KEGG   Homo sapiens (human): 1639
Entry
1639              CDS       T01001                                 
Symbol
DCTN1, DAP-150, DP-150, HMND14, P135
Name
(RefSeq) dynactin subunit 1
  KO
K04648  dynactin 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04814  Motor proteins
hsa04962  Vasopressin-regulated water reabsorption
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
Network
nt06181  Salmonella
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01159  Mutation-caused aberrant TUBA4A to retrograde axonal transport
N01160  Mutation-caused aberrant SOD1 to retrograde axonal transport
N01295  Rab7-regulated microtubule minus-end directed transport
N01534  Dynein recruitment to the kinetochore
Disease
H00058  Amyotrophic lateral sclerosis (ALS)
H00856  Distal hereditary motor neuropathies
H00879  Perry syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    1639 (DCTN1)
 09150 Organismal Systems
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    1639 (DCTN1)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    1639 (DCTN1)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    1639 (DCTN1)
   05016 Huntington disease
    1639 (DCTN1)
   05022 Pathways of neurodegeneration - multiple diseases
    1639 (DCTN1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    1639 (DCTN1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1639 (DCTN1)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    1639 (DCTN1)
Membrane trafficking [BR:hsa04131]
 Endosome - Golgi transport
  Rab GTPases and associated proteins
   Rab associated proteins
    1639 (DCTN1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Dynactin complex
     1639 (DCTN1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dynactins
     1639 (DCTN1)
SSDB
Motif
Pfam: Dynactin CAP_GLY TMF_DNA_bd
Other DBs
NCBI-GeneID: 1639
NCBI-ProteinID: NP_004073
OMIM: 601143
HGNC: 2711
Ensembl: ENSG00000204843
UniProt: Q14203 Q6MZZ3
Structure
LinkDB
Position
2:complement(74361155..74391866)
AA seq 1278 aa
MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV
ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE
GTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSS
SEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE
DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT
ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL
KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE
STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE
TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA
SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG
GDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSL
SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL
TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDI
ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAV
LQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM
NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK
IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ
ADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGS
VPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPG
SELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVE
KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRH
RLVLTQEQLHQLHSRLIS
NT seq 3837 nt   +upstreamnt  +downstreamnt
atggcacagagcaagaggcacgtgtacagccggacgcccagcggcagcaggatgagtgcg
gaggcaagcgcccggcctctgcgggtgggctcccgtgtagaggtgattggaaaaggccac
cgaggcactgtggcctatgttggagccacactgtttgccactggcaaatgggtaggcgtg
attctggatgaagcaaagggcaaaaatgatggaactgttcaaggcaggaagtacttcact
tgtgatgaagggcatggcatctttgtgcgccagtcccagatccaggtatttgaagatgga
gcagatactacttccccagagacacctgattcttctgcttcaaaagtcctcaaaagagag
ggaactgatacaactgcaaagactagcaaactgcggggactgaagcctaagaaggcaccg
acagcccgaaagaccacaactcggcgacccaagcccacgcgcccagccagtactggggtg
gctggggccagtagctccctgggcccctctggctcagcgtcagcaggtgagctgagcagc
agtgagcccagcaccccggctcagactccgctggcagcacccatcatccccacgccggtc
ctcacctctcctggagcagtccccccgcttccttccccatccaaggaggaggagggacta
agggctcaggtgcgggacctggaggagaaactagagaccctgagactgaaacgggcagaa
gacaaagcaaagctaaaagagctggagaaacacaaaatccagctggagcaggtgcaggaa
tggaagagcaaaatgcaggagcagcaggccgacctgcagcggcgcctcaaggaggcgaga
aaggaagccaaggaggcgctggaggcaaaggaacgctatatggaggagatggctgatact
gctgatgccattgagatggccactttggacaaggagatggctgaagagcgggctgagtcc
ctgcagcaggaggtggaggcactgaaggagcgggtggacgagctcactactgacttagag
atcctcaaggctgagattgaagagaagggctcagatggcgctgcatccagttatcagctc
aagcagcttgaggagcagaatgcccgcctgaaggatgccctggtgaggatgcgggatctt
tcttcctcagagaagcaggagcatgtgaagctccagaagctcatggaaaagaagaaccaa
gagctggaagttgtgaggcaacagcgggagcgtctgcaggaggagctaagccaggcagag
agcaccattgatgagctcaaggagcaggtggatgctgctctgggtgctgaggagatggtg
gagatgctgacagatcggaacctgaatctggaagagaaagtgcgcgagttgagggagact
gtgggagacttggaagcgatgaatgagatgaacgatgagctgcaggagaatgcacgtgag
acagaactggagctgcgggagcagctggacatggcaggcgcgcgggttcgtgaggcccag
aagcgtgtggaggcagcccaggagacggttgcagactaccagcagaccatcaagaagtac
cgccagctgaccgcccatctacaggatgtgaatcgggaactgacaaaccagcaggaagca
tctgtggagaggcaacagcagccacctccagagacctttgacttcaaaatcaagtttgct
gagactaaggcccatgccaaggcaattgagatggaattgaggcagatggaggtggcccag
gccaatcgacacatgtccctgctgacagccttcatgcctgacagcttccttcggccaggt
ggggaccatgactgcgttctggtgctgttgctcatgcctcgtctcatttgcaaggcagag
ctgatccggaagcaggcccaggagaagtttgaactaagtgagaactgttcagagcggcct
gggctgcgaggagctgctggggagcaactcagctttgctgctggactggtgtactcgctg
agcctgctgcaggccacgctacaccgctatgagcatgccctctctcagtgcagtgtggat
gtgtataagaaagtgggcagcctgtaccctgagatgagtgcccatgagcgctccttggat
ttcctcattgaactgctgcacaaggatcagctggatgagactgtcaatgtggagcctctc
accaaggccatcaagtactatcagcatctgtacagcatccaccttgccgaacagcctgag
gactgtactatgcagctggctgaccacattaagttcacgcagagtgctctggactgcatg
agtgtggaggtaggacggctgcgtgccttcttgcagggtgggcaggaggctacagatatt
gccctcctgctccgggatctggaaacttcatgcagtgacatccgccagttctgcaagaag
atccgaaggcgaatgccagggacagatgctcctgggatcccagctgcactggcctttgga
ccacaggtatctgacacgctcctagactgcaggaaacacttgacgtgggtcgtggctgtg
ctgcaggaggtggcagctgctgctgcccagctcattgccccactggcagagaatgagggg
ctacttgtggctgctctggaggaactggctttcaaagcaagcgagcagatctatgggacc
ccctccagcagcccctatgagtgtctgcgccagtcatgcaacatcctcatcagtaccatg
aacaagctggccacagccatgcaggagggggagtatgatgcagagcggccccccagcaag
cctccaccggttgaactgcgggctgctgcccttcgtgcagagatcacagatgctgaaggc
ctgggtttgaagctcgaagatcgagagacagttattaaggagttgaagaagtcactcaag
attaagggagaggagctaagtgaggccaatgtgcggctgagcctcctggagaagaagttg
gacagtgctgccaaggatgcagatgagcgcatcgagaaagtccagactcggctggaggag
acccaggcactgctgcgaaagaaggagaaagagtttgaggagacaatggatgcactccag
gctgacatcgaccagctggaggcagagaaggcagaactaaagcagcgtctgaacagccag
tccaaacgcacgattgagggactccggggccctcctccttcaggcattgctactctggtc
tctggcattgctggtgaagaacagcagcgaggagccatccctgggcaggctccagggtct
gtgccaggcccagggctggtgaaggactcaccactgctgcttcagcagatctctgccatg
aggctgcacatctcccagctccagcatgagaacagcatcctcaagggagcccagatgaag
gcatccttggcatccctgccccctctgcatgttgcaaagctatcccatgagggccctggc
agtgagttaccagctggagcgctgtatcgtaagaccagccagctgctggagacattgaat
caattgagcacacacacgcacgtagtagacatcactcgcaccagccctgctgccaagagc
ccgtcggcccaacttatggagcaagtggctcagcttaagtccctgagtgacaccgtcgag
aagctcaaggatgaggtcctcaaggagacagtatctcagcgccctggagccacagtaccc
actgactttgccaccttcccttcatcagccttcctcagggccaaggaggagcagcaggat
gacacagtctacatgggcaaagtgaccttctcatgtgcggctggttttggacagcgacac
cggctggtgctgacccaggagcagctgcaccagcttcacagtcgcctcatctcctaa

KEGG   Homo sapiens (human): 10540
Entry
10540             CDS       T01001                                 
Symbol
DCTN2, DCTN50, DYNAMITIN, HEL-S-77, RBP50
Name
(RefSeq) dynactin subunit 2
  KO
K10424  dynactin 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04814  Motor proteins
hsa04962  Vasopressin-regulated water reabsorption
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
Network
nt06181  Salmonella
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N01159  Mutation-caused aberrant TUBA4A to retrograde axonal transport
N01160  Mutation-caused aberrant SOD1 to retrograde axonal transport
N01295  Rab7-regulated microtubule minus-end directed transport
N01534  Dynein recruitment to the kinetochore
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    10540 (DCTN2)
 09150 Organismal Systems
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    10540 (DCTN2)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    10540 (DCTN2)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    10540 (DCTN2)
   05016 Huntington disease
    10540 (DCTN2)
   05022 Pathways of neurodegeneration - multiple diseases
    10540 (DCTN2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10540 (DCTN2)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10540 (DCTN2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Dynactin complex
     10540 (DCTN2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dynactins
     10540 (DCTN2)
SSDB
Motif
Pfam: Dynamitin ALIX_LYPXL_bnd PI_PP_I MRP-S27 ZapB
Other DBs
NCBI-GeneID: 10540
NCBI-ProteinID: NP_001248342
OMIM: 607376
HGNC: 2712
Ensembl: ENSG00000175203
UniProt: Q13561 A0A384MDU9
LinkDB
Position
12:complement(57530051..57547192)
AA seq 401 aa
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELTSTSVEHIIVNPNAAYDKFKDK
RVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKI
KTTVKESATEEKLTPVLLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQ
LEATKNSKGGSGGKTTGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELETAVRC
DQDAQNPLSAGLQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIAKHKASV
EDADTQSKVHQLYETIQRWSPIASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMI
ANSLKDNTTLLTQVQTTMRENLATVEGNFASIDERMKKLGK
NT seq 1206 nt   +upstreamnt  +downstreamnt
atggcggaccctaaatacgccgaccttcccggcattgccaggaatgagccagatgtttat
gaaactagcgacctacctgaggatgatcaagcggagttcgatgcggaggagctgacaagc
acaagtgtggaacacatcattgtcaatcctaatgctgcctatgacaagttcaaggacaag
agagtggggacaaagggacttgatttctcagatcgtattggaaaaaccaagaggacagga
tatgaatctggagaatatgagatgcttggagagggtctgggagtgaaggagacaccccag
caaaagtaccagcgcctactgcatgaggtccaagagctgacaactgaagttgaaaaaatc
aagacgacagtgaaggagtcagccacagaggagaagctgacccctgtgttgctggctaaa
cagctggcagccctgaagcagcagctggttgcttcccacctggagaagctgctgggacca
gatgctgcaatcaaccttaccgaccccgatggcgccctggctaagcgcctactactgcag
ctggaagcaacaaagaacagcaaagggggatcagggggaaaaaccactgggaccccccca
gatagcagccttgtcacttatgaactacattctcggcctgagcaggacaagttctctcaa
gctgccaaagtcgcagaacttgaaaagcgcctgacagagctggagacagctgtacgttgt
gatcaggatgctcagaatcccctttctgcaggtctacagggagcctgtctcatggagact
gtagagctgttgcaagcaaaggtgagcgccctagaccttgcagttttggatcaagtggag
gctcggctacagagtgtcctgggaaaggtgaacgagattgccaagcataaagcctctgta
gaagatgcagatacacaaagcaaggtgcaccagctatatgaaactatacagcgctggagc
cccattgcctccaccctccctgagctggtgcagagacttgtcaccatcaagcagctgcac
gagcaagccatgcagtttggtcagctcctgacacacttggataccacccagcagatgatt
gctaattccttgaaggacaataccaccctcttgacccaggtgcagacaaccatgcgtgaa
aacctggccacagttgaggggaactttgccagcattgatgaacggatgaagaagctggga
aagtga

KEGG   Homo sapiens (human): 11258
Entry
11258             CDS       T01001                                 
Symbol
DCTN3, DCTN-22, DCTN22
Name
(RefSeq) dynactin subunit 3
  KO
K10425  dynactin 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04814  Motor proteins
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
Network
nt06181  Salmonella
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N01159  Mutation-caused aberrant TUBA4A to retrograde axonal transport
N01160  Mutation-caused aberrant SOD1 to retrograde axonal transport
N01295  Rab7-regulated microtubule minus-end directed transport
N01534  Dynein recruitment to the kinetochore
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    11258 (DCTN3)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    11258 (DCTN3)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    11258 (DCTN3)
   05016 Huntington disease
    11258 (DCTN3)
   05022 Pathways of neurodegeneration - multiple diseases
    11258 (DCTN3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    11258 (DCTN3)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    11258 (DCTN3)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Dynactin complex
     11258 (DCTN3)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dynactins
     11258 (DCTN3)
SSDB
Motif
Pfam: Dynactin_p22 DUF4011 Spidroin_MaSp DivIC DUF6827
Other DBs
NCBI-GeneID: 11258
NCBI-ProteinID: NP_009165
OMIM: 607387
HGNC: 2713
Ensembl: ENSG00000137100
UniProt: O75935
LinkDB
Position
9:complement(34613546..34620495)
AA seq 186 aa
MAGLTDLQRLQARVEELERWVYGPGGARGSRKVADGLVKVQVALGNISSKRERVKILYKK
IEDLIKYLDPEYIDRIAIPDASKLQFILAEEQFILSQVALLEQVNALVPMLDSAHIKAVP
EHAARLQRLAQIHIQQQDQCVEITEESKALLEEYNKTTMLLSKQFVQWDELLCQLEAATQ
VKPAEE
NT seq 561 nt   +upstreamnt  +downstreamnt
atggcgggtctgactgacttgcagcggctacaggcccgagtggaagagctggagcgctgg
gtgtacgggccgggcggggcgcgcggctcacggaaggtggctgacggcctggtcaaggtg
caggtggctttggggaacatttccagcaagagggagagggtgaagattctctacaaaaag
attgaagatctgatcaagtacctggatcctgagtacatcgaccgcattgccatacctgat
gcctctaagctgcaattcatcctagcagaggagcagtttatcctttcccaggttgcactc
ctggagcaggtgaatgccttggtgcccatgctggacagtgctcacatcaaagccgttcct
gagcatgctgcccgcctgcagcgcttggcccagatccacattcagcagcaggaccagtgt
gtggaaatcactgaggagtccaaggctctcctggaggaatacaacaagactacaatgctt
ctctccaagcaattcgtgcagtgggatgagctactttgccagctagaggccgccacgcaa
gtgaagccagcagaggagtga

KEGG   Homo sapiens (human): 51164
Entry
51164             CDS       T01001                                 
Symbol
DCTN4, DYN4, P62
Name
(RefSeq) dynactin subunit 4
  KO
K10426  dynactin 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04814  Motor proteins
hsa04962  Vasopressin-regulated water reabsorption
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
Network
nt06181  Salmonella
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N01159  Mutation-caused aberrant TUBA4A to retrograde axonal transport
N01160  Mutation-caused aberrant SOD1 to retrograde axonal transport
N01295  Rab7-regulated microtubule minus-end directed transport
N01534  Dynein recruitment to the kinetochore
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    51164 (DCTN4)
 09150 Organismal Systems
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    51164 (DCTN4)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    51164 (DCTN4)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    51164 (DCTN4)
   05016 Huntington disease
    51164 (DCTN4)
   05022 Pathways of neurodegeneration - multiple diseases
    51164 (DCTN4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    51164 (DCTN4)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    51164 (DCTN4)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Dynactin complex
     51164 (DCTN4)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dynactins
     51164 (DCTN4)
SSDB
Motif
Pfam: Dynactin_p62
Other DBs
NCBI-GeneID: 51164
NCBI-ProteinID: NP_057305
OMIM: 614758
HGNC: 15518
Ensembl: ENSG00000132912
UniProt: Q9UJW0 A0A0S2Z5D4 Q9NSJ5
LinkDB
Position
5:complement(150708440..150759017)
AA seq 460 aa
MASLLQSDRVLYLVQGEKKVRAPLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPS
AEAKLKKNRCANCFDCPGCMHTLSTRATSISTQLPDDPAKTTMKKAYYLACGFCRWTSRD
VGMADKSVASGGWQEPENPHTQRMNKLIEYYQQLAQKEKVERDRKKLARRRNYMPLAFSD
KYGLGTRLQRPRAGASISTLAGLSLKEGEDQKEIKIEPAQAVDEVEPLPEDYYTRPVNLT
EVTTLQQRLLQPDFQPVCASQLYPRHKHLLIKRSLRCRKCEHNLSKPEFNPTSIKFKIQL
VAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGDPDDINSTAKVVV
PPKELVLAGKDAAAEYDELAEPQDFQDDPDIIAFRKANKVGIFIKVTPQREEGEVTVCFK
MKHDFKNLAAPIRPIEESDQGTEVIWLTQHVELSLGPLLP
NT seq 1383 nt   +upstreamnt  +downstreamnt
atggcgtccttgctgcagtcggaccgggttctctatctagtccagggagaaaagaaggtt
cgggccccgctctcgcaactctacttctgccgctattgtagcgaactgcggtcgctggaa
tgtgtgtctcacgaggtggactcccattattgtcccagttgtttagaaaatatgccatcg
gctgaagccaaactaaaaaagaatagatgtgccaattgttttgactgtcctggctgcatg
cacaccctctctactcgggccacgagcatctccacacagcttccagatgacccagccaag
accaccatgaagaaagcctattacctggcatgtggattttgtcgctggacgtctagagat
gtgggcatggcagacaaatctgtagctagtggcggttggcaggaacctgaaaatcctcac
acacaacggatgaacaaattgattgaatattaccagcagcttgctcagaaagagaaggtt
gagcgagatcgcaagaaactggcacgacgtagaaactatatgcctctggctttttcggac
aaatatggtcttggaaccaggcttcagcgaccacgagctggtgcatccatcagtaccctt
gccggactttcccttaaagaaggagaggatcagaaagagataaagattgagccagctcag
gctgtggatgaagtggaacctctacctgaagactattatacaagaccagtaaatttaaca
gaggtaacaacccttcagcagcgtctgttacagcctgacttccagccagtctgtgcttca
cagctctatcctcgccacaaacatcttctgatcaaacggtccctgcgctgccgtaaatgt
gaacataatttgagcaagccagaatttaacccaacgtcaatcaaattcaaaatccagctg
gtcgctgtcaattatattccagaagtgagaatcatgtcaattcccaaccttcgctacatg
aaggagagccaggtcctcctgactcttacaaatccagttgagaacctcacccatgtgact
ctcttcgagtgtgaggagggggaccctgatgatatcaacagcactgctaaggtggtggtg
cctcccaaagagctcgttttagctggcaaggatgcagcagcagagtacgatgagttggca
gaacctcaagactttcaggacgatcctgacattatagccttcagaaaggccaacaaagtg
ggtattttcatcaaagttacaccacagcgtgaggagggtgaagtgaccgtgtgcttcaag
atgaagcatgattttaaaaacctggcagcccccattcgccccattgaagaaagtgaccag
ggaacagaagtcatctggctcacccagcatgtggaacttagcttgggcccacttcttcct
taa

KEGG   Homo sapiens (human): 84516
Entry
84516             CDS       T01001                                 
Symbol
DCTN5
Name
(RefSeq) dynactin subunit 5
  KO
K10427  dynactin 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04814  Motor proteins
hsa04962  Vasopressin-regulated water reabsorption
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
Network
nt06181  Salmonella
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N01159  Mutation-caused aberrant TUBA4A to retrograde axonal transport
N01160  Mutation-caused aberrant SOD1 to retrograde axonal transport
N01295  Rab7-regulated microtubule minus-end directed transport
N01534  Dynein recruitment to the kinetochore
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    84516 (DCTN5)
 09150 Organismal Systems
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    84516 (DCTN5)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    84516 (DCTN5)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    84516 (DCTN5)
   05016 Huntington disease
    84516 (DCTN5)
   05022 Pathways of neurodegeneration - multiple diseases
    84516 (DCTN5)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    84516 (DCTN5)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    84516 (DCTN5)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Dynactin complex
     84516 (DCTN5)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dynactins
     84516 (DCTN5)
SSDB
Motif
Pfam: DCTN5 Hexapep Hexapep_2 Fucokinase
Other DBs
NCBI-GeneID: 84516
NCBI-ProteinID: NP_115875
OMIM: 612962
HGNC: 24594
Ensembl: ENSG00000166847
UniProt: Q9BTE1
Structure
LinkDB
Position
16:23641466..23677472
AA seq 182 aa
MELGELLYNKSEYIETASGNKVSRQSVLCGSQNIVLNGKTIVMNDCIIRGDLANVRVGRH
CVVKSRSVIRPPFKKFSKGVAFFPLHIGDHVFIEEDCVVNAAQIGSYVHVGKNCVIGRRC
VLKDCCKILDNTVLPPETVVPPFTVFSGCPGLFSGELPECTQELMIDVTKSYYQKFLPLT
QV
NT seq 549 nt   +upstreamnt  +downstreamnt
atggagttgggcgagctgctctacaacaagtctgagtacatcgagacggcatctgggaac
aaagtcagtcgccagtcagtgttgtgtggaagccagaacatcgttctcaatggcaagacc
attgtgatgaatgactgtattatccgaggggatctggcaaatgtaagagttggacgtcat
tgtgttgtgaaaagtcgtagtgtcataaggccaccattcaagaagttcagcaaaggtgtt
gcattctttcctttacatattggagaccatgtctttattgaggaagattgtgtggtcaac
gcagcacagattggttcctatgttcatgttgggaagaactgtgtgattgggcgccgatgt
gtgttgaaagactgctgcaaaattcttgacaacacagtattacctccagaaactgtggtt
ccaccattcactgtcttctcaggctgcccaggactcttctcaggggagctcccggagtgc
actcaggagctgatgattgacgtcaccaagagctactaccagaagtttttgcccctgacg
caagtctag

KEGG   Homo sapiens (human): 10671
Entry
10671             CDS       T01001                                 
Symbol
DCTN6, WS-3, WS3, p27
Name
(RefSeq) dynactin subunit 6
  KO
K10428  dynactin 6
Organism
hsa  Homo sapiens (human)
Pathway
hsa04814  Motor proteins
hsa04962  Vasopressin-regulated water reabsorption
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
Network
nt06181  Salmonella
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N01159  Mutation-caused aberrant TUBA4A to retrograde axonal transport
N01160  Mutation-caused aberrant SOD1 to retrograde axonal transport
N01295  Rab7-regulated microtubule minus-end directed transport
N01534  Dynein recruitment to the kinetochore
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    10671 (DCTN6)
 09150 Organismal Systems
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    10671 (DCTN6)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    10671 (DCTN6)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    10671 (DCTN6)
   05016 Huntington disease
    10671 (DCTN6)
   05022 Pathways of neurodegeneration - multiple diseases
    10671 (DCTN6)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10671 (DCTN6)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10671 (DCTN6)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Dynactin complex
     10671 (DCTN6)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dynactins
     10671 (DCTN6)
SSDB
Motif
Pfam: Hexapep DCTN5
Other DBs
NCBI-GeneID: 10671
NCBI-ProteinID: NP_006562
OMIM: 612963
HGNC: 16964
Ensembl: ENSG00000104671
UniProt: O00399
Structure
LinkDB
Position
8:30156369..30183639
AA seq 190 aa
MAEKTQKSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQA
LIINAYPDNITPDTEDPEPKPMIIGTNNVFEVGCYSQAMKMGDNNVIESKAYVGRNVILT
SGCIIGACCNLNTFEVIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKT
MKGSSTPVKN
NT seq 573 nt   +upstreamnt  +downstreamnt
atggcggagaagactcaaaagagtgtgaagattgctcctggagcagttgtatgtgtagaa
agtgaaatcagaggagatgtaactatcggacctcggacagtgatccaccctaaagcaaga
attattgcggaagccgggccaatagtgattggcgaagggaacctaatagaagaacaggcc
cttatcataaatgcttacccagataatatcactcctgacactgaagatccagaaccaaaa
cctatgatcattggcaccaataatgtgtttgaagttggctgttattcccaagccatgaag
atgggagataataatgtcattgaatcaaaagcatatgtaggcagaaatgtaatattgaca
agtggctgcatcattggggcttgttgcaacctaaatacatttgaagtcatccctgagaat
acggtgatctatggtgcagactgccttcgtcgggtgcagactgagcgaccgcagccccag
acactacagctggatttcttgatgaaaatcttgccaaattaccaccacctaaagaagact
atgaaaggaagctcaactccagtaaagaactaa

KEGG   Homo sapiens (human): 10121
Entry
10121             CDS       T01001                                 
Symbol
ACTR1A, ARP1, Arp1A, CTRN1
Name
(RefSeq) actin related protein 1A
  KO
K16575  centractin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04814  Motor proteins
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
Network
nt06181  Salmonella
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N01159  Mutation-caused aberrant TUBA4A to retrograde axonal transport
N01160  Mutation-caused aberrant SOD1 to retrograde axonal transport
N01295  Rab7-regulated microtubule minus-end directed transport
N01534  Dynein recruitment to the kinetochore
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    10121 (ACTR1A)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    10121 (ACTR1A)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    10121 (ACTR1A)
   05016 Huntington disease
    10121 (ACTR1A)
   05022 Pathways of neurodegeneration - multiple diseases
    10121 (ACTR1A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10121 (ACTR1A)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10121 (ACTR1A)
   04147 Exosome [BR:hsa04147]
    10121 (ACTR1A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Dynactin complex
     10121 (ACTR1A)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actins
    Actin-related proteins
     10121 (ACTR1A)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of bladder cancer cells
   10121 (ACTR1A)
SSDB
Motif
Pfam: Actin
Other DBs
NCBI-GeneID: 10121
NCBI-ProteinID: NP_005727
OMIM: 605143
HGNC: 167
Ensembl: ENSG00000138107
UniProt: P61163 A0A384NQ21
LinkDB
Position
10:complement(102479229..102502712)
AA seq 376 aa
MESYDVIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHVRVMAGALEGDIFIGP
KAEEHRGLLSIRYPMEHGIVKDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPRKN
RERAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSI
MRIDIAGRDVSRFLRLYLRKEGYDFHSSSEFEIVKAIKERACYLSINPQKDETLETEKAQ
YYLPDGSTIEIGPSRFRAPELLFRPDLIGEESEGIHEVLVFAIQKSDMDLRRTLFSNIVL
SGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAPQERLYSTWIGGSILASLDTFKKMWVSK
KEYEEDGARSIHRKTF
NT seq 1131 nt   +upstreamnt  +downstreamnt
atggagtcctacgatgtgatcgccaaccagcctgtcgtgatcgacaacggatccggtgtg
attaaagctggttttgctggtgatcagatccccaaatactgctttccaaactatgtgggc
cgacccaagcacgttcgtgtcatggcaggagcccttgaaggcgacatcttcattggcccc
aaagctgaggagcaccgagggctgctttcaatccgctatcccatggagcatggcatcgtc
aaggattggaacgacatggaacgcatttggcaatatgtctattctaaggaccagctgcag
actttctcagaggagcatcctgtgctcctgactgaggcgcctttaaacccacgaaaaaac
cgggaacgagctgccgaagttttcttcgagaccttcaatgtgcccgctcttttcatctcc
atgcaagctgtactcagcctttacgctacaggcaggaccacaggggtggtgctggattct
ggggatggagtcacccatgctgtgcccatctatgagggctttgccatgccccactccatc
atgcgcatcgacatcgcgggccgggacgtctctcgcttcctgcgcctctacctgcgtaag
gagggctacgacttccactcatcctctgagtttgagattgtcaaggccataaaagaaaga
gcctgttacctatccataaacccccaaaaggatgagacgctagagacagagaaagctcag
tactacctgcctgatggcagcaccattgagattggtccttcccgattccgggcccctgag
ttgctcttcaggccagatttgattggagaggagagtgaaggcatccacgaggtcctggtg
ttcgccattcagaagtcagacatggacctgcggcgcacgcttttctctaacattgtcctc
tcaggaggctctaccctgttcaaaggttttggtgacaggctcctgagtgaagtgaagaaa
ctagctccaaaagatgtgaagatcaggatatctgcacctcaggagagactgtattccacg
tggattgggggctccatccttgcctccctggacacctttaagaagatgtgggtctccaaa
aaggaatatgaggaagacggtgcccgatccatccacagaaaaaccttctaa

KEGG   Homo sapiens (human): 10120
Entry
10120             CDS       T01001                                 
Symbol
ACTR1B, ARP1B, CTRN2, PC3
Name
(RefSeq) actin related protein 1B
  KO
K16575  centractin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04814  Motor proteins
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
Network
nt06181  Salmonella
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N01159  Mutation-caused aberrant TUBA4A to retrograde axonal transport
N01160  Mutation-caused aberrant SOD1 to retrograde axonal transport
N01295  Rab7-regulated microtubule minus-end directed transport
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    10120 (ACTR1B)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    10120 (ACTR1B)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    10120 (ACTR1B)
   05016 Huntington disease
    10120 (ACTR1B)
   05022 Pathways of neurodegeneration - multiple diseases
    10120 (ACTR1B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10120 (ACTR1B)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10120 (ACTR1B)
   04147 Exosome [BR:hsa04147]
    10120 (ACTR1B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Dynactin complex
     10120 (ACTR1B)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actins
    Actin-related proteins
     10120 (ACTR1B)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of bladder cancer cells
   10120 (ACTR1B)
SSDB
Motif
Pfam: Actin
Other DBs
NCBI-GeneID: 10120
NCBI-ProteinID: NP_005726
OMIM: 605144
HGNC: 168
Ensembl: ENSG00000115073
UniProt: P42025
LinkDB
Position
2:complement(97655939..97664044)
AA seq 376 aa
MESYDIIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHMRVMAGALEGDLFIGP
KAEEHRGLLTIRYPMEHGVVRDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPSKN
REKAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSI
MRVDIAGRDVSRYLRLLLRKEGVDFHTSAEFEVVRTIKERACYLSINPQKDEALETEKVQ
YTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVVAFAIHKSDMDLRRTLFANIVL
SGGSTLFKGFGDRLLSEVKKLAPKDIKIKISAPQERLYSTWIGGSILASLDTFKKMWVSK
KEYEEDGSRAIHRKTF
NT seq 1131 nt   +upstreamnt  +downstreamnt
atggagtcctacgacatcatcgccaaccagcctgtggtcatcgacaacggttcgggggtg
attaaagctggctttgcaggagaccagattcccaaatactgtttcccaaactatgtcggg
cggccgaagcacatgcgggtgatggctggagccctggagggggacctcttcatcggacca
aaagcagaggagcaccgggggctgctgaccatccgctaccccatggagcacggcgtggtg
cgagactggaacgacatggaacgcatctggcagtacgtctactccaaggatcagctgcag
accttctcggaggagcatcctgtgctcctcacggaggccccgctcaacccgagtaagaac
cgggagaaggcggcagaggtgttctttgagaccttcaacgtgccggccctgttcatctcc
atgcaggctgtgctcagtctgtacgcaacaggacgcacgacaggagtggttctagactca
ggggacggggtcactcatgctgtgcccatctatgagggctttgccatgcctcactccatc
atgcgggtggacattgccggccgcgacgtctcccgctacctccgactcctgctgcgcaag
gaaggggttgacttccatacctcggctgagtttgaggttgtccggacaatcaaagagcga
gcgtgctacctgtccatcaacccacagaaggatgaggctctggagacggagaaggtgcag
tacacgttgccagacggcagcacgcttgatgtggggcctgcacgattccgggcccccgag
ctgctgttccagccggaccttgtcggggatgagagtgaggggctccatgaggtggtggcc
ttcgccatacacaagtccgacatggacctgcgccggacgctgttcgccaacatcgtgctc
tcaggtggctcaacgcttttcaaaggcttcggagaccgattactcagtgaagtgaagaag
cttgccccaaaggatatcaaaatcaagatctcagccccgcaggaacggctgtactccaca
tggattggcggctccatcctggcctcgctggacacttttaagaagatgtgggtgtccaaa
aaggagtatgaagaggatggctcccgtgctattcatcgcaaaactttctag

KEGG   Homo sapiens (human): 55860
Entry
55860             CDS       T01001                                 
Symbol
ACTR10, ACTR11, Arp10, Arp11, HARP11
Name
(RefSeq) actin related protein 10
  KO
K16576  actin-related protein 10
Organism
hsa  Homo sapiens (human)
Pathway
hsa04814  Motor proteins
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
Network
nt06181  Salmonella
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N01159  Mutation-caused aberrant TUBA4A to retrograde axonal transport
N01160  Mutation-caused aberrant SOD1 to retrograde axonal transport
N01295  Rab7-regulated microtubule minus-end directed transport
N01534  Dynein recruitment to the kinetochore
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    55860 (ACTR10)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    55860 (ACTR10)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    55860 (ACTR10)
   05016 Huntington disease
    55860 (ACTR10)
   05022 Pathways of neurodegeneration - multiple diseases
    55860 (ACTR10)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    55860 (ACTR10)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    55860 (ACTR10)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Dynactin complex
     55860 (ACTR10)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actins
    Actin-related proteins
     55860 (ACTR10)
SSDB
Motif
Pfam: Actin
Other DBs
NCBI-GeneID: 55860
NCBI-ProteinID: NP_060947
OMIM: 619731
HGNC: 17372
Ensembl: ENSG00000131966
UniProt: Q9NZ32
LinkDB
Position
14:58200149..58235636
AA seq 417 aa
MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKRAGMPKPVRVVQYNIN
TEELYSYLKEFIHILYFRHLLVNPRDRRVVIIESVLCPSHFRETLTRVLFKYFEVPSVLL
APSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLL
EQCTVDTSVAKEQSLPSVMGSVPEGVLEDIKARTCFVSDLKRGLKIQAAKFNIDGNNERP
SPPPNVDYPLDGEKILHILGSIRDSVVEILFEQDNEEQSVATLILDSLIQCPIDTRKQLA
ENLVVIGGTSMLPGFLHRLLAEIRYLVEKPKYKKALGTKTFRIHTPPAKANCVAWLGGAI
FGALQDILGSRSVSKEYYNQTGRIPDWCSLNNPPLEMMFDVGKTQPPLMKRAFSTEK
NT seq 1254 nt   +upstreamnt  +downstreamnt
atgccgctctacgagggcctggggagcggcggggagaagacggcggtcgtgatcgacctg
ggagaggcctttaccaagtgtggatttgctggagaaactggtccaagatgtataattcct
agtgtgataaaaagagctgggatgcctaagcctgtcagagttgttcagtataatatcaat
acagaagaattatattcctacctaaaggaattcatccacatactatatttcaggcatcta
ttggtgaatcccagagaccgccgagttgtgattatcgaatcggtattatgtccttctcac
ttcagagagacactcactcgtgttcttttcaaatattttgaggttccatctgtcttgctt
gctccaagtcatctaatggctcttctgacgcttggaattaattctgccatggtcctagat
tgtggatatagggaaagcctggtgttacccatatatgaaggaatcccagttctaaattgt
tggggagcactacccctaggaggaaaagctcttcacaaagagttggaaactcaactattg
gaacaatgtactgttgacacaagtgttgctaaagaacagagccttccctcagtgatgggt
tcagttccggaaggtgtcttagaggacattaaagcgcgtacttgctttgtaagtgatctg
aagcgaggactaaaaatccaagcagcaaaatttaatattgatgggaataatgagcgtccc
tccccacccccaaatgttgactatccattagatggagagaagattttacatatccttgga
tcaatcagagattcagttgtggaaattctttttgaacaagataatgaagagcaatcagtt
gccactttaatattggattcccttatacagtgtccgatagacaccaggaagcaactagca
gagaatttggtagtcataggtggcacttctatgttgccaggatttctccacagattgctt
gcagaaataaggtatttggtagaaaaaccaaaatataaaaaagcacttggcactaagaca
tttcgaattcatactccacctgcaaaagctaattgtgtggcctggttgggaggggctatt
tttggagcattacaagatatacttgggagccgttctgtttcaaaggaatattataatcag
acgggccgtatacctgattggtgttctctcaataacccacctttggaaatgatgtttgat
gtcgggaaaactcaaccacctctgatgaagagagcattttccactgagaaatag

KEGG   Homo sapiens (human): 25981
Entry
25981             CDS       T01001                                 
Symbol
DNAH1, CILD37, DNAHC1, HDHC7, HL-11, HL11, HSRF-1, SPGF18, XLHSRF-1
Name
(RefSeq) dynein axonemal heavy chain 1
  KO
K10408  dynein axonemal heavy chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04814  Motor proteins
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N01159  Mutation-caused aberrant TUBA4A to retrograde axonal transport
N01160  Mutation-caused aberrant SOD1 to retrograde axonal transport
Disease
H00564  Primary ciliary dyskinesia
H01282  Spermatogenic failure
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    25981 (DNAH1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    25981 (DNAH1)
   05016 Huntington disease
    25981 (DNAH1)
   05022 Pathways of neurodegeneration - multiple diseases
    25981 (DNAH1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins [BR:hsa03037]
    25981 (DNAH1)
   04812 Cytoskeleton proteins [BR:hsa04812]
    25981 (DNAH1)
Cilium and associated proteins [BR:hsa03037]
 Motile cilia and associated proteins
  Dynein arm
   25981 (DNAH1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dyneins
     25981 (DNAH1)
SSDB
Motif
Pfam: AAA_6 DHC_N2 Dynein_C AAA_8 AAA_9 AAA_7 AAA_lid_11 MT Dynein_heavy Dynein_AAA_lid AAA_5 AAA_lid_1 DYN_lid AAA_22 AAA_18 DEAD Mg_chelatase ABC_tran AAA_29 TBK1_CCD1 Seryl_tRNA_N DUF7018 Intu_longin_3
Other DBs
NCBI-GeneID: 25981
NCBI-ProteinID: NP_056327
OMIM: 603332
HGNC: 2940
Ensembl: ENSG00000114841
UniProt: Q9P2D7 A0A140VJI6
Structure
LinkDB
Position
3:52310920..52400492
AA seq 4265 aa
MEQPNSKGYSLGRTPQGPECSSAPAVQVGTHRGLEYNPGKILPGSDYGLGNPPALDPKLP
HLPLPPAPPTLSDLGQPRKSPLTGTDKKYPLMKQRGFYSDILSPGTLDQLGEVCRGPRMS
QNLLRQADLDKFTPRVGSFEVPEDFQERMEQQCIGSTTRLLAQTDFPLQAYEPKMQVPFQ
VLPGQHPRKIEIERRKQQYLSLDIEQLLFSQGIDSNKLMPRHLDHQHPQTIEQGHDPIFP
IYLPLKVFDNEDFDCRTPREWINMGLEPGSLDRKPVPGKALLPTDDFLGHEDPKSQKLKY
KWCEVGVLDYDEEKKLYLVHKTDEKGLVRDEMGRPILNAGVTTEGRPPLQVCQYWVPRIQ
LLFCAEDPCMFAQRVVQANALRKNTEALLLYNLYVDCMPSDGQHVISEQSLSKIKQWALS
TPRMRKGPSVLEHLSSLAREVSLDYERSMNKINFDHVVSSKPETFSYVTLPKKEEEQVPE
RGLVSVPKYHFWEQKEDFTFVSLLTRPEVITALSKVRAECNKVTAMSLFHSSLSKYSHLE
EFEQIQSQTFSQVQMFLKDSWISSLKVAMRSSLRDMSKGWYNLYETNWEVYLMSKLRKLM
ELVKYMLQDTLRFLVQDSLASFSQFISDTCCSVLNCTDDMVWGDDLINSPYRPRKNPLFI
MDLVLDSSGVHYSTPLEQFEASLLNLFDKGILATHAVPQLEKLVMEDIFISGDPLLESVG
LHEPLVEELRATIASAVSKAMIPLQAYAKEYRKYLELNNNDIASFLKTYQTQGLLAQEVR
EVVLTHLREKEILDSSLPSSIIIGPFYINTDNVKQSLSKKRKALATSVLDILAKNLHKEV
DSICEEFRSISRKIYEKPNSIEELAELREWMKGIPERLVGLEERIVKVMDDYQVMDEFLY
NLSSDDFNDKWIASNWPSKILGQIELVQQQHVEDEEKFRKIQIMDQNNFQEKLEGLQLVV
AGFSIHVEISRAHEIANEVRRVKKQLKDCQQLAMLYNNRERIFSLPITNYDKLSRMVKEF
QPYLDLWTTASDWLRWSESWMNDPLSAIDAEQLEKNVVEAFKTMHKCVKQFKDMPACQEV
ALDIRARIEEFKPYIPLIQGLRNPGMRIRHWETLSNQININVRPKANLTFARCLEMNLQD
HIESISKVAEVAGKEYAIEQALDKMEKEWSTILFNVLPYKATDTYILKSPDEASQLLDDH
IVMTQNMSFSPYKKPFEQRINSWENKLKLTQEVLEEWLNCQRSWLYLEPIFSSEDINQQL
PVESKRYQTMERIWKKIMKNAYENREVINVCSDLRMLDSLRDCNKILDLVQKGLSEYLET
KRSAFPRFYFLSDDELLEILSQTKDPTAVQPHLRKCFENIARLLFQEDLEITHMYSAEGE
EVQLCFSIYPSSNVEDWLREVERSMKASVHDIIEKAIRAYPTMPRTQWVLNWPGQVTIAG
CQTYWTMEVAEALEAGNLRSQLFPQLCQQLSDLVALVRGKLSRMQRAVLSALIVIEVHAK
DVVSKLIQENVVSVNDFQWISQLRYYWTNNDLYIRAVNAEFIYGYEYLGNSGRLVITPLT
DRCYLTLTGALHLKFGGAPAGPAGTGKTETTKDLGKALAIQTVVFNCSDQLDFMAMGKFF
KGLASAGAWACFDEFNRIDIEVLSVVAQQITTIQKAQQQRVERFMFEGVEIPLVPSCAVF
ITMNPGYAGRTELPDNLKALFRPVAMMVPDYAMITEISLYSFGFNEASVLAKKITTTFKL
SSEQLSSQDHYDFGMRAVKTVISAAGNLKRENPSMNEELICLRAIRDVNVPKFLQEDLKL
FSGIVSDLFPTIKEEDTDYGILDEAIREACRNSNLKDVEGFLTKCIQLYETTVVRHGLML
VGPTGSGKSTCYRVLAAAMTSLKGQPSISGGMYEAVNYYVLNPKSITMGQLYGEFDLLTH
EWTDGIFSSFIRAGAITSDTNKKWYMFDGPVDAIWIENMNTVLDDNKKLCLSSGEIIKLT
EAMTMMFEVQDLAVASPATVSRCGMVYLEPSILGLMPFIECWLRKLPPLLKPYEEHFKAL
FVSFLEESISFVRSSVKEVIASTNCNLTMSLLKLLDCFFKPFLPREGLKKIPSEKLSRIV
ELIEPWFIFSLIWSVGATGDSSGRTSFSHWLRLKMENEQLTLLFPEEGLVFDYRLEDAGI
SGTNDSEDEEEEYKQVAWVKWMDSSAPFTMVPDTNYCNIIVPTMDTVQMSHLLDMLLTNK
KPVLCIGPTGTGKTLTISDKLLKNLALDYISHFLTFSARTSANQTQDFIDSKLDKRRKGV
FGPPLGRNFIFFIDDLNMPALETYGAQPPIELLRQWMDHGGWYDRKIIGAFKNLVDINFV
CAMGPPGGGRNTVTPRLMRHFNYLSFAEMDEVSKKRIFSTILGNWLDGLLGEKSYRERVP
GAPHIAHFTEPLVEATIMVYATITSQLLPTPAKSHYTFNLRDLSKVFQGMLMADPAKVED
QVQLLRLWYHENCRVFRDRLVNEEDRSWFDQLLKRCMEQWEVTFNKVCPFQPILYGDFMS
PGSDVKSYELITSESKMMQVIEEYIEDYNQINTAKLKLVLFMDAMSHICRISRTLRQALG
NALLLGVGGSGRSSLTRLASHMAEYECFQIELSKNYGMSEWRDDVKKVLLKAGLQNLPIT
FLFSDTQIKNESFLEDINNVLNSGDIPNLYTADEQDQIVSTMRPYIQEQGLQPTKANLMA
AYTGRVRSNIHMVLCMSPIGEVFRARLRQFPSLVNCCTIDWFNEWPAEALKSVATVFLNE
IPELESSQEEIQGLIQVCVYIHQSVSKKCIEYLAELTRHNYVTPKSYLELLHIFSILIGQ
KKLELKTAKNRMKSGLDKLLRTSEDVAKMQEDLESMHPLLEEAAKDTMLTMEQIKVDTAI
AEETRNSVQTEEIKANEKAKKAQAIADDAQKDLDEALPALDAALASLRNLNKNDVTEVRA
MQRPPPGVKLVIEAVCIMKGIKPKKVPGEKPGTKVDDYWEPGKGLLQDPGHFLESLFKFD
KDNIGDVVIKAIQPYIDNEEFQPATIAKVSKACTSICQWVRAMHKYHFVAKAVEPKRQAL
LEAQDDLGVTQRILDEAKQRLREVEDGIATMQAKYRECITKKEELELKCEQCEQRLGRAG
KLINGLSDEKVRWQETVENLQYMLNNISGDVLVAAGFVAYLGPFTGQYRTVLYDSWVKQL
RSHNVPHTSEPTLIGTLGNPVKIRSWQIAGLPNDTLSVENGVINQFSQRWTHFIDPQSQA
NKWIKNMEKDNGLDVFKLSDRDFLRSMENAIRFGKPCLLENVGEELDPALEPVLLKQTYK
QQGNTVLKLGDTVIPYHEDFRMYITTKLPNPHYTPEISTKLTLINFTLSPSGLEDQLLGQ
VVAEERPDLEEAKNQLIISNAKMRQELKDIEDQILYRLSSSEGNPVDDMELIKVLEASKM
KAAEIQAKVRIAEQTEKDIDLTRMEYIPVAIRTQILFFCVSDLANVDPMYQYSLEWFLNI
FLSGIANSERADNLKKRISNINRYLTYSLYSNVCRSLFEKHKLMFAFLLCVRIMMNEGKI
NQSEWRYLLSGGSISIMTENPAPDWLSDRAWRDILALSNLPTFSSFSSDFVKHLSEFRVI
FDSLEPHREPLPGIWDQYLDQFQKLLVLRCLRGDKVTNAMQDFVATNLEPRFIEPQTANL
SVVFKDSNSTTPLIFVLSPGTDPAADLYKFAEEMKFSKKLSAISLGQGQGPRAEAMMRSS
IERGKWVFFQNCHLAPSWMPALERLIEHINPDKVHRDFRLWLTSLPSNKFPVSILQNGSK
MTIEPPRGVRANLLKSYSSLGEDFLNSCHKVMEFKSLLLSLCLFHGNALERRKFGPLGFN
IPYEFTDGDLRICISQLKMFLDEYDDIPYKVLKYTAGEINYGGRVTDDWDRRCIMNILED
FYNPDVLSPEHSYSASGIYHQIPPTYDLHGYLSYIKSLPLNDMPEIFGLHDNANITFAQN
ETFALLGTIIQLQPKSSSAGSQGREEIVEDVTQNILLKVPEPINLQWVMAKYPVLYEESM
NTVLVQEVIRYNRLLQVITQTLQDLLKALKGLVVMSSQLELMAASLYNNTVPELWSAKAY
PSLKPLSSWVMDLLQRLDFLQAWIQDGIPAVFWISGFFFPQAFLTGTLQNFARKFVISID
TISFDFKVMFEAPSELTQRPQVGCYIHGLFLEGARWDPEAFQLAESQPKELYTEMAVIWL
LPTPNRKAQDQDFYLCPIYKTLTRAGTLSTTGHSTNYVIAVEIPTHQPQRHWIKRGVALI
CALDY
NT seq 12798 nt   +upstreamnt  +downstreamnt
atggagcagcctaacagtaaaggctatagcctgggaaggacccctcagggcccagagtgc
agcagtgctcctgcagtccaagtggggacccacaggggcctagagtataacccggggaag
attcttccaggatcagactatgggttgggaaatcctccagcccttgaccccaagctccca
catttacccctgcccccggccccacccacactctcagacttggggcagccacggaagtca
cccctgacaggcactgataagaagtacccgctgatgaagcagcgtgggttctactccgac
atcctcagccctggaaccttagatcaacttggggaggtatgtcgtggcccccgaatgagc
cagaacctcctgcggcaggctgaccttgacaagttcaccccaagagtcggaagctttgag
gttcctgaagacttccaggagcgcatggagcagcagtgcatcgggtccaccacccggctg
ctcgcccagactgacttcccactgcaggcctacgagcccaagatgcaggtgcctttccag
gtgctgccaggccagcatcctcgcaagattgagatcgagaggaggaaacagcagtacctg
agcctggacattgagcagttgctgttcagccagggcatcgactccaacaagctcatgccc
aggcacctggaccaccagcacccccaaaccatcgaacagggccatgacccaatcttcccc
atctacctcccactgaaggtatttgacaatgaggactttgactgccggactcccagagag
tggatcaacatgggcttggagccagggtctctggacaggaaacctgtcccgggaaaagcc
ctcttgcccactgatgacttcctggggcatgaggaccccaagagtcagaagctgaagtac
aaatggtgcgaggtcggcgtcctggactacgacgaggagaagaagctatacctggtacac
aagacagacgagaaaggcctggtgcgagatgagatggggaggcccatcctgaatgcaggg
gtcaccactgaaggaaggccaccccttcaggtctgtcagtactgggtgccacggatccag
cttctcttctgcgctgaggacccttgcatgttcgcacaacgtgtggtccaggccaacgcc
ctgcgcaagaacacggaagcactgctgctctacaacttgtatgtggactgcatgccctct
gacggccagcatgtcatcagtgaacagagcctgagcaagatcaagcagtgggccctgagc
acgcctcggatgcgcaaaggcccctcggttctagagcacctcagcagtcttgccagagaa
gtgagcctggactatgagcgcagcatgaacaagatcaactttgaccacgttgtctcttcc
aagcccgagaccttctcctacgtcaccctccccaagaaggaggaggagcaggtgcctgag
cgagggctggtgagtgtccccaagtaccacttctgggagcagaaggaggacttcactttc
gtgtccctgctcacacggccagaggtcatcacggccctcagcaaggtgagggccgagtgc
aacaaggtgaccgccatgtccctgttccactcgagcctctccaagtacagccacctggag
gaatttgagcagatccagtcacagaccttctcccaggtgcagatgttcctcaaggacagc
tggatcagctcgctaaaggtggccatgcgcagcagcctgcgcgacatgagcaagggctgg
tacaacctctacgagaccaactgggaggtgtacctcatgtccaagctgcgcaagctgatg
gagctggtgaagtacatgctgcaggacacactgcgcttcctggtgcaggactcacttgcc
agcttctcacagttcatcagcgacacctgttgcagcgtgctcaactgcaccgatgacatg
gtctggggtgacgacttaattaacagcccctacaggccccggaagaatcccctgttcatc
atggacctggtgctggacagctctggggtgcactatagcaccccactggagcagtttgag
gcatctctgctgaacctcttcgacaagggcatcctggccacccatgccgtgccccagctg
gagaagctggtgatggaggacatcttcatcagcggtgaccccctgctggagtccgtgggc
cttcatgagccactggtggaagagctacgggccaccattgccagtgccgtgtccaaggcc
atgatcccactgcaggcctacgccaaggagtaccgaaagtacctggagctgaacaacaat
gacattgcctcctttctcaaaacctaccagacgcagggcctgttggcccaggaggtgcgg
gaggtagtgctcacccacctgcgggagaaggagatcctggacagctcgctgcccagcagc
atcatcattgggcctttctacatcaacaccgacaatgtcaagcagagcctgtccaagaaa
cgcaaggccctggccacttccgtgctggacatccttgccaagaacctgcataaggaggtg
gatagcatctgcgaggagttccgcagcatcagccgcaagatctatgagaagcccaacagc
attgaggagctggctgagctgcgagagtggatgaagggcatcccggagaggctggtgggc
ctggaggagcggattgtgaaggtcatggatgactaccaggtcatggatgaattcctctac
aacctcagctcagatgacttcaatgacaaatggattgccagcaactggccttctaagatc
cttgggcagatagagctggtgcagcagcagcatgtggaggatgaggagaagttccgcaaa
atccagatcatggatcagaacaacttccaagagaagctggaagggctgcagctggtagta
gctggcttctccatccatgtggagatttcacgtgcacacgagatcgccaacgaggtgcgg
cgtgtcaagaagcagctgaaggactgccagcagctggccatgctctacaacaaccgcgag
cgcatcttcagcttgcccatcaccaattatgacaagctctccaggatggtgaaggagttc
caaccctacctggacctttggaccacagcgtctgactggctgcgctggtcggagagctgg
atgaatgaccccctctctgccatcgatgctgagcagctggagaagaacgtggttgaagcc
ttcaagaccatgcacaagtgcgtgaagcagtttaaggacatgccagcctgccaggaagtg
gccttggacatccgggcccgcatcgaggagttcaaaccatacatcccactgatccagggg
ctgcgcaaccctggcatgcggatccggcactgggagacactgtccaaccagatcaacatc
aatgtcaggcccaaggccaacctgacctttgctcgctgcctggagatgaacctgcaggac
catatcgagagcatcagcaaggtggctgaggtggctggcaaggagtacgccatcgagcag
gcactggacaagatggagaaggagtggtcgaccatcctgttcaatgtactgccctacaag
gcgacagacacctacatcctgaagagcccggacgaggcctcacagctgctggacgaccac
atcgtcatgacccagaatatgtcattttcaccctacaagaagccctttgagcagcgcatc
aactcctgggagaacaaactgaagctgacccaggaggttctggaggagtggctgaactgt
cagcggtcctggctctacctggagcccatctttagctctgaggacatcaaccagcagctg
cctgtggagagcaagcgctaccagaccatggagcggatctggaagaagatcatgaagaat
gcctacgagaaccgggaggtgatcaatgtgtgttccgacctgagaatgctggacagcctg
cgggactgcaacaagattctggacctggtgcagaagggcctcagcgagtatctggagacc
aagaggagcgccttccccagattctacttcctgtcagatgatgaactactagagatcttg
tcgcagacaaaggaccccacggccgtgcagccacacctgcgcaagtgcttcgagaacatc
gctcggctgctattccaggaggacctggagatcacgcacatgtactcagccgagggggag
gaggtacagttgtgcttctccatctacccctccagcaacgtggaggactggctgcgggag
gtggagcgcagcatgaaggccagtgtgcacgacatcattgagaaggccatcagggcctac
cccacgatgcccaggacccagtgggttctgaactggcctggccaggtgaccatcgctggg
tgccagacctactggaccatggaggtggcagaggctctggaggccggcaacctcagaagc
caactgttcccccagctctgccagcagctcagtgatctggtggcccttgtgcgggggaag
ctgtcccgcatgcagcgggcagtgctgtcagcgctaatcgtcattgaggtccatgccaag
gacgtggtgagcaagctaatccaggagaacgtggtcagcgtgaatgacttccagtggatc
tcacagctgaggtactactggacaaataatgacctgtatatccgtgctgtgaatgctgag
ttcatctatggctatgagtacctgggcaacagtgggaggctggtgatcacgcccctcacc
gacaggtgctacctgacactgaccggagctctgcacctcaagtttgggggtgccccagct
ggcccagctggcacaggcaaaactgagaccaccaaagacctgggtaaggccttggccata
cagaccgttgtgttcaactgctctgaccagctcgacttcatggccatgggcaagttcttc
aagggcctggccagtgctggggcctgggcctgcttcgacgagttcaatcgcatcgacatc
gaggtgctgtctgtggtggcgcagcagatcaccaccatccagaaggcgcagcagcagcgg
gtggaacgcttcatgtttgagggtgtggagatcccactggtgccatcctgcgcagtgttt
atcaccatgaacccgggctacgctggccgcacggagctgcctgacaatctgaaggcgctc
ttccgacccgtggccatgatggttccagattacgccatgatcactgagatctccctctat
tcctttggctttaatgaggccagtgtgctggctaagaagatcacaaccaccttcaagctg
tcttctgagcagctcagctcccaggatcactatgacttcgggatgagagccgtgaaaact
gtgatctcggctgctgggaacctcaagcgagaaaaccccagcatgaatgaggagctgatc
tgcctccgggccatccgtgatgtgaacgtgcccaagttcctgcaggaggacctcaagctc
ttctctggcatcgtgtccgacctgtttcccaccatcaaggaggaggacacggactacggc
atcctggatgaggccatccgcgaggcctgcaggaacagcaacctcaaggatgtggagggc
ttcctgacaaagtgcatccagctctacgagaccacggtggtacgacacggcctcatgctc
gtcgggcccacaggctccggcaagagtacttgttacagagtcctggcagctgccatgacg
tcactgaaagggcagccatccatcagtggtggcatgtacgaggctgtcaactactacgtg
ctcaaccccaagtccatcacgatgggccagctgtacggggagtttgacctcctcacccat
gagtggacagacgggatattctcctcgttcatccgggcgggggccatcacctccgacacc
aacaagaagtggtacatgttcgatgggccggtggatgccatctggattgagaacatgaac
acggtgctggatgacaacaagaagctgtgcctcagctctggggagatcatcaagctcaca
gaggcaatgaccatgatgttcgaggtgcaagacctggcggtggcttcaccagctacagtc
tcccgctgtggcatggtgtacctggagcccagcatcctggggctcatgcccttcatcgag
tgctggctgaggaagctgcctcccttgctgaagccctatgaggagcatttcaaggccctc
tttgtcagcttcctggaggaatccatctccttcgttcggtcctcagtgaaggaggtgatc
gcctcaaccaactgcaacctgaccatgagcctcctcaagctgctggactgcttcttcaag
ccctttctgcctagagagggcctcaagaaaataccctctgaaaagctgagtcgcatcgta
gagttgatcgagccctggttcatcttctccctgatctggagcgtgggtgccactggggac
agcagtggccgcaccagtttcagccactggctaaggctcaagatggagaacgaacagctg
actctgcttttcccagaagaggggctggtgttcgattacaggctggaggacgcgggcatc
agtggcaccaacgacagtgaggatgaagaggaggaatacaagcaggttgcctgggtgaag
tggatggactcctcagctccattcaccatggtaccagacaccaactactgcaacatcatt
gtgcccaccatggacaccgtgcagatgtcccatttactggacatgctgctcaccaacaag
aagcccgtgctgtgcattgggccaacaggcacggggaagacgctcaccatctctgacaag
ctcctcaagaacctggcactggattacatcagccacttcctcaccttctcagcccgcact
tcagccaaccagacccaggacttcattgacagcaagctggacaagaggcggaagggtgtg
tttggaccacctctggggcgcaactttatcttcttcatcgatgacctgaacatgccggcc
ctggagacctacggtgcacagccacccatcgagctgttgcgccagtggatggaccacggc
ggctggtacgaccgcaagatcattggtgccttcaagaacctagtggacatcaactttgtc
tgtgccatgggccccccgggtggaggcaggaacaccgtcaccccgcggctgatgcgtcac
ttcaactacctgtctttcgctgagatggacgaggtcagcaagaaacgcatcttctccacc
atcctgggcaactggttggatggactccttggagaaaaaagctaccgggagcgtgtgcct
ggggccccccacattgcccacttcacggagccccttgtggaagccaccatcatggtgtat
gcaaccatcacctcccagctgctgcccactccagccaagtcccactacaccttcaacctg
agggacctctccaaggtcttccaaggcatgctcatggctgacccggccaaggtcgaggac
caagtgcagctgctgcgactgtggtatcacgagaactgccgcgtgttccgggaccgactg
gtgaatgaggaggaccgcagctggttcgaccagctcctcaagcgctgcatggagcagtgg
gaggtgaccttcaacaaggtctgccccttccagcccattctttacggggacttcatgtca
ccaggctccgatgtcaagtcctacgagctcatcaccagtgagagtaagatgatgcaggtg
atagaggagtacatagaggactacaaccagatcaacacggccaagctgaagctggtcctc
ttcatggacgccatgagccacatctgtcgcatcagccgcaccctacgccaggcgctgggc
aatgcactcctgctgggcgtgggtggcagcggccgcagctccctcacaaggctcgcctcg
cacatggccgagtacgagtgcttccagattgaactatccaagaactacggcatgtccgag
tggcgagatgatgtgaagaaggtcctgctcaaggcgggcctacagaacctacccatcacc
ttcctcttctcagacacccagatcaagaacgaatccttcctggaagatatcaacaacgtc
ctaaactctggtgacattcccaatctgtatactgcggacgagcaggaccagatcgtcagc
accatgcggccctatatccaggagcagggcctacagcccaccaaggccaacctcatggct
gcttacacagggcgtgtgcgcagcaacatccacatggtgctgtgcatgagccccatcgga
gaggtcttccgagctcgtctgaggcagtttccctccctggtcaactgctgtaccatcgac
tggtttaacgagtggccggcagaagccctgaagtctgtggccaccgtgttcctcaatgag
atcccagaactggaatcctcccaggaagaaatccaaggactgatccaggtctgtgtgtac
atccaccagtcggtgtccaagaagtgcatcgagtacctggcagagctgacccgccacaac
tatgtgacccccaagagctacttggagctgcttcatattttctccatcctcatcgggcag
aagaaactggagctgaaaactgccaagaaccgcatgaagagcggcctcgacaagctgctg
cgcacttctgaggatgtagccaagatgcaggaggacctggagagtatgcaccccctgctg
gaggaggctgccaaggacaccatgctcaccatggagcagatcaaggtggatacggccatc
gccgaggagacccggaattcagtgcagacagaggagatcaaagccaatgagaaggccaag
aaggcacaagctattgctgacgatgcccagaaggacctggacgaggcgttgccagccctg
gatgcggctctggccagcctgcgcaacctcaacaagaacgatgtgaccgaggtacgtgcc
atgcagcggccacccccgggtgtgaaactggtcatagaagctgtgtgcattatgaaaggc
atcaagcccaagaaggtgcctggagaaaagccaggcaccaaggtggatgactactgggag
cctggcaaggggctgctgcaggacccgggccacttccttgagagcctcttcaagtttgac
aaggacaacattggggatgtggtgatcaaagccatccagccgtacatcgataatgaagag
ttccagccagccaccattgccaaggtgtccaaggcttgcacctccatctgccagtgggtg
cgcgccatgcacaagtaccactttgtggccaaggccgtggagcccaagcggcaagccctg
ctggaggcccaggatgacctgggggtgacacagaggatcctggatgaggcaaaacagcgc
cttcgtgaggtggaggacggcatcgccacaatgcaggctaagtaccgggaatgcattacc
aagaaggaggagctggagctgaagtgtgagcagtgtgagcagcggctgggccgagctggc
aagctcatcaacgggctgtcggatgagaaggtgcgctggcaggagacggtggagaacctg
cagtacatgctcaacaacatctccggcgatgtcctggtggccgctggctttgtggcctac
ctgggccccttcacgggccagtaccgcacggtgctctacgacagctgggtcaagcagctc
aggagccacaatgtcccacacacctccgagcccacgctaatcgggacgctggggaaccct
gtgaagatccgatcgtggcagatcgctggcctccccaacgacacactgtcagtggagaac
ggggtcatcaaccagttttcccagcgctggacccacttcattgaccctcagagccaggcc
aacaaatggatcaagaacatggagaaggacaatgggctggatgtgttcaagttgagtgac
cgcgacttcctgcgcagcatggagaacgccatccgctttggcaagccatgtctcctggag
aacgtgggcgaggagctagacccagccctggagccagtgctgctcaagcagacgtacaag
cagcagggaaacacggtgctgaagctgggggacacggtgatcccctaccatgaggacttc
aggatgtacatcaccaccaagctgcccaacccacactacacgcccgagatctccaccaaa
ctcaccctcatcaacttcaccctgtcgcccagtggcctagaggaccagctactgggccag
gtagtggcagaggagcgacccgacctggaggaggccaagaaccagctgattatcagtaat
gccaagatgcgccaggagctgaaggacattgaggaccagatcctgtaccggctcagctcc
tccgagggcaaccctgtagatgacatggaactcatcaaggtgctggaagcctccaagatg
aaggctgctgagatccaggccaaagtcaggattgcagagcagacggagaaggacatcgac
ctgacgcgcatggagtacatacccgtggccatccgcacccagatcctcttcttctgtgtg
tccgacctggccaacgtggaccccatgtaccagtactcccttgagtggtttctcaacatc
ttcctctcgggcatcgccaactcagagagagcagacaacctgaagaagcgcatctccaac
atcaaccgctacctgacctacagcctctacagcaacgtctgccgcagcctctttgagaag
cacaagctgatgtttgccttcctgctgtgtgttcgcatcatgatgaacgagggcaaaatc
aaccagagtgagtggcgatacctcctgtctgggggctccatctcgatcatgactgagaat
ccggcaccggactggctgtcagaccgggcttggcgagacatcctagcactctcgaacctg
ccaaccttttcctccttctcttccgacttcgtgaagcacctctcagaattccgggtcatc
ttcgacagccttgagccccaccgggagcctttgcctggcatctgggaccagtacctagac
cagttccagaagctgctagtcctccgctgcctgcgtggggacaaggttaccaacgccatg
caggactttgtggccaccaacctggagccacgcttcattgaaccccagacagccaatctg
tcagtggtgttcaaagactccaactccaccacacccctcatctttgtgctgtcacccggc
acagaccctgctgccgacctctacaagtttgccgaagaaatgaagttctccaaaaagctc
tctgccatctccctgggccaggggcagggccctcgggcagaagccatgatgcgcagctcc
atagagaggggcaaatgggtcttcttccagaactgccacctggcaccaagctggatgcca
gccctagaacgcctcatcgagcacatcaaccccgacaaggtacacagggacttccgcctc
tggctcaccagcctgcccagcaacaagttcccagtgtccatcctgcagaacggctccaag
atgaccattgagccgccacgcggtgtcagggccaacctgctgaagtcctatagtagcctt
ggtgaagacttcctcaactcctgccacaaggtgatggagttcaagtctctgctgctgtct
ctgtgcttgttccatgggaacgccctggagcgccgtaagtttgggcccctgggcttcaac
atcccctatgagttcacggatggagatctgcgcatctgcatcagccagctcaagatgttc
ctggacgaatatgatgacatcccctacaaggtcctcaagtacacggcaggggagatcaat
tacgggggccgtgtcactgatgactgggaccggcgctgcatcatgaacatcttggaggac
ttctacaaccctgacgtgctctcccctgagcacagctacagcgcctcgggcatctaccac
cagatcccgcctacctacgacctccacggctacctctcctacatcaagagcctcccactc
aatgatatgcctgagatctttggcctgcatgacaatgccaacatcacctttgcccagaac
gagacgttcgccctcctgggcaccatcatccagctgcaacccaaatcatcttctgcaggc
agccagggccgggaggagatagtggaggacgtcacccaaaacattctgctcaaggtgcct
gagcctatcaacttgcaatgggtgatggccaagtacccagtgctgtatgaggaatcaatg
aacacagtactagtacaagaggtcattaggtacaatcggctgctgcaggtgatcacacag
acactgcaagacctactcaaggcactcaaggggctggtagtgatgtcctctcagctggag
ctgatggctgccagcctgtacaacaatactgtgcctgagctctggagtgccaaggcctac
ccatcgctcaagcctctgtcatcatgggtcatggacctgctgcaacgcctggactttctg
caggcctggatccaagatggcatcccagctgtcttctggatcagtggattcttcttcccc
caggctttcttaacaggcactctgcagaattttgcccgcaaatttgtcatctccattgac
accatctcctttgatttcaaggtgatgtttgaggcaccatcagagttaacacaaagaccc
caagtagggtgctatatccatggattattcctggaaggtgcccgctgggatccagaggcc
ttccagctggctgagtctcagcccaaggagctgtacacagagatggccgttatctggctc
ttgccaacacccaaccgcaaggcccaggaccaggacttttacctgtgccccatctacaag
acactgactcgtgctggaacactatcaaccacaggacactctaccaactatgtcattgct
gtggagatccccacccatcagccccagcgacactggataaagcgtggtgtggccctcatc
tgtgccctggactactag

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