Homo sapiens (human): 1803 Help Entry 1803              CDS       T01001                                  Symbol DPP4, ADABP, ADCP2, CD26, DPPIV, TP103 Name (RefSeq) dipeptidyl peptidase 4   KO K01278   dipeptidyl-peptidase 4 [EC:3.4.14.5] Organism hsa  Homo sapiens (human) Pathway hsa03272   Virion - Hepatitis viruses hsa04974   Protein digestion and absorption Drug target Alogliptin:  D06553<JP/US> Anagliptin:  D09780<JP> Carmegliptin (DG01281):  D08631 D09326 Denagliptin tosylate:  D06578 Dutogliptin (DG01282):  D09333 D09334 Evogliptin:  D11023 Gemigliptin:  D10502 Gosogliptin:  D09625 Linagliptin (DG03274):  D09566<JP/US> D12703 Omarigliptin:  D10317<JP> Saxagliptin (DG00119):  D08996 D09753<JP/US> D10262<US> Sitagliptin (DG00118):  D06645<JP/US> D08516<US> D12294 D13055<US> Teneligliptin (DG01283):  D08616 D09756<JP> D11968 Trelagliptin (DG01284):  D10178 D10179<JP> Vildagliptin:  D07080<JP> Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03272 Virion - Hepatitis viruses     1803 (DPP4)  09150 Organismal Systems   09154 Digestive system    04974 Protein digestion and absorption     1803 (DPP4)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     1803 (DPP4)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     1803 (DPP4)    04090 CD molecules [BR:hsa04090]     1803 (DPP4) Enzymes [BR:hsa01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.14  Dipeptidyl-peptidases and tripeptidyl-peptidases     3.4.14.5  dipeptidyl-peptidase IV      1803 (DPP4) Peptidases and inhibitors [BR:hsa01002]  Serine peptidases   Family S9: prolyl oligopeptidase family    1803 (DPP4) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)    1803 (DPP4)   Exosomal proteins of epithelial cells    1803 (DPP4)   Exosomal proteins of colorectal cancer cells    1803 (DPP4) CD molecules [BR:hsa04090]  Proteins   1803 (DPP4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  DPPIV_N Peptidase_S9 DPPIV_rep DLH LIP Abhydrolase_6 Beta-prop_THOC3 Abhydrolase_2 Peptidase_S15 Motif Other DBs NCBI-GeneID:  1803 NCBI-ProteinID:  NP_001926 OMIM:  102720 HGNC:  3009 Ensembl:  ENSG00000197635 UniProt:  P27487 Structure PDBPDBj LinkDB All DBs Position 2:complement(161992245..162074215) Genome browser AA seq 766 aa AA seqDB search MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSL RWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNY VKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNL PSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF YSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYL CDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPS EPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISN EYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLY TLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKY PLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGT FEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWE YYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQIS KALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP NT seq 2301 nt NT seq  +upstreamnt  +downstreamnt atgaagacaccgtggaaggttcttctgggactgctgggtgctgctgcgcttgtcaccatc atcaccgtgcccgtggttctgctgaacaaaggcacagatgatgctacagctgacagtcgc aaaacttacactctaactgattacttaaaaaatacttatagactgaagttatactcctta agatggatttcagatcatgaatatctctacaaacaagaaaataatatcttggtattcaat gctgaatatggaaacagctcagttttcttggagaacagtacatttgatgagtttggacat tctatcaatgattattcaatatctcctgatgggcagtttattctcttagaatacaactac gtgaagcaatggaggcattcctacacagcttcatatgacatttatgatttaaataaaagg cagctgattacagaagagaggattccaaacaacacacagtgggtcacatggtcaccagtg ggtcataaattggcatatgtttggaacaatgacatttatgttaaaattgaaccaaattta ccaagttacagaatcacatggacggggaaagaagatataatatataatggaataactgac tgggtttatgaagaggaagtcttcagtgcctactctgctctgtggtggtctccaaacggc acttttttagcatatgcccaatttaacgacacagaagtcccacttattgaatactccttc tactctgatgagtcactgcagtacccaaagactgtacgggttccatatccaaaggcagga gctgtgaatccaactgtaaagttctttgttgtaaatacagactctctcagctcagtcacc aatgcaacttccatacaaatcactgctcctgcttctatgttgataggggatcactacttg tgtgatgtgacatgggcaacacaagaaagaatttctttgcagtggctcaggaggattcag aactattcggtcatggatatttgtgactatgatgaatccagtggaagatggaactgctta gtggcacggcaacacattgaaatgagtactactggctgggttggaagatttaggccttca gaacctcattttacccttgatggtaatagcttctacaagatcatcagcaatgaagaaggt tacagacacatttgctatttccaaatagataaaaaagactgcacatttattacaaaaggc acctgggaagtcatcgggatagaagctctaaccagtgattatctatactacattagtaat gaatataaaggaatgccaggaggaaggaatctttataaaatccaacttagtgactataca aaagtgacatgcctcagttgtgagctgaatccggaaaggtgtcagtactattctgtgtca ttcagtaaagaggcgaagtattatcagctgagatgttccggtcctggtctgcccctctat actctacacagcagcgtgaatgataaagggctgagagtcctggaagacaattcagctttg gataaaatgctgcagaatgtccagatgccctccaaaaaactggacttcattattttgaat gaaacaaaattttggtatcagatgatcttgcctcctcattttgataaatccaagaaatat cctctactattagatgtgtatgcaggcccatgtagtcaaaaagcagacactgtcttcaga ctgaactgggccacttaccttgcaagcacagaaaacattatagtagctagctttgatggc agaggaagtggttaccaaggagataagatcatgcatgcaatcaacagaagactgggaaca tttgaagttgaagatcaaattgaagcagccagacaattttcaaaaatgggatttgtggac aacaaacgaattgcaatttggggctggtcatatggagggtacgtaacctcaatggtcctg ggatcgggaagtggcgtgttcaagtgtggaatagccgtggcgcctgtatcccggtgggag tactatgactcagtgtacacagaacgttacatgggtctcccaactccagaagacaacctt gaccattacagaaattcaacagtcatgagcagagctgaaaattttaaacaagttgagtac ctccttattcatggaacagcagatgataacgttcactttcagcagtcagctcagatctcc aaagccctggtcgatgttggagtggatttccaggcaatgtggtatactgatgaagaccat ggaatagctagcagcacagcacaccaacatatatatacccacatgagccacttcataaaa caatgtttctctttaccttag

Homo sapiens (human): 4224 Help Entry 4224              CDS       T01001                                  Symbol MEP1A, PPHA Name (RefSeq) meprin A subunit alpha   KO K01395   meprin A [EC:3.4.24.18] Organism hsa  Homo sapiens (human) Pathway hsa04974   Protein digestion and absorption Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09154 Digestive system    04974 Protein digestion and absorption     4224 (MEP1A)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     4224 (MEP1A)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     4224 (MEP1A) Enzymes [BR:hsa01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.24  Metalloendopeptidases     3.4.24.18  meprin A      4224 (MEP1A) Peptidases and inhibitors [BR:hsa01002]  Metallo peptidases   Family M12: astacin/adamalysin family    4224 (MEP1A) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of epithelial cells    4224 (MEP1A) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Astacin MAM MATH_2 TRAF-mep_MATH EGF Motif Other DBs NCBI-GeneID:  4224 NCBI-ProteinID:  NP_005579 OMIM:  600388 HGNC:  7015 Ensembl:  ENSG00000112818 UniProt:  Q16819 Structure PDBPDBj LinkDB All DBs Position 6:46793389..46845984 Genome browser AA seq 746 aa AA seqDB search MAWIRSTCILFFTLLFAHIAAVPIKYLPEENVHDADFGEQKDISEINLAAGLDLFQGDIL LQKSRNGLRDPNTRWTFPIPYILADNLGLNAKGAILYAFEMFRLKSCVDFKPYEGESSYI IFQQFDGCWSEVGDQHVGQNISIGQGCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWW DQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTITAKIPEFNSIIG QRLDFSAIDLERLNRMYNCTTTHTLLDHCTFEKANICGMIQGTRDDTDWAHQDSAQAGEV DHTLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQFFYKMTGSPSDRLVV WVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKGDPQNSTGGIY LDDITLTETPCPTGVWTVRNFSQVLENTSKGDKLQSPRFYNSEGYGFGVTLYPNSRESSG YLRLAFHVCSGENDAILEWPVENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSPAIND TVIWDRPSRVGTYHTDCNCFRSIDLGWSGFISHQMLKRRSFLKNDDLIIFVDFEDITHLS QTEVPTKGKRLSPQGLILQGQEQQVSEEGSGKAMLEEALPVSLSQGQPSRQKRSVENTGP LEDHNWPQYFRDPCDPNPCQNDGICVNVKGMASCRCISGHAFFYTGERCQAVQVHGSVLG MVIGGTAGVIFLTFSIIAILSQRPRK NT seq 2241 nt NT seq  +upstreamnt  +downstreamnt atggcttggattagatccacttgcattctcttttttaccttgctttttgcccacatagca gctgtaccgattaagtatcttcctgaagaaaatgtacatgatgcagattttggtgaacag aaggatatttcagaaatcaatttagctgcaggcttggacctctttcaaggggacatcctc ttgcagaaatccagaaatggcctgagagacccaaacaccaggtggacgttccccattcct tacatcttggctgataatttggggctgaatgctaaaggagccattctgtatgcctttgag atgttccgtctcaagtcctgtgtggatttcaagccctatgaaggagagagctcatatatc atatttcaacagtttgatgggtgctggtctgaggttggtgaccaacatgtgggacagaac atttccattggccaaggatgtgcctataaggccatcatagaacacgagatcctgcatgct ttgggattttaccacgagcagtcaaggacggaccgggatgattatgtgaacatctggtgg gaccaaattctttcaggttaccagcacaactttgacacctatgatgatagcttaatcaca gacctcaatacaccctatgattatgagtctttgatgcactaccagcctttctcatttaac aagaatgcaagtgttcccaccatcacagccaagatccctgagtttaactccattatcgga cagcgcctggatttcagtgccattgatttagagaggctgaaccgaatgtacaattgcacc acaactcacactcttttggaccactgtacttttgagaaggcaaacatctgtggaatgatt cagggcaccagagatgacactgactgggcccatcaggacagtgctcaggctggagaagtg gatcacaccttgttgggacaatgcacaggtgccggctacttcatgcagttcagcaccagc tcggggtccgcggaagaggcagccctactggagtctcggattctttacccaaagaggaag cagcagtgcctgcaatttttctataaaatgacgggaagtccttcagacagactcgttgtc tgggtcaggagggatgacagcacaggcaatgttcgcaagttggtgaaggtgcagactttt caaggagatgatgaccacaattggaaaattgcccatgtggtgctcaaagaggaacagaag tttcgctaccttttccagggcacaaaaggcgaccctcagaactcaactgggggaatttac ctagatgacatcactctgacagaaaccccctgccccacaggggtctggacagtccggaat ttctcccaagtccttgagaacaccagcaaaggggacaagcttcagagccctcgattctac aattcggagggatatggttttggggtaactttatacccaaatagcagagaaagctctggt tacttgagacttgcttttcatgtgtgcagtggggagaacgatgctatcctggagtggccg gtagaaaacagacaggtgataattaccatccttgaccaggagcctgatgtccggaacagg atgtcctcaagcatggtgttcactacctcgaagtcgcacacatctccagcgataaatgac actgtcatctgggacaggccgtccagggtgggaacctatcatacggactgtaattgtttt agaagcatcgacttgggctggagtggtttcatttcccaccaaatgctgaaaaggaggagt ttcctgaaaaatgatgacctcatcatatttgtggactttgaagatatcacccacctcagc cagactgaagttcccactaaaggcaaaagactgagcccccaaggcctcattctccaaggc caggagcagcaggtctccgaagaaggttcgggaaaggccatgttagaggaagccctacct gtcagcctgagccaggggcagcccagccgacagaagcggtcggtggagaacacaggcccc ctggaggaccataactggccacagtacttcagagacccatgtgacccaaacccttgccaa aatgacggcatctgtgtgaacgtgaaggggatggcgagctgcaggtgcatctctggacat gctttcttctacacgggggagcgctgtcaggccgtgcaggtgcacggcagtgtcctgggc atggtgatcggaggcacggctggcgtgatcttcttgaccttctccatcatcgccatcctt tcccaaaggccaaggaagtga

Homo sapiens (human): 4225 Help Entry 4225              CDS       T01001                                  Symbol MEP1B Name (RefSeq) meprin A subunit beta   KO K08606   meprin B [EC:3.4.24.63] Organism hsa  Homo sapiens (human) Pathway hsa04974   Protein digestion and absorption Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09154 Digestive system    04974 Protein digestion and absorption     4225 (MEP1B)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     4225 (MEP1B) Enzymes [BR:hsa01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.24  Metalloendopeptidases     3.4.24.63  meprin B      4225 (MEP1B) Peptidases and inhibitors [BR:hsa01002]  Metallo peptidases   Family M12: astacin/adamalysin family    4225 (MEP1B) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Astacin MAM MATH_2 TRAF-mep_MATH EGF Motif Other DBs NCBI-GeneID:  4225 NCBI-ProteinID:  NP_005916 OMIM:  600389 HGNC:  7020 Ensembl:  ENSG00000141434 UniProt:  Q16820 Structure PDBPDBj LinkDB All DBs Position 18:32190039..32220404 Genome browser AA seq 701 aa AA seqDB search MDLWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQI RNSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFK GSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRI LSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMD FSDSDLLKLNQLYNCSSSLSFMDSCSFELENVCGMIQSSGDNADWQRVSQVPRGPESDHS NMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIR EYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDI NLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAFQIYLNLAHVTNAGIYFHLI SGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVG TVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQIQLTP APSVQDLCSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEKRGSTRDTIVIAVSST VAVFALMLIITLVSVYCTRKKYRERMSSNRPNLTPQNQHAF NT seq 2106 nt NT seq  +upstreamnt  +downstreamnt atggatttatggaatctgtcttggtttctgttcttggatgctcttctcgtgatttctggc ttggcaactccagaaaactttgatgtagatggcggaatggaccaggacatatttgatatc aatgaaggtttgggactggatctttttgagggtgacatcagacttgatagggcacaaatt agaaattccatcattggagaaaagtatagatggcctcataccattccatatgttctagaa gatagcttggaaatgaatgctaagggagttatcctcaatgcatttgaacgttatcgcctt aaaacatgtattgactttaagccttgggctggagaaacaaactatatatcagtgttcaag ggcagtggctgctggtcttcagtaggaaataggcgggttgggaagcaagaactttccatc ggggcaaactgtgaccgaatagcaacagttcaacacgagttcctccacgctctgggattc tggcatgagcagtcgcgttctgaccgggatgactatgtcaggataatgtgggacagaatt ctgtcaggcagagagcacaattttaacacctatagtgacgatatatcagattccctgaat gttccctatgattacacttcagtaatgcactacagtaaaactgcattccaaaatggaaca gagccgacaattgtcacaagaatctcagactttgaggatgtgatcggccaacgaatggat ttcagtgactctgatctcctaaagttgaatcaactgtataactgctcctcttccttgagt tttatggactcgtgcagttttgaactggaaaatgtgtgtggcatgatccaaagttcagga gataatgctgactggcaacgggtttcacaggttcccagggggccagagagtgatcactcc aacatgggccagtgccaaggttctggtttcttcatgcatttcgatagcagctctgtaaat gtgggggccacagcagtgctggaaagtagaacgctgtaccctaaaagaggatttcagtgc ctgcaattttacttatataacagtggcagtgaaagtgatcaactgaacatctatatcagg gagtattctgcagacaatgtggatggcaatttaacccttgtggaagaaataaaagaaata cccactgggagctggcaactttatcatgtaacattgaaagtgaccaagaagtttagagtg gtgtttgaaggacgcaaaggctctggtgcatcactgggtggtctgtctattgatgacatc aatctttcggaaacacggtgccctcatcatatctggcatataaggaatttcacacagttc attggcagcccaaatggaactctgtatagccctccattttactcttctaaaggttatgcc tttcagatttacttaaatctagcccatgtgactaatgcagggatatatttccacttgatc tctggagccaatgatgatcaattacagtggccatgtccttggcaacaagccacaatgaca cttttggatcaaaatcctgacattcgacagcgtatgtccaatcagcggagtataactaca gacccatttatgaccaccgataatggaaactatttctgggacaggccttctaaagtggga acagtggctttgttctctaatggaactcagtttagaagaggtgggggctatggaaccagt gcctttataacccacgaaaggctgaaaagcagagattttataaaaggagatgatgtttat atcctactgacagtggaagacatatctcacctcaactctacacaaatccagctaacacca gcccctagtgttcaagacctctgctcaaaaaccacctgtaaaaatgacggtgtctgcact gttcgagatggcaaagctgagtgcaggtgccagtcaggggaagactggtggtacatggga gaaaggtgtgaaaagagaggctccacccgagacaccatagtcattgctgtttcatctact gttgctgtgtttgccttgatgctgatcatcacccttgtcagtgtctattgcaccaggaag aaatatcgtgaaaggatgagctcaaatcgaccaaatttgactccgcaaaatcagcatgct ttttga

Homo sapiens (human): 4311 Help Entry 4311              CDS       T01001                                  Symbol MME, CALLA, CD10, CMT2T, NEP, SCA43, SFE Name (RefSeq) membrane metalloendopeptidase   KO K01389   neprilysin [EC:3.4.24.11] Organism hsa  Homo sapiens (human) Pathway hsa04614   Renin-angiotensin system hsa04640   Hematopoietic cell lineage hsa04974   Protein digestion and absorption hsa05010   Alzheimer disease Network nt06460  Alzheimer disease   Element N01415   NEP-mediated Abeta degradation N01416   Mercury to NEP-mediated Abeta degradation Disease H00063   Spinocerebellar ataxia (SCA) H00264   Charcot-Marie-Tooth disease Drug target Candoxatril:  D01070 Candoxatrilat:  D03349 Ecadotril:  D03929 Omapatrilat:  D01970 Racecadotril:  D08464 Sacubitril:  D10225 Valsartan and sacubitril:  D10226<JP/US> Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09151 Immune system    04640 Hematopoietic cell lineage     4311 (MME)   09152 Endocrine system    04614 Renin-angiotensin system     4311 (MME)   09154 Digestive system    04974 Protein digestion and absorption     4311 (MME)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     4311 (MME)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     4311 (MME)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     4311 (MME)    04090 CD molecules [BR:hsa04090]     4311 (MME) Enzymes [BR:hsa01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.24  Metalloendopeptidases     3.4.24.11  neprilysin      4311 (MME) Peptidases and inhibitors [BR:hsa01002]  Metallo peptidases   Family M13: neprilysin family    4311 (MME) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    4311 (MME) CD molecules [BR:hsa04090]  Proteins   4311 (MME) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Peptidase_M13_N Peptidase_M13 PEX14-like_2nd Motif Other DBs NCBI-GeneID:  4311 NCBI-ProteinID:  NP_000893 OMIM:  120520 HGNC:  7154 Ensembl:  ENSG00000196549 UniProt:  P08473 Structure PDBPDBj LinkDB All DBs Position 3:155024202..155183729 Genome browser AA seq 750 aa AA seqDB search MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW NT seq 2253 nt NT seq  +upstreamnt  +downstreamnt atgggcaagtcagaaagtcagatggatataactgatatcaacactccaaagccaaagaag aaacagcgatggactccactggagatcagcctctcggtccttgtcctgctcctcaccatc atagctgtgacaatgatcgcactctatgcaacctacgatgatggtatttgcaagtcatca gactgcataaaatcagctgctcgactgatccaaaacatggatgccaccactgagccttgt acagactttttcaaatatgcttgcggaggctggttgaaacgtaatgtcattcccgagacc agctcccgttacggcaactttgacattttaagagatgaactagaagtcgttttgaaagat gtccttcaagaacccaaaactgaagatatagtagcagtgcagaaagcaaaagcattgtac aggtcttgtataaatgaatctgctattgatagcagaggtggagaacctctactcaaactg ttaccagacatatatgggtggccagtagcaacagaaaactgggagcaaaaatatggtgct tcttggacagctgaaaaagctattgcacaactgaattctaaatatgggaaaaaagtcctt attaatttgtttgttggcactgatgataagaattctgtgaatcatgtaattcatattgac caacctcgacttggcctcccttctagagattactatgaatgcactggaatctataaagag gcttgtacagcatatgtggattttatgatttctgtggccagattgattcgtcaggaagaa agattgcccatcgatgaaaaccagcttgctttggaaatgaataaagttatggaattggaa aaagaaattgccaatgctacggctaaacctgaagatcgaaatgatccaatgcttctgtat aacaagatgacattggcccagatccaaaataacttttcactagagatcaatgggaagcca ttcagctggttgaatttcacaaatgaaatcatgtcaactgtgaatattagtattacaaat gaggaagatgtggttgtttatgctccagaatatttaaccaaacttaagcccattcttacc aaatattctgccagagatcttcaaaatttaatgtcctggagattcataatggatcttgta agcagcctcagccgaacctacaaggagtccagaaatgctttccgcaaggccctttatggt acaacctcagaaacagcaacttggagacgttgtgcaaactatgtcaatgggaatatggaa aatgctgtggggaggctttatgtggaagcagcatttgctggagagagtaaacatgtggtc gaggatttgattgcacagatccgagaagtttttattcagactttagatgacctcacttgg atggatgccgagacaaaaaagagagctgaagaaaaggccttagcaattaaagaaaggatc ggctatcctgatgacattgtttcaaatgataacaaactgaataatgagtacctcgagttg aactacaaagaagatgaatacttcgagaacataattcaaaatttgaaattcagccaaagt aaacaactgaagaagctccgagaaaaggtggacaaagatgagtggataagtggagcagct gtagtcaatgcattttactcttcaggaagaaatcagatagtcttcccagccggcattctg cagccccccttctttagtgcccagcagtccaactcattgaactatgggggcatcggcatg gtcataggacacgaaatcacccatggcttcgatgacaatggcagaaactttaacaaagat ggagacctcgttgactggtggactcaacagtctgcaagtaactttaaggagcaatcccag tgcatggtgtatcagtatggaaacttttcctgggacctggcaggtggacagcaccttaat ggaattaatacactgggagaaaacattgctgataatggaggtcttggtcaagcatacaga gcctatcagaattatattaaaaagaatggcgaagaaaaattacttcctggacttgaccta aatcacaaacaactatttttcttgaactttgcacaggtgtggtgtggaacctataggcca gagtatgcggttaactccattaaaacagatgtgcacagtccaggcaatttcaggattatt gggactttgcagaactctgcagagttttcagaagcctttcactgccgcaagaattcatac atgaatccagaaaagaagtgccgggtttggtga

Homo sapiens (human): 5547 Help Entry 5547              CDS       T01001                                  Symbol PRCP, HUMPCP, PCP Name (RefSeq) prolylcarboxypeptidase   KO K01285   lysosomal Pro-X carboxypeptidase [EC:3.4.16.2] Organism hsa  Homo sapiens (human) Pathway hsa04614   Renin-angiotensin system hsa04974   Protein digestion and absorption Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09152 Endocrine system    04614 Renin-angiotensin system     5547 (PRCP)   09154 Digestive system    04974 Protein digestion and absorption     5547 (PRCP)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     5547 (PRCP) Enzymes [BR:hsa01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.16  Serine-type carboxypeptidases     3.4.16.2  lysosomal Pro-Xaa carboxypeptidase      5547 (PRCP) Peptidases and inhibitors [BR:hsa01002]  Serine peptidases   Family S28    5547 (PRCP) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Peptidase_S28 Hydrolase_4 Peptidase_S37 DUF2920 Abhydrolase_6 Peptidase_S9 Abhydrolase_1 Motif Other DBs NCBI-GeneID:  5547 NCBI-ProteinID:  NP_005031 OMIM:  176785 HGNC:  9344 Ensembl:  ENSG00000137509 UniProt:  P42785 Structure PDBPDBj LinkDB All DBs Position 11:complement(82822936..82901644) Genome browser AA seq 496 aa AA seqDB search MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHF GFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFA EHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSY GGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRS WDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQP LPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWS YQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHT NIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRH MKNWIRDFYDSAGKQH NT seq 1491 nt NT seq  +upstreamnt  +downstreamnt atgggccgccgagccctcctgctcctgcttctgtcttttctggcgccctgggccaccata gccctccggccggccttaagggccctcggcagcctacacttgccaaccaaccccacatcc ctcccggctgtagccaagaactattcggttctctacttccaacagaaggttgatcatttt ggatttaatactgtgaaaacttttaatcagcggtacctagtagctgataaatactggaag aaaaatggtggatcaatacttttctacactggtaatgaaggggacattatctggttttgt aataacacggggttcatgtgggatgtggctgaggaactgaaagctatgttggtgtttgct gaacatcgatactatggagagtctctcccctttggtgacaactcattcaaggattccaga cacttgaatttcctgacatcagaacaagctctggctgattttgcagagttaatcaaacac ttgaaaagaacaatcccaggagctgaaaatcaacctgtcattgccataggaggctcctat ggtggcatgcttgccgcctggtttaggatgaaatatcctcatatggtagttggagctctt gcagcttctgcccctatctggcagtttgaggatttagtaccttgtggtgtatttatgaag atcgtaactacagattttaggaaaagcggtccacattgttcagagagcatccacaggtcc tgggatgccattaatcgactctcaaatactggcagtggtttgcagtggcttactggagcc cttcacttatgcagcccattaacttctcaggacatccaacatttgaaagactggatctct gaaacctgggtgaatctggcaatggtggactatccttatgcctctaactttttacagcct ttgcctgcttggcctatcaaggtagtgtgccagtatttgaaaaatcccaatgtatctgat tcactgctgctgcagaatattttccaagctctgaatgtatattacaattattcgggccag gtgaaatgcctgaatatttcagagacagcaactagcagtctgggaacactgggttggagc tatcaggcctgcacagaagtagtcatgcccttttgtactaatggtgtcgatgacatgttt gaacctcactcatggaacttaaaggaactttctgatgactgttttcaacagtggggtgtg agaccaaggccctcctggatcactactatgtatggaggcaaaaacattagttcacacaca aacattgttttcagcaatggtgaactagacccctggtcaggaggtggagtaactaaggat atcacagacactctggttgcagtcaccatctcagagggggcccaccacttagatctccgc accaagaatgccttggatcctatgtctgtgctgttagcccgctccttggaagttagacat atgaagaattggatcagagatttctatgacagtgcgggaaagcagcactga

Homo sapiens (human): 59272 Help Entry 59272             CDS       T01001                                  Symbol ACE2, ACEH Name (RefSeq) angiotensin converting enzyme 2   KO K09708   angiotensin-converting enzyme 2 [EC:3.4.17.23] Organism hsa  Homo sapiens (human) Pathway hsa04614   Renin-angiotensin system hsa04974   Protein digestion and absorption hsa05171   Coronavirus disease - COVID-19 Network nt06171  SARS coronavirus 2 (SARS-CoV-2)   Element N01307   SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03262 Virion - Coronavirus     59272 (ACE2)  09150 Organismal Systems   09152 Endocrine system    04614 Renin-angiotensin system     59272 (ACE2)   09154 Digestive system    04974 Protein digestion and absorption     59272 (ACE2)  09160 Human Diseases   09172 Infectious disease: viral    05171 Coronavirus disease - COVID-19     59272 (ACE2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     59272 (ACE2)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     59272 (ACE2) Enzymes [BR:hsa01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.17  Metallocarboxypeptidases     3.4.17.23  angiotensin-converting enzyme 2      59272 (ACE2) Peptidases and inhibitors [BR:hsa01002]  Metallo peptidases   Family M2    59272 (ACE2) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    59272 (ACE2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Peptidase_M2 Collectrin KIAA1549 Glycophorin_A Motif Other DBs NCBI-GeneID:  59272 NCBI-ProteinID:  NP_001358344 OMIM:  300335 HGNC:  13557 Ensembl:  ENSG00000130234 UniProt:  Q9BYF1 Structure PDBPDBj LinkDB All DBs Position X:complement(15518197..15607211) Genome browser AA seq 805 aa AA seqDB search MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQ NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTIL NTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLY EEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHL HAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQ AWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILM CTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKS IGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEM KREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLH KCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNK NSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKN QMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDN SLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENP YASIDISKGENNPGFQNTDDVQTSF NT seq 2418 nt NT seq  +upstreamnt  +downstreamnt atgtcaagctcttcctggctccttctcagccttgttgctgtaactgctgctcagtccacc attgaggaacaggccaagacatttttggacaagtttaaccacgaagccgaagacctgttc tatcaaagttcacttgcttcttggaattataacaccaatattactgaagagaatgtccaa aacatgaataatgctggggacaaatggtctgcctttttaaaggaacagtccacacttgcc caaatgtatccactacaagaaattcagaatctcacagtcaagcttcagctgcaggctctt cagcaaaatgggtcttcagtgctctcagaagacaagagcaaacggttgaacacaattcta aatacaatgagcaccatctacagtactggaaaagtttgtaacccagataatccacaagaa tgcttattacttgaaccaggtttgaatgaaataatggcaaacagtttagactacaatgag aggctctgggcttgggaaagctggagatctgaggtcggcaagcagctgaggccattatat gaagagtatgtggtcttgaaaaatgagatggcaagagcaaatcattatgaggactatggg gattattggagaggagactatgaagtaaatggggtagatggctatgactacagccgcggc cagttgattgaagatgtggaacatacctttgaagagattaaaccattatatgaacatctt catgcctatgtgagggcaaagttgatgaatgcctatccttcctatatcagtccaattgga tgcctccctgctcatttgcttggtgatatgtggggtagattttggacaaatctgtactct ttgacagttccctttggacagaaaccaaacatagatgttactgatgcaatggtggaccag gcctgggatgcacagagaatattcaaggaggccgagaagttctttgtatctgttggtctt cctaatatgactcaaggattctgggaaaattccatgctaacggacccaggaaatgttcag aaagcagtctgccatcccacagcttgggacctggggaagggcgacttcaggatccttatg tgcacaaaggtgacaatggacgacttcctgacagctcatcatgagatggggcatatccag tatgatatggcatatgctgcacaaccttttctgctaagaaatggagctaatgaaggattc catgaagctgttggggaaatcatgtcactttctgcagccacacctaagcatttaaaatcc attggtcttctgtcacccgattttcaagaagacaatgaaacagaaataaacttcctgctc aaacaagcactcacgattgttgggactctgccatttacttacatgttagagaagtggagg tggatggtctttaaaggggaaattcccaaagaccagtggatgaaaaagtggtgggagatg aagcgagagatagttggggtggtggaacctgtgccccatgatgaaacatactgtgacccc gcatctctgttccatgtttctaatgattactcattcattcgatattacacaaggaccctt taccaattccagtttcaagaagcactttgtcaagcagctaaacatgaaggccctctgcac aaatgtgacatctcaaactctacagaagctggacagaaactgttcaatatgctgaggctt ggaaaatcagaaccctggaccctagcattggaaaatgttgtaggagcaaagaacatgaat gtaaggccactgctcaactactttgagcccttatttacctggctgaaagaccagaacaag aattcttttgtgggatggagtaccgactggagtccatatgcagaccaaagcatcaaagtg aggataagcctaaaatcagctcttggagataaagcatatgaatggaacgacaatgaaatg tacctgttccgatcatctgttgcatatgctatgaggcagtactttttaaaagtaaaaaat cagatgattctttttggggaggaggatgtgcgagtggctaatttgaaaccaagaatctcc tttaatttctttgtcactgcacctaaaaatgtgtctgatatcattcctagaactgaagtt gaaaaggccatcaggatgtcccggagccgtatcaatgatgctttccgtctgaatgacaac agcctagagtttctggggatacagccaacacttggacctcctaaccagccccctgtttcc atatggctgattgtttttggagttgtgatgggagtgatagtggttggcattgtcatcctg atcttcactgggatcagagatcggaagaagaaaaataaagcaagaagtggagaaaatcct tatgcctccatcgatattagcaaaggagaaaataatccaggattccaaaacactgatgat gttcagacctccttttag

Homo sapiens (human): 7512 Help Entry 7512              CDS       T01001                                  Symbol XPNPEP2, AEACEI, APP2 Name (RefSeq) X-prolyl aminopeptidase 2   KO K14208   Xaa-Pro aminopeptidase 2 [EC:3.4.11.9] Organism hsa  Homo sapiens (human) Pathway hsa04974   Protein digestion and absorption Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09154 Digestive system    04974 Protein digestion and absorption     7512 (XPNPEP2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     7512 (XPNPEP2)   09183 Protein families: signaling and cellular processes    00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]     7512 (XPNPEP2) Enzymes [BR:hsa01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.11  Aminopeptidases     3.4.11.9  Xaa-Pro aminopeptidase      7512 (XPNPEP2) Peptidases and inhibitors [BR:hsa01002]  Metallo peptidases   Family M24    7512 (XPNPEP2) Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]  Enzymes   7512 (XPNPEP2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Creatinase_N_2 Peptidase_M24 Peptidase_M24_C Creatinase_N Motif Other DBs NCBI-GeneID:  7512 NCBI-ProteinID:  NP_003390 OMIM:  300145 HGNC:  12823 Ensembl:  ENSG00000122121 UniProt:  O43895 LinkDB All DBs Position X:129738979..129769536 Genome browser AA seq 674 aa AA seqDB search MARAHWGCCPWLVLLCACAWGHTKPVDLGGQDVRNCSTNPPYLPVTVVNTTMSLTALRQQ MQTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMKKAAVWTDSRYWTQ AERQMDCNWELHKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNRQL VSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPTAVLLS ALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCV QIEDYSQVRDSIQAYSLGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTKAVKNSK EQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFSGAEIVDKFRGEEQFSSGPSFETIS ASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYT RVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVGFQ SNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGSYLTFEVVSFVPYDRNL IDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQLLEEFEWLQQHTEPLAARAPDTASWAS VLVVSTLAILGWSV NT seq 2025 nt NT seq  +upstreamnt  +downstreamnt atggcccgggctcactggggctgctgcccctggctggtcctcctctgtgcttgtgcctgg ggccacacaaagccagtggaccttggagggcaggatgtgagaaactgttccaccaacccc ccttaccttccagttactgtggtcaataccacaatgtcactcacagccctccgccagcag atgcagacccagaatctctcagcctacatcatcccaggcacagatgctcacatgaacgag tacatcggccaacatgacgagaggcgtgcgtggattacaggctttacagggtctgcagga actgcagtggtgactatgaagaaagcagctgtctggaccgacagtcgctactggactcag gctgagcggcagatggactgcaactgggagctccataaggaagttggcaccactcctatt gtcacctggctcctcaccgagattcctgctggagggcgtgtgggttttgaccccttcctc ttgtccattgacacctgggagagttatgatctggccctccaaggctctaacagacagctg gtgtccatcacaaccaatcttgtggacctggtatggggatcagagaggccaccggttcca aatcaacccatttatgccctgcaggaggcattcacagggagcacttggcaggagaaagta tctggcgtccgaagccagatgcagaagcatcaaaaggtcccgactgccgtccttctgtcg gcgcttgaggagacggcctggctcttcaaccttcgagccagtgacatcccctataacccc ttcttctattcctacacgctgctcacagactcttctattaggttgtttgcaaacaagagt cgctttagctccgaaaccttgagctatctgaactccagttgcacaggccccatgtgtgtg caaatcgaggattacagccaagttcgtgacagcatccaggcctactcattgggagatgtg aggatctggattgggaccagctataccatgtatgggatctatgaaatgatacccaaggag aaactcgtgacagacacctactccccagtgatgatgaccaaggcagtgaagaacagcaag gagcaggccctcctcaaggccagccacgtgcgggacgctgtggctgtgatccggtacttg gtctggctggagaagaacgtgcccaaaggcacagtggatgagttctcgggggcagagatc gtggacaagttccgaggagaagaacagttctcctccggacccagttttgaaaccatctct gctagtggtctgaatgctgccctggcccactacagcccgaccaaggagctgaaccgcaag ctgtcctcagatgagatgtacctgctggactctggggggcagtactgggacgggaccaca gacatcaccagaacagtccactggggcaccccctctgccttccagaaggaggcatacacc cgtgtgctgataggaaatattgacctgtccaggctcatctttcccgctgctacatcaggg cgaatggtggaggcctttgcccgcagagccttgtgggatgctggtctcaattatggtcat gggacaggccacggcattggcaacttcctgtgtgtgcatgagtggccagtgggattccag tccaacaacatcgctatggccaagggcatgttcacttccattgaacctggttactataag gatggagaatttgggatccgtctcgaagatgtggctctcgtggtagaagcaaagaccaag tacccagggagctacctgacctttgaagtggtatcatttgtgccctatgaccggaacctc atcgatgtcagcctgctgtctcccgagcatctccagtacctgaatcgctactaccagacc atccgggagaaggtgggtccagagctgcagaggcgccagctactagaggagttcgagtgg cttcaacagcacacagagcccctggccgccagggccccagacaccgcctcctgggcctct gtgttagtggtctccacccttgccatccttggctggagtgtctag

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