KEGG   Homo sapiens (human): 163702
Entry
163702            CDS       T01001                                 
Symbol
IFNLR1, CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2
Name
(RefSeq) interferon lambda receptor 1
  KO
K05140  interferon lambda receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Drug target
Peginterferon lambda-1a: D10078
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    163702 (IFNLR1)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    163702 (IFNLR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    163702 (IFNLR1)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  IL10/28 receptor family
   163702 (IFNLR1)
SSDB
Motif
Pfam: Tissue_fac
Other DBs
NCBI-GeneID: 163702
NCBI-ProteinID: NP_734464
OMIM: 607404
HGNC: 18584
Ensembl: ENSG00000185436
UniProt: Q8IU57
Structure
LinkDB
Position
1:complement(24154168..24187289)
AA seq 520 aa
MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQ
SSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYL
FEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQ
PVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLPSLLILLL
VIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLCPQKELTR
GVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQEHQAPGHS
EAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPGQGPGGDG
HQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLTFCWESSP
EEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR
NT seq 1563 nt   +upstreamnt  +downstreamnt
atggcggggcccgagcgctggggccccctgctcctgtgcctgctgcaggccgctccaggg
aggccccgtctggcccctccccagaatgtgacgctgctctcccagaacttcagcgtgtac
ctgacatggctcccagggcttggcaacccccaggatgtgacctattttgtggcctatcag
agctctcccacccgtagacggtggcgcgaagtggaagagtgtgcgggaaccaaggagctg
ctatgttctatgatgtgcctgaagaaacaggacctgtacaacaagttcaagggacgcgtg
cggacggtttctcccagctccaagtccccctgggtggagtccgaatacctggattacctt
tttgaagtggagccggccccacctgtcctggtgctcacccagacggaggagatcctgagt
gccaatgccacgtaccagctgcccccctgcatgcccccactggatctgaagtatgaggtg
gcattctggaaggagggggccggaaacaagaccctatttccagtcactccccatggccag
ccagtccagatcactctccagccagctgccagcgaacaccactgcctcagtgccagaacc
atctacacgttcagtgtcccgaaatacagcaagttctctaagcccacctgcttcttgctg
gaggtcccagaagccaactgggctttcctggtgctgccatcgcttctgatactgctgtta
gtaattgccgcagggggtgtgatctggaagaccctcatggggaacccctggtttcagcgg
gcaaagatgccacgggccctggacttttctggacacacacaccctgtggcaacctttcag
cccagcagaccagagtccgtgaatgacttgttcctctgtccccaaaaggaactgaccaga
ggggtcaggccgacgcctcgagtcagggccccagccacccaacagacaagatggaagaag
gaccttgcagaggacgaagaggaggaggatgaggaggacacagaagatggcgtcagcttc
cagccctacattgaaccaccttctttcctggggcaagagcaccaggctccagggcactcg
gaggctggtggggtggactcagggaggcccagggctcctctggtcccaagcgaaggctcc
tctgcttgggattcttcagacagaagctgggccagcactgtggactcctcctgggacagg
gctgggtcctctggctatttggctgagaaggggccaggccaagggccgggtggggatggg
caccaagaatctctcccaccacctgaattctccaaggactcgggtttcctggaagagctc
ccagaagataacctctcctcctgggccacctggggcaccttaccaccggagccgaatctg
gtccctgggggacccccagtttctcttcagacactgaccttctgctgggaaagcagccct
gaggaggaagaggaggcgagggaatcagaaattgaggacagcgatgcgggcagctggggg
gctgagagcacccagaggaccgaggacaggggccggacattggggcattacatggccagg
tga

KEGG   Homo sapiens (human): 3454
Entry
3454              CDS       T01001                                 
Symbol
IFNAR1, AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC, IMD106
Name
(RefSeq) interferon alpha and beta receptor subunit 1
  KO
K05130  interferon receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04217  Necroptosis
hsa04380  Osteoclast differentiation
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06219  JAK-STAT signaling (cancer)
nt06222  IFN signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06517  TLR signaling
nt06518  JAK-STAT signaling
nt06527  Necroptosis
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N00150  Type I IFN signaling pathway
N00471  EBV LMP2A/2B to IFN signaling pathway
N01558  Type I interferon to Jak-STAT signaling pathway
N01662  IFN-RIPK1/3 signaling pathway
Disease
H02525  Disorders of innate immunity
Drug target
Albinterferon alfa-2b: D08844
Anifrolumab: D11082<JP/US>
Interferon alfa natural: D03305<JP>
Interferon alfa-2a: D00745
Interferon alfa-2b: D02745
Interferon alfa-n1: D04552
Interferon alfacon-1: D02744
Interferon alpha  
(abbr) INFalpha (DG01750): D04553
Interferon beta natural: D03304
Interferon beta-1a: D04554<JP/US>
Interferon beta-1b: D00746<JP/US>
Peginterferon alfa-2a: D02747<JP/US>
Peginterferon alfa-2b: D02748
Peginterferon beta-1a: D10483<US>
Ropeginterferon alfa-2b: D11027<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3454 (IFNAR1)
   04151 PI3K-Akt signaling pathway
    3454 (IFNAR1)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3454 (IFNAR1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    3454 (IFNAR1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    3454 (IFNAR1)
   04621 NOD-like receptor signaling pathway
    3454 (IFNAR1)
   04650 Natural killer cell mediated cytotoxicity
    3454 (IFNAR1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    3454 (IFNAR1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3454 (IFNAR1)
  09172 Infectious disease: viral
   05161 Hepatitis B
    3454 (IFNAR1)
   05160 Hepatitis C
    3454 (IFNAR1)
   05171 Coronavirus disease - COVID-19
    3454 (IFNAR1)
   05164 Influenza A
    3454 (IFNAR1)
   05162 Measles
    3454 (IFNAR1)
   05168 Herpes simplex virus 1 infection
    3454 (IFNAR1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    3454 (IFNAR1)
   05169 Epstein-Barr virus infection
    3454 (IFNAR1)
   05165 Human papillomavirus infection
    3454 (IFNAR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    3454 (IFNAR1)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  IFN receptor family
   3454 (IFNAR1)
SSDB
Motif
Pfam: Interfer-bind Tissue_fac fn3 Pombe_5TM
Other DBs
NCBI-GeneID: 3454
NCBI-ProteinID: NP_000620
OMIM: 107450
HGNC: 5432
Ensembl: ENSG00000142166
UniProt: P17181
Structure
LinkDB
Position
21:33324395..33359864
AA seq 557 aa
MMVVLLGATTLVLVAVAPWVLSAAAGGKNLKSPQKVEVDIIDDNFILRWNRSDESVGNVT
FSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSF
TPFRKAQIGPPEVHLEAEDKAIVIHISPGTKDSVMWALDGLSFTYSLVIWKNSSGVEERI
ENIYSRHKIYKLSPETTYCLKVKAALLTSWKIGVYSPVHCIKTTVENELPPPENIEVSVQ
NQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYKWKQIPDCENVKTTQCVFPQNVFQK
GIYLLRVQASDGNNTSFWSEEIKFDTEIQAFLLPPVFNIRSLSDSFHIYIGAPKQSGNTP
VIQDYPLIYEIIFWENTSNAERKIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSV
FSDAVCEKTKPGNTSKIWLIVGICIALFALPFVIYAAKVFLRCINYVFFPSLKPSSSIDE
YFSEQPLKNLLLSTSEEQIEKCFIIENISTIATVEETNQTDEDHKKYSSQTSQDSGNYSN
EDESESKTSEELQQDFV
NT seq 1674 nt   +upstreamnt  +downstreamnt
atgatggtcgtcctcctgggcgcgacgaccctagtgctcgtcgccgtggcgccatgggtg
ttgtccgcagccgcaggtggaaaaaatctaaaatctcctcaaaaagtagaggtcgacatc
atagatgacaactttatcctgaggtggaacaggagcgatgagtctgtcgggaatgtgact
ttttcattcgattatcaaaaaactgggatggataattggataaaattgtctgggtgtcag
aatattactagtaccaaatgcaacttttcttcactcaagctgaatgtttatgaagaaatt
aaattgcgtataagagcagaaaaagaaaacacttcttcatggtatgaggttgactcattt
acaccatttcgcaaagctcagattggtcctccagaagtacatttagaagctgaagataag
gcaatagtgatacacatctctcctggaacaaaagatagtgttatgtgggctttggatggt
ttaagctttacatatagcttagttatctggaaaaactcttcaggtgtagaagaaaggatt
gaaaatatttattccagacataaaatttataaactctcaccagagactacttattgtcta
aaagttaaagcagcactacttacgtcatggaaaattggtgtctatagtccagtacattgt
ataaagaccacagttgaaaatgaactacctccaccagaaaatatagaagtcagtgtccaa
aatcagaactatgttcttaaatgggattatacatatgcaaacatgacctttcaagttcag
tggctccacgcctttttaaaaaggaatcctggaaaccatttgtataaatggaaacaaata
cctgactgtgaaaatgtcaaaactacccagtgtgtctttcctcaaaacgttttccaaaaa
ggaatttaccttctccgcgtacaagcatctgatggaaataacacatctttttggtctgaa
gagataaagtttgatactgaaatacaagctttcctacttcctccagtctttaacattaga
tcccttagtgattcattccatatctatatcggtgctccaaaacagtctggaaacacgcct
gtgatccaggattatccactgatttatgaaattattttttgggaaaacacttcaaatgct
gagagaaaaattatcgagaaaaaaactgatgttacagttcctaatttgaaaccactgact
gtatattgtgtgaaagccagagcacacaccatggatgaaaagctgaataaaagcagtgtt
tttagtgacgctgtatgtgagaaaacaaaaccaggaaatacctctaaaatttggcttata
gttggaatttgtattgcattatttgctctcccgtttgtcatttatgctgcgaaagtcttc
ttgagatgcatcaattatgtcttctttccatcacttaaaccttcttccagtatagatgag
tatttctctgaacagccattgaagaatcttctgctttcaacttctgaggaacaaatcgaa
aaatgtttcataattgaaaatataagcacaattgctacagtagaagaaactaatcaaact
gatgaagatcataaaaaatacagttcccaaactagccaagattcaggaaattattctaat
gaagatgaaagcgaaagtaaaacaagtgaagaactacagcaggactttgtatga

KEGG   Homo sapiens (human): 3455
Entry
3455              CDS       T01001                                 
Symbol
IFNAR2, IFN-R, IFN-R-2, IFN-alpha-REC, IFNABR, IFNARB, IMD45
Name
(RefSeq) interferon alpha and beta receptor subunit 2
  KO
K05131  interferon receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04217  Necroptosis
hsa04380  Osteoclast differentiation
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa05160  Hepatitis C
hsa05162  Measles
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06219  JAK-STAT signaling (cancer)
nt06222  IFN signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06517  TLR signaling
nt06518  JAK-STAT signaling
nt06527  Necroptosis
  Element
N00053  Cytokine-Jak-STAT signaling pathway
N00150  Type I IFN signaling pathway
N00471  EBV LMP2A/2B to IFN signaling pathway
N01558  Type I interferon to Jak-STAT signaling pathway
N01560  Regulation of type I interferon to Jak-STAT signaling pathway, USP18
N01662  IFN-RIPK1/3 signaling pathway
Disease
H00412  Hepatitis B
H02525  Disorders of innate immunity
Drug target
Albinterferon alfa-2b: D08844
Anifrolumab: D11082<JP/US>
Interferon alfa natural: D03305<JP>
Interferon alfa-2a: D00745
Interferon alfa-2b: D02745
Interferon alfa-n1: D04552
Interferon alfacon-1: D02744
Interferon alpha  
(abbr) INFalpha (DG01750): D04553
Interferon beta natural: D03304
Interferon beta-1a: D04554<JP/US>
Interferon beta-1b: D00746<JP/US>
Peginterferon alfa-2a: D02747<JP/US>
Peginterferon alfa-2b: D02748
Peginterferon beta-1a: D10483<US>
Ropeginterferon alfa-2b: D11027<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3455 (IFNAR2)
   04151 PI3K-Akt signaling pathway
    3455 (IFNAR2)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3455 (IFNAR2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    3455 (IFNAR2)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    3455 (IFNAR2)
   04621 NOD-like receptor signaling pathway
    3455 (IFNAR2)
   04650 Natural killer cell mediated cytotoxicity
    3455 (IFNAR2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    3455 (IFNAR2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3455 (IFNAR2)
  09172 Infectious disease: viral
   05160 Hepatitis C
    3455 (IFNAR2)
   05171 Coronavirus disease - COVID-19
    3455 (IFNAR2)
   05164 Influenza A
    3455 (IFNAR2)
   05162 Measles
    3455 (IFNAR2)
   05168 Herpes simplex virus 1 infection
    3455 (IFNAR2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    3455 (IFNAR2)
   05169 Epstein-Barr virus infection
    3455 (IFNAR2)
   05165 Human papillomavirus infection
    3455 (IFNAR2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    3455 (IFNAR2)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  IFN receptor family
   3455 (IFNAR2)
SSDB
Motif
Pfam: Tissue_fac Interfer-bind
Other DBs
NCBI-GeneID: 3455
NCBI-ProteinID: NP_001276054
OMIM: 602376
HGNC: 5433
Ensembl: ENSG00000159110
UniProt: P48551
Structure
LinkDB
Position
21:33229938..33265664
AA seq 515 aa
MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS
IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF
SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK
HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE
SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD
MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLI
DPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGR
ITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPT
FPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR
NT seq 1548 nt   +upstreamnt  +downstreamnt
atgcttttgagccagaatgccttcatcttcagatcacttaatttggttctcatggtgtat
atcagcctcgtgtttggtatttcatatgattcgcctgattacacagatgaatcttgcact
ttcaagatatcattgcgaaatttccggtccatcttatcatgggaattaaaaaaccactcc
attgtaccaactcactatacattgctgtatacaatcatgagtaaaccagaagatttgaag
gtggttaagaactgtgcaaataccacaagatcattttgtgacctcacagatgagtggaga
agcacacacgaggcctatgtcaccgtcctagaaggattcagcgggaacacaacgttgttc
agttgctcacacaatttctggctggccatagacatgtcttttgaaccaccagagtttgag
attgttggttttaccaaccacattaatgtgatggtgaaatttccatctattgttgaggaa
gaattacagtttgatttatctctcgtcattgaagaacagtcagagggaattgttaagaag
cataaacccgaaataaaaggaaacatgagtggaaatttcacctatatcattgacaagtta
attccaaacacgaactactgtgtatctgtttatttagagcacagtgatgagcaagcagta
ataaagtctcccttaaaatgcaccctccttccacctggccaggaatcagaatcagcagaa
tctgccaaaataggaggaataattactgtgtttttgatagcattggtcttgacaagcacc
atagtgacactgaaatggattggttatatatgcttaagaaatagcctccccaaagtcttg
aattttcataactttttagcctggccatttcctaacctgccaccgttggaagccatggat
atggtggaggtcatttacatcaacagaaagaagaaagtgtgggattataattatgatgat
gaaagtgatagcgatactgaggcagcgcccaggacaagtggcggtggctataccatgcat
ggactgactgtcaggcctctgggtcaggcctctgccacctctacagaatcccagttgata
gacccggagtccgaggaggagcctgacctgcctgaggttgatgtggagctccccacgatg
ccaaaggacagccctcagcagttggaactcttgagtgggccctgtgagaggagaaagagt
ccactccaggacccttttcccgaagaggactacagctccacggaggggtctgggggcaga
attaccttcaatgtggacttaaactctgtgtttttgagagttcttgatgacgaggacagt
gacgacttagaagcccctctgatgctatcgtctcatctggaagagatggttgacccagag
gatcctgataatgtgcaatcaaaccatttgctggccagcggggaagggacacagccaacc
tttcccagcccctcttcagagggcctgtggtccgaagatgctccatctgatcaaagtgac
acttctgagtcagatgttgaccttggggatggttatataatgagatga

KEGG   Homo sapiens (human): 3588
Entry
3588              CDS       T01001                                 
Symbol
IL10RB, CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IBD25, IL-10R2, IL-10RB
Name
(RefSeq) interleukin 10 receptor subunit beta
  KO
K05135  interleukin 10 receptor beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04630  JAK-STAT signaling pathway
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05163  Human cytomegalovirus infection
Network
nt06167  Human cytomegalovirus (HCMV)
nt06518  JAK-STAT signaling
  Element
N00415  IL10 family to Jak-STAT signaling pathway
N00416  HCMV vIL10 to IL10-JAK-STAT signaling pathway
Disease
H00286  Crohn disease
H00412  Hepatitis B
H01227  Inflammatory bowel disease (IBD)
Drug target
Ilodecakin: D04505
Pegilodecakin: D11200
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    3588 (IL10RB)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    3588 (IL10RB)
   04061 Viral protein interaction with cytokine and cytokine receptor
    3588 (IL10RB)
 09160 Human Diseases
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    3588 (IL10RB)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    3588 (IL10RB)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    3588 (IL10RB)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    3588 (IL10RB)
   04090 CD molecules [BR:hsa04090]
    3588 (IL10RB)
Cytokine receptors [BR:hsa04050]
 Interleukin receptor families
  IL10/28 receptor family
   3588 (IL10RB)
CD molecules [BR:hsa04090]
 Proteins
  3588 (IL10RB)
SSDB
Motif
Pfam: Interfer-bind Tissue_fac fn3 XK-related MP_p6
Other DBs
NCBI-GeneID: 3588
NCBI-ProteinID: NP_000619
OMIM: 123889
HGNC: 5965
Ensembl: ENSG00000243646
UniProt: Q08334
Structure
LinkDB
Position
21:33266367..33310182
AA seq 325 aa
MAWSLGSWLGGCLLVSALGMVPPPENVRMNSVNFKNILQWESPAFAKGNLTFTAQYLSYR
IFQDKCMNTTLTECDFSSLSKYGDHTLRVRAEFADEHSDWVNITFCPVDDTIIGPPGMQV
EVLADSLHMRFLAPKIENEYETWTMKNVYNSWTYNVQYWKNGTDEKFQITPQYDFEVLRN
LEPWTTYCVQVRGFLPDRNKAGEWSEPVCEQTTHDETVPSWMVAVILMASVFMVCLALLG
CFALLWCVYKKTKYAFSPRNSLPQHLKEFLGHPHHNTLLFFSFPLSDENDVFDKLSVIAE
DSESGKQNPGDSCSLGTPPGQGPQS
NT seq 978 nt   +upstreamnt  +downstreamnt
atggcgtggagccttgggagctggctgggtggctgcctgctggtgtcagcattgggaatg
gtaccacctcccgaaaatgtcagaatgaattctgttaatttcaagaacattctacagtgg
gagtcacctgcttttgccaaagggaacctgactttcacagctcagtacctaagttatagg
atattccaagataaatgcatgaatactaccttgacggaatgtgatttctcaagtctttcc
aagtatggtgaccacaccttgagagtcagggctgaatttgcagatgagcattcagactgg
gtaaacatcaccttctgtcctgtggatgacaccattattggaccccctggaatgcaagta
gaagtacttgctgattctttacatatgcgtttcttagcccctaaaattgagaatgaatac
gaaacttggactatgaagaatgtgtataactcatggacttataatgtgcaatactggaaa
aacggtactgatgaaaagtttcaaattactccccagtatgactttgaggtcctcagaaac
ctggagccatggacaacttattgtgttcaagttcgagggtttcttcctgatcggaacaaa
gctggggaatggagtgagcctgtctgtgagcaaacaacccatgacgaaacggtcccctcc
tggatggtggccgtcatcctcatggcctcggtcttcatggtctgcctggcactcctcggc
tgcttcgccttgctgtggtgcgtttacaagaagacaaagtacgccttctcccctaggaat
tctcttccacagcacctgaaagagtttttgggccatcctcatcataacacacttctgttt
ttctcctttccattgtcggatgagaatgatgtttttgacaagctaagtgtcattgcagaa
gactctgagagcggcaagcagaatcctggtgacagctgcagcctcgggaccccgcctggg
caggggccccaaagctag

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