KEGG   Homo sapiens (human): 1548
Entry
1548              CDS       T01001                                 
Symbol
CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB
Name
(RefSeq) cytochrome P450 family 2 subfamily A member 6
  KO
K17683  cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00232  Caffeine metabolism
hsa00830  Retinol metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05417  Lipid and atherosclerosis
Network
nt06250  DNA adduct formation
  Element
N01379  NNK to DNA adducts
N01380  NNK to DNA adducts
N01381  NNK to DNA adducts
N01382  NNK to DNA adducts
Disease
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    1548 (CYP2A6)
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    1548 (CYP2A6)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1548 (CYP2A6)
   00982 Drug metabolism - cytochrome P450
    1548 (CYP2A6)
   00983 Drug metabolism - other enzymes
    1548 (CYP2A6)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    1548 (CYP2A6)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    1548 (CYP2A6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1548 (CYP2A6)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-
     1548 (CYP2A6)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1548 (CYP2A6)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1548
NCBI-ProteinID: NP_000753
OMIM: 122720
HGNC: 2610
Ensembl: ENSG00000255974
Vega: OTTHUMG00000182713
Pharos: P11509(Tchem)
UniProt: P11509
Structure
LinkDB
Position
19:complement(40843541..40850447)
AA seq 494 aa
MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK
ISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN
GERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSN
VISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQL
LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFI
GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQ
RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEK
GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGF
ATIPRNYTMSFLPR
NT seq 1485 nt   +upstreamnt  +downstreamnt
atgctggcctcagggatgcttctggtggccttgctggtctgcctgactgtaatggtcttg
atgtctgtttggcagcagaggaagagcaaggggaagctgcctccgggacccaccccattg
cccttcattggaaactacctgcagctgaacacagagcagatgtacaactccctcatgaag
atcagtgagcgctatggccccgtgttcaccattcacttggggccccggcgggtcgtggtg
ctgtgtggacatgatgccgtcagggaggctctggtggaccaggctgaggagttcagcggg
cgaggcgagcaagccaccttcgactgggtcttcaaaggctatggcgtggtattcagcaac
ggggagcgcgccaagcagctccggcgcttctccatcgccaccctgcgggacttcggggtg
ggcaagcgaggcatcgaggagcgcatccaggaggaggcgggcttcctcatcgacgccctc
cggggcactggcggcgccaatatcgatcccaccttcttcctgagccgcacagtctccaat
gtcatcagctccattgtctttggggaccgctttgactataaggacaaagagttcctgtca
ctgttgcgcatgatgctaggaatcttccagttcacgtcaacctccacggggcagctctat
gagatgttctcttcggtgatgaaacacctgccaggaccacagcaacaggcctttcagttg
ctgcaagggctggaggacttcatagccaagaaggtggagcacaaccagcgcacgctggat
cccaattccccacgggacttcattgactcctttctcatccgcatgcaggaggaggagaag
aaccccaacacggagttctacttgaaaaacctggtgatgaccacgttgaacctcttcatt
gggggcaccgagaccgtcagcaccaccctgcgctatggcttcttgctgctcatgaagcac
ccagaggtggaggccaaggtccatgaggagattgacagagtgatcggcaagaaccggcag
cccaagtttgaggaccgggccaagatgccctacatggaggcagtgatccacgagatccaa
agatttggagacgtgatccccatgagtttggcccgcagagtcaaaaaggacaccaagttt
cgggatttcttcctccctaagggcaccgaagtgtaccctatgctgggctctgtgctgaga
gaccccagtttcttctccaacccccaggacttcaatccccagcacttcctgaatgagaag
gggcagtttaagaagagtgatgcttttgtgcccttttccatcggaaagcggaactgtttc
ggagaaggcctggccagaatggagctctttctcttcttcaccaccgtcatgcagaacttc
cgcctcaagtcctcccagtcacctaaggacattgacgtgtcccccaaacacgtgggcttt
gccacgatcccacgaaactacaccatgagcttcctgccccgctga

KEGG   Homo sapiens (human): 1549
Entry
1549              CDS       T01001                                 
Symbol
CYP2A7, CPA7, CPAD, CYP2A, CYPIIA7, P450-IIA4
Name
(RefSeq) cytochrome P450 family 2 subfamily A member 7
  KO
K17683  cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00232  Caffeine metabolism
hsa00830  Retinol metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    1549 (CYP2A7)
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    1549 (CYP2A7)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1549 (CYP2A7)
   00982 Drug metabolism - cytochrome P450
    1549 (CYP2A7)
   00983 Drug metabolism - other enzymes
    1549 (CYP2A7)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    1549 (CYP2A7)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    1549 (CYP2A7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1549 (CYP2A7)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-
     1549 (CYP2A7)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1549 (CYP2A7)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1549
NCBI-ProteinID: NP_000755
OMIM: 608054
HGNC: 2611
Ensembl: ENSG00000198077
Vega: OTTHUMG00000182715
Pharos: P20853(Tbio)
UniProt: P20853
LinkDB
Position
19:complement(40875439..40882231)
AA seq 494 aa
MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK
FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN
GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN
VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL
LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI
AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ
RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK
GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF
ATIPRNYTMSFLPR
NT seq 1485 nt   +upstreamnt  +downstreamnt
atgctggcctcagggctgcttctggtggccttgctggcctgcctgactgtgatggtcttg
atgtctgtctggcagcagaggaagagcagggggaagctgcctccgggacccaccccactg
cccttcattggaaactacctccagctgaacacagagcacatatgtgactccatcatgaag
ttcagtgagtgctatggccccgtgttcaccattcacttggggccccggcgggtcgtggtg
ctgtgtggacatgatgccgtcagggaggctctggtggaccaggctgaggagttcagcggg
cgaggcgagcaagccaccttcgactgggtcttcaaaggctatggcgtggcgttcagcaac
ggggagcgcgccaagcagctcctgcgctttgccatcgccaccctgagggacttcggggtg
ggcaagcgaggcatcgaggagcgcatccaggaggagtcgggcttcctcatcgaggccatc
cggagcacgcacggcgccaatatcgatcccaccttcttcctgagccgcacagtctccaat
gtcatcagctccattgtctttggggaccgctttgactatgaggacaaagagttcctgtca
ctgctgagcatgatgctaggaatcttccagttcacgtcaacctccacggggcagctctat
gagatgttctcttcggtgatgaaacacctgccaggaccacagcaacaggcctttaagttg
ctgcaagggctggaggacttcatagccaagaaggtggagcacaaccagcgcacgctggat
cccaattccccacaggacttcatcgactcctttctcatccacatgcaggaggaggagaag
aaccccaacacggagttctacttgaagaacctgatgatgagcacgttgaacctcttcatt
gcaggcaccgagacggtcagcaccaccctgcgctatggcttcttgctgctcatgaagcac
ccagaggtggaggccaaggtccatgaggagattgacagagtgatcggcaagaaccggcag
cccaagtttgaggaccggaccaagatgccctacatggaggcagtgatccacgagatccaa
agatttggagacgtgatccccatgagtttggcccgcagggttaaaaaggacaccaagttt
cgggattttttcctccctaagggcaccgaagtgttccctatgctgggctccgtgctgaga
gaccccagcttcttctccaaccctcaggacttcaatccccagcatttcctggatgacaag
gggcagtttaagaagagtgatgcttttgtgcccttttccatcggaaagcggaactgtttc
ggagaaggcctggccagaatggagctctttctcttcttcaccaccgtcatgcagaacttc
cgcctcaagtcctcccagtcacctaaggacattgacgtgtcccccaaacacgtggtcttt
gccacgatcccacgaaactacaccatgagcttcctgccccgctga

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