Homo sapiens (human): 2180
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Entry
2180 CDS
T01001
Symbol
ACSL1, ACS1, FACL1, FACL2, LACS, LACS1, LACS2
Name
(RefSeq) long-chain-fatty-acid--CoA ligase 1 isoform a
KO
K01897
long-chain-fatty-acid---CoA ligase [EC:
6.2.1.3
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00061
Fatty acid biosynthesis
hsa00071
Fatty acid degradation
hsa01100
Metabolic pathways
hsa01212
Fatty acid metabolism
hsa03320
PPAR signaling pathway
hsa04146
Peroxisome
hsa04216
Ferroptosis
hsa04714
Thermogenesis
hsa04920
Adipocytokine signaling pathway
Module
hsa_M00086
beta-Oxidation, acyl-CoA synthesis
Network
nt06020
beta-Oxidation in mitochondria
Element
N00765
beta-Oxidation, acyl-CoA synthesis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00061 Fatty acid biosynthesis
2180 (ACSL1)
00071 Fatty acid degradation
2180 (ACSL1)
09140 Cellular Processes
09141 Transport and catabolism
04146 Peroxisome
2180 (ACSL1)
09143 Cell growth and death
04216 Ferroptosis
2180 (ACSL1)
09150 Organismal Systems
09152 Endocrine system
04920 Adipocytokine signaling pathway
2180 (ACSL1)
03320 PPAR signaling pathway
2180 (ACSL1)
09159 Environmental adaptation
04714 Thermogenesis
2180 (ACSL1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01004 Lipid biosynthesis proteins [BR:
hsa01004
]
2180 (ACSL1)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
2180 (ACSL1)
Enzymes [BR:
hsa01000
]
6. Ligases
6.2 Forming carbon-sulfur bonds
6.2.1 Acid-thiol ligases
6.2.1.3 long-chain-fatty-acid---CoA ligase
2180 (ACSL1)
Lipid biosynthesis proteins [BR:
hsa01004
]
Acyl-CoA ligase
Long/very long chain acyl-CoA ligase
2180 (ACSL1)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of breast milk
2180 (ACSL1)
Exosomal proteins of breast cancer cells
2180 (ACSL1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
AMP-binding
AMP-binding_C
Motif
Other DBs
NCBI-GeneID:
2180
NCBI-ProteinID:
NP_001273637
OMIM:
152425
HGNC:
3569
UniProt:
P33121
A8K9T3
LinkDB
All DBs
Position
4:complement(184755595..184826594)
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AA seq
698 aa
AA seq
DB search
MQAHELFRYFRMPELVDFRQYVRTLPTNTLMGFGAFAALTTFWYATRPKPLKPPCDLSMQ
SVEVAGSGGARRSALLDSDEPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKPDQPYEW
LSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDT
LGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQR
CGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAF
VKATENTVNPCPDDTLISFLPLAHMFERVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQP
TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKV
QSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHV
GAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD
IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAI
VVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHP
ELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLYSTIKV
NT seq
2097 nt
NT seq
+upstream
nt +downstream
nt
atgcaagcccatgagctgttccggtattttcgaatgccagagctggttgacttccgacag
tacgtgcgtactcttccgaccaacacgcttatgggcttcggagcttttgcagcactcacc
accttctggtacgccacgagacccaaacccctgaagccgccatgcgacctctccatgcag
tcagtggaagtggcgggtagtggtggtgcacgaagatccgcactacttgacagcgacgag
cccttggtgtatttctatgatgatgtcacaacattatacgaaggtttccagaggggaata
caggtgtcaaataatggcccttgtttaggctctcggaaaccagaccaaccctatgaatgg
ctttcatataaacaggttgcagaattgtcggagtgcataggctcagcactgatccagaag
ggcttcaagactgccccagatcagttcattggcatctttgctcaaaatagacctgagtgg
gtgattattgaacaaggatgctttgcttattcgatggtgatcgttccactttatgatacc
cttggaaatgaagccatcacgtacatagtcaacaaagctgaactctctctggtttttgtt
gacaagccagagaaggccaaactcttattagagggtgtagaaaataagttaataccaggc
cttaaaatcatagttgtcatggatgcctacggcagtgaactggtggaacgaggccagagg
tgtggggtggaagtcaccagcatgaaggcgatggaggacctgggaagagccaacagacgg
aagcccaagcctccagcacctgaagatcttgcagtaatttgtttcacaagtggaactaca
ggcaaccccaaaggagcaatggtcactcaccgaaacatagtgagcgattgttcagctttt
gtgaaagcaacagagaatacagtcaatccttgcccagatgatactttgatatctttcttg
cctctcgcccatatgtttgagagagttgtagagtgtgtaatgctgtgtcatggagctaaa
atcggatttttccaaggagatatcaggctgctcatggatgacctcaaggtgcttcaaccc
actgtcttccccgtggttccaagactgctgaaccggatgtttgaccgaattttcggacaa
gcaaacaccacgctgaagcgatggctcttggactttgcctccaagaggaaagaagcagag
cttcgcagcggcatcatcagaaacaacagcctgtgggaccggctgatcttccacaaagta
cagtcgagcctgggcggaagagtccggctgatggtgacaggagccgccccggtgtctgcc
actgtgctgacgttcctcagagcagccctgggctgtcagttttatgaaggatacggacag
acagagtgcactgccgggtgctgcctgaccatgcctggagactggaccgcaggccatgtt
ggggccccgatgccgtgcaatttgataaaacttgttgatgtggaagaaatgaattacatg
gctgccgagggcgagggcgaggtgtgtgtgaaagggccaaatgtatttcagggctacttg
aaggacccagcgaaaacagcagaagctttggacaaagacggctggttacacacaggggac
attggaaaatggttaccaaatggcaccttgaaaattatcgaccggaaaaagcacatattt
aagctggcacaaggagaatacatagcccctgaaaagattgaaaatatctacatgcgaagt
gagcctgttgctcaggtgtttgtccacggagaaagcctgcaggcatttctcattgcaatt
gtggtaccagatgttgagacattatgttcctgggcccaaaagagaggatttgaagggtcg
tttgaggaactgtgcagaaataaggatgtcaaaaaagctatcctcgaagatatggtgaga
cttgggaaggattctggtctgaaaccatttgaacaggtcaaaggcatcacattgcaccct
gaattattttctatcgacaatggccttctgactccaacaatgaaggcgaaaaggccagag
ctgcggaactatttcaggtcgcagatagatgacctctattccactatcaaggtttag
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