KEGG T01001: 2768

Homo sapiens (human): 2768

Entry

2768              CDS       T01001

Symbol

GNA12, HG1M1, NNX3, RMP, gep

Name

(RefSeq) G protein subunit alpha 12

K04346

guanine nucleotide-binding protein subunit alpha-12

Organism

hsa Homo sapiens (human)

Pathway

hsa04010

MAPK signaling pathway

hsa04022

cGMP-PKG signaling pathway

hsa04071

Sphingolipid signaling pathway

hsa04072

Phospholipase D signaling pathway

hsa04081

Hormone signaling

hsa04270

Vascular smooth muscle contraction

hsa04730

Long-term depression

hsa04810

Regulation of actin cytoskeleton

hsa04928

Parathyroid hormone synthesis, secretion and action

hsa05130

Pathogenic Escherichia coli infection

hsa05163

Human cytomegalovirus infection

hsa05200

Pathways in cancer

Network

nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06325  Hormone/cytokine signaling
nt06533  Chemokine signaling

Element

N00405

CXCR4-GNA12/13-Rho signaling pathway

N00406

HCMV US28 to GNA12/13-Rho signaling pathway

N01097

LPA-GNA12/13-RhoA signaling pathway

N01768

CXCR4-GNA12/13 signaling pathway

N01793

GAL-GALR signaling pathway

Disease

H02434

Diffuse large B-cell lymphoma, not otherwise specified

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    2768 (GNA12)
   04072 Phospholipase D signaling pathway
    2768 (GNA12)
   04071 Sphingolipid signaling pathway
    2768 (GNA12)
   04022 cGMP-PKG signaling pathway
    2768 (GNA12)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    2768 (GNA12)
09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    2768 (GNA12)
09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    2768 (GNA12)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    2768 (GNA12)
  09156 Nervous system
   04730 Long-term depression
    2768 (GNA12)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2768 (GNA12)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    2768 (GNA12)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    2768 (GNA12)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2768 (GNA12)
   04031 GTP-binding proteins [BR:hsa04031]
    2768 (GNA12)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of hepatic cells
   2768 (GNA12)
GTP-binding proteins [BR:hsa04031]
Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 4 (G12/13)
    2768 (GNA12)

SSDB

Motif

Pfam:

G-alpha Arf Gtr1_RagA GTP_EFTU FtsK_SpoIIIE

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

7:complement(2728105..2844308)

AA seq 381 aa
MSGVVRTLSRCLLPAEAGGARERRAGSGARDAEREARRRSRDIDALLARERRAVRRLVKI
LLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQ
YSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVK
YFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQ
CFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDL
LVEKVKTVSIKKHFPDFRGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDTENVR
FVFHAVKDTILQENLKDIMLQ

NT seq 1146 nt +upstreamnt +downstreamnt
atgtccggggtggtgcggaccctcagccgctgcctgctgccggccgaggccggcggggcc
cgcgagcgcagggcgggcagcggcgcgcgcgacgcggagcgcgaggcccggaggcgtagc
cgcgacatcgacgcgctgctggcccgcgagcggcgcgcggtccggcgcctggtgaagatc
ctgctgctgggcgcgggcgagagcggcaagtccacgttcctcaagcagatgcgcatcatc
cacggccgcgagttcgaccagaaggcgctgctggagttccgcgacaccatcttcgacaac
atcctcaagggctcaagggttcttgttgatgcacgagataagcttggcattccttggcag
tattctgaaaatgagaagcatgggatgttcctgatggccttcgagaacaaggcggggctg
cctgtggagccggccaccttccagctgtacgtcccggccctgagcgcactctggagggat
tctggcatcagggaggctttcagccggagaagcgagtttcagctgggggagtcggtgaag
tacttcctggacaacttggaccggatcggccagctgaattactttcctagtaagcaagat
atcctgctggctaggaaagccaccaagggaattgtggagcatgacttcgttattaagaag
atcccctttaagatggtggatgtgggcggccagcggtcccagcgccagaagtggttccag
tgcttcgacgggatcacgtccatcctgttcatggtctcctccagcgagtacgaccaggtc
ctcatggaggacaggcgcaccaaccggctggtggagtccatgaacatcttcgagaccatc
gtcaacaacaagctcttcttcaacgtctccatcattctcttcctcaacaagatggacctc
ctggtggagaaggtgaagaccgtgagcatcaagaagcacttcccggacttcaggggcgac
ccgcacaggctggaggacgtccagcgctacctggtccagtgcttcgacaggaagagacgg
aaccgcagcaagccactcttccaccacttcaccaccgccatcgacaccgagaacgtccgc
ttcgtgttccatgctgtgaaagacaccatcctgcaggagaacctgaaggacatcatgctg
cagtga

Homo sapiens (human): 55970

Entry

55970             CDS       T01001

Symbol

GNG12, HG3A

Name

(RefSeq) G protein subunit gamma 12

K04347

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Organism

hsa Homo sapiens (human)

Pathway

hsa04010

MAPK signaling pathway

hsa04014

Ras signaling pathway

hsa04062

Chemokine signaling pathway

hsa04081

Hormone signaling

hsa04082

Neuroactive ligand signaling

hsa04151

PI3K-Akt signaling pathway

hsa04371

Apelin signaling pathway

hsa04713

Circadian entrainment

hsa04723

Retrograde endocannabinoid signaling

hsa04724

Glutamatergic synapse

hsa04725

Cholinergic synapse

hsa04726

Serotonergic synapse

hsa04727

GABAergic synapse

hsa04728

Dopaminergic synapse

hsa04810

Regulation of actin cytoskeleton

hsa04926

Relaxin signaling pathway

hsa05032

Morphine addiction

hsa05034

Alcoholism

hsa05163

Human cytomegalovirus infection

hsa05167

Kaposi sarcoma-associated herpesvirus infection

hsa05170

Human immunodeficiency virus 1 infection

hsa05200

Pathways in cancer

Network

nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167  Human cytomegalovirus (HCMV)
nt06224  CXCR signaling (cancer)
nt06530  PI3K signaling
nt06533  Chemokine signaling
nt06544  Neuroactive ligand signaling

Element

N00152

CXCR-GNB/G-ERK signaling pathway

N00153

CCR/CXCR-GNB/G-PI3K-RAC signaling pathway

N00154

CXCR-GNB/G-PI3K-AKT signaling pathway

N00157

KSHV vGPCR to GNB/G-ERK signaling pathway

N00158

KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway

N00178

KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway

N00399

CCR2-GNB/G-PI3K-NFKB signaling pathway

N00400

HCMV US28 to GNB/G-PI3K-NFKB signaling pathway

N00408

LPAR-GNB/G-Rho signaling pathway

N00409

HCMV UL33 to GNB/G-Rho signaling pathway

N00413

CXCR4-GNB/G-PLCB-PKC signaling pathway

N00428

CCR5-GNB/G-PLCB/G-PKC signaling pathway

N00433

CXCR4-GNB/G-RAC signaling pathway

N00434

HIV gp120 to CXCR4-GNB/G-RAC signaling pathway

N01657

GPCR-PI3K signaling pathway

N01746

CCR/CXCR-GNB/G-PI3K signaling pathway

N01769

CCR5-GNB/G-PLCB/G signaling pathway

N01770

CCR2-GNB/G-PI3K signaling pathway

N01771

CXCR4-GNB/G signaling pathway

N01889

Gbeta/gamma-KCNJ signaling

N01899

Gbeta/gamma-CACNA signaling

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    55970 (GNG12)
   04014 Ras signaling pathway
    55970 (GNG12)
   04371 Apelin signaling pathway
    55970 (GNG12)
   04151 PI3K-Akt signaling pathway
    55970 (GNG12)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    55970 (GNG12)
   04081 Hormone signaling
    55970 (GNG12)
09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    55970 (GNG12)
09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    55970 (GNG12)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    55970 (GNG12)
  09156 Nervous system
   04724 Glutamatergic synapse
    55970 (GNG12)
   04727 GABAergic synapse
    55970 (GNG12)
   04725 Cholinergic synapse
    55970 (GNG12)
   04728 Dopaminergic synapse
    55970 (GNG12)
   04726 Serotonergic synapse
    55970 (GNG12)
   04723 Retrograde endocannabinoid signaling
    55970 (GNG12)
  09159 Environmental adaptation
   04713 Circadian entrainment
    55970 (GNG12)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    55970 (GNG12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    55970 (GNG12)
   05163 Human cytomegalovirus infection
    55970 (GNG12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    55970 (GNG12)
  09165 Substance dependence
   05032 Morphine addiction
    55970 (GNG12)
   05034 Alcoholism
    55970 (GNG12)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    55970 (GNG12)
   04031 GTP-binding proteins [BR:hsa04031]
    55970 (GNG12)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   55970 (GNG12)
  Exosomal proteins of colorectal cancer cells
   55970 (GNG12)
GTP-binding proteins [BR:hsa04031]
Heterotrimeric G-proteins
  Gamma Subunits
   Gamma [OT]
    55970 (GNG12)

SSDB

Motif

Pfam:

G-gamma CP12

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

LinkDB

Position

1:complement(67701475..67833467)

AA seq 72 aa
MSSKTASTNNIAQARRTVQQLRLEASIERIKVSKASADLMSYCEEHARSDPLLIGIPTSE
NPFKDKKTCIIL

NT seq 219 nt +upstreamnt +downstreamnt
atgtccagcaaaacagcaagcaccaacaatatagcccaggcaaggagaactgtgcagcag
ttaagattagaagcctccattgaaagaataaaggtttcgaaggcatcagcggacctcatg
tcctactgtgaggaacatgccaggagtgaccctttgctgataggaataccaacttcagaa
aaccctttcaaggataaaaaaacttgcatcatcttatag

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