KEGG   Homo sapiens (human): 1543
Entry
1543              CDS       T01001                                 
Symbol
CYP1A1, AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX
Name
(RefSeq) cytochrome P450 family 1 subfamily A member 1
  KO
K07408  cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00380  Tryptophan metabolism
hsa00830  Retinol metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa01100  Metabolic pathways
hsa04913  Ovarian steroidogenesis
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05417  Lipid and atherosclerosis
Network
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06251  CYP-mediated ROS formation
nt06360  Cushing syndrome
  Element
N00317  AhR signaling pathway
N01365  TCDD to Ahr signaling pathway
N01366  BaP to Ahr signaling pathway
N01367  PCB to Ahr signaling pathway
N01368  HCB to Ahr signaling pathway
N01374  BaP to DNA adducts
N01375  DMBA to DNA adducts
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
N01404  17beta-estradiol to CYP-mediated metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    1543 (CYP1A1)
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    1543 (CYP1A1)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    1543 (CYP1A1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1543 (CYP1A1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    1543 (CYP1A1)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    1543 (CYP1A1)
   05207 Chemical carcinogenesis - receptor activation
    1543 (CYP1A1)
   05208 Chemical carcinogenesis - reactive oxygen species
    1543 (CYP1A1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    1543 (CYP1A1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1543 (CYP1A1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1543 (CYP1A1)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP1 family
   1543 (CYP1A1)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1543
NCBI-ProteinID: NP_000490
OMIM: 108330
HGNC: 2595
Ensembl: ENSG00000140465
Pharos: P04798(Tchem)
UniProt: P04798 A0N0X8
Structure
LinkDB
Position
15:complement(74719542..74725528)
AA seq 512 aa
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
NT seq 1539 nt   +upstreamnt  +downstreamnt
atgcttttcccaatctccatgtcggccacggagtttcttctggcctctgtcatcttctgt
ctggtattctgggtaatcagggcctcaagacctcaggtccccaaaggcctgaagaatcca
ccagggccatggggctggcctctgattgggcacatgctgaccctgggaaagaacccgcac
ctggcactgtcaaggatgagccagcagtatggggacgtgctgcagatccgaattggctcc
acacccgtggtggtgctgagcggcctggacaccatccggcaggccctggtgcggcagggc
gatgatttcaagggccggcccgacctctacaccttcaccctcatcagtaatggtcagagc
atgtccttcagcccagactctggaccagtgtgggctgcccgccggcgcctggcccagaat
ggcctgaaaagtttctccattgcctctgacccagcctcctcaacctcctgctacctggaa
gagcatgtgagcaaggaggctgaggtcctgataagcacgttgcaggagctgatggcaggg
cctgggcactttaacccctacaggtatgtggtggtatcagtgaccaatgtcatctgtgcc
atttgctttggccggcgctatgaccacaaccaccaagaactgcttagcctagtcaacctg
aataataatttcggggaggtggttggctctggaaacccagctgacttcatccctattctt
cgctacctacccaacccttccctgaatgccttcaaggacctgaatgagaagttctacagc
ttcatgcagaagatggtcaaggagcactacaaaacctttgagaagggccacatccgggac
atcacagacagcctgattgagcactgtcaggagaagcagctggatgagaacgccaatgtc
cagctgtcagatgagaagatcattaacatcgtcttggacctctttggagctgggtttgac
acagtcacaactgctatctcctggagcctcatgtatttggtgatgaaccccagggtacag
agaaagatccaagaggagctagacacagtgattggcaggtcacggcggccccggctctct
gacagatcccatctgccctatatggaggccttcatcctggagaccttccgacactcttcc
ttcgtccccttcaccatcccccacagcacaacaagagacacaagtttgaaaggcttttac
atccccaaggggcgttgtgtctttgtaaaccagtggcagatcaaccatgaccagaagcta
tgggtcaacccatctgagttcctacctgaacggtttctcacccctgatggtgctatcgac
aaggtgttaagtgagaaggtgattatctttggcatgggcaagcggaagtgtatcggtgag
accattgcccgctgggaggtctttctcttcctggctatcctgctgcaacgggtggaattc
agcgtgccactgggcgtgaaggtggacatgacccccatctatgggctaaccatgaagcat
gcctgctgtgagcacttccaaatgcagctgcgctcttag

KEGG   Homo sapiens (human): 1545
Entry
1545              CDS       T01001                                 
Symbol
CYP1B1, ASGD6, CP1B, CYPIB1, GLC3A, P4501B1
Name
(RefSeq) cytochrome P450 family 1 subfamily B member 1
  KO
K07410  cytochrome P450 family 1 subfamily B1 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00380  Tryptophan metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa04913  Ovarian steroidogenesis
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05206  MicroRNAs in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06251  CYP-mediated ROS formation
nt06360  Cushing syndrome
  Element
N00317  AhR signaling pathway
N01365  TCDD to Ahr signaling pathway
N01366  BaP to Ahr signaling pathway
N01367  PCB to Ahr signaling pathway
N01374  BaP to DNA adducts
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
N01405  17beta-estradiol to CYP-mediated metabolism
Disease
H01159  Anterior segment dysgenesis
H01203  Primary congenital glaucoma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    1545 (CYP1B1)
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    1545 (CYP1B1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1545 (CYP1B1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    1545 (CYP1B1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    1545 (CYP1B1)
   05204 Chemical carcinogenesis - DNA adducts
    1545 (CYP1B1)
   05207 Chemical carcinogenesis - receptor activation
    1545 (CYP1B1)
   05208 Chemical carcinogenesis - reactive oxygen species
    1545 (CYP1B1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1545 (CYP1B1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1545 (CYP1B1)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP1 family
   1545 (CYP1B1)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1545
NCBI-ProteinID: NP_000095
OMIM: 601771
HGNC: 2597
Ensembl: ENSG00000138061
Pharos: Q16678(Tchem)
UniProt: Q16678 Q53TK1
Structure
LinkDB
Position
2:complement(38067509..38076151)
AA seq 543 aa
MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI
GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF
ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL
LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL
VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSA
EKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAEL
DQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVV
FVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL
FLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKE
TCQ
NT seq 1632 nt   +upstreamnt  +downstreamnt
atgggcaccagcctcagcccgaacgacccttggccgctaaacccgctgtccatccagcag
accacgctcctgctactcctgtcggtgctggccactgtgcatgtgggccagcggctgctg
aggcaacggaggcggcagctccggtccgcgcccccgggcccgtttgcgtggccactgatc
ggaaacgcggcggcggtgggccaggcggctcacctctcgttcgctcgcctggcgcggcgc
tacggcgacgttttccagatccgcctgggcagctgccccatagtggtgctgaatggcgag
cgcgccatccaccaggccctggtgcagcagggctcggccttcgccgaccggccggccttc
gcctccttccgtgtggtgtccggcggccgcagcatggctttcggccactactcggagcac
tggaaggtgcagcggcgcgcagcccacagcatgatgcgcaacttcttcacgcgccagccg
cgcagccgccaagtcctcgagggccacgtgctgagcgaggcgcgcgagctggtggcgctg
ctggtgcgcggcagcgcggacggcgccttcctcgacccgaggccgctgaccgtcgtggcc
gtggccaacgtcatgagtgccgtgtgtttcggctgccgctacagccacgacgaccccgag
ttccgtgagctgctcagccacaacgaagagttcgggcgcacggtgggcgcgggcagcctg
gtggacgtgatgccctggctgcagtacttccccaacccggtgcgcaccgttttccgcgaa
ttcgagcagctcaaccgcaacttcagcaacttcatcctggacaagttcttgaggcactgc
gaaagccttcggcccggggccgccccccgcgacatgatggacgcctttatcctctctgcg
gaaaagaaggcggccggggactcgcacggtggtggcgcgcggctggatttggagaacgta
ccggccactatcactgacatcttcggcgccagccaggacaccctgtccaccgcgctgcag
tggctgctcctcctcttcaccaggtatcctgatgtgcagactcgagtgcaggcagaattg
gatcaggtcgtggggagggaccgtctgccttgtatgggtgaccagcccaacctgccctat
gtcctggccttcctttatgaagccatgcgcttctccagctttgtgcctgtcactattcct
catgccaccactgccaacacctctgtcttgggctaccacattcccaaggacactgtggtt
tttgtcaaccagtggtctgtgaatcatgacccactgaagtggcctaacccggagaacttt
gatccagctcgattcttggacaaggatggcctcatcaacaaggacctgaccagcagagtg
atgattttttcagtgggcaaaaggcggtgcattggcgaagaactttctaagatgcagctt
tttctcttcatctccatcctggctcaccagtgcgatttcagggccaacccaaatgagcct
gcgaaaatgaatttcagttatggtctaaccattaaacccaagtcatttaaagtcaatgtc
actctcagagagtccatggagctccttgatagtgctgtccaaaatttacaagccaaggaa
acttgccaataa

KEGG   Homo sapiens (human): 119391
Entry
119391            CDS       T01001                                 
Symbol
GSTO2, GSTO_2-2, bA127L20.1
Name
(RefSeq) glutathione S-transferase omega 2
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    119391 (GSTO2)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    119391 (GSTO2)
   00982 Drug metabolism - cytochrome P450
    119391 (GSTO2)
   00983 Drug metabolism - other enzymes
    119391 (GSTO2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119391 (GSTO2)
   05204 Chemical carcinogenesis - DNA adducts
    119391 (GSTO2)
   05207 Chemical carcinogenesis - receptor activation
    119391 (GSTO2)
   05208 Chemical carcinogenesis - reactive oxygen species
    119391 (GSTO2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    119391 (GSTO2)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    119391 (GSTO2)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    119391 (GSTO2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    119391 (GSTO2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     119391 (GSTO2)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   119391 (GSTO2)
SSDB
Motif
Pfam: GST_N_3 GST_N_2 GST_N GST_C_2 Glutaredoxin GST_C GST_C_3
Other DBs
NCBI-GeneID: 119391
NCBI-ProteinID: NP_899062
OMIM: 612314
HGNC: 23064
Ensembl: ENSG00000065621
Pharos: Q9H4Y5(Tbio)
UniProt: Q9H4Y5
Structure
LinkDB
Position
10:104269184..104304950
AA seq 243 aa
MSGDATRTLGKGSQPPGPVPEGLIRIYSMRFCPYSHRTRLVLKAKDIRHEVVNINLRNKP
EWYYTKHPFGHIPVLETSQCQLIYESVIACEYLDDAYPGRKLFPYDPYERARQKMLLELF
CKVPHLTKECLVALRCGRECTNLKAALRQEFSNLEEILEYQNTTFFGGTCISMIDYLLWP
WFERLDVYGILDCVSHTPALRLWISAMKWDPTVCALLMDKSIFQGFLNLYFQNNPNAFDF
GLC
NT seq 732 nt   +upstreamnt  +downstreamnt
atgtctggggatgcgaccaggaccctggggaaaggaagccagcccccagggccagtcccg
gaggggctgatccgcatctacagcatgaggttctgcccctattctcacaggacccgcctc
gtcctcaaggccaaagacatcagacatgaagtggtcaacattaacctgagaaacaagcct
gaatggtactatacaaagcacccttttggccacattcctgtcctggagaccagccaatgt
caactgatctatgaatctgttattgcttgtgagtacctggatgatgcttatccaggaagg
aagctgtttccatatgacccttatgaacgagctcgccaaaagatgttattggagctattt
tgtaaggtcccacatttgaccaaggagtgcctggtagcgttgagatgtgggagagaatgc
actaatctgaaggcagccctgcgtcaggaattcagcaacctggaagagattcttgagtat
cagaacaccaccttctttggtggaacctgtatatccatgattgattacctcctctggccc
tggtttgagcggctggatgtgtatgggatactggactgtgtgagccacacgccagccctg
cggctctggatatcagccatgaagtgggaccccacagtctgtgctcttctcatggataag
agcattttccagggcttcttgaatctctattttcagaacaaccctaatgcctttgacttt
gggctgtgctga

KEGG   Homo sapiens (human): 221357
Entry
221357            CDS       T01001                                 
Symbol
GSTA5
Name
(RefSeq) glutathione S-transferase alpha 5
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    221357 (GSTA5)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    221357 (GSTA5)
   00982 Drug metabolism - cytochrome P450
    221357 (GSTA5)
   00983 Drug metabolism - other enzymes
    221357 (GSTA5)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    221357 (GSTA5)
   05204 Chemical carcinogenesis - DNA adducts
    221357 (GSTA5)
   05207 Chemical carcinogenesis - receptor activation
    221357 (GSTA5)
   05208 Chemical carcinogenesis - reactive oxygen species
    221357 (GSTA5)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    221357 (GSTA5)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    221357 (GSTA5)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    221357 (GSTA5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    221357 (GSTA5)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     221357 (GSTA5)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   221357 (GSTA5)
SSDB
Motif
Pfam: GST_C_3 GST_C GST_N GST_N_3 GST_C_2
Other DBs
NCBI-GeneID: 221357
NCBI-ProteinID: NP_714543
OMIM: 607605
HGNC: 19662
Ensembl: ENSG00000182793
Pharos: Q7RTV2(Tdark)
UniProt: Q7RTV2
LinkDB
Position
6:complement(52831692..52846245)
AA seq 222 aa
MAEKPKLHYSNARGSMESIRWLLAAAGVELEEKFLESAEDLDKLRNDGSLLFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDMKERALIDMYTEGIVDLTEMILLLLICQPEERDAK
TALVKEKIKNRYFPAFEKVLKSHRQDYLVGNKLSWADIHLVELFYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSQRKPPMDEKSLEEARKIFRF
NT seq 669 nt   +upstreamnt  +downstreamnt
atggcagagaagcccaagctccactactccaatgcacggggcagtatggagtccattcgg
tggctcctggctgcagctggagtagagttggaagagaaatttctagaatctgcagaagat
ttggacaagttaagaaatgatgggagtttgctgttccagcaagtaccaatggttgagatt
gacgggatgaagctggtgcagaccagagccattcttaactacattgccagcaaatacaac
ctttatgggaaagacatgaaggagagagccctgattgatatgtacacagaaggtatagta
gatttgactgaaatgatccttcttctgctcatatgtcaaccagaggaaagagatgccaag
actgccttggtcaaagagaaaataaaaaatcgctacttccctgcctttgaaaaagtctta
aagagccacagacaagactaccttgttggcaacaagctgagctgggctgacattcacctg
gtggaacttttctactacgtggaagagcttgactcgagtcttatctccagcttccctctg
ctgaaggccctgaaaaccagaatcagcaacctgcccacggtgaagaagtttctgcagcct
ggcagccagagaaagcctcccatggatgagaaatctttagaagaagcaaggaagattttc
aggttttaa

KEGG   Homo sapiens (human): 2938
Entry
2938              CDS       T01001                                 
Symbol
GSTA1, GST-epsilon, GST2, GSTA1-1, GTH1
Name
(RefSeq) glutathione S-transferase alpha 1
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2938 (GSTA1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2938 (GSTA1)
   00982 Drug metabolism - cytochrome P450
    2938 (GSTA1)
   00983 Drug metabolism - other enzymes
    2938 (GSTA1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2938 (GSTA1)
   05204 Chemical carcinogenesis - DNA adducts
    2938 (GSTA1)
   05207 Chemical carcinogenesis - receptor activation
    2938 (GSTA1)
   05208 Chemical carcinogenesis - reactive oxygen species
    2938 (GSTA1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2938 (GSTA1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2938 (GSTA1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2938 (GSTA1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2938 (GSTA1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2938 (GSTA1)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2938 (GSTA1)
SSDB
Motif
Pfam: GST_N GST_C GST_C_3 GST_N_3
Other DBs
NCBI-GeneID: 2938
NCBI-ProteinID: NP_665683
OMIM: 138359
HGNC: 4626
Ensembl: ENSG00000243955
Pharos: P08263(Tchem)
UniProt: P08263 A0A140VJK4
Structure
LinkDB
Position
6:complement(52791371..52803816)
AA seq 222 aa
MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAK
LALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF
NT seq 669 nt   +upstreamnt  +downstreamnt
atggcagagaagcccaagctccactacttcaatgcacggggcagaatggagtccacccgg
tggctcctggctgcagctggagtagagtttgaagagaaatttataaaatctgcagaagat
ttggacaagttaagaaatgatggatatttgatgttccagcaagtgccaatggttgagatt
gatgggatgaagctggtgcagaccagagccattctcaactacattgccagcaaatacaac
ctctatgggaaagacataaaggagagagccctgattgatatgtatatagaaggtatagca
gatttgggtgaaatgatcctccttctgcccgtatgtccacctgaggaaaaagatgccaag
cttgccttgatcaaagagaaaataaaaaatcgctacttccctgcctttgaaaaagtctta
aagagccatggacaagactaccttgttggcaacaagctgagccgggctgacattcatctg
gtggaacttctctactacgtcgaggagcttgactccagtcttatctccagcttccctctg
ctgaaggccctgaaaaccagaatcagcaacctgcccacagtgaagaagtttctacagcct
ggcagcccaaggaagcctcccatggatgagaaatctttagaagaagcaaggaagattttc
aggttttaa

KEGG   Homo sapiens (human): 2939
Entry
2939              CDS       T01001                                 
Symbol
GSTA2, GST2, GSTA2-2, GTA2, GTH2
Name
(RefSeq) glutathione S-transferase alpha 2
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2939 (GSTA2)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2939 (GSTA2)
   00982 Drug metabolism - cytochrome P450
    2939 (GSTA2)
   00983 Drug metabolism - other enzymes
    2939 (GSTA2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2939 (GSTA2)
   05204 Chemical carcinogenesis - DNA adducts
    2939 (GSTA2)
   05207 Chemical carcinogenesis - receptor activation
    2939 (GSTA2)
   05208 Chemical carcinogenesis - reactive oxygen species
    2939 (GSTA2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2939 (GSTA2)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2939 (GSTA2)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2939 (GSTA2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2939 (GSTA2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2939 (GSTA2)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2939 (GSTA2)
SSDB
Motif
Pfam: GST_C GST_N GST_C_3 GST_N_3
Other DBs
NCBI-GeneID: 2939
NCBI-ProteinID: NP_000837
OMIM: 138360
HGNC: 4627
Ensembl: ENSG00000244067
Pharos: P09210(Tbio)
UniProt: P09210 A0A140VKE2 A8K987
Structure
LinkDB
Position
6:complement(52750087..52763475)
AA seq 222 aa
MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAK
LALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF
NT seq 669 nt   +upstreamnt  +downstreamnt
atggcagagaagcccaagctccactactccaatatacggggcagaatggagtccatccgg
tggctcctggctgcagctggagtagagtttgaagagaaatttataaaatctgcagaagat
ttggacaagttaagaaatgatggatatttgatgttccagcaagtgccaatggttgagatt
gatgggatgaagctggtgcagaccagagccattctcaactacattgccagcaaatacaac
ctctatgggaaagacataaaggagaaagccctgattgatatgtatatagaaggtatagca
gatttgggtgaaatgatccttcttctgccctttagtcaacctgaggaacaagatgccaag
cttgccttgatccaagagaaaacaaaaaatcgctacttccctgcctttgaaaaagtctta
aagagccacggacaagactaccttgttggcaacaagctgagccgggctgacattcacctg
gtggaacttctctactacgtggaagagcttgactctagccttatttccagcttccctctg
ctgaaggccctgaaaaccagaatcagtaacctgcccacagtgaagaagtttctacagcct
ggcagcccaaggaagcctcccatggatgagaaatctttagaagaatcaaggaagattttc
aggttttaa

KEGG   Homo sapiens (human): 2940
Entry
2940              CDS       T01001                                 
Symbol
GSTA3, GSTA3-3, GTA3
Name
(RefSeq) glutathione S-transferase alpha 3
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2940 (GSTA3)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2940 (GSTA3)
   00982 Drug metabolism - cytochrome P450
    2940 (GSTA3)
   00983 Drug metabolism - other enzymes
    2940 (GSTA3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2940 (GSTA3)
   05204 Chemical carcinogenesis - DNA adducts
    2940 (GSTA3)
   05207 Chemical carcinogenesis - receptor activation
    2940 (GSTA3)
   05208 Chemical carcinogenesis - reactive oxygen species
    2940 (GSTA3)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2940 (GSTA3)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2940 (GSTA3)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2940 (GSTA3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2940 (GSTA3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2940 (GSTA3)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2940 (GSTA3)
SSDB
Motif
Pfam: GST_N GST_C_3 GST_C
Other DBs
NCBI-GeneID: 2940
NCBI-ProteinID: NP_000838
OMIM: 605449
HGNC: 4628
Ensembl: ENSG00000174156
Pharos: Q16772(Tbio)
UniProt: Q16772
Structure
LinkDB
Position
6:complement(52896646..52909698)
AA seq 222 aa
MAGKPKLHYFNGRGRMEPIRWLLAAAGVEFEEKFIGSAEDLGKLRNDGSLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYTEGMADLNEMILLLPLCRPEEKDAK
IALIKEKTKSRYFPAFEKVLQSHGQDYLVGNKLSRADISLVELLYYVEELDSSLISNFPL
LKALKTRISNLPTVKKFLQPGSPRKPPADAKALEEARKIFRF
NT seq 669 nt   +upstreamnt  +downstreamnt
atggcagggaagcccaagcttcactacttcaatggacggggcagaatggagcccatccgg
tggctcttggctgcagctggagtggagtttgaagagaaatttataggatctgcagaagat
ttgggaaagttaagaaatgatgggagtttgatgttccagcaagtaccaatggttgagatt
gatgggatgaagttggtacagaccagagccattctcaactacattgccagcaaatacaac
ctctacgggaaagacataaaggagagagccctaattgatatgtatacagaaggtatggca
gatttgaatgaaatgatccttcttctgcccttatgtcgacctgaggaaaaagatgccaag
attgccttgatcaaagagaaaacaaaaagtcgctatttccctgccttcgaaaaagtgtta
cagagccatggacaagactaccttgttggcaacaagctgagccgggctgacattagcctg
gtggaacttctctactatgtggaagagcttgactccagccttatctccaacttccctctg
ctgaaggccctgaaaaccagaatcagcaacctgcccacggtgaagaagtttctacagcct
ggcagcccaaggaagcctcccgcagatgcaaaagctttagaagaagccagaaagattttc
aggttttaa

KEGG   Homo sapiens (human): 2941
Entry
2941              CDS       T01001                                 
Symbol
GSTA4, GSTA4-4, GTA4
Name
(RefSeq) glutathione S-transferase alpha 4
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2941 (GSTA4)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2941 (GSTA4)
   00982 Drug metabolism - cytochrome P450
    2941 (GSTA4)
   00983 Drug metabolism - other enzymes
    2941 (GSTA4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2941 (GSTA4)
   05204 Chemical carcinogenesis - DNA adducts
    2941 (GSTA4)
   05207 Chemical carcinogenesis - receptor activation
    2941 (GSTA4)
   05208 Chemical carcinogenesis - reactive oxygen species
    2941 (GSTA4)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2941 (GSTA4)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2941 (GSTA4)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2941 (GSTA4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2941 (GSTA4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2941 (GSTA4)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2941 (GSTA4)
SSDB
Motif
Pfam: GST_C_3 GST_N GST_C GST_C_2 CbeA_antitoxin GST_N_3
Other DBs
NCBI-GeneID: 2941
NCBI-ProteinID: NP_001503
OMIM: 605450
HGNC: 4629
Ensembl: ENSG00000170899
Pharos: O15217(Tbio)
UniProt: O15217 A0A024RD58
Structure
LinkDB
Position
6:complement(52977953..52995284)
AA seq 222 aa
MAARPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLYKLQDGNHLLFQQVPMVEI
DGMKLVQTRSILHYIADKHNLFGKNLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKE
VVNMAQKAIIRYFPVFEKILRGHGQSFLVGNQLSLADVILLQTILALEEKIPNILSAFPF
LQEYTVKLSNIPTIKRFLEPGSKKKPPPDEIYVRTVYNIFRP
NT seq 669 nt   +upstreamnt  +downstreamnt
atggcagcaaggcccaagctccactatcccaacggaagaggccggatggagtccgtgaga
tgggttttagctgccgccggagtcgagtttgatgaagaatttctggaaacaaaagaacag
ttgtacaagttgcaggatggtaaccacctgctgttccaacaagtgcccatggttgaaatt
gacgggatgaagttggtacagacccgaagcattctccactacatagcagacaagcacaat
ctctttggcaagaacctcaaggagagaaccctgattgacatgtacgtggaggggacactg
gatctgctggaactgcttatcatgcatcctttcttaaaaccagatgatcagcaaaaggaa
gtggttaacatggcccagaaggctataattagatactttcctgtgtttgaaaagatttta
aggggtcacggacaaagctttcttgttggtaatcagctgagccttgcagatgtgatttta
ctccaaaccattttagctctagaagagaaaattcctaatatcctgtctgcatttcctttc
ctccaggaatacacagtgaaactaagtaatatccctacaattaagagattccttgaacct
ggcagcaagaagaagcctccccctgatgaaatttatgtgagaaccgtctacaacatcttt
aggccataa

KEGG   Homo sapiens (human): 2944
Entry
2944              CDS       T01001                                 
Symbol
GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1
Name
(RefSeq) glutathione S-transferase mu 1
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2944 (GSTM1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2944 (GSTM1)
   00982 Drug metabolism - cytochrome P450
    2944 (GSTM1)
   00983 Drug metabolism - other enzymes
    2944 (GSTM1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2944 (GSTM1)
   05204 Chemical carcinogenesis - DNA adducts
    2944 (GSTM1)
   05207 Chemical carcinogenesis - receptor activation
    2944 (GSTM1)
   05208 Chemical carcinogenesis - reactive oxygen species
    2944 (GSTM1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2944 (GSTM1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2944 (GSTM1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2944 (GSTM1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2944 (GSTM1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2944 (GSTM1)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2944 (GSTM1)
SSDB
Motif
Pfam: GST_N GST_C_3 GST_C GST_C_6 GST_N_3 GST_C_2
Other DBs
NCBI-GeneID: 2944
NCBI-ProteinID: NP_000552
OMIM: 138350
HGNC: 4632
Ensembl: ENSG00000134184
Pharos: P09488(Tbio)
UniProt: P09488 X5DR03
Structure
LinkDB
Position
1:109687817..109693745
AA seq 218 aa
MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQTMDNHMQLGMICYNPEF
EKLKPKYLEELPEKLKLYSEFLGKRPWFAGNKITFVDFLVYDVLDLHRIFEPKCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPRPVFSKMAVWGNK
NT seq 657 nt   +upstreamnt  +downstreamnt
atgcccatgatactggggtactgggacatccgcgggctggcccacgccatccgcctgctc
ctggaatacacagactcaagctatgaggaaaagaagtacacgatgggggacgctcctgat
tatgacagaagccagtggctgaatgaaaaattcaagctgggcctggactttcccaatctg
ccctacttgattgatggggctcacaagatcacccagagcaacgccatcttgtgctacatt
gcccgcaagcacaacctgtgtggggagacagaagaggagaagattcgtgtggacattttg
gagaaccagaccatggacaaccatatgcagctgggcatgatctgctacaatccagaattt
gagaaactgaagccaaagtacttggaggaactccctgaaaagctaaagctctactcagag
tttctggggaagcggccatggtttgcaggaaacaagatcacttttgtagattttctcgtc
tatgatgtccttgacctccaccgtatatttgagcccaagtgcttggacgccttcccaaat
ctgaaggacttcatctcccgctttgagggcttggagaagatctctgcctacatgaagtcc
agccgcttcctcccaagacctgtgttctcaaagatggctgtctggggcaacaagtag

KEGG   Homo sapiens (human): 2946
Entry
2946              CDS       T01001                                 
Symbol
GSTM2, GST4, GSTM, GSTM2-2, GTHMUS
Name
(RefSeq) glutathione S-transferase mu 2
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06227  Nuclear receptor signaling
nt06250  DNA adduct formation
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2946 (GSTM2)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    2946 (GSTM2)
   00982 Drug metabolism - cytochrome P450
    2946 (GSTM2)
   00983 Drug metabolism - other enzymes
    2946 (GSTM2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2946 (GSTM2)
   05204 Chemical carcinogenesis - DNA adducts
    2946 (GSTM2)
   05207 Chemical carcinogenesis - receptor activation
    2946 (GSTM2)
   05208 Chemical carcinogenesis - reactive oxygen species
    2946 (GSTM2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    2946 (GSTM2)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    2946 (GSTM2)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    2946 (GSTM2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    2946 (GSTM2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     2946 (GSTM2)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   2946 (GSTM2)
SSDB
Motif
Pfam: GST_N GST_C GST_C_3 GST_C_6 GST_C_2 GST_N_3 Bromo_TP
Other DBs
NCBI-GeneID: 2946
NCBI-ProteinID: NP_000839
OMIM: 138380
HGNC: 4634
Ensembl: ENSG00000213366
Pharos: P28161(Tchem)
UniProt: P28161 A0A384P5E9 Q0D2I8
Structure
LinkDB
Position
1:109668057..109683997
AA seq 218 aa
MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDILENQFMDSRMQLAKLCYDPDF
EKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPRPVFTKMAVWGNK
NT seq 657 nt   +upstreamnt  +downstreamnt
atgcccatgacactggggtactggaacatccgcgggctggcccattccatccgcctgctc
ctggaatacacagactcaagctacgaggaaaagaagtacacgatgggggacgctcctgat
tatgacagaagccagtggctgaatgaaaaattcaagctgggcctggactttcccaatctg
ccctacttgattgatgggactcacaagatcacccagagcaacgccatcctgcggtacatt
gcccgcaagcacaacctgtgcggggaatcagaaaaggagcagattcgcgaagacattttg
gagaaccagtttatggacagccgtatgcagctggccaaactctgctatgacccagatttt
gagaaactgaaaccagaatacctgcaggcactccctgaaatgctgaagctctactcacag
tttctggggaagcagccatggtttcttggggacaagatcacctttgtggatttcatcgct
tatgatgtccttgagagaaaccaagtatttgagcccagctgcctggatgccttcccaaac
ctgaaggacttcatctcccgatttgagggcttggagaagatctctgcctacatgaagtcc
agccgcttcctcccaagacctgtgttcacaaagatggctgtctggggcaacaagtag

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