Homo sapiens (human): 23438
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Entry
23438 CDS
T01001
Symbol
HARS2, HARSL, HARSR, HO3, HisRS, PRLTS2
Name
(RefSeq) histidyl-tRNA synthetase 2, mitochondrial
KO
K01892
histidyl-tRNA synthetase [EC:
6.1.1.21
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00970
Aminoacyl-tRNA biosynthesis
Disease
H02095
Perrault syndrome
Drug target
Efzofitimod:
D12612
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09122 Translation
00970 Aminoacyl-tRNA biosynthesis
23438 (HARS2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01007 Amino acid related enzymes [BR:
hsa01007
]
23438 (HARS2)
09182 Protein families: genetic information processing
03016 Transfer RNA biogenesis [BR:
hsa03016
]
23438 (HARS2)
Enzymes [BR:
hsa01000
]
6. Ligases
6.1 Forming carbon-oxygen bonds
6.1.1 Ligases forming aminoacyl-tRNA and related compounds
6.1.1.21 histidine---tRNA ligase
23438 (HARS2)
Amino acid related enzymes [BR:
hsa01007
]
Aminoacyl-tRNA synthetase
Class II (A)
23438 (HARS2)
Transfer RNA biogenesis [BR:
hsa03016
]
Eukaryotic type
Aminoacyl-tRNA synthetases (AARSs)
Other AARSs
23438 (HARS2)
Prokaryotic type
23438 (HARS2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
tRNA-synt_His
HGTP_anticodon
HGTP_anticodon2
Motif
Other DBs
NCBI-GeneID:
23438
NCBI-ProteinID:
NP_036340
OMIM:
600783
HGNC:
4817
Ensembl:
ENSG00000112855
UniProt:
P49590
LinkDB
All DBs
Position
5:140691455..140699305
Genome browser
AA seq
506 aa
AA seq
DB search
MPLLGLLPRRAWASLLSQLLRPPCASCTGAVRCQSQVAEAVLTSQLKAHQEKPNFIIKTP
KGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGLMYDLKD
QGGELLSLRYDLTVPFARYLAMNKVKKMKRYHVGKVWRRESPTIVQGRYREFCQCDFDIA
GQFDPMIPDAECLKIMCEILSGLQLGDFLIKVNDRRIVDGMFAVCGVPESKFRAICSSID
KLDKMAWKDVRHEMVVKKGLAPEVADRIGDYVQCHGGVSLVEQMFQDPRLSQNKQALEGL
GDLKLLFEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVLLQTPTQAGEEPLNVGSVAA
GGRYDGLVGMFDPKGHKVPCVGLSIGVERIFYIVEQRMKTKGEKVRTTETQVFVATPQKN
FLQERLKLIAELWDSGIKAEMLYKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGVIKIR
SVASREEVAIKRENFVAEIQKRLSES
NT seq
1521 nt
NT seq
+upstream
nt +downstream
nt
atgcccctgctcggacttcttcccaggagggcctgggcttcgctgctcagccagctcctg
cgaccgccctgcgcttcgtgcaccggggcggtccgttgccaaagccaggttgcagaggca
gtgttaacatcccaactgaaagcacatcaagagaaaccaaattttattatcaagacccca
aagggtaccagggatcttagtcctcagcatatggttgtgagggagaaaattcttgatttg
gttatcagctgctttaaacgtcatggagcaaaggggatggacaccccagcatttgagctg
aaggaaaccctgactgagaagtatggagaggactctgggctcatgtatgatctgaaggat
caaggtggagagctgttgtccctccgctatgaccttactgttccctttgctcgttatctg
gccatgaataaggtgaagaagatgaaacgttatcatgttggaaaggtgtggcggcgagag
agcccaaccatagtccaaggccgttatagggagttctgccagtgtgattttgacattgct
ggtcagtttgaccctatgatccccgatgcagagtgtttgaagatcatgtgtgaaatccta
agtggattgcagttgggagactttctcattaaggtaaatgaccggcggattgtggatggg
atgtttgctgtctgtggtgttcctgaaagcaagttccgtgccatctgctcctccatagat
aaactagacaagatggcttggaaagatgtgagacatgagatggtggtgaagaaaggcctg
gctcctgaggtggctgatcgaattggggactatgtccagtgtcatggtggggtatcccta
gtagagcaaatgtttcaggatcccagactatcccagaacaagcaggccctggagggcctg
ggagacctaaagctgctatttgaatacctgactttatttggaattgctgataagatctcc
tttgacctcagcctggctcggggcctagactactatacaggagtgatctatgaagcagtg
ctgctgcagaccccaactcaggctggggaggagcccctgaatgtgggcagtgtggctgct
ggtgggcgctatgatgggctggtgggcatgtttgaccccaagggccacaaggtgccatgt
gtgggactcagcattggggttgagcgaatcttctacattgtggagcagaggatgaagacc
aaaggtgagaaggtgcggactacagagactcaagtgtttgtggccacaccacagaagaac
tttctccaagaacggttgaagcttattgcagagctttgggattctggaatcaaggcagag
atgctatacaagaacaaccccaaactattaacccagctgcactattgtgagagcacaggc
attccactggtggtcattattggtgagcaagaactgaaagaaggggtcatcaagatccgt
tcagtggccagcagagaggaggtggccattaaacgggaaaattttgtggctgaaattcag
aagcgactgtctgagtcttga
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