Homo sapiens (human): 26191
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Entry
26191 CDS
T01001
Symbol
PTPN22, LYP, LYP1, LYP2, PEP, PTPN22.5, PTPN22.6, PTPN8
Name
(RefSeq) tyrosine-protein phosphatase non-receptor type 22 isoform 1
KO
K18024
tyrosine-protein phosphatase non-receptor type 12/18/22 [EC:
3.1.3.48
]
Organism
hsa
Homo sapiens (human)
Disease
H00080
Systemic lupus erythematosus
H00408
Type 1 diabetes mellitus
H00630
Rheumatoid arthritis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:
hsa01009
]
26191 (PTPN22)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.48 protein-tyrosine-phosphatase
26191 (PTPN22)
Protein phosphatases and associated proteins [BR:
hsa01009
]
Protein tyrosine phosphatases (PTPs)
Class I PTPs (Classical)
Non-receptor PTPs
26191 (PTPN22)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Y_phosphatase
Y_phosphatase3
PTP-SAK
Tc-R-P
DSPc
Motif
Other DBs
NCBI-GeneID:
26191
NCBI-ProteinID:
NP_057051
OMIM:
600716
HGNC:
9652
Ensembl:
ENSP00000352833.5
UniProt:
Q9Y2R2
B4DZW8
Structure
PDB
PDBj
LinkDB
All DBs
Position
1:complement(113813811..113871759)
Genome browser
AA seq
807 aa
AA seq
DB search
MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRY
KDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEY
SVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS
ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAI
DYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDK
HSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSE
ISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSL
LFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSC
FVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSW
PPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQES
AVLATAPRIDDEIPPPLPVWTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTS
EPKKFDDSVILRPSKSVKLRSPKSELHQDRSSPPPPLPERTLESFFLADEDCMQAQSIET
YSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLKILRNMKKSICNSCPPNKPAESVQSNNS
SSFLNFGFANRFSKPKGPRNPPPTWNI
NT seq
2424 nt
NT seq
+upstream
nt +downstream
nt
atggaccaaagagaaattctgcagaagttcctggatgaggcccaaagcaagaaaattact
aaagaggagtttgccaatgaatttctgaagctgaaaaggcaatctaccaagtacaaggca
gacaaaacctatcctacaactgtggctgagaagcccaagaatatcaagaaaaacagatat
aaggatattttgccctatgattatagccgggtagaactatccctgataacctctgatgag
gattccagctacatcaatgccaacttcattaagggagtttatggacccaaggcttatatt
gccacccagggtcctttatctacaaccctcctggacttctggaggatgatttgggaatat
agtgtccttatcattgttatggcatgcatggagtatgaaatgggaaagaaaaagtgtgag
cgctactgggctgagccaggagagatgcagctggaatttggccctttctctgtatcctgt
gaagctgaaaaaaggaaatctgattatataatcaggactctaaaagttaagttcaatagt
gaaactcgaactatctaccagtttcattacaagaattggccagaccatgatgtaccttca
tctatagaccctattcttgagctcatctgggatgtacgttgttaccaagaggatgacagt
gttcccatatgcattcactgcagtgctggctgtggaaggactggtgttatttgtgctatt
gattatacatggatgttgctaaaagatgggataattcctgagaacttcagtgttttcagt
ttgatccgggaaatgcggacacagaggccttcattagttcaaacgcaggaacaatatgaa
ctggtctacaatgctgtattagaactatttaagagacagatggatgttatcagagataaa
cattctggaacagagagtcaagcaaagcattgtattcctgagaaaaatcacactctccaa
gcagactcttattctcctaatttaccaaaaagtaccacaaaagcagcaaaaatgatgaac
caacaaaggacaaaaatggaaatcaaagaatcttcttcctttgactttaggacttctgaa
ataagtgcaaaagaagagctagttttgcaccctgctaaatcaagcacttcttttgacttt
ctggagctaaattacagttttgacaaaaatgctgacacaaccatgaaatggcagacaaag
gcatttccaatagttggggagcctcttcagaagcatcaaagtttggatttgggctctctt
ttgtttgagggatgttctaattctaaacctgtaaatgcagcaggaagatattttaattca
aaggtgccaataacacggaccaaatcaactccttttgaattgatacagcagagagaaacc
aaggaggtggacagcaaggaaaacttttcttatttggaatctcaaccacatgattcttgt
tttgtagagatgcaggctcaaaaagtaatgcatgtttcttcagcagaactgaattattca
ctgccatatgactctaaacaccaaatacgtaatgcctctaatgtaaagcaccatgactct
agtgctcttggtgtatattcttacatacctttagtggaaaatccttatttttcatcatgg
cctccaagtggtaccagttctaagatgtctcttgatttacctgagaagcaagatggaact
gtttttccttcttctctgttgccaacatcctctacatccctcttctcttattacaattca
catgattctttatcactgaattctccaaccaatatttcctcactattgaaccaggagtca
gctgtactagcaactgctccaaggatagatgatgaaatcccccctccacttcctgtatgg
acacctgaatcatttattgtggttgaggaagctggagaattctcaccaaatgttcccaaa
tccttatcctcagctgtgaaggtaaaaattggaacatcactggaatggggtggaacatct
gaaccaaagaaatttgatgactctgtgatacttagaccaagcaagagtgtaaaactccga
agtcctaaatcagaactacatcaagatcgttcttctcccccacctcctctcccagaaaga
actctagagtccttctttcttgccgatgaagattgtatgcaggcccaatctatagaaaca
tattctactagctatcctgacaccatggaaaattcaacatcttcaaaacagacactgaag
actcctggaaaaagtttcacaaggagtaagagtttgaaaattttgcgaaacatgaaaaag
agtatctgtaattcttgcccaccaaacaagcctgcagaatctgttcagtcaaataactcc
agctcatttctgaattttggttttgcaaaccgtttttcaaaacccaaaggaccaaggaat
ccaccaccaacttggaatatttaa
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integrated database retrieval system
