KEGG   Homo sapiens (human): 169355
Entry
169355            CDS       T01001                                 
Symbol
IDO2, INDOL1
Name
(RefSeq) indoleamine 2,3-dioxygenase 2
  KO
K00463  indoleamine 2,3-dioxygenase [EC:1.13.11.52]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00380  Tryptophan metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa05143  African trypanosomiasis
Module
hsa_M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate
hsa_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD
Drug target
Indoximod: D10640
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    169355 (IDO2)
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05143 African trypanosomiasis
    169355 (IDO2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.52  indoleamine 2,3-dioxygenase
     169355 (IDO2)
SSDB
Motif
Pfam: IDO DUF1864
Other DBs
NCBI-GeneID: 169355
NCBI-ProteinID: NP_919270
OMIM: 612129
HGNC: 27269
Ensembl: ENSG00000188676
Pharos: Q6ZQW0(Tbio)
UniProt: Q6ZQW0
LinkDB
Position
8:39934651..40016392
AA seq 407 aa
MEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIANKLPQLIDAHQLQ
AHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSR
NLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFILVTALVEKEAVP
GIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSG
WKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYM
PPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYHITMVTKYLITAAA
KAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
NT seq 1224 nt   +upstreamnt  +downstreamnt
atggagccccacagaccgaatgtgaagacagcagtgccattgtctttggaaagctatcac
atatctgaagagtatggctttcttcttccagattctctgaaagaacttccagatcattat
aggccttggatggaaattgccaacaaacttcctcaattgattgatgctcaccagcttcaa
gctcatgtggacaagatgcccctgctgagctgccagttcctgaagggtcaccgggagcag
cgcctggcccacctggtcctgagcttcctcaccatgggttatgtctggcaggaaggagag
gcgcagcctgcagaggtcctgccaaggaatcttgcccttccatttgtcgaagtctccagg
aacttggggctccctcctatcctggtccactcagacttggtgctgacgaactggaccaaa
aaagatccagacggattcctggaaattgggaacctggagaccatcatctcatttcctggg
ggagagagcctgcatggttttatactggtgactgctttggtagagaaagaagcagtgcct
gggataaaggctcttgttcaggccacgaatgctatcttgcagcccaaccaggaggccctg
ctccaagccctgcagcgactgagactgtctattcaggacatcaccaaaaccttaggacag
atgcatgattatgtagatccagacatattttatgcaggcatccggatctttctctctgga
tggaaagacaacccagcaatgcctgcagggctgatgtatgaaggagtttcccaagagccc
ctgaaatactccggcgggagtgcagctcagagcacagtgcttcatgcctttgatgagttc
ttaggcattcgtcatagcaaggaaagtggtgactttctgtacagaatgagggattacatg
cctccttcccataaggccttcatagaagacatccactcagcaccttccctgagggactac
atcctgtcatctggacaggaccacttgctgacagcttataaccagtgtgtgcaggccctg
gcagagctgcggagctatcacatcaccatggtcaccaaatacctcatcacagctgcagcc
aaggcaaagcatgggaagccaaaccatctcccagggcctcctcaggctttaaaagacagg
ggcacaggtggaaccgcagttatgagctttcttaagagtgtcagggataagaccttggag
tcaatccttcacccacgtggttag

KEGG   Homo sapiens (human): 3620
Entry
3620              CDS       T01001                                 
Symbol
IDO1, IDO, IDO-1, INDO
Name
(RefSeq) indoleamine 2,3-dioxygenase 1
  KO
K00463  indoleamine 2,3-dioxygenase [EC:1.13.11.52]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00380  Tryptophan metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa05143  African trypanosomiasis
Module
hsa_M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate
hsa_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD
Drug target
Epacadostat: D11049
Indoximod: D10640
Linrodostat (DG03010): D11412 D11413
Navoximod: D11255
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    3620 (IDO1)
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05143 African trypanosomiasis
    3620 (IDO1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.52  indoleamine 2,3-dioxygenase
     3620 (IDO1)
SSDB
Motif
Pfam: IDO DUF1864 Meckelin
Other DBs
NCBI-GeneID: 3620
NCBI-ProteinID: NP_002155
OMIM: 147435
HGNC: 6059
Ensembl: ENSG00000131203
Pharos: P14902(Tchem)
UniProt: P14902 A0A348GSI3
Structure
LinkDB
Position
8:39913891..39928790
AA seq 403 aa
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
NT seq 1212 nt   +upstreamnt  +downstreamnt
atggcacacgctatggaaaactcctggacaatcagtaaagagtaccatattgatgaagaa
gtgggctttgctctgccaaatccacaggaaaatctacctgatttttataatgactggatg
ttcattgctaaacatctgcctgatctcatagagtctggccagcttcgagaaagagttgag
aagttaaacatgctcagcattgatcatctcacagaccacaagtcacagcgccttgcacgt
ctagttctgggatgcatcaccatggcatatgtgtggggcaaaggtcatggagatgtccgt
aaggtcttgccaagaaatattgctgttccttactgccaactctccaagaaactggaactg
cctcctattttggtttatgcagactgtgtcttggcaaactggaagaaaaaggatcctaat
aagcccctgacttatgagaacatggacgttttgttctcatttcgtgatggagactgcagt
aaaggattcttcctggtctctctattggtggaaatagcagctgcttctgcaatcaaagta
attcctactgtattcaaggcaatgcaaatgcaagaacgggacactttgctaaaggcgctg
ttggaaatagcttcttgcttggagaaagcccttcaagtgtttcaccaaatccacgatcat
gtgaacccaaaagcatttttcagtgttcttcgcatatatttgtctggctggaaaggcaac
ccccagctatcagacggtctggtgtatgaagggttctgggaagacccaaaggagtttgca
gggggcagtgcaggccaaagcagcgtctttcagtgctttgacgtcctgctgggcatccag
cagactgctggtggaggacatgctgctcagttcctccaggacatgagaagatatatgcca
ccagctcacaggaacttcctgtgctcattagagtcaaatccctcagtccgtgagtttgtc
ctttcaaaaggtgatgctggcctgcgggaagcttatgacgcctgtgtgaaagctctggtc
tccctgaggagctaccatctgcaaatcgtgactaagtacatcctgattcctgcaagccag
cagccaaaggagaataagacctctgaagacccttcaaaactggaagccaaaggaactgga
ggcactgatttaatgaatttcctgaagactgtaagaagtacaactgagaaatcccttttg
aaggaaggttaa

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