Homo sapiens (human): 22901 Help Entry 22901             CDS       T01001                                  Symbol ARSG, USH4 Name (RefSeq) arylsulfatase G   KO K12381   arylsulfatase G [EC:3.1.6.-] Organism hsa  Homo sapiens (human) Pathway hsa04142   Lysosome Disease H00779   Usher syndrome Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09141 Transport and catabolism    04142 Lysosome     22901 (ARSG) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Sulfatase Sulfatase_C SGSH_C Motif Other DBs NCBI-GeneID:  22901 NCBI-ProteinID:  NP_001254656 OMIM:  610008 HGNC:  24102 Ensembl:  ENSG00000141337 UniProt:  Q96EG1 LinkDB All DBs Position 17:68259170..68452019 Genome browser AA seq 525 aa AA seqDB search MGWLFLKVLLAGVSFSGFLYPLVDFCISGKTRGQKPNFVIILADDMGWGDLGANWAETKD TANLDKMASEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTRNFAVTSVGGLPLNETT LAEVLQQAGYVTGIIGKWHLGHHGSYHPNFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPA CPQGDGPSRNLQRDCYTDVALPLYENLNIVEQPVNLSSLAQKYAEKATQFIQRASTSGRP FLLYVALAHMHVPLPVTQLPAAPRGRSLYGAGLWEMDSLVGQIKDKVDHTVKENTFLWFT GDNGPWAQKCELAGSVGPFTGFWQTRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTST ALLSVLDIFPTVVALAQASLPQGRRFDGVDVSEVLFGRSQPGHRVLFHPNSGAAGEFGAL QTVRLERYKAFYITGGARACDGSTGPELQHKFPLIFNLEDDTAEAVPLERGGAEYQAVLP EVRKVLADVLQDIANDNISSADYTQDPSVTPCCNPYQIACRCQAA NT seq 1578 nt NT seq  +upstreamnt  +downstreamnt atgggctggctttttctaaaggttttgttggcgggagtgagtttctcaggatttctttat cctcttgtggatttttgcatcagtgggaaaacaagaggacagaagccaaactttgtgatt attttggccgatgacatggggtggggtgacctgggagcaaactgggcagaaacaaaggac actgccaaccttgataagatggcttcggagggaatgaggtttgtggatttccatgcagct gcctccacctgctcaccctcccgggcttccttgctcaccggccggcttggccttcgcaat ggagtcacacgcaactttgcagtcacttctgtgggaggccttccgctcaacgagaccacc ttggcagaggtgctgcagcaggcgggttacgtcactgggataataggcaaatggcatctt ggacaccacggctcttatcaccccaacttccgtggttttgattactactttggaatccca tatagccatgatatgggctgtactgatactccaggctacaaccaccctccttgtccagcg tgtccacagggtgatggaccatcaaggaaccttcaaagagactgttacactgacgtggcc ctccctctttatgaaaacctcaacattgtggagcagccggtgaacttgagcagccttgcc cagaagtatgctgagaaagcaacccagttcatccagcgtgcaagcaccagcgggaggccc ttcctgctctatgtggctctggcccacatgcacgtgcccttacctgtgactcagctacca gcagcgccacggggcagaagcctgtatggtgcagggctctgggagatggacagtctggtg ggccagatcaaggacaaagttgaccacacagtgaaggaaaacacattcctctggtttaca ggagacaatggcccgtgggctcagaagtgtgagctagcgggcagtgtgggtcccttcact ggattttggcaaactcgtcaagggggaagtccagccaagcagacgacctgggaaggaggg caccgggtcccagcactggcttactggcctggcagagttccagttaatgtcaccagcact gccttgttaagcgtgctggacatttttccaactgtggtagccctggcccaggccagctta cctcaaggacggcgctttgatggtgtggacgtctccgaggtgctctttggccggtcacag cctgggcacagggtgctgttccaccccaacagcggggcagctggagagtttggagccctg cagactgtccgcctggagcgttacaaggccttctacattaccggtggagccagggcgtgt gatgggagcacggggcctgagctgcagcataagtttcctctgattttcaacctggaagac gataccgcagaagctgtgcccctagaaagaggtggtgcggagtaccaggctgtgctgccc gaggtcagaaaggttcttgcagacgtcctccaagacattgccaacgacaacatctccagc gcagattacactcaggacccttcagtaactccctgctgtaatccctaccaaattgcctgc cgctgtcaagccgcataa

Homo sapiens (human): 410 Help Entry 410               CDS       T01001                                  Symbol ARSA, ASA, MLD Name (RefSeq) arylsulfatase A   KO K01134   arylsulfatase A [EC:3.1.6.8] Organism hsa  Homo sapiens (human) Pathway hsa00600   Sphingolipid metabolism hsa01100   Metabolic pathways hsa04142   Lysosome Network nt06014  Sphingolipid degradation   Element N00647   Hydrolysis of galactosylceramide sulfate Disease H00127   Metachromatic leukodystrophy H00423   Sphingolipidosis Drug target Atidarsagene autotemcel:  D12877<US> Cebsulfase alfa:  D12462 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00600 Sphingolipid metabolism     410 (ARSA)  09140 Cellular Processes   09141 Transport and catabolism    04142 Lysosome     410 (ARSA) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.6  Sulfuric-ester hydrolases     3.1.6.8  cerebroside-sulfatase      410 (ARSA) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Sulfatase Sulfatase_C SGSH_C Phosphodiest DUF2477 DUF1501 Motif Other DBs NCBI-GeneID:  410 NCBI-ProteinID:  NP_000478 OMIM:  607574 HGNC:  713 Ensembl:  ENSG00000100299 UniProt:  P15289 A0A0C4DFZ2 B4DVI5 Structure PDB LinkDB All DBs Position 22:complement(50622754..50628152) Genome browser AA seq 509 aa AA seqDB search MSMGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLR FTDFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLT GMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVP IPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSF AERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLL RCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDL SPLLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASS SLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVA RGEDPALQICCHPGCTPRPACCHCPDPHA NT seq 1530 nt NT seq  +upstreamnt  +downstreamnt atgtccatgggggcaccgcggtccctcctcctggccctggctgctggcctggccgttgcc cgtccgcccaacatcgtgctgatctttgccgacgacctcggctatggggacctgggctgc tatgggcaccccagctctaccactcccaacctggaccagctggcggcgggagggctgcgg ttcacagacttctacgtgcctgtgtctctgtgcacaccctctagggccgccctcctgacc ggccggctcccggttcggatgggcatgtaccctggcgtcctggtgcccagctcccggggg ggcctgcccctggaggaggtgaccgtggccgaagtcctggctgcccgaggctacctcaca ggaatggccggcaagtggcaccttggggtggggcctgagggggccttcctgcccccccat cagggcttccatcgatttctaggcatcccgtactcccacgaccagggcccctgccagaac ctgacctgcttcccgccggccactccttgcgacggtggctgtgaccagggcctggtcccc atcccactgttggccaacctgtccgtggaggcgcagcccccctggctgcccggactagag gcccgctacatggctttcgcccatgacctcatggccgacgcccagcgccaggatcgcccc ttcttcctgtactatgcctctcaccacacccactaccctcagttcagtgggcagagcttt gcagagcgttcaggccgcgggccatttggggactccctgatggagctggatgcagctgtg gggaccctgatgacagccataggggacctggggctgcttgaagagacgctggtcatcttc actgcagacaatggacctgagaccatgcgtatgtcccgaggcggctgctccggtctcttg cggtgtggaaagggaacgacctacgagggcggtgtccgagagcctgccttggccttctgg ccaggtcatatcgctcccggcgtgacccacgagctggccagctccctggacctgctgcct accctggcagccctggctggggccccactgcccaatgtcaccttggatggctttgacctc agccccctgctgctgggcacaggcaagagccctcggcagtctctcttcttctacccgtcc tacccagacgaggtccgtggggtttttgctgtgcggactggaaagtacaaggctcacttc ttcacccagggctctgcccacagtgataccactgcagaccctgcctgccacgcctccagc tctctgactgctcatgagcccccgctgctctatgacctgtccaaggaccctggtgagaac tacaacctgctggggggtgtggccggggccaccccagaggtgctgcaagccctgaaacag cttcagctgctcaaggcccagttagacgcagctgtgaccttcggccccagccaggtggcc cggggcgaggaccccgccctgcagatctgctgtcatcctggctgcaccccccgcccagct tgctgccattgcccagatccccatgcctga

Homo sapiens (human): 411 Help Entry 411               CDS       T01001                                  Symbol ARSB, ASB, G4S, MPS6 Name (RefSeq) arylsulfatase B   KO K01135   arylsulfatase B [EC:3.1.6.12] Organism hsa  Homo sapiens (human) Pathway hsa00531   Glycosaminoglycan degradation hsa01100   Metabolic pathways hsa04142   Lysosome Module hsa_M00076   Dermatan sulfate degradation hsa_M00077   Chondroitin sulfate degradation Network nt06012  Glycosaminoglycan degradation   Element N00610   Dermatan sulfate degradation Disease H00131   Mucopolysaccharidosis type VI H00421   Mucopolysaccharidosis Drug target Galsulfase:  D06565<JP/US> Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09107 Glycan biosynthesis and metabolism    00531 Glycosaminoglycan degradation     411 (ARSB)  09140 Cellular Processes   09141 Transport and catabolism    04142 Lysosome     411 (ARSB) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.6  Sulfuric-ester hydrolases     3.1.6.12  N-acetylgalactosamine-4-sulfatase      411 (ARSB) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Sulfatase Phosphodiest Sulfatase_C Motif Other DBs NCBI-GeneID:  411 NCBI-ProteinID:  NP_000037 OMIM:  611542 HGNC:  714 Ensembl:  ENSG00000113273 UniProt:  P15848 Structure PDB LinkDB All DBs Position 5:complement(78777209..78985958) Genome browser AA seq 533 aa AA seqDB search MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRD PEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM NT seq 1602 nt NT seq  +upstreamnt  +downstreamnt atgggtccgcgcggcgcggcgagcttgccccgaggccccggacctcggcggctgctcctc cccgtcgtcctcccgctgctgctgctgctgttgttggcgccgccgggctcgggcgccggg gccagccggccgccccacctggtcttcttgctggcagacgacctaggctggaacgacgtc ggcttccacggctcccgcatccgcacgccgcacctggacgcgctggcggccggcggggtg ctcctggacaactactacacgcagccgctgtgcacgccgtcgcggagccagctgctcact ggccgctaccagatccgtacaggtttacagcaccaaataatctggccctgtcagcccagc tgtgttcctctggatgaaaaactcctgccccagctcctaaaagaagcaggttatactacc catatggtcggaaaatggcacctgggaatgtaccggaaagaatgccttccaacccgccga ggatttgatacctactttggatatctcctgggtagtgaagattattattcccatgaacgc tgtacattaattgacgctctgaatgtcacacgatgtgctcttgattttcgagatggcgaa gaagttgcaacaggatataaaaatatgtattcaacaaacatattcaccaaaagggctata gccctcataactaaccatccaccagagaagcctctgtttctctaccttgctctccagtct gtgcatgagccccttcaggtccctgaggaatacttgaagccatatgactttatccaagac aagaacaggcatcactatgcaggaatggtgtcccttatggatgaagcagtaggaaatgtc actgcagctttaaaaagcagtgggctctggaacaacacggtgttcatcttttctacagat aacggagggcagactttggcagggggtaataactggccccttcgaggaagaaaatggagc ctgtgggaaggaggcgtccgaggggtgggctttgtggcaagccccttgctgaagcagaag ggcgtgaagaaccgggagctcatccacatctctgactggctgccaacactcgtgaagctg gccaggggacacaccaatggcacaaagcctctggatggcttcgacgtgtggaaaaccatc agtgaaggaagcccatcccccagaattgagctgctgcataatattgacccgaacttcgtg gactcttcaccgtgtcccaggaacagcatggctccagcaaaggatgactcttctcttcca gaatattcagcctttaacacatctgtccatgctgcaattagacatggaaattggaaactc ctcacgggctacccaggctgtggttactggttccctccaccgtctcaatacaatgtttct gagataccctcatcagacccaccaaccaagaccctctggctctttgatattgatcgggac cctgaagaaagacatgacctgtccagagaatatcctcacatcgtcacaaagctcctgtcc cgcctacagttctaccataaacactcagtccccgtgtacttccctgcacaggacccccgc tgtgatcccaaggccactggggtgtggggcccttggatgtag

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