KEGG   Homo sapiens (human): 2339
Entry
2339              CDS       T01001                                 
Symbol
FNTA, FPTA, PGGT1A, PTAR2
Name
(RefSeq) farnesyltransferase, CAAX box, alpha
  KO
K05955  protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha [EC:2.5.1.58 2.5.1.59]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00900  Terpenoid backbone biosynthesis
Drug target
Lonafarnib: D04768<US>
Tipifarnib: D03720
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    2339 (FNTA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases [BR:hsa01006]
    2339 (FNTA)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.58  protein farnesyltransferase
     2339 (FNTA)
    2.5.1.59  protein geranylgeranyltransferase type I
     2339 (FNTA)
Prenyltransferases [BR:hsa01006]
 Protein prenylation
  Farnesyltransferase/geranylgeranyltransferase 1
   2339 (FNTA)
SSDB
Motif
Pfam: PPTA
Other DBs
NCBI-GeneID: 2339
NCBI-ProteinID: NP_002018
OMIM: 134635
HGNC: 3782
Ensembl: ENSG00000168522
Vega: OTTHUMG00000165279
Pharos: P49354(Tbio)
UniProt: P49354
Structure
LinkDB
Position
8:43056323..43085785
AA seq 379 aa
MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDS
PSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLT
RDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLR
DPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQR
YFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLL
DLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIG
RSLQSKHSTENDSPTNVQQ
NT seq 1140 nt   +upstreamnt  +downstreamnt
atggcggccaccgagggggtcggggaggctgcgcaagggggcgagcccgggcagccggcg
caacccccgccccagccgcacccaccgccgccccagcagcagcacaaggaagagatggcg
gccgaggctggggaagccgtggcgtcccccatggacgacgggtttgtgagcctggactcg
ccctcctatgtcctgtacagggacagagcagaatgggctgatatagatccggtgccgcag
aatgatggccccaatcccgtggtccagatcatttatagtgacaaatttagagatgtttat
gattacttccgagctgtcctgcagcgtgatgaaagaagtgaacgagcttttaagctaacc
cgggatgctattgagttaaatgcagccaattatacagtgtggcatttccggagagttctt
ttgaagtcacttcagaaggatctacatgaggaaatgaactacatcactgcaataattgag
gagcagcccaaaaactatcaagtttggcatcataggcgagtattagtggaatggctaaga
gatccatctcaggagcttgaatttattgctgatattcttaatcaggatgcaaagaattat
catgcctggcagcatcgacaatgggttattcaggaatttaaactttgggataatgagctg
cagtatgtggaccaacttctgaaagaggatgtgagaaataactctgtctggaaccaaaga
tacttcgttatttctaacaccactggctacaatgatcgtgctgtattggagagagaagtc
caatacactctggaaatgattaaactagtaccacataatgaaagtgcatggaactatttg
aaagggattttgcaggatcgtggtctttccaaatatcctaatctgttaaatcaattactt
gatttacaaccaagtcatagttccccctacctaattgcctttcttgtggatatctatgaa
gacatgctagaaaatcagtgtgacaataaggaagacattcttaataaagcattagagtta
tgtgaaatcctagctaaagaaaaggacactataagaaaggaatattggagatacattgga
agatcccttcaaagcaaacacagcacagaaaatgactcaccaacaaatgtacagcaataa

KEGG   Homo sapiens (human): 2342
Entry
2342              CDS       T01001                                 
Symbol
FNTB, FPTB
Name
(RefSeq) farnesyltransferase, CAAX box, beta
  KO
K05954  protein farnesyltransferase subunit beta [EC:2.5.1.58]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00900  Terpenoid backbone biosynthesis
Drug target
Lonafarnib: D04768<US>
Tipifarnib: D03720
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    2342 (FNTB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases [BR:hsa01006]
    2342 (FNTB)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.58  protein farnesyltransferase
     2342 (FNTB)
Prenyltransferases [BR:hsa01006]
 Protein prenylation
  Farnesyltransferase/geranylgeranyltransferase 1
   2342 (FNTB)
SSDB
Motif
Pfam: Prenyltrans SQHop_cyclase_C
Other DBs
NCBI-GeneID: 2342
NCBI-ProteinID: NP_002019
OMIM: 134636
HGNC: 3785
Ensembl: ENSG00000257365
Vega: OTTHUMG00000142811
Pharos: P49356(Tbio)
UniProt: P49356 A0A384MEJ5
Structure
LinkDB
Position
14:64986895..65062650
AA seq 437 aa
MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS
SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
IVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQY
LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
GVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF
YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPV
PGFEELKDETSAEPATD
NT seq 1314 nt   +upstreamnt  +downstreamnt
atggcttctccgagttctttcacctactattgccctccatcttcctcccccgtctggtca
gagccgctgtacagtctgaggcccgagcacgcgcgagagcggttgcaggacgactcggtg
gaaacagtcacgtccatagaacaggcaaaagtagaagaaaagatccaagaggtcttcagt
tcttacaagttcaaccaccttgtaccaaggcttgttttgcagagggagaagcacttccat
tatctgaaaagaggccttcgacaactgacagatgcctatgagtgtctggatgccagccgc
ccatggctctgctattggatcctgcacagcttggaactgctagatgaacccatcccccag
atagtggctacagatgtgtgtcagttcctggagctgtgtcagagcccagaaggtggcttt
ggaggaggacccggtcagtatccacaccttgcacccacatatgcagcagtcaatgcattg
tgcatcattggcaccgaggaggcctatgacatcattaacagagagaagcttcttcagtat
ttgtactccctgaagcaacctgacggctcctttctcatgcatgtcggaggtgaggtggat
gtgagaagcgcatactgtgctgcctccgtagcctcgctgaccaacatcatcactccagac
ctctttgagggcactgctgaatggatagcaaggtgtcagaactgggaaggtggcattggc
ggggtaccagggatggaagcccatggtggctataccttctgtggcctggccgcgctggta
atcctcaagagggaacgttccttgaacttgaagagcttattacaatgggtgacaagccgg
cagatgcgatttgaaggaggatttcagggccgctgcaacaagctggtggatggctgctac
tccttctggcaggcggggctcctgcccctgctccaccgcgcactgcacgcccaaggtgac
cctgcccttagcatgagccactggatgttccatcagcaggccctgcaggagtacatcctg
atgtgctgccagtgccctgcgggggggcttctggataaacctggcaagtcgcgtgatttc
taccacacctgctactgcctgagcggcctgtccatagcccagcacttcggcagcggagcc
atgttgcatgatgtggtcctgggtgtgcccgaaaacgctctgcagcccactcacccagtg
tacaacattggaccagacaaggtgatccaggccactacatactttctacagaagccagtc
ccaggttttgaggagcttaaggatgagacatcggcagagcctgcaaccgactag

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