Homo sapiens (human): 26275
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Entry
26275 CDS
T01001
Symbol
HIBCH, HIBYLCOAH
Name
(RefSeq) 3-hydroxyisobutyryl-CoA hydrolase
KO
K05605
3-hydroxyisobutyryl-CoA hydrolase [EC:
3.1.2.4
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00280
Valine, leucine and isoleucine degradation
hsa00410
beta-Alanine metabolism
hsa00640
Propanoate metabolism
hsa01100
Metabolic pathways
hsa01200
Carbon metabolism
Network
nt06024
Valine, leucine and isoleucine degradation
Element
N00852
Valine degradation
Disease
H01349
Methacrylic aciduria
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00640 Propanoate metabolism
26275 (HIBCH)
09105 Amino acid metabolism
00280 Valine, leucine and isoleucine degradation
26275 (HIBCH)
09106 Metabolism of other amino acids
00410 beta-Alanine metabolism
26275 (HIBCH)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.2 Thioester hydrolases
3.1.2.4 3-hydroxyisobutyryl-CoA hydrolase
26275 (HIBCH)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
ECH_2
ECH_1
DUF4600
Motif
Other DBs
NCBI-GeneID:
26275
NCBI-ProteinID:
NP_055177
OMIM:
610690
HGNC:
4908
Ensembl:
ENSG00000198130
UniProt:
Q6NVY1
A0A140VJL0
Structure
PDB
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All DBs
Position
2:complement(190189735..190319826)
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AA seq
386 aa
AA seq
DB search
MGQREMWRLMSRFNAFKRTNTILHHLRMSKHTDAAEEVLLEKKGCTGVITLNRPKFLNAL
TLNMIRQIYPQLKKWEQDPETFLIIIKGAGGKAFCAGGDIRVISEAEKAKQKIAPVFFRE
EYMLNNAVGSCQKPYVALIHGITMGGGVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGG
GYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLEEDLLALKSPSKENI
ASVLENYHTESKIDRDKSFILEEHMDKINSCFSANTVEEIIENLQQDGSSFALEQLKVIN
KMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWK
PADLKEVTEEDLNNHFKSLGSSDLKF
NT seq
1161 nt
NT seq
+upstream
nt +downstream
nt
atggggcagcgcgagatgtggaggctcatgtcgaggtttaatgcattcaaaaggactaat
accatactgcaccatttgagaatgtccaagcacacagatgcagcagaagaggtgctattg
gaaaaaaaaggttgcacgggagtcataacactaaacagaccaaagttcctcaatgcactg
actcttaatatgattcggcagatttatccacagctaaagaagtgggaacaagatcctgaa
actttcctgatcattataaagggagcaggaggaaaggctttctgtgccgggggtgatatc
agagtgatctcggaagctgaaaaggcaaaacagaagatagctccagttttcttcagagaa
gaatatatgctgaataatgctgttggttcttgccagaaaccttatgttgcacttattcat
ggaattacaatgggtgggggagttggtctctcagtccatgggcaatttcgagtggctaca
gaaaagtgtctttttgctatgccagaaactgcaataggactgttccctgatgtgggtgga
ggttatttcttgccacgactccaaggaaaacttggttacttccttgcattaacaggattc
agactaaaaggaagagatgtgtacagagcaggaattgctacacactttgtagattctgaa
aagttggccatgttagaggaagatttgttagccttgaaatctccttcaaaagaaaatatt
gcatctgtcttagaaaattaccatacagagtctaagattgatcgagacaagtcttttata
cttgaggaacacatggacaaaataaacagttgtttttcagccaatactgtggaagaaatt
attgaaaacttacagcaagatggttcatcttttgccctagagcaattgaaggtaattaat
aaaatgtctccaacatctctaaagatcacactaaggcaactcatggaggggtcttcaaag
accttgcaagaagtactaactatggagtatcggctaagtcaagcttgtatgagaggtcat
gactttcatgaaggcgttagagctgttttaattgataaagaccagagtccaaaatggaaa
ccagctgatctaaaagaagttactgaggaagatttgaataatcactttaagtctttggga
agcagtgatttgaaattttga
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