KEGG   Homo sapiens (human): 2872
Entry
2872              CDS       T01001                                 
Symbol
MKNK2, GPRK7, MNK2
Name
(RefSeq) MAPK interacting serine/threonine kinase 2
  KO
K04372  MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04910  Insulin signaling pathway
Drug target
Merestinib: D11763
Tomivosertib (DG03019): D11452 D11481
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    2872 (MKNK2)
   04066 HIF-1 signaling pathway
    2872 (MKNK2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    2872 (MKNK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2872 (MKNK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     2872 (MKNK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  MAPKAPK family [OT]
   2872 (MKNK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo zf-RRN7 ABC_trans_aux Pkinase_fungal
Other DBs
NCBI-GeneID: 2872
NCBI-ProteinID: NP_951009
OMIM: 605069
HGNC: 7111
Ensembl: ENSG00000099875
UniProt: Q9HBH9 B3KS07
Structure
LinkDB
Position
19:complement(2037471..2051244)
AA seq 465 aa
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
NT seq 1398 nt   +upstreamnt  +downstreamnt
atggtgcagaagaaaccagccgaacttcagggtttccaccgttcgttcaaggggcagaac
cccttcgagctggccttctccctagaccagcccgaccacggagactctgactttggcctg
cagtgctcagcccgccctgacatgcccgccagccagcccattgacatcccggacgccaag
aagaggggcaagaagaagaagcgcggccgggccaccgacagcttctcgggcaggtttgaa
gacgtctaccagctgcaggaagatgtgctgggggagggcgctcatgcccgagtgcagacc
tgcatcaacctgatcaccagccaggagtacgccgtcaagatcattgagaagcagccaggc
cacattcggagcagggttttcagggaggtggagatgctgtaccagtgccagggacacagg
aacgtcctagagctgattgagttcttcgaggaggaggaccgcttctacctggtgtttgag
aagatgcggggaggctccatcctgagccacatccacaagcgccggcacttcaacgagctg
gaggccagcgtggtggtgcaggacgtggccagcgccttggactttctgcataacaaaggc
atcgcccacagggacctaaagccggaaaacatcctctgtgagcaccccaaccaggtctcc
cccgtgaagatctgtgacttcgacctgggcagcggcatcaaactcaacggggactgctcc
cctatctccaccccggagctgctcactccgtgcggctcggcggagtacatggccccggag
gtagtggaggccttcagcgaggaggctagcatctacgacaagcgctgcgacctgtggagc
ctgggcgtcatcttgtatatcctactcagcggctacccgcccttcgtgggccgctgtggc
agcgactgcggctgggaccgcggcgaggcctgccctgcctgccagaacatgctgtttgag
agcatccaggagggcaagtacgagttccccgacaaggactgggcccacatctcctgcgct
gccaaagacctcatctccaagctgctggtccgtgacgccaagcagaggctgagtgccgcc
caagtcctgcagcacccctgggttcaggggtgcgccccggagaacaccttgcccactccc
atggtcctgcagaggaacagctgtgccaaagacctcacgtccttcgcggctgaggccatt
gccatgaaccggcagctggcccagcacgacgaggacctggctgaggaggaggccgcgggg
cagggccagcccgtcctggtccgagctacctcacgctgcctgcagctgtctccaccctcc
cagtccaagctggcgcagcggcggcaaagggccagtctgtcctcggccccagtggtcctg
gtgggagaccacgcctga

KEGG   Homo sapiens (human): 8569
Entry
8569              CDS       T01001                                 
Symbol
MKNK1, MNK1
Name
(RefSeq) MAPK interacting serine/threonine kinase 1
  KO
K04372  MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04910  Insulin signaling pathway
Drug target
Merestinib: D11763
Tomivosertib (DG03019): D11452 D11481
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    8569 (MKNK1)
   04066 HIF-1 signaling pathway
    8569 (MKNK1)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    8569 (MKNK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    8569 (MKNK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     8569 (MKNK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  MAPKAPK family [OT]
   8569 (MKNK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr zf-RRN7 APH
Other DBs
NCBI-GeneID: 8569
NCBI-ProteinID: NP_003675
OMIM: 606724
HGNC: 7110
Ensembl: ENSG00000079277
UniProt: Q9BUB5
Structure
LinkDB
Position
1:complement(46557407..46604268)
AA seq 453 aa
MGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNG
KEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSI
LAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSS
DPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPE
LTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWD
RGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHP
WVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLC
SMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
NT seq 1362 nt   +upstreamnt  +downstreamnt
atgggcagtagcgaaccccttcccatcgcagatggtgacaggaggaggaagaagaagcgg
aggggccgggccactgactccttgccaggaaagtttgaagatatgtacaagctgacctct
gaattgcttggagagggagcctatgccaaagttcaaggtgccgtgagcctacagaatggc
aaagagtatgccgtcaaaatcatcgagaaacaagcagggcacagtcggagtagggtgttt
cgagaggtggagacgctgtatcagtgtcagggaaacaagaacattttggagctgattgag
ttctttgaagatgacacaaggttttacttggtctttgagaaattgcaaggaggttccatc
ttagcccacatccagaagcaaaagcacttcaatgagcgagaagccagccgagtggtgcgg
gacgttgctgctgcccttgacttcctgcataccaaagacaaagtctctctctgtcaccta
ggctggagtgctatggcgccatcagggctcactgcagccccaacctccctgggctccagt
gatcctcccacctcagcctcccaagtagctgggactacaggcattgctcatcgtgatctg
aaaccagaaaatatattgtgtgaatctccagaaaaggtgtctccagtgaaaatctgtgac
tttgacttgggcagtgggatgaaactgaacaactcctgtacccccataaccacaccagag
ctgaccaccccatgtggctctgcagaatacatggcccctgaggtagtggaggtcttcacg
gaccaggccacattctacgacaagcgctgtgacctgtggagcctgggcgtggtcctctac
atcatgctgagtggctacccacccttcgtgggtcactgcggggccgactgtggctgggac
cggggcgaggtctgcagggtgtgccagaacaagctgtttgaaagcatccaggaaggcaag
tatgagtttcctgacaaggactgggcacacatctccagtgaagccaaagacctcatctcc
aagctcctggtgcgagatgcaaagcagagacttagcgccgcccaagttctgcagcaccca
tgggtgcaggggcaagctccagaaaagggactccccacgccgcaagtcctccagaggaac
agcagcacaatggacctgacgctcttcgcagctgaggccatcgcccttaaccgccagcta
tctcagcacgaagagaacgaactagcagaggagccagaggcactagctgatggcctctgc
tccatgaagctttcccctccctgcaagtcacgcctggcccggagacgggccctggcccag
gcaggccgtggtgaagacaggagcccgcccacagcactctga

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