaggagaaagccctgattgatatgtatatagaaggtatagca
gatttgggtgaaatgatccttcttctgccctttagtcaacctgaggaacaagatgccaag
cttgccttgatccaagagaaaacaaaaaatcgctacttccctgcctttgaaaaagtctta
aagagccacggacaagactaccttgttggcaacaagctgagccgggctgacattcacctg
gtggaacttctctactacgtggaagagcttgactctagccttatttccagcttccctctg
ctgaaggccctgaaaaccagaatcagtaacctgcccacagtgaagaagtttctacagcct
ggcagcccaaggaagcctcccatggatgagaaatctttagaagaatcaaggaagattttc
aggttttaa

KEGG   Homo sapiens (human): 2940
Entry
2940              CDS       T01001                                 

Symbol
GSTA3, GSTA3-3, GTA3
Name
(RefSeq) glutathione S-transferase alpha 3
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2940 (GSTA3)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2940 (GSTA3)
   00982 Drug metabolism - cytochrome P450
    2940 (GSTA3)
   00983 Drug metabolism - other enzymes
    2940 (GSTA3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2940 (GSTA3)
   05204 Chemical carcinogenesis - DNA adducts
    2940 (GSTA3)
   05207 Chemical carcinogenesis - receptor activation
    2940 (GSTA3)
   05208 Chemical carcinogenesis - reactive oxygen species
    2940 (GSTA3)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2940 (GSTA3)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2940 (GSTA3)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2940 (GSTA3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2940 (GSTA3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2940 (GSTA3)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2940 (GSTA3)
SSDB
Motif
Pfam: GST_C_3 GST_N GST_C GST_N_3 DUF3825
Other DBs
NCBI-GeneID: 2940
NCBI-ProteinID: NP_000838
OMIM: 605449
HGNC: 4628
Ensembl: ENSG00000174156
Vega: OTTHUMG00000014865
Pharos: Q16772(Tbio)
UniProt: Q16772
LinkDB
Structure
PDB: 
2VCV 1TDI

Position
6p12.2
AA seq 222 aa
MAGKPKLHYFNGRGRMEPIRWLLAAAGVEFEEKFIGSAEDLGKLRNDGSLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYTEGMADLNEMILLLPLCRPEEKDAK
IALIKEKTKSRYFPAFEKVLQSHGQDYLVGNKLSRADISLVELLYYVEELDSSLISNFPL
LKALKTRISNLPTVKKFLQPGSPRKPPADAKALEEARKIFRF
NT seq 669 nt   +upstreamnt  +downstreamnt
atggcagggaagcccaagcttcactacttcaatggacggggcagaatggagcccatccgg
tggctcttggctgcagctggagtggagtttgaagagaaatttataggatctgcagaagat
ttgggaaagttaagaaatgatgggagtttgatgttccagcaagtaccaatggttgagatt
gatgggatgaagttggtacagaccagagccattctcaactacattgccagcaaatacaac
ctctacgggaaagacataaaggagagagccctaattgatatgtatacagaaggtatggca
gatttgaatgaaatgatccttcttctgcccttatgtcgacctgaggaaaaagatgccaag
attgccttgatcaaagagaaaacaaaaagtcgctatttccctgccttcgaaaaagtgtta
cagagccatggacaagactaccttgttggcaacaagctgagccgggctgacattagcctg
gtggaacttctctactatgtggaagagcttgactccagccttatctccaacttccctctg
ctgaaggccctgaaaaccagaatcagcaacctgcccacggtgaagaagtttctacagcct
ggcagcccaaggaagcctcccgcagatgcaaaagctttagaagaagccagaaagattttc
aggttttaa

KEGG   Homo sapiens (human): 2941
Entry
2941              CDS       T01001                                 

Symbol
GSTA4, GSTA4-4, GTA4
Name
(RefSeq) glutathione S-transferase alpha 4
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2941 (GSTA4)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2941 (GSTA4)
   00982 Drug metabolism - cytochrome P450
    2941 (GSTA4)
   00983 Drug metabolism - other enzymes
    2941 (GSTA4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2941 (GSTA4)
   05204 Chemical carcinogenesis - DNA adducts
    2941 (GSTA4)
   05207 Chemical carcinogenesis - receptor activation
    2941 (GSTA4)
   05208 Chemical carcinogenesis - reactive oxygen species
    2941 (GSTA4)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2941 (GSTA4)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2941 (GSTA4)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2941 (GSTA4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2941 (GSTA4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2941 (GSTA4)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2941 (GSTA4)
SSDB
Motif
Pfam: GST_C_3 GST_N GST_C GST_C_2 GST_N_3 CbeA_antitoxin
Other DBs
NCBI-GeneID: 2941
NCBI-ProteinID: NP_001503
OMIM: 605450
HGNC: 4629
Ensembl: ENSG00000170899
Vega: OTTHUMG00000014868
Pharos: O15217(Tbio)
UniProt: O15217 A0A024RD58
LinkDB
Structure
PDB: 
3IK7 1GUL 1GUM

Position
6p12.2
AA seq 222 aa
MAARPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLYKLQDGNHLLFQQVPMVEI
DGMKLVQTRSILHYIADKHNLFGKNLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKE
VVNMAQKAIIRYFPVFEKILRGHGQSFLVGNQLSLADVILLQTILALEEKIPNILSAFPF
LQEYTVKLSNIPTIKRFLEPGSKKKPPPDEIYVRTVYNIFRP
NT seq 669 nt   +upstreamnt  +downstreamnt
atggcagcaaggcccaagctccactatcccaacggaagaggccggatggagtccgtgaga
tgggttttagctgccgccggagtcgagtttgatgaagaatttctggaaacaaaagaacag
ttgtacaagttgcaggatggtaaccacctgctgttccaacaagtgcccatggttgaaatt
gacgggatgaagttggtacagacccgaagcattctccactacatagcagacaagcacaat
ctctttggcaagaacctcaaggagagaaccctgattgacatgtacgtggaggggacactg
gatctgctggaactgcttatcatgcatcctttcttaaaaccagatgatcagcaaaaggaa
gtggttaacatggcccagaaggctataattagatactttcctgtgtttgaaaagatttta
aggggtcacggacaaagctttcttgttggtaatcagctgagccttgcagatgtgatttta
ctccaaaccattttagctctagaagagaaaattcctaatatcctgtctgcatttcctttc
ctccaggaatacacagtgaaactaagtaatatccctacaattaagagattccttgaacct
ggcagcaagaagaagcctccccctgatgaaatttatgtgagaaccgtctacaacatcttt
aggccataa

KEGG   Homo sapiens (human): 2944
Entry
2944              CDS       T01001                                 

Symbol
GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1
Name
(RefSeq) glutathione S-transferase mu 1
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2944 (GSTM1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2944 (GSTM1)
   00982 Drug metabolism - cytochrome P450
    2944 (GSTM1)
   00983 Drug metabolism - other enzymes
    2944 (GSTM1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2944 (GSTM1)
   05204 Chemical carcinogenesis - DNA adducts
    2944 (GSTM1)
   05207 Chemical carcinogenesis - receptor activation
    2944 (GSTM1)
   05208 Chemical carcinogenesis - reactive oxygen species
    2944 (GSTM1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2944 (GSTM1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2944 (GSTM1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2944 (GSTM1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2944 (GSTM1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2944 (GSTM1)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2944 (GSTM1)
SSDB
Motif
Pfam: GST_N GST_C_3 GST_C GST_C_6 GST_C_2 GST_N_3
Other DBs
NCBI-GeneID: 2944
NCBI-ProteinID: NP_000552
OMIM: 138350
HGNC: 4632
Ensembl: ENSG00000134184
Vega: OTTHUMG00000011635
Pharos: P09488(Tbio)
UniProt: P09488 X5DR03
LinkDB
Structure
PDB: 
1XW6 1XWK 1YJ6 1GTU 2F3M

Position
1p13.3
AA seq 218 aa
MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQTMDNHMQLGMICYNPEF
EKLKPKYLEELPEKLKLYSEFLGKRPWFAGNKITFVDFLVYDVLDLHRIFEPKCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPRPVFSKMAVWGNK
NT seq 657 nt   +upstreamnt  +downstreamnt
atgcccatgatactggggtactgggacatccgcgggctggcccacgccatccgcctgctc
ctggaatacacagactcaagctatgaggaaaagaagtacacgatgggggacgctcctgat
tatgacagaagccagtggctgaatgaaaaattcaagctgggcctggactttcccaatctg
ccctacttgattgatggggctcacaagatcacccagagcaacgccatcttgtgctacatt
gcccgcaagcacaacctgtgtggggagacagaagaggagaagattcgtgtggacattttg
gagaaccagaccatggacaaccatatgcagctgggcatgatctgctacaatccagaattt
gagaaactgaagccaaagtacttggaggaactccctgaaaagctaaagctctactcagag
tttctggggaagcggccatggtttgcaggaaacaagatcacttttgtagattttctcgtc
tatgatgtccttgacctccaccgtatatttgagcccaagtgcttggacgccttcccaaat
ctgaaggacttcatctcccgctttgagggcttggagaagatctctgcctacatgaagtcc
agccgcttcctcccaagacctgtgttctcaaagatggctgtctggggcaacaagtag

KEGG   Homo sapiens (human): 2946
Entry
2946              CDS       T01001                                 

Symbol
GSTM2, GST4, GSTM, GSTM2-2, GTHMUS
Name
(RefSeq) glutathione S-transferase mu 2
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2946 (GSTM2)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2946 (GSTM2)
   00982 Drug metabolism - cytochrome P450
    2946 (GSTM2)
   00983 Drug metabolism - other enzymes
    2946 (GSTM2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2946 (GSTM2)
   05204 Chemical carcinogenesis - DNA adducts
    2946 (GSTM2)
   05207 Chemical carcinogenesis - receptor activation
    2946 (GSTM2)
   05208 Chemical carcinogenesis - reactive oxygen species
    2946 (GSTM2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2946 (GSTM2)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2946 (GSTM2)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2946 (GSTM2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2946 (GSTM2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2946 (GSTM2)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2946 (GSTM2)
SSDB
Motif
Pfam: GST_N GST_C GST_C_3 GST_C_6 GST_C_2 GST_N_3 Bromo_TP
Other DBs
NCBI-GeneID: 2946
NCBI-ProteinID: NP_000839
OMIM: 138380
HGNC: 4634
Ensembl: ENSG00000213366
Vega: OTTHUMG00000011638
Pharos: P28161(Tchem)
UniProt: P28161 A0A384P5E9 Q0D2I8
LinkDB
Structure
PDB: 

Position
1p13.3
AA seq 218 aa
MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDILENQFMDSRMQLAKLCYDPDF
EKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPRPVFTKMAVWGNK
NT seq 657 nt   +upstreamnt  +downstreamnt
atgcccatgacactggggtactggaacatccgcgggctggcccattccatccgcctgctc
ctggaatacacagactcaagctacgaggaaaagaagtacacgatgggggacgctcctgat
tatgacagaagccagtggctgaatgaaaaattcaagctgggcctggactttcccaatctg
ccctacttgattgatgggactcacaagatcacccagagcaacgccatcctgcggtacatt
gcccgcaagcacaacctgtgcggggaatcagaaaaggagcagattcgcgaagacattttg
gagaaccagtttatggacagccgtatgcagctggccaaactctgctatgacccagatttt
gagaaactgaaaccagaatacctgcaggcactccctgaaatgctgaagctctactcacag
tttctggggaagcagccatggtttcttggggacaagatcacctttgtggatttcatcgct
tatgatgtccttgagagaaaccaagtatttgagcccagctgcctggatgccttcccaaac
ctgaaggacttcatctcccgatttgagggcttggagaagatctctgcctacatgaagtcc
agccgcttcctcccaagacctgtgttcacaaagatggctgtctggggcaacaagtag

KEGG   Homo sapiens (human): 2947
Entry
2947              CDS       T01001                                 

Symbol
GSTM3, GST5, GSTB, GSTM3-3, GTM3
Name
(RefSeq) glutathione S-transferase mu 3
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2947 (GSTM3)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2947 (GSTM3)
   00982 Drug metabolism - cytochrome P450
    2947 (GSTM3)
   00983 Drug metabolism - other enzymes
    2947 (GSTM3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2947 (GSTM3)
   05204 Chemical carcinogenesis - DNA adducts
    2947 (GSTM3)
   05207 Chemical carcinogenesis - receptor activation
    2947 (GSTM3)
   05208 Chemical carcinogenesis - reactive oxygen species
    2947 (GSTM3)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2947 (GSTM3)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2947 (GSTM3)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2947 (GSTM3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2947 (GSTM3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2947 (GSTM3)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2947 (GSTM3)
SSDB
Motif
Pfam: GST_N GST_C GST_C_3 GST_N_3 GST_C_6
Other DBs
NCBI-GeneID: 2947
NCBI-ProteinID: NP_000840
OMIM: 138390
HGNC: 4635
Ensembl: ENSG00000134202
Vega: OTTHUMG00000011640
Pharos: P21266(Tbio)
UniProt: P21266 Q6FGJ9
LinkDB
Structure
PDB: 
3GTU

Position
1p13.3
AA seq 225 aa
MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQWLDVKFKLDLD
FPNLPYLLDGKNKITQSNAILRYIARKHNMCGETEEEKIRVDIIENQVMDFRTQLIRLCY
SSDHEKLKPQYLEELPGQLKQFSMFLGKFSWFAGEKLTFVDFLTYDILDQNRIFDPKCLD
EFPNLKAFMCRFEALEKIAAYLQSDQFCKMPINNKMAQWGNKPVC
NT seq 678 nt   +upstreamnt  +downstreamnt
atgtcgtgcgagtcgtctatggttctcgggtactgggatattcgtgggctggcgcacgcc
atccgcctgctcctggagttcacggatacctcttatgaggagaaacggtacacgtgcggg
gaagctcctgactatgatcgaagccaatggctggatgtgaaattcaagctagacctggac
tttcctaatctgccctacctcctggatgggaagaacaagatcacccagagcaatgccatc
ttgcgctacatcgctcgcaagcacaacatgtgtggtgagactgaagaagaaaagattcga
gtggacatcatagagaaccaagtaatggatttccgcacacaactgataaggctctgttac
agctctgaccacgaaaaactgaagcctcagtacttggaagagctacctggacaactgaaa
caattctccatgtttctggggaaattctcatggtttgccggggaaaagctcacctttgtg
gattttctcacctatgatatcttggatcagaaccgtatatttgaccccaagtgcctggat
gagttcccaaacctgaaggctttcatgtgccgttttgaggctttggagaaaatcgctgcc
tacttacagtctgatcagttctgcaagatgcccatcaacaacaagatggcccagtggggc
aacaagcctgtatgctga

KEGG   Homo sapiens (human): 2948
Entry
2948              CDS       T01001                                 

Symbol
GSTM4, GSTM4-4, GTM4
Name
(RefSeq) glutathione S-transferase mu 4
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2948 (GSTM4)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2948 (GSTM4)
   00982 Drug metabolism - cytochrome P450
    2948 (GSTM4)
   00983 Drug metabolism - other enzymes
    2948 (GSTM4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2948 (GSTM4)
   05204 Chemical carcinogenesis - DNA adducts
    2948 (GSTM4)
   05207 Chemical carcinogenesis - receptor activation
    2948 (GSTM4)
   05208 Chemical carcinogenesis - reactive oxygen species
    2948 (GSTM4)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2948 (GSTM4)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2948 (GSTM4)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2948 (GSTM4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2948 (GSTM4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2948 (GSTM4)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2948 (GSTM4)
SSDB
Motif
Pfam: GST_N GST_C_3 GST_C GST_C_6 GST_N_3 GST_C_2 Bromo_TP
Other DBs
NCBI-GeneID: 2948
NCBI-ProteinID: NP_000841
OMIM: 138333
HGNC: 4636
Ensembl: ENSG00000168765
Vega: OTTHUMG00000011642
Pharos: Q03013(Tbio)
UniProt: Q03013 A0A140VKE3
LinkDB
Structure
PDB: 
4GTU

Position
1p13.3
AA seq 218 aa
MSMTLGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQAMDVSNQLARVCYSPDF
EKLKPEYLEELPTMMQHFSQFLGKRPWFVGDKITFVDFLAYDVLDLHRIFEPNCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPKPLYTRVAVWGNK
NT seq 657 nt   +upstreamnt  +downstreamnt
atgtccatgacactggggtactgggacatccgcgggctggcccacgccatccgcctgctc
ctggaatacacagactcaagctacgaggaaaagaagtatacgatgggggacgctcctgac
tatgacagaagccagtggctgaatgaaaaattcaagctgggcctggactttcccaatctg
ccctacttgattgatggggctcacaagatcacccagagcaacgccatcctgtgctacatt
gcccgcaagcacaacctgtgtggggagacagaagaggagaagattcgtgtggacattttg
gagaaccaggctatggacgtctccaatcagctggccagagtctgctacagccctgacttt
gagaaactgaagccagaatacttggaggaacttcctacaatgatgcagcacttctcacag
ttcctggggaagaggccatggtttgttggagacaagatcacctttgtagatttcctcgcc
tatgatgtccttgacctccaccgtatatttgagcccaactgcttggacgcctttccaaat
ctgaaggacttcatctcccgctttgagggcttggagaagatctctgcctacatgaagtcc
agccgcttcctcccaaaacctctgtacacaagggtggctgtctggggcaacaagtaa

KEGG   Homo sapiens (human): 2949
Entry
2949              CDS       T01001                                 

Symbol
GSTM5, GSTM5-5, GTM5
Name
(RefSeq) glutathione S-transferase mu 5
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2949 (GSTM5)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2949 (GSTM5)
   00982 Drug metabolism - cytochrome P450
    2949 (GSTM5)
   00983 Drug metabolism - other enzymes
    2949 (GSTM5)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2949 (GSTM5)
   05204 Chemical carcinogenesis - DNA adducts
    2949 (GSTM5)
   05207 Chemical carcinogenesis - receptor activation
    2949 (GSTM5)
   05208 Chemical carcinogenesis - reactive oxygen species
    2949 (GSTM5)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2949 (GSTM5)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2949 (GSTM5)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2949 (GSTM5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2949 (GSTM5)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2949 (GSTM5)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2949 (GSTM5)
SSDB
Motif
Pfam: GST_N GST_C GST_C_3 GST_C_2 GST_C_6 GST_N_3
Other DBs
NCBI-GeneID: 2949
NCBI-ProteinID: NP_000842
OMIM: 138385
HGNC: 4637
Ensembl: ENSG00000134201
Vega: OTTHUMG00000011644
Pharos: P46439(Tbio)
UniProt: P46439 Q5T8R2
LinkDB
Position
1p13.3
AA seq 218 aa
MPMTLGYWDIRGLAHAIRLLLEYTDSSYVEKKYTLGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILRYIARKHNLCGETEEEKIRVDILENQVMDNHMELVRLCYDPDF
EKLKPKYLEELPEKLKLYSEFLGKRPWFAGDKITFVDFLAYDVLDMKRIFEPKCLDAFLN
LKDFISRFEGLKKISAYMKSSQFLRGLLFGKSATWNSK
NT seq 657 nt   +upstreamnt  +downstreamnt
atgcccatgactctggggtactgggacatccgtgggctggcccacgccatccgcttgctc
ctggaatacacagactcaagctatgtggaaaagaagtacacgctgggggacgctcctgac
tatgacagaagccagtggctgaatgaaaaattcaagctgggcctggactttcccaatctg
ccctacttgattgatggggctcacaagatcacccagagcaatgccatcctgcgctacatt
gcccgcaagcacaacctgtgtggggagacagaagaggagaagattcgtgtggacattttg
gagaaccaggttatggataaccacatggagctggtcagactgtgctatgacccagatttt
gagaaactgaagccaaaatacttggaggaactccctgaaaagctaaagctctactcagag
tttctggggaagcggccatggtttgcaggagacaagatcacctttgtggatttccttgcc
tatgatgtccttgacatgaagcgtatatttgagcccaagtgcttggacgccttcctaaac
ttgaaggacttcatctcccgctttgagggtttgaagaagatctctgcctacatgaagtcc
agccaattcctccgaggtcttttgtttggaaagtcagctacatggaacagcaaatag

KEGG   Homo sapiens (human): 2950
Entry
2950              CDS       T01001                                 

Symbol
GSTP1, DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI
Name
(RefSeq) glutathione S-transferase pi 1
  KO
K23790  glutathione S-transferase P [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05215  Prostate cancer
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Disease
H00024  Prostate cancer
Drug target
Ezatiostat hydrochloride: D08917
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2950 (GSTP1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2950 (GSTP1)
   00982 Drug metabolism - cytochrome P450
    2950 (GSTP1)
   00983 Drug metabolism - other enzymes
    2950 (GSTP1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2950 (GSTP1)
   05204 Chemical carcinogenesis - DNA adducts
    2950 (GSTP1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2950 (GSTP1)
   05215 Prostate cancer
    2950 (GSTP1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2950 (GSTP1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2950 (GSTP1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2950 (GSTP1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2950 (GSTP1)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2950 (GSTP1)
SSDB
Motif
Pfam: GST_C_3 GST_C GST_N GST_C_2 GST_N_3
Other DBs
NCBI-GeneID: 2950
NCBI-ProteinID: NP_000843
OMIM: 134660
HGNC: 4638
Ensembl: ENSG00000084207
Vega: OTTHUMG00000137430
Pharos: P09211(Tchem)
UniProt: P09211 V9HWE9
LinkDB
Structure
PDB: 

Position
11q13.2
AA seq 210 aa
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
NT seq 633 nt   +upstreamnt  +downstreamnt
atgccgccctacaccgtggtctatttcccagttcgaggccgctgcgcggccctgcgcatg
ctgctggcagatcagggccagagctggaaggaggaggtggtgaccgtggagacgtggcag
gagggctcactcaaagcctcctgcctatacgggcagctccccaagttccaggacggagac
ctcaccctgtaccagtccaataccatcctgcgtcacctgggccgcacccttgggctctat
gggaaggaccagcaggaggcagccctggtggacatggtgaatgacggcgtggaggacctc
cgctgcaaatacatctccctcatctacaccaactatgaggcgggcaaggatgactatgtg
aaggcactgcccgggcaactgaagccttttgagaccctgctgtcccagaaccagggaggc
aagaccttcattgtgggagaccagatctccttcgctgactacaacctgctggacttgctg
ctgatccatgaggtcctagcccctggctgcctggatgcgttccccctgctctcagcatat
gtggggcgcctcagtgcccggcccaagctcaaggccttcctggcctcccctgagtacgtg
aacctccccatcaatggcaacgggaaacagtga

KEGG   Homo sapiens (human): 2952
Entry
2952              CDS       T01001                                 

Symbol
GSTT1
Name
(RefSeq) glutathione S-transferase theta 1
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2952 (GSTT1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2952 (GSTT1)
   00982 Drug metabolism - cytochrome P450
    2952 (GSTT1)
   00983 Drug metabolism - other enzymes
    2952 (GSTT1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2952 (GSTT1)
   05204 Chemical carcinogenesis - DNA adducts
    2952 (GSTT1)
   05207 Chemical carcinogenesis - receptor activation
    2952 (GSTT1)
   05208 Chemical carcinogenesis - reactive oxygen species
    2952 (GSTT1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2952 (GSTT1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2952 (GSTT1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2952 (GSTT1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2952 (GSTT1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2952 (GSTT1)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2952 (GSTT1)
SSDB
Motif
Pfam: GST_N_3 GST_N GST_N_2 GST_C GST_C_3 GST_N_4 GST_C_2
Other DBs
NCBI-GeneID: 2952
NCBI-ProteinID: NP_000844
OMIM: 600436
HGNC: 4641
Pharos: P30711(Tbio)
UniProt: P30711
LinkDB
Structure
PDB: 
2C3N 2C3Q 2C3T

Position
22q11.23
AA seq 240 aa
MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGQHLSDAFAQVNPLKKVPALKDG
DFTLTESVAILLYLTRKYKVPDYWYPQDLQARARVDEYLAWQHTTLRRSCLRALWHKVMF
PVFLGEPVSPQTLAATLAELDVTLQLLEDKFLQNKAFLTGPHISLADLVAITELMHPVGA
GCQVFEGRPKLATWRQRVEAAVGEDLFQEAHEVILKAKDFPPADPTIKQKLMPWVLAMIR
NT seq 723 nt   +upstreamnt  +downstreamnt
atgggcctggagctgtacctggacctgctgtcccagccctgccgcgctgtttacatcttt
gccaagaagaacgacattcccttcgagctgcgcatcgtggatctgattaaaggtcagcac
ttaagcgatgcctttgcccaggtgaaccccctcaagaaggtgccagccttgaaggacggg
gacttcaccttgacggagagtgtggccatcctgctctacctgacgcgcaaatataaggtc
cctgactactggtaccctcaggacctgcaggcccgtgcccgtgtggatgagtacctggca
tggcagcacacgactctgcggagaagctgcctccgggccttgtggcataaggtgatgttc
cctgttttcctgggtgagccagtatctccccagacactggcagccaccctggcagagttg
gatgtgaccctgcagttgctcgaggacaagttcctccagaacaaggccttccttactggt
cctcacatctccttagctgacctcgtagccatcacggagctgatgcatcccgtgggtgct
ggctgccaagtcttcgaaggccgacccaagctggccacatggcggcagcgcgtggaggca
gcagtgggggaggacctcttccaggaggcccatgaggtcattctgaaggccaaggacttc
ccacctgcagaccccaccataaagcagaagctgatgccctgggtgctggccatgatccgg
tga

KEGG   Homo sapiens (human): 2953
Entry
2953              CDS       T01001                                 

Symbol
GSTT2
Name
(RefSeq) glutathione S-transferase theta 2 (gene/pseudogene)
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2953 (GSTT2)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2953 (GSTT2)
   00982 Drug metabolism - cytochrome P450
    2953 (GSTT2)
   00983 Drug metabolism - other enzymes
    2953 (GSTT2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2953 (GSTT2)
   05204 Chemical carcinogenesis - DNA adducts
    2953 (GSTT2)
   05207 Chemical carcinogenesis - receptor activation
    2953 (GSTT2)
   05208 Chemical carcinogenesis - reactive oxygen species
    2953 (GSTT2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2953 (GSTT2)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2953 (GSTT2)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2953 (GSTT2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2953 (GSTT2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2953 (GSTT2)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2953 (GSTT2)
SSDB
Motif
Pfam: GST_N GST_N_3 GST_C GST_N_2 GST_C_2 GST_C_3
Other DBs
NCBI-GeneID: 2953
NCBI-ProteinID: NP_000845
OMIM: 600437
HGNC: 4642
Ensembl: ENSG00000099984
Vega: OTTHUMG00000150786
Pharos: P0CG29(Tbio)
UniProt: P0CG29
LinkDB
Structure
PDB: 
4MPG 4MPF

Position
22q11.23
AA seq 244 aa
MGLELFLDLVSQPSRAVYIFAKKNGIPLELRTVDLVKGQHKSKEFLQINSLGKLPTLKDG
DFILTESSAILIYLSCKYQTPDHWYPSDLQARARVHEYLGWHADCIRGTFGIPLWVQVLG
PLIGVQVPKEKVERNRTAMDQALQWLEDKFLGDRPFLAGQQVTLADLMALEELMQPVALG
YELFEGRPRLAAWRGRVEAFLGAELCQEAHSIILSILEQAAKKTLPTPSPEAYQAMLLRI
ARIP
NT seq 735 nt   +upstreamnt  +downstreamnt
atgggcctagagctgtttcttgacctggtgtcccagcccagccgcgccgtctacatcttc
gccaagaagaatggcatccccttagagctgcgcaccgtggatttggtcaaagggcagcac
aagagcaaggagttcttgcagatcaacagcctggggaaactgccgacgctcaaggatggt
gatttcatcttgaccgaaagctcggccatcctgatttacctgagctgtaagtaccagacg
ccggaccactggtatccatctgacctgcaggctcgtgcccgtgttcatgagtacctgggc
tggcatgccgactgcatccgtggcacctttggtatacccctgtgggtccaggtgttgggg
ccactcattggggtccaggtgcccaaggagaaggtggaacgcaacaggactgccatggac
caggccctgcaatggctggaggacaagttcctgggggacaggcccttcctcgctggccag
caggtgacactggctgatctcatggccctggaggagctgatgcagccggtggctctcggc
tatgaactgtttgagggacggccacgactggcagcatggcgtggacgagtggaggctttc
ctgggtgctgagctatgccaggaggcccacagcatcatcttgagcatcctggaacaggcg
gccaagaaaaccctcccaacaccctcaccagaggcctatcaggctatgctgcttcgaatc
gccaggatcccctga

KEGG   Homo sapiens (human): 4257
Entry
4257              CDS       T01001                                 

Symbol
MGST1, GST12, MGST, MGST-I
Name
(RefSeq) microsomal glutathione S-transferase 1
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    4257 (MGST1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    4257 (MGST1)
   00982 Drug metabolism - cytochrome P450
    4257 (MGST1)
   00983 Drug metabolism - other enzymes
    4257 (MGST1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    4257 (MGST1)
   05204 Chemical carcinogenesis - DNA adducts
    4257 (MGST1)
   05207 Chemical carcinogenesis - receptor activation
    4257 (MGST1)
   05208 Chemical carcinogenesis - reactive oxygen species
    4257 (MGST1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    4257 (MGST1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    4257 (MGST1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    4257 (MGST1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    4257 (MGST1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     4257 (MGST1)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   4257 (MGST1)
SSDB
Motif
Pfam: MAPEG
Other DBs
NCBI-GeneID: 4257
NCBI-ProteinID: NP_001247440
OMIM: 138330
HGNC: 7061
Ensembl: ENSG00000008394
Vega: OTTHUMG00000168816
Pharos: P10620(Tbio)
UniProt: P10620 A0A024RAX2
LinkDB
Position
12p12.3
AA seq 155 aa
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAK
KYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIA
YLTPLPQPNRALSFFVGYGVTLSMAYRLLKSKLYL
NT seq 468 nt   +upstreamnt  +downstreamnt
atggttgacctcacccaggtaatggatgatgaagtattcatggcttttgcatcctatgca
acaattattctttcaaaaatgatgcttatgagtactgcaactgcattctatagattgaca
agaaaggtttttgccaatccagaagactgtgtagcatttggcaaaggagaaaatgccaag
aagtatcttcgaacagatgacagagtagaacgtgtacgcagagcccacctgaatgacctt
gaaaatattattccatttcttggaattggcctcctgtattccttgagtggtcccgacccc
tctacagccatcctgcacttcagactatttgtcggagcacggatctaccacaccattgca
tatttgacaccccttccccagccaaatagagctttgagtttttttgttggatatggagtt
actctttccatggcttacaggttgctgaaaagtaaattgtacctgtaa

KEGG   Homo sapiens (human): 4258
Entry
4258              CDS       T01001                                 

Symbol
MGST2, GST2, MGST-II
Name
(RefSeq) microsomal glutathione S-transferase 2
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    4258 (MGST2)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    4258 (MGST2)
   00982 Drug metabolism - cytochrome P450
    4258 (MGST2)
   00983 Drug metabolism - other enzymes
    4258 (MGST2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    4258 (MGST2)
   05204 Chemical carcinogenesis - DNA adducts
    4258 (MGST2)
   05207 Chemical carcinogenesis - receptor activation
    4258 (MGST2)
   05208 Chemical carcinogenesis - reactive oxygen species
    4258 (MGST2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    4258 (MGST2)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    4258 (MGST2)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    4258 (MGST2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    4258 (MGST2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     4258 (MGST2)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   4258 (MGST2)
SSDB
Motif
Pfam: MAPEG
Other DBs
NCBI-GeneID: 4258
NCBI-ProteinID: NP_001191295
OMIM: 601733
HGNC: 7063
Ensembl: ENSG00000085871
Vega: OTTHUMG00000133382
Pharos: Q99735(Tbio)
UniProt: Q99735
LinkDB
Position
4q31.1
AA seq 147 aa
MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFY
PIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTL
LGALGIANSFLDEYLDLNIAKKLRRQF
NT seq 444 nt   +upstreamnt  +downstreamnt
atggccgggaactcgatcctgctggctgctgtctctattctctcggcctgtcagcaaagt
tattttgctttgcaagttggaaaggcaagattaaaatacaaagttacgcccccagcagtc
actgggtcaccagagtttgagagagtatttcgggcacaacaaaactgtgtggagttttat
cctatattcataattacattgtggatggctgggtggtatttcaaccaagtttttgctact
tgtctgggtctggtgtacatatatggccgtcacctatacttctggggatattcagaagct
gctaaaaaacggatcaccggtttccgactgagtctggggattttggccttgttgaccctc
ctaggtgccctgggaattgcaaacagctttctggatgaatatctggacctcaatattgcc
aagaaactgaggcggcaattctaa

KEGG   Homo sapiens (human): 4259
Entry
4259              CDS       T01001                                 

Symbol
MGST3, GST-III
Name
(RefSeq) microsomal glutathione S-transferase 3
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    4259 (MGST3)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    4259 (MGST3)
   00982 Drug metabolism - cytochrome P450
    4259 (MGST3)
   00983 Drug metabolism - other enzymes
    4259 (MGST3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    4259 (MGST3)
   05204 Chemical carcinogenesis - DNA adducts
    4259 (MGST3)
   05207 Chemical carcinogenesis - receptor activation
    4259 (MGST3)
   05208 Chemical carcinogenesis - reactive oxygen species
    4259 (MGST3)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    4259 (MGST3)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    4259 (MGST3)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    4259 (MGST3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    4259 (MGST3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     4259 (MGST3)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   4259 (MGST3)
SSDB
Motif
Pfam: MAPEG
Other DBs
NCBI-GeneID: 4259
NCBI-ProteinID: NP_004519
OMIM: 604564
HGNC: 7064
Ensembl: ENSG00000143198
Vega: OTTHUMG00000034627
Pharos: O14880(Tbio)
UniProt: O14880 A0A024R8Z1
LinkDB
Position
1q24.1
AA seq 152 aa
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRA
HQNTLEVYPPFLFFLAVGGVYHPRIASGLGLAWIVGRVLYAYGYYTGEPSKRSRGALGSI
ALLGLVGTTVCSAFQHLGWVKSGLGSGPKCCH
NT seq 459 nt   +upstreamnt  +downstreamnt
atggctgtcctctctaaggaatatggttttgtgcttctaactggtgctgccagctttata
atggtggcccacctagccatcaatgtttccaaggcccgcaagaagtacaaagtggagtat
cctatcatgtacagcacggaccctgaaaatgggcacatcttcaactgcattcagcgagcc
caccagaacacgttggaagtgtatcctcccttcttattttttctagctgttggaggtgtt
taccacccgcgtatagcttctggcctgggcttggcctggattgttggacgagttctttat
gcttatggctattacacgggagaacccagcaagcgtagtcgaggagccctggggtccatc
gccctcctgggcttggtgggcacaactgtgtgctctgctttccagcatcttggttgggtt
aaaagtggcttgggcagtggacccaaatgctgccattaa

KEGG   Homo sapiens (human): 653689
Entry
653689            CDS       T01001                                 

Symbol
GSTT2B, GSTT2P
Name
(RefSeq) glutathione S-transferase theta 2B
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    653689 (GSTT2B)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    653689 (GSTT2B)
   00982 Drug metabolism - cytochrome P450
    653689 (GSTT2B)
   00983 Drug metabolism - other enzymes
    653689 (GSTT2B)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    653689 (GSTT2B)
   05204 Chemical carcinogenesis - DNA adducts
    653689 (GSTT2B)
   05207 Chemical carcinogenesis - receptor activation
    653689 (GSTT2B)
   05208 Chemical carcinogenesis - reactive oxygen species
    653689 (GSTT2B)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    653689 (GSTT2B)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    653689 (GSTT2B)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    653689 (GSTT2B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    653689 (GSTT2B)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     653689 (GSTT2B)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   653689 (GSTT2B)
SSDB
Motif
Pfam: GST_N GST_N_3 GST_C GST_N_2 GST_C_2 GST_C_3
Other DBs
NCBI-GeneID: 653689
NCBI-ProteinID: NP_001074312
HGNC: 33437
Ensembl: ENSG00000133433
Vega: OTTHUMG00000150774
Pharos: P0CG30(Tbio)
UniProt: P0CG30 G9J6Q5
LinkDB
Structure
PDB: 
1LJR 2LJR 3LJR

Position
22q11.23
AA seq 244 aa
MGLELFLDLVSQPSRAVYIFAKKNGIPLELRTVDLVKGQHKSKEFLQINSLGKLPTLKDG
DFILTESSAILIYLSCKYQTPDHWYPSDLQARARVHEYLGWHADCIRGTFGIPLWVQVLG
PLIGVQVPEEKVERNRTAMDQALQWLEDKFLGDRPFLAGQQVTLADLMALEELMQPVALG
YELFEGRPRLAAWRGRVEAFLGAELCQEAHSIILSILEQAAKKTLPTPSPEAYQAMLLRI
ARIP
NT seq 735 nt   +upstreamnt  +downstreamnt
atgggcctagagctgtttcttgacctggtgtcccagcccagccgcgccgtctacatcttc
gccaagaagaatggcatccccttagagctgcgcaccgtggatttggtcaaagggcagcac
aagagcaaggagttcttgcagatcaacagcctggggaaactgccgacgctcaaggatggt
gatttcatcttgaccgaaagctcggccatcctgatttacctgagctgtaagtaccagacg
ccggaccactggtatccatctgacctgcaggctcgtgcccgtgttcatgagtacctgggc
tggcatgccgactgcatccgtggcacctttggtatacccctgtgggtccaggtgttgggg
ccactcattggggtccaggtgcccgaggagaaggtggaacgcaacaggactgccatggac
caggccctgcaatggctggaggacaagttcctgggggacaggcccttcctcgctggccag
caggtgacactggctgatctcatggccctggaggagctgatgcagccggtggctctcggc
tatgaactgtttgagggacggccacgactggcagcatggcgtggacgagtggaggctttc
ctgggtgctgagctatgccaggaggcccacagcatcatcttgagcatcctggaacaggcg
gccaagaaaaccctcccaacaccctcaccagaggcctatcaggctatgctgcttcgaatc
gccaggatcccctga

KEGG   Homo sapiens (human): 9446
Entry
9446              CDS       T01001                                 

Symbol
GSTO1, GSTO_1-1, GSTTLp28, HEL-S-21, P28, SPG-R
Name
(RefSeq) glutathione S-transferase omega 1
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06252  Mitochondrial ROS formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
N01392  Arsenic to electron transfer in complex II
N01393  Arsenic to electron transfer in complex II
N01394  Arsenic to electron transfer in complex IV
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    9446 (GSTO1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    9446 (GSTO1)
   00982 Drug metabolism - cytochrome P450
    9446 (GSTO1)
   00983 Drug metabolism - other enzymes
    9446 (GSTO1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    9446 (GSTO1)
   05204 Chemical carcinogenesis - DNA adducts
    9446 (GSTO1)
   05207 Chemical carcinogenesis - receptor activation
    9446 (GSTO1)
   05208 Chemical carcinogenesis - reactive oxygen species
    9446 (GSTO1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    9446 (GSTO1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    9446 (GSTO1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    9446 (GSTO1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    9446 (GSTO1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     9446 (GSTO1)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   9446 (GSTO1)
SSDB
Motif
Pfam: GST_N_3 GST_N_2 GST_N GST_C_3 GST_C GST_C_2 Glutaredoxin GST_C_5
Other DBs
NCBI-GeneID: 9446
NCBI-ProteinID: NP_004823
OMIM: 605482
HGNC: 13312
Ensembl: ENSG00000148834
Vega: OTTHUMG00000019001
Pharos: P78417(Tbio)
UniProt: P78417 V9HWG9
LinkDB
Structure
PDB: 

Position
10q25.1
AA seq 241 aa
MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKP
EWFFKKNPFGLVPVLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELF
SKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEVLTNKKTTFFGGNSISMIDYLIWPW
FERLEAMKLNECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGFLELYLQNSPEACDYG
L
NT seq 726 nt   +upstreamnt  +downstreamnt
atgtccggggagtcagccaggagcttggggaagggaagcgcgcccccggggccggtcccg
gagggctcgatccgcatctacagcatgaggttctgcccgtttgctgagaggacgcgtcta
gtcctgaaggccaagggaatcaggcatgaagtcatcaatatcaacctgaaaaataagcct
gagtggttctttaagaaaaatccctttggtctggtgccagttctggaaaacagtcagggt
cagctgatctacgagtctgccatcacctgtgagtacctggatgaagcatacccagggaag
aagctgttgccggatgacccctatgagaaagcttgccagaagatgatcttagagttgttt
tctaaggtgccatccttggtaggaagctttattagaagccaaaataaagaagactatgct
ggcctaaaagaagaatttcgtaaagaatttaccaagctagaggaggttctgactaataag
aagacgaccttctttggtggcaattctatctctatgattgattacctcatctggccctgg
tttgaacggctggaagcaatgaagttaaatgagtgtgtagaccacactccaaaactgaaa
ctgtggatggcagccatgaaggaagatcccacagtctcagccctgcttactagtgagaaa
gactggcaaggtttcctagagctctacttacagaacagccctgaggcctgtgactatggg
ctctga

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