Homo sapiens (human): 1777 Help Entry 1777              CDS       T01001                                  Symbol DNASE2, AIPCS, DNASE2A, DNL, DNL2 Name (RefSeq) deoxyribonuclease 2, lysosomal   KO K01158   deoxyribonuclease II [EC:3.1.22.1] Organism hsa  Homo sapiens (human) Pathway hsa04142   Lysosome hsa04623   Cytosolic DNA-sensing pathway Network nt06520  CGAS-STING signaling   Element N01571   DNA degradation by extracellular/endolysosomal DNAse Disease H02608   Autoinflammatory-pancytopenia syndrome Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09141 Transport and catabolism    04142 Lysosome     1777 (DNASE2)  09150 Organismal Systems   09151 Immune system    04623 Cytosolic DNA-sensing pathway     1777 (DNASE2) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.22  Endodeoxyribonucleases producing 3'-phosphomonoesters     3.1.22.1  deoxyribonuclease II      1777 (DNASE2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  DNase_II Motif Other DBs NCBI-GeneID:  1777 NCBI-ProteinID:  NP_001366 OMIM:  126350 HGNC:  2960 Ensembl:  ENSG00000105612 UniProt:  O00115 LinkDB All DBs Position 19:complement(12875209..12881449) Genome browser AA seq 360 aa AA seqDB search MIPLLLAALLCVPAGALTCYGDSGQPVDWFVVYKLPALRGSGEAAQRGLQYKYLDESSGG WRDGRALINSPEGAVGRSLQPLYRSNTSQLAFLLYNDQPPQPSKAQDSSMRGHTKGVLLL DHDGGFWLVHSVPNFPPPASSAAYSWPHSACTYGQTLLCVSFPFAQFSKMGKQLTYTYPW VYNYQLEGIFAQEFPDLENVVKGHHVSQEPWNSSITLTSQAGAVFQSFAKFSKFGDDLYS GWLAAALGTNLQVQFWHKTVGILPSNCSDIWQVLNVNQIAFPGPAGPSFNSTEDHSKWCV SPKGPWTCVGDMNRNQGEEQRGGGTLCAQLPALWKAFQPLVKNYQPCNGMARKPSRAYKI NT seq 1083 nt NT seq  +upstreamnt  +downstreamnt atgatcccgctgctgctggcagcgctgctgtgcgtccccgccggggccctgacctgctac ggggactccgggcagcctgtagactggttcgtggtctacaagctgccagctcttagaggg tccggggaggcggcgcagagagggctgcagtacaagtatctggacgagagctccggaggc tggcgggacggcagggcactcatcaacagcccggagggggccgtgggccgaagcctgcag ccgctgtaccggagcaacaccagccagctcgccttcctgctctacaatgaccaaccgcct caacccagcaaggctcaggactcttccatgcgtgggcacacgaagggtgtcctgctcctt gaccacgatgggggcttctggctggtccacagtgtacctaacttccctccaccggcctcc tctgctgcatacagctggcctcatagcgcctgtacctacgggcagaccctgctctgtgtg tcttttcccttcgctcagttctcgaagatgggcaagcagctgacctacacctacccctgg gtctataactaccagctggaagggatctttgcccaggaattccccgacttggagaatgtg gtcaagggccaccacgttagccaagaaccctggaacagcagcatcacactcacatcccag gccggggctgttttccagagctttgccaagttcagcaaatttggagatgacctgtactcc ggctggttggcagcagcccttggtaccaacctgcaggtccagttctggcacaaaactgta ggcatcctgccctctaactgctcggatatctggcaggttctgaatgtgaaccagatagct ttccctggaccagccggcccaagcttcaacagcacagaggaccactccaaatggtgcgtg tccccaaaagggccctggacctgcgtgggtgacatgaatcggaaccagggagaggagcaa cggggtgggggcacactgtgtgcccagctgccagccctctggaaagccttccagccgctg gtgaagaactaccagccctgtaatggcatggccaggaagcccagcagagcttataagatc taa

Homo sapiens (human): 58511 Help Entry 58511             CDS       T01001                                  Symbol DNASE2B, DLAD Name (RefSeq) deoxyribonuclease 2 beta   KO K01158   deoxyribonuclease II [EC:3.1.22.1] Organism hsa  Homo sapiens (human) Pathway hsa04142   Lysosome hsa04623   Cytosolic DNA-sensing pathway Network nt06520  CGAS-STING signaling   Element N01571   DNA degradation by extracellular/endolysosomal DNAse Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09141 Transport and catabolism    04142 Lysosome     58511 (DNASE2B)  09150 Organismal Systems   09151 Immune system    04623 Cytosolic DNA-sensing pathway     58511 (DNASE2B) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.22  Endodeoxyribonucleases producing 3'-phosphomonoesters     3.1.22.1  deoxyribonuclease II      58511 (DNASE2B) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  DNase_II Motif Other DBs NCBI-GeneID:  58511 NCBI-ProteinID:  NP_067056 OMIM:  608057 HGNC:  28875 Ensembl:  ENSG00000137976 UniProt:  Q8WZ79 Q66K39 LinkDB All DBs Position 1:84398484..84415018 Genome browser AA seq 361 aa AA seqDB search MKQKMMARLLRTSFALLFLGLFGVLGAATISCRNEEGKAVDWFTFYKLPKRQNKESGETG LEYLYLDSTTRSWRKSEQLMNDTKSVLGRTLQQLYEAYASKSNNTAYLIYNDGVPKPVNY SRKYGHTKGLLLWNRVQGFWLIHSIPQFPPIPEEGYDYPPTGRRNGQSGICITFKYNQYE AIDSQLLVCNPNVYSCSIPATFHQELIHMPQLCTRASSSEIPGRLLTTLQSAQGQKFLHF AKSDSFLDDIFAAWMAQRLKTHLLTETWQRKRQELPSNCSLPYHVYNIKAIKLSRHSYFS SYQDHAKWCISQKGTKNRWTCIGDLNRSPHQAFRSGGFICTQNWQIYQAFQGLVLYYESC K NT seq 1086 nt NT seq  +upstreamnt  +downstreamnt atgaaacagaaaatgatggcaagactgctaagaacatcctttgctttgctcttccttggc ctctttggggtgctgggggcagcaacaatttcatgcagaaatgaagaagggaaagctgtg gactggtttactttttataagttacctaaaagacaaaacaaggaaagtggagagactggg ttagagtacctgtacctagactctacaactagaagctggaggaagagtgagcaactaatg aatgacaccaagagtgttttgggaaggacattacaacagctatatgaagcatatgcctct aagagtaacaacacagcctatctaatatacaatgatggagtccctaaacctgtgaattac agcagaaagtatggacacaccaaaggtttactgctgtggaacagagttcaagggttctgg ctgattcattccatccctcagtttcctccaattccggaagaaggctatgattatccaccc acagggagacgaaatggacaaagtggcatctgcataactttcaagtacaaccagtatgag gcaatagattctcagctcttggtctgcaaccccaacgtctatagctgctccatcccagcc acctttcaccaggagctcattcacatgccccagctgtgcaccagggccagctcatcagag attcctggcaggctcctcaccacacttcagtcggcccagggacaaaaattcctccatttt gcaaagtcggattcttttcttgacgacatctttgcagcctggatggctcaacggctgaag acacacttgttaacagaaacctggcagcgaaaaagacaagagcttccttcaaactgctcc cttccttaccatgtctacaatataaaagcaattaaattatcacgacactcttatttcagt tcttatcaagatcatgccaagtggtgtatttcccaaaagggcaccaaaaatcgctggaca tgtattggagacctaaatcggagtccacaccaagccttcagaagtggaggattcatttgt acccagaattggcaaatttaccaagcatttcaaggattagtattatactatgaaagctgt aagtaa

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