KEGG   Homo sapiens (human): 2911
Entry
2911              CDS       T01001                                 

Gene name
GRM1, GPRC1A, MGLU1, MGLUR1, PPP1R85, SCA44, SCAR13
Definition
(RefSeq) glutamate metabotropic receptor 1
  KO
K04603  metabotropic glutamate receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04068  FoxO signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction
hsa04720  Long-term potentiation
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04730  Long-term depression
hsa04742  Taste transduction
hsa04915  Estrogen signaling pathway
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06410  Calcium signaling
nt06440  Transcription
nt06462  Spinocerebellar ataxia
nt06463  Parkinson disease
  Element
N00953  mGluR1-TRPC3 signaling pathway
N00954  Mutation-activated GRM1 to mGluR1-TRPC3 signaling pathway
N00955  Mutation-inactivated PRKCG to mGluR1-TRPC3 signaling pathway
N00956  Mutation-activated PRKCG to mGluR1-TRPC3 signaling pathway
N00957  Mutation-caused abberant ATXN2/3 to mGluR5-Ca2+ -apoptotic pathway
N00958  Mutation-activated ITPR1 to mGluR1-TRPC3 signaling pathway
N00959  ITPR1-reduced expression to mGluR1-TRPC3 signaling pathway
N00960  Mutation-caused aberrant SPTBN2 to mGluR1-TRPC3 signaling pathway
N00965  RORA-mediated transcription
N00966  Mutation-caused aberrant ATXN1 to RORA-mediated transcription
Disease
H00063  Spinocerebellar ataxia (SCA)
H01891  Autosomal recessive spinocerebellar ataxias
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    2911 (GRM1)
   04020 Calcium signaling pathway
    2911 (GRM1)
   04072 Phospholipase D signaling pathway
    2911 (GRM1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2911 (GRM1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    2911 (GRM1)
 09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    2911 (GRM1)
  09156 Nervous system
   04724 Glutamatergic synapse
    2911 (GRM1)
   04720 Long-term potentiation
    2911 (GRM1)
   04730 Long-term depression
    2911 (GRM1)
   04723 Retrograde endocannabinoid signaling
    2911 (GRM1)
  09157 Sensory system
   04742 Taste transduction
    2911 (GRM1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    2911 (GRM1)
   05022 Pathways of neurodegeneration - multiple diseases
    2911 (GRM1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    2911 (GRM1)
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2911 (GRM1)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     2911 (GRM1)
G protein-coupled receptors [BR:hsa04030]
 Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   2911 (GRM1)
SSDB
Motif
Pfam: ANF_receptor 7tm_3 GluR_Homer-bdg NCD3G DUF5438 DUF2318 AAA_34
Other DBs
NCBI-GeneID: 2911
NCBI-ProteinID: NP_001264993
OMIM: 604473
HGNC: 4593
Ensembl: ENSG00000152822
Vega: OTTHUMG00000015752
Pharos: Q13255(Tchem)
UniProt: Q13255 Q59HC2
LinkDB
Structure
PDB: 
3KS9

Position
6q24.3
AA seq 1194 aa
MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAE
KVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSI
EFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDI
PQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESG
MDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLL
SAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLD
TNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAM
AHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYD
IMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGE
VSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFS
CLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQ
RLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTL
VVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPAN
FNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA
KPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGG
GQVPKGQHMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEE
EDAQPIRFSPPGSPSMVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQ
QQPPPQQKSLMDQLQGVVSNFSTAIPDFHAVLAGPGGPGNGLRSLYPPPPPPQHLQMLPL
QLSTFGEELVSPPADDDDDSERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPD
DSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQSSSTL
NT seq 3585 nt   +upstreamnt  +downstreamnt
atggtcgggctccttttgttttttttcccagcgatctttttggaggtgtcccttctcccc
agaagccccggcaggaaagtgttgctggcaggagcgtcgtctcagcgctcggtggccaga
atggacggagatgtcatcattggagccctcttctcagtccatcaccagcctccggccgag
aaagtgcccgagaggaagtgtggggagatcagggagcagtatggcatccagagggtggag
gccatgttccacacgttggataagatcaacgcggacccggtcctcctgcccaacatcacc
ctgggcagtgagatccgggactcctgctggcactcttccgtggctctggaacagagcatt
gagttcattagggactctctgatttccattcgagatgagaaggatgggatcaaccggtgt
ctgcctgacggccagtccctccccccaggcaggactaagaagcccattgcgggagtgatc
ggtcccggctccagctctgtagccattcaagtgcagaacctgctccagctcttcgacatc
ccccagatcgcttattcagccacaagcatcgacctgagtgacaaaactttgtacaaatac
ttcctgagggttgtcccttctgacactttgcaggcaagggccatgcttgacatagtcaaa
cgttacaattggacctatgtctctgcagtccacacggaagggaattatggggagagcgga
atggacgctttcaaagagctggctgcccaggaaggcctctgtatcgcccattctgacaaa
atctacagcaacgctggggagaagagctttgaccgactcttgcgcaaactccgagagagg
cttcccaaggctagagtggtggtctgcttctgtgaaggcatgacagtgcgaggactcctg
agcgccatgcggcgccttggcgtcgtgggcgagttctcactcattggaagtgatggatgg
gcagacagagatgaagtcattgaaggttatgaggtggaagccaacgggggaatcacgata
aagctgcagtctccagaggtcaggtcatttgatgattatttcctgaaactgaggctggac
actaacacgaggaatccctggttccctgagttctggcaacatcggttccagtgccgcctt
ccaggacaccttctggaaaatcccaactttaaacgaatctgcacaggcaatgaaagctta
gaagaaaactatgtccaggacagtaagatggggtttgtcatcaatgccatctatgccatg
gcacatgggctgcagaacatgcaccatgccctctgccctggccacgtgggcctctgcgat
gccatgaagcccatcgacggcagcaagctgctggacttcctcatcaagtcctcattcatt
ggagtatctggagaggaggtgtggtttgatgagaaaggagacgctcctggaaggtatgat
atcatgaatctgcagtacactgaagctaatcgctatgactatgtgcacgttggaacctgg
catgaaggagtgctgaacattgatgattacaaaatccagatgaacaagagtggagtggtg
cggtctgtgtgcagtgagccttgcttaaagggccagattaaggttatacggaaaggagaa
gtgagctgctgctggatttgcacggcctgcaaagagaatgaatatgtgcaagatgagttc
acctgcaaagcttgtgacttgggatggtggcccaatgcagatctaacaggctgtgagccc
attcctgtgcgctatcttgagtggagcaacatcgaatccattatagccatcgccttttca
tgcctgggaatccttgttaccttgtttgtcaccctaatctttgtactgtaccgggacaca
ccagtggtcaaatcctccagtcgggagctctgctacatcatcctagctggcatcttcctt
ggttatgtgtgcccattcactctcattgccaaacctactaccacctcctgctacctccag
cgcctcttggttggcctctcctctgcgatgtgctactctgctttagtgactaaaaccaat
cgtattgcacgcatcctggctggcagcaagaagaagatctgcacccggaagcccaggttc
atgagtgcctgggctcaggtgatcattgcctcaattctgattagtgtgcaactaaccctg
gtggtaaccctgatcatcatggaaccccctatgcccattctgtcctacccaagtatcaag
gaagtctaccttatctgcaataccagcaacctgggtgtggtggcccctttgggctacaat
ggactcctcatcatgagctgtacctactatgccttcaagacccgcaacgtgcccgccaac
ttcaacgaggccaaatatatcgcgttcaccatgtacaccacctgtatcatctggctagct
tttgtgcccatttactttgggagcaactacaagatcatcacaacttgctttgcagtgagt
ctcagtgtaacagtggctctggggtgcatgttcactcccaagatgtacatcattattgcc
aagcctgagaggaatgtccgcagtgccttcaccacctctgatgttgtccgcatgcatgtt
ggcgatggcaagctgccctgccgctccaacactttcctcaacatcttccgaagaaagaag
gcaggggcagggaatgccaattctaatggcaagtctgtgtcatggtctgaaccaggtgga
ggacaggtgcccaagggacagcatatgtggcaccgcctctctgtgcacgtgaagaccaat
gagacggcctgcaaccaaacagccgtcatcaagcccctcactaaaagttaccaaggctct
ggcaagagcctgaccttttcagataccagcaccaagaccctttacaacgtagaggaggag
gaggatgcccagccgattcgctttagcccgcctggtagcccttccatggtggtgcacagg
cgcgtgccaagcgcggcgaccactccgcctctgccgtcccacctgaccgcagaggagacc
cccctcttcctggccgaaccagccctccccaagggcttgccccctcctctccagcagcag
cagcaaccccctccacagcagaaatcgctgatggaccagctccagggagtggtcagcaac
ttcagtaccgcgatcccggattttcacgcggtgctggcaggccccggtggtcccgggaac
gggctgcggtccctgtacccgcccccgccacctccgcagcacctgcagatgctgccgctg
cagctgagcacctttggggaggagctggtctccccgcccgcggacgacgacgacgacagc
gagaggtttaagctcctccaggagtacgtgtatgagcacgagcgggaagggaacacggaa
gaagacgaactggaagaggaggaggaggacctgcaggcggccagcaaactgaccccggat
gattcgcctgcgctgacgcctccgtcgcctttccgcgactcggtggcctcgggcagctcg
gtgcccagctcccccgtgtccgagtcggtgctctgcacccctcccaacgtatcctacgcc
tctgtcattctgcgggactacaagcaaagctcttccaccctgtaa

KEGG   Homo sapiens (human): 2912
Entry
2912              CDS       T01001                                 

Gene name
GRM2, GLUR2, GPRC1B, MGLUR2, mGlu2
Definition
(RefSeq) glutamate metabotropic receptor 2
  KO
K04605  metabotropic glutamate receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa05030  Cocaine addiction
Drug target
Eglumegad  
Eglumetad (DG01987): D03966 D08908
Pomaglumetad methionil (DG02201): D09949 D10896
Talaglumetad hydrochloride: D09008
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    2912 (GRM2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2912 (GRM2)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2912 (GRM2)
 09160 Human Diseases
  09165 Substance dependence
   05030 Cocaine addiction
    2912 (GRM2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2912 (GRM2)
G protein-coupled receptors [BR:hsa04030]
 Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   2912 (GRM2)
SSDB
Motif
Pfam: ANF_receptor 7tm_3 NCD3G DUF543
Other DBs
NCBI-GeneID: 2912
NCBI-ProteinID: NP_000830
OMIM: 604099
HGNC: 4594
Ensembl: ENSG00000164082
Vega: OTTHUMG00000156902
Pharos: Q14416(Tchem)
UniProt: Q14416
LinkDB
Structure
PDB: 

Position
3p21.2
AA seq 872 aa
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
NT seq 2619 nt   +upstreamnt  +downstreamnt
atgggatcgctgcttgcgctcctggcactgctgctgctgtggggtgctgtggctgagggc
ccagccaagaaggtgctgaccctggagggagacttggtgctgggtgggctgttcccagtg
caccagaagggcggcccagcagaggactgtggtcctgtcaatgagcaccgtggcatccag
cgcctggaggccatgctttttgcactggaccgcatcaaccgtgacccgcacctgctgcct
ggcgtgcgcctgggtgcacacatcctcgacagttgctccaaggacacacatgcgctggag
caggcactggactttgtgcgtgcctcactcagccgtggtgctgatggctcacgccacatc
tgccccgacggctcttatgcgacccatggtgatgctcccactgccatcactggtgttatt
ggcggttcctacagtgatgtctccatccaggtggccaacctcttgaggctatttcagatc
ccacagattagctacgcctctaccagtgccaagctgagtgacaagtcccgctatgactac
tttgcccgcacagtgcctcctgacttcttccaagccaaggccatggctgagattctccgc
ttcttcaactggacctatgtgtccactgtggcgtctgagggcgactatggcgagacaggc
attgaggcctttgagctagaggctcgtgcccgcaacatctgtgtggccacctcggagaaa
gtgggccgtgccatgagccgcgcggcctttgagggtgtggtgcgagccctgctgcagaag
cccagtgcccgcgtggctgtcctgttcacccgttctgaggatgcccgggagctgcttgct
gccagccagcgcctcaatgccagcttcacctgggtggccagtgatggttggggggccctg
gagagtgtggtggcaggcagtgagggggctgctgagggtgctatcaccatcgagctggcc
tcctaccccatcagtgactttgcctcctacttccagagcctggacccttggaacaacagc
cggaacccctggttccgtgaattctgggagcagaggttccgctgcagcttccggcagcga
gactgcgcagcccactctctccgggctgtgccctttgagcaggagtccaagatcatgttt
gtggtcaatgcagtgtacgccatggcccatgcgctccacaacatgcaccgtgccctctgc
cccaacaccacccggctctgtgacgcgatgcggccagttaacgggcgccgcctctacaag
gactttgtgctcaacgtcaagtttgatgccccctttcgcccagctgacacccacaatgag
gtccgctttgaccgctttggtgatggtattggccgctacaacatcttcacctatctgcgt
gcaggcagtgggcgctatcgctaccagaaggtgggctactgggcagaaggcttgactctg
gacaccagcctcatcccatgggcctcaccctcagccggccccctgcccgcctctcgctgc
agtgagccctgcctccagaatgaggtgaagagtgtgcagccgggcgaagtctgctgctgg
ctctgcattccgtgccagccctatgagtaccgattggacgaattcacttgcgctgattgt
ggcctgggctactggcccaatgccagcctgactggctgcttcgaactgccccaggagtac
atccgctggggcgatgcctgggctgtgggacctgtcaccatcgcctgcctcggtgccctg
gccaccctctttgtgctgggtgtctttgtgcggcacaatgccacaccagtggtcaaggcc
tcaggtcgggagctctgctacatcctgctgggtggtgtcttcctctgctactgcatgacc
ttcatcttcattgccaagccatccacggcagtgtgtaccttacggcgtcttggtttgggc
actgccttctctgtctgctactcagccctgctcaccaagaccaaccgcattgcacgcatc
ttcggtggggcccgggagggtgcccagcggccacgcttcatcagtcctgcctcacaggtg
gccatctgcctggcacttatctcgggccagctgctcatcgtggtcgcctggctggtggtg
gaggcaccgggcacaggcaaggagacagcccccgaacggcgggaggtggtgacactgcgc
tgcaaccaccgcgatgcaagtatgttgggctcgctggcctacaatgtgctcctcatcgcg
ctctgcacgctttatgccttcaagactcgcaagtgccccgaaaacttcaacgaggccaag
ttcattggcttcaccatgtacaccacctgcatcatctggctggcattcctgcccatcttc
tatgtcacctccagtgactaccgggtacagaccaccaccatgtgcgtgtcagtcagcctc
agcggctccgtggtgcttggctgcctctttgcgcccaagctgcacatcatcctcttccag
ccgcagaagaacgtggttagccaccgggcacccaccagccgctttggcagtgctgctgcc
agggccagctccagccttggccaagggtctggctcccagtttgtccccactgtttgcaat
ggccgtgaggtggtggactcgacaacgtcatcgctttga

KEGG   Homo sapiens (human): 2913
Entry
2913              CDS       T01001                                 

Gene name
GRM3, GLUR3, GPRC1C, MGLUR3, mGlu3
Definition
(RefSeq) glutamate metabotropic receptor 3
  KO
K04606  metabotropic glutamate receptor 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa05030  Cocaine addiction
Drug target
Pomaglumetad methionil (DG02201): D09949 D10896
Talaglumetad hydrochloride: D09008
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    2913 (GRM3)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2913 (GRM3)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2913 (GRM3)
 09160 Human Diseases
  09165 Substance dependence
   05030 Cocaine addiction
    2913 (GRM3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2913 (GRM3)
G protein-coupled receptors [BR:hsa04030]
 Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   2913 (GRM3)
SSDB
Motif
Pfam: ANF_receptor 7tm_3 NCD3G Peripla_BP_6
Other DBs
NCBI-GeneID: 2913
NCBI-ProteinID: NP_000831
OMIM: 601115
HGNC: 4595
Ensembl: ENSG00000198822
Vega: OTTHUMG00000022884
Pharos: Q14832(Tchem)
UniProt: Q14832 A4D1D0
LinkDB
Structure
PDB: 
4XAR 3SM9 6B7H 5CNM 5CNK

Position
7q21.11-q21.12
AA seq 879 aa
MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS
DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSY
LKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK
HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLA
EKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH
LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
NT seq 2640 nt   +upstreamnt  +downstreamnt
atgaagatgttgacaagactgcaagttcttaccttagctttgttttcaaagggattttta
ctctctttaggggaccataactttctaaggagagagattaaaatagaaggtgaccttgtt
ttagggggcctgtttcctattaacgaaaaaggcactggaactgaagaatgtgggcgaatc
aatgaagaccgagggattcaacgcctggaagccatgttgtttgctattgatgaaatcaac
aaagatgattacttgctaccaggagtgaagttgggtgttcacattttggatacatgttca
agggatacctatgcattggagcaatcactggagtttgtcagggcatctttgacaaaagtg
gatgaagctgagtatatgtgtcctgatggatcctatgccattcaagaaaacatcccactt
ctcattgcaggggtcattggtggctcttatagcagtgtttccatacaggtggcaaacctg
ctgcggctcttccagatccctcagatcagctacgcatccaccagcgccaaactcagtgat
aagtcgcgctatgattactttgccaggaccgtgccccccgacttctaccaggccaaagcc
atggctgagatcttgcgcttcttcaactggacctacgtgtccacagtagcctccgagggt
gattacggggagacagggatcgaggccttcgagcaggaagcccgcctgcgcaacatctgc
atcgctacggcggagaaggtgggccgctccaacatccgcaagtcctacgacagcgtgatc
cgagaactgttgcagaagcccaacgcgcgcgtcgtggtcctcttcatgcgcagcgacgac
tcgcgggagctcattgcagccgccagccgcgccaatgcctccttcacctgggtggccagc
gacggctggggcgcgcaggagagcatcatcaagggcagcgagcatgtggcctacggcgcc
atcaccctggagctggcctcccagcctgtccgccagttcgaccgctacttccagagcctc
aacccctacaacaaccaccgcaacccctggttccgggacttctgggagcaaaagtttcag
tgcagcctccagaacaaacgcaaccacaggcgcgtctgcgacaagcacctggccatcgac
agcagcaactacgagcaagagtccaagatcatgtttgtggtgaacgcggtgtatgccatg
gcccacgctttgcacaaaatgcagcgcaccctctgtcccaacactaccaagctttgtgat
gctatgaagatcctggatgggaagaagttgtacaaggattacttgctgaaaatcaacttc
acggctccattcaacccaaataaagatgcagatagcatagtcaagtttgacacttttgga
gatggaatggggcgatacaacgtgttcaatttccaaaatgtaggtggaaagtattcctac
ttgaaagttggtcactgggcagaaaccttatcgctagatgtcaactctatccactggtcc
cggaactcagtccccacttcccagtgcagcgacccctgtgcccccaatgaaatgaagaat
atgcaaccaggggatgtctgctgctggatttgcatcccctgtgaaccctacgaatacctg
gctgatgagtttacctgtatggattgtgggtctggacagtggcccactgcagacctaact
ggatgctatgaccttcctgaggactacatcaggtgggaagacgcctgggccattggccca
gtcaccattgcctgtctgggttttatgtgtacatgcatggttgtaactgtttttatcaag
cacaacaacacacccttggtcaaagcatcgggccgagaactctgctacatcttattgttt
ggggttggcctgtcatactgcatgacattcttcttcattgccaagccatcaccagtcatc
tgtgcattgcgccgactcgggctggggagttccttcgctatctgttactcagccctgctg
accaagacaaactgcattgcccgcatcttcgatggggtcaagaatggcgctcagaggcca
aaattcatcagccccagttctcaggttttcatctgcctgggtctgatcctggtgcaaatt
gtgatggtgtctgtgtggctcatcctggaggccccaggcaccaggaggtatacccttgca
gagaagcgggaaacagtcatcctaaaatgcaatgtcaaagattccagcatgttgatctct
cttacctacgatgtgatcctggtgatcttatgcactgtgtacgccttcaaaacgcggaag
tgcccagaaaatttcaacgaagctaagttcataggttttaccatgtacaccacgtgcatc
atctggttggccttcctccctatattttatgtgacatcaagtgactacagagtgcagacg
acaaccatgtgcatctctgtcagcctgagtggctttgtggtcttgggctgtttgtttgca
cccaaggttcacatcatcctgtttcaaccccagaagaatgttgtcacacacagactgcac
ctcaacaggttcagtgtcagtggaactgggaccacatactctcagtcctctgcaagcacg
tatgtgccaacggtgtgcaatgggcgggaagtcctcgactccaccacctcatctctgtga

KEGG   Homo sapiens (human): 2914
Entry
2914              CDS       T01001                                 

Gene name
GRM4, GPRC1D, MGLUR4, mGlu4
Definition
(RefSeq) glutamate metabotropic receptor 4
  KO
K04607  metabotropic glutamate receptor 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa04742  Taste transduction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    2914 (GRM4)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2914 (GRM4)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2914 (GRM4)
  09157 Sensory system
   04742 Taste transduction
    2914 (GRM4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2914 (GRM4)
G protein-coupled receptors [BR:hsa04030]
 Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   2914 (GRM4)
SSDB
Motif
Pfam: ANF_receptor 7tm_3 NCD3G Peripla_BP_6 Haem_degrading
Other DBs
NCBI-GeneID: 2914
NCBI-ProteinID: NP_000832
OMIM: 604100
HGNC: 4596
Ensembl: ENSG00000124493
Vega: OTTHUMG00000014538
Pharos: Q14833(Tchem)
UniProt: Q14833 A1L4F9
LinkDB
Position
6p21.31
AA seq 912 aa
MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR
GSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL
TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA
STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQ
KSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRA
NQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI
WFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL
HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY
QLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCW
HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIA
ATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG
LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVV
DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET
FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP
KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALAT
KQTYVTYTNHAI
NT seq 2739 nt   +upstreamnt  +downstreamnt
atgcctgggaagagaggcttgggctggtggtgggcccggctgcccctttgcctgctcctc
agcctttacggcccctggatgccttcctccctgggaaagcccaaaggccaccctcacatg
aattccatccgcatagatggggacatcacactgggaggcctgttcccggtgcatggccgg
ggctcagagggcaagccctgtggagaacttaagaaggaaaagggcatccaccggctggag
gccatgctgttcgccctggatcgcatcaacaacgacccggacctgctgcctaacatcacg
ctgggcgcccgcattctggacacctgctccagggacacccatgccctcgagcagtcgctg
acctttgtgcaggcgctcatcgagaaggatggcacagaggtccgctgtggcagtggcggc
ccacccatcatcaccaagcctgaacgtgtggtgggtgtcatcggtgcttcagggagctcg
gtctccatcatggtggccaacatccttcgcctcttcaagataccccagatcagctacgcc
tccacagcgccagacctgagtgacaacagccgctacgacttcttctcccgcgtggtgccc
tcggacacgtaccaggcccaggccatggtggacatcgtccgtgccctcaagtggaactat
gtgtccacagtggcctcggagggcagctatggtgagagcggtgtggaggccttcatccag
aagtcccgtgaggacgggggcgtgtgcatcgcccagtcggtgaagataccacgggagccc
aaggcaggcgagttcgacaagatcatccgccgcctcctggagacttcgaacgccagggca
gtcatcatctttgccaacgaggatgacatcaggcgtgtgctggaggcagcacgaagggcc
aaccagacaggccatttcttctggatgggctctgacagctggggctccaagattgcacct
gtgctgcacctggaggaggtggctgagggtgctgtcacgatcctccccaagaggatgtcc
gtacgaggcttcgaccgctacttctccagccgcacgctggacaacaaccggcgcaacatc
tggtttgccgagttctgggaggacaacttccactgcaagctgagccgccacgccctcaag
aagggcagccacgtcaagaagtgcaccaaccgtgagcgaattgggcaggattcagcttat
gagcaggaggggaaggtgcagtttgtgatcgatgccgtgtacgccatgggccacgcgctg
cacgccatgcaccgtgacctgtgtcccggccgcgtggggctctgcccgcgcatggaccct
gtagatggcacccagctgcttaagtacatccgaaacgtcaacttctcaggcatcgcaggg
aaccctgtgaccttcaatgagaatggagatgcgcctgggcgctatgacatctaccaatac
cagctgcgcaacgattctgccgagtacaaggtcattggctcctggactgaccacctgcac
cttagaatagagcggatgcactggccggggagcgggcagcagctgccccgctccatctgc
agcctgccctgccaaccgggtgagcggaagaagacagtgaagggcatgccttgctgctgg
cactgcgagccttgcacagggtaccagtaccaggtggaccgctacacctgtaagacgtgt
ccctatgacatgcggcccacagagaaccgcacgggctgccggcccatccccatcatcaag
cttgagtggggctcgccctgggccgtgctgcccctcttcctggccgtggtgggcatcgct
gccacgttgttcgtggtgatcacctttgtgcgctacaacgacacgcccatcgtcaaggcc
tcgggccgtgaactgagctacgtgctgctggcaggcatcttcctgtgctatgccaccacc
ttcctcatgatcgctgagcccgaccttggcacctgctcgctgcgccgaatcttcctggga
ctagggatgagcatcagctatgcagccctgctcaccaagaccaaccgcatctaccgcatc
ttcgagcagggcaagcgctcggtcagtgccccacgcttcatcagccccgcctcacagctg
gccatcaccttcagcctcatctcgctgcagctgctgggcatctgtgtgtggtttgtggtg
gacccctcccactcggtggtggacttccaggaccagcggacactcgacccccgcttcgcc
aggggtgtgctcaagtgtgacatctcggacctgtcgctcatctgcctgctgggctacagc
atgctgctcatggtcacgtgcaccgtgtatgccatcaagacacgcggcgtgcccgagacc
ttcaatgaggccaagcccattggcttcaccatgtacaccacttgcatcgtctggctggcc
ttcatccccatcttctttggcacctcgcagtcggccgacaagctgtacatccagacgacg
acgctgacggtctcggtgagtctgagcgcctcggtgtccctgggaatgctctacatgccc
aaagtctacatcatcctcttccacccggagcagaacgtgcccaagcgcaagcgcagcctc
aaagccgtcgttacggcggccaccatgtccaacaagttcacgcagaagggcaacttccgg
cccaacggagaggccaagtctgagctctgcgagaaccttgaggccccagcgctggccacc
aaacagacttacgtcacttacaccaaccatgcaatctag

KEGG   Homo sapiens (human): 2915
Entry
2915              CDS       T01001                                 

Gene name
GRM5, GPRC1E, MGLUR5, PPP1R86, mGlu5
Definition
(RefSeq) glutamate metabotropic receptor 5
  KO
K04604  metabotropic glutamate receptor 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction
hsa04720  Long-term potentiation
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer disease
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06410  Calcium signaling
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
  Element
N00984  mGluR5-Ca2+ -apoptotic pathway
N00985  Mutation-caused aberrant Htt to mGluR5-Ca2+ -apoptotic pathway
N01002  Mutation-caused aberrant Abeta to mGluR5-Ca2+ -apoptotic pathway
Drug target
Fenobam: D04155
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    2915 (GRM5)
   04072 Phospholipase D signaling pathway
    2915 (GRM5)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2915 (GRM5)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    2915 (GRM5)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2915 (GRM5)
   04720 Long-term potentiation
    2915 (GRM5)
   04723 Retrograde endocannabinoid signaling
    2915 (GRM5)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2915 (GRM5)
   05016 Huntington disease
    2915 (GRM5)
   05022 Pathways of neurodegeneration - multiple diseases
    2915 (GRM5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2915 (GRM5)
G protein-coupled receptors [BR:hsa04030]
 Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   2915 (GRM5)
SSDB
Motif
Pfam: ANF_receptor 7tm_3 GluR_Homer-bdg NCD3G DUF5438
Other DBs
NCBI-GeneID: 2915
NCBI-ProteinID: NP_001137303
OMIM: 604102
HGNC: 4597
Ensembl: ENSG00000168959
Vega: OTTHUMG00000134306
Pharos: P41594(Tchem)
UniProt: P41594
LinkDB
Structure
PDB: 

Position
11q14.2-q14.3
AA seq 1212 aa
MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAV
REQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISS
EEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLS
DKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGI
CIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFL
LLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQ
HRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCP
GYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFD
YINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKEN
EYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVV
FIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYS
ALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIM
HDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYT
TCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTS
TVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMG
NGGRATMSSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRG
LGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPS
PISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMML
STAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAA
RESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTL
IIRDYTQSSSSL
NT seq 3639 nt   +upstreamnt  +downstreamnt
atggtccttctgttgatcctgtcagtcttacttttgaaagaagatgtccgtgggagtgca
cagtccagtgagaggagggtggtggctcacatgccgggtgacatcattattggagctctc
ttttctgttcatcaccagcctactgtggacaaagttcatgagaggaagtgtggggcggtc
cgtgaacagtatggcattcagagagtggaggccatgctgcataccctggaaaggatcaat
tcagaccccacactcttgcccaacatcacactgggctgtgagataagggactcctgctgg
cattcggctgtggccctagagcagagcattgagttcataagagattccctcatttcttca
gaagaggaagaaggcttggtacgctgtgtggatggctcctcctcttccttccgctccaag
aagcccatagtaggggtcattgggcctggctccagttctgtagccattcaggtccagaat
ttgctccagcttttcaacatacctcagattgcttactcagcaaccagcatggatctgagt
gacaagactctgttcaaatatttcatgagggttgtgccttcagatgctcagcaggcaagg
gccatggtggacatagtgaagaggtacaactggacctatgtatcagccgtgcacacagaa
ggcaactatggagaaagtgggatggaagccttcaaagatatgtcagcgaaggaagggatt
tgcatcgcccactcttacaaaatctacagtaatgcaggggagcagagctttgataagctg
ctgaagaagctcacaagtcacttgcccaaggcccgggtggtggcctgcttctgtgagggc
atgacggtgagaggtctgctgatggccatgaggcgcctgggtctagcgggagaatttctg
cttctgggcagtgatggctgggctgacaggtatgatgtgacagatggatatcagcgagaa
gctgttggtggcatcacaatcaagctccaatctcccgatgtcaagtggtttgatgattat
tatctgaagctccggccagaaacaaaccaccgaaacccttggtttcaagaattttggcag
catcgttttcagtgccgactggaagggtttccacaggagaacagcaaatacaacaagact
tgcaatagttctctgactctgaaaacacatcatgttcaggattccaaaatgggatttgtg
atcaacgccatctattcgatggcctatgggctccacaacatgcagatgtccctctgccca
ggctatgcaggactctgtgatgccatgaagccaattgatggacggaaacttttggagtcc
ctgatgaaaaccaattttactggggtttctggagatacgatcctattcgatgagaatgga
gactctccaggaaggtatgaaataatgaatttcaaggaaatgggaaaagattactttgat
tatatcaacgttggaagttgggacaatggagaattaaaaatggatgatgatgaagtatgg
tccaagaaaagcaacatcatcagatctgtgtgcagtgaaccatgtgagaaaggccagatc
aaggtgatccgaaagggagaagtcagctgttgttggacctgtacaccttgtaaggagaat
gagtatgtctttgatgagtacacatgcaaggcatgccaactggggtcttggcccactgat
gatctcacaggttgtgacttgatcccagtacagtatcttcgatggggtgaccctgaaccc
attgcagctgtggtgtttgcctgccttggcctcctggccaccctgtttgttactgtagtc
ttcatcatttaccgtgatacaccagtagtcaagtcctcaagcagggaactctgctacatt
atccttgctggcatctgcctgggctacttatgtaccttctgcctcattgcgaagcccaaa
cagatttactgctaccttcagagaattggcattggtctctccccagccatgagctactca
gcccttgtaacaaagaccaaccgtattgcaaggatcctggctggcagcaagaagaagatc
tgtaccaaaaagcccagattcatgagtgcctgtgcccagctagtgattgctttcattctc
atatgcatccagttgggcatcatcgttgccctctttataatggagcctcctgacataatg
catgactacccaagcattcgagaagtctacctgatctgtaacaccaccaacctaggagtt
gtcactccacttggatacaatggattgttgattttgagctgcaccttctatgcgttcaag
accagaaatgttccagctaacttcaacgaggccaagtatatcgccttcacaatgtacacg
acctgcattatatggctagcttttgtgccaatctactttggcagcaactacaaaatcatc
accatgtgtttctcggtcagcctcagtgccacagtggccctaggctgcatgtttgtgccg
aaggtgtacatcatcctggccaaaccagagagaaacgtgcgcagcgccttcaccacatct
accgtggtgcgcatgcatgtaggggatggcaagtcatcctccgcagccagcagatccagc
agcctagtcaacctgtggaagagaaggggctcctctggggaaaccttaaggtacaaagac
aggagactggcccagcacaagtcggaaatagagtgtttcacccccaaagggagtatgggg
aatggtgggagagcaacaatgagcagttccaatggaaaatccgtcacgtgggcccagaat
gagaagagcagccgggggcagcacctgtggcagcgcctgtccatccacatcaacaagaaa
gaaaaccccaaccaaacggccgtcatcaagcccttccccaagagcacggagagccgtggc
ctgggcgctggcgctggcgcaggcgggagcgctgggggcgtgggggccacgggcggtgcg
ggctgcgcaggcgccggcccaggcgggcccgagtccccagacgccggccccaaggcgctg
tatgatgtggccgaggctgaggagcacttcccggcgcccgcgcggccgcgctcaccgtcg
cccatcagcacgctgagccaccgcgcgggctcggccagccgcacggacgacgatgtgccg
tcgctgcactcggagcctgtggcgcgcagcagctcctcgcagggctccctcatggagcag
atcagcagtgtggtcacccgcttcacggccaacatcagcgagctcaactccatgatgctg
tccaccgcggcccccagccccggcgtcggcgccccgctctgctcgtcctacctgatcccc
aaagagatccagttgcccacgaccatgacgacctttgccgaaatccagcctctgccggcc
atcgaagtcacgggaggcgcgcagcccgcggcaggggcgcaggcggctggggacgcggcc
cgggagagccccgcggccggtcccgaggctgcggccgccaagccagacctggaggagctg
gtggctctcaccccgccgtcccccttcagagactcggtggactcggggagcacaaccccc
aactcgccagtgtccgagtcggccctctgtatcccgtcgtctcccaaatatgacactctt
atcataagagattacactcagagctcctcgtcgttgtga

KEGG   Homo sapiens (human): 2916
Entry
2916              CDS       T01001                                 

Gene name
GRM6, CSNB1B, GPRC1F, MGLUR6, mGlu6
Definition
(RefSeq) glutamate metabotropic receptor 6
  KO
K04608  metabotropic glutamate receptor 6
Organism
hsa  Homo sapiens (human)
Pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
Disease
H00787  Congenital stationary night blindness
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    2916 (GRM6)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2916 (GRM6)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2916 (GRM6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    2916 (GRM6)
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2916 (GRM6)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     2916 (GRM6)
G protein-coupled receptors [BR:hsa04030]
 Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   2916 (GRM6)
SSDB
Motif
Pfam: ANF_receptor 7tm_3 NCD3G Peripla_BP_6
Other DBs
NCBI-GeneID: 2916
NCBI-ProteinID: NP_000834
OMIM: 604096
HGNC: 4598
Ensembl: ENSG00000113262
Vega: OTTHUMG00000130889
Pharos: O15303(Tbio)
UniProt: O15303
LinkDB
Position
5q35.3
AA seq 877 aa
MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQL
KKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGR
GDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPE
LSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREA
GGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGH
FLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEF
WEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQ
ALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNG
SASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHC
EACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVAT
TTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLG
TTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARP
PHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFN
EAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKT
YVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
NT seq 2634 nt   +upstreamnt  +downstreamnt
atggcgcggccccggagagcccgggagccgctgctcgtggcgctgctgccgctggcgtgg
ctggcgcaggcgggcctggcgcgcgcggcgggctctgtgcgcctggcgggcggcctgacg
ctgggcggcctgttcccggtgcacgcgcggggcgcggcgggccgggcgtgcgggcagctg
aagaaggagcagggcgtgcaccggctggaggccatgctgtacgcgctggaccgcgtcaac
gccgaccccgagctgctgcccggcgtgcgcctgggcgcgcggctgctggacacctgctcg
cgggacacctacgcgctggagcaggcgctgagcttcgtgcaggcgctgatccgcggccgc
ggcgacggcgacgaggtgggcgtgcgctgcccgggaggcgtccctccgctgcgccccgcg
ccccccgagcgcgtcgtggccgtcgtgggcgcctcggccagctccgtctccatcatggtc
gccaacgtgctgcgcctgtttgcgataccccagatcagctatgcctccacagccccggag
ctcagcgactccacacgctatgacttcttctcccgggtggtgccacccgactcctaccag
gcgcaggccatggtggacatcgtgagggcactgggatggaactatgtgtccacgctggcc
tccgagggcaactatggcgaaagtggggttgaggccttcgttcagatctcccgagaggct
gggggggtctgtattgcccagtctatcaagattcccagggaaccaaagccaggagagttc
agcaaggtgatcaggagactcatggagacgcccaacgcccggggcatcatcatctttgcc
aatgaggatgacatcaggcgggtcctggaggcagctcgccaggccaacctgaccggccac
ttcctgtgggtcggctcagacagctggggagccaagacctcacccatcttgagcctggag
gacgtggccgttggggccatcaccatcctgcccaaaagggcctccatcgacggatttgac
cagtacttcatgactcgatccctggagaacaaccgcaggaacatctggttcgccgagttc
tgggaagagaattttaactgcaaactgaccagctcaggtacccagtcagacgattccacc
cgcaaatgcacaggcgaggaacgcatcggccgggactccacctacgagcaggagggcaag
gtgcagtttgtgattgatgcggtgtacgccattgcccacgccctccacagcatgcaccag
gcgctctgccctgggcacacaggcctgtgcccggcgatggaacccactgatgggcggatg
cttctgcagtacattcgagctgtccgcttcaatggcagcgcaggaacccctgtgatgttc
aacgagaacggagatgcgcccgggcggtacgacatcttccagtaccaggcgaccaatggc
agtgccagcagtggcgggtaccaggcagtgggccagtgggcagagaccctcagactggat
gtggaggccctgcagtggtctggcgacccccacgaggtgccctcgtctctgtgcagcctg
ccctgcgggccgggggagcggaagaagatggtgaagggcgtcccctgctgttggcactgc
gaggcctgtgacgggtaccgcttccaggtggacgagttcacatgcgaggcctgtcctggg
gacatgaggcccacgcccaaccacacgggctgccgccccacacctgtggtgcgcctgagc
tggtcctccccctgggcagccccgccgctcctcctggccgtgctgggcatcgtggccact
accacggtggtggccaccttcgtgcggtacaacaacacgcccatcgtccgggcctcgggc
cgagagctcagctacgtcctcctcaccggcatcttcctcatctacgccatcaccttcctc
atggtggctgagcctggggccgcggtctgtgccgcccgcaggctcttcctgggcctgggc
acgaccctcagctactctgccctgctcaccaagaccaaccgtatctaccgcatctttgag
cagggcaagcgctcggtcacaccccctcccttcatcagccccacctcacagctggtcatc
accttcagcctcacctccctgcaggtggtggggatgatagcatggctgggggcccggccc
ccacacagcgtgattgactatgaggaacagcggacggtggaccccgagcaggccagaggg
gtgctcaagtgcgacatgtcggatctgtctctcatcggctgcctgggctacagcctcctg
ctcatggtcacgtgcacagtgtacgccatcaaggcccgtggcgtgcccgagaccttcaac
gaggccaagcccatcggcttcaccatgtacaccacctgcatcatctggctggcattcgtg
cccatcttctttggcactgcccagtcagctgaaaagatctacatccagacaaccacgcta
accgtgtccttgagcctgagtgcctcggtgtccctcggcatgctctacgtacccaaaacc
tacgtcatcctcttccatccagagcagaatgtgcagaagcgaaagcggagcctcaaggcc
acctccacggtggcagccccacccaagggcgaggatgcagaggcccacaagtag

KEGG   Homo sapiens (human): 2917
Entry
2917              CDS       T01001                                 

Gene name
GRM7, GLUR7, GPRC1G, MGLU7, MGLUR7, NEDSHBA, PPP1R87
Definition
(RefSeq) glutamate metabotropic receptor 7
  KO
K04609  metabotropic glutamate receptor 7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
Disease
H02470  Neurodevelopmental disorder with structural brain abnormalities
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    2917 (GRM7)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2917 (GRM7)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2917 (GRM7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    2917 (GRM7)
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2917 (GRM7)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     2917 (GRM7)
G protein-coupled receptors [BR:hsa04030]
 Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   2917 (GRM7)
SSDB
Motif
Pfam: ANF_receptor 7tm_3 NCD3G Peripla_BP_6 DUF2318
Other DBs
NCBI-GeneID: 2917
NCBI-ProteinID: NP_000835
OMIM: 604101
HGNC: 4599
Ensembl: ENSG00000196277
Vega: OTTHUMG00000125549
Pharos: Q14831(Tbio)
UniProt: Q14831 B2R693 Q59G95
LinkDB
Structure
PDB: 
5C5C 3MQ4

Position
3p26.1
AA seq 915 aa
MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK
GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL
TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA
STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ
ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK
RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR
NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH
ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIF
QYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP
CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAML
GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV
FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW
FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV
PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML
YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS
PAAKKKYVSYNNLVI
NT seq 2748 nt   +upstreamnt  +downstreamnt
atggtccagctgaggaagctgctccgcgtcctgactttgatgaagttcccctgctgcgtg
ctggaggtgctcctgtgcgcgctggcggcggcggcgcgcggccaggagatgtacgccccg
cactcaatccggatcgagggggacgtcaccctcggggggctgttccccgtgcacgccaag
ggtcccagcggagtgccctgcggcgacatcaagagggaaaacgggatccacaggctggaa
gcgatgctctacgccctggaccagatcaacagtgatcccaacctactgcccaacgtgacg
ctgggcgcgcggatcctggacacttgttccagggacacttacgcgctcgaacagtcgctt
actttcgtccaggcgctcatccagaaggacacctccgacgtgcgctgcaccaacggcgaa
ccgccggttttcgtcaagccggagaaagtagttggagtgattggggcttcggggagttcg
gtctccatcatggtagccaacatcctgaggctcttccagatcccccagattagttatgca
tcaacggcacccgagctaagtgatgaccggcgctatgacttcttctctcgcgtggtgcca
cccgattccttccaagcccaggccatggtagacattgtaaaggccctaggctggaattat
gtgtctaccctcgcatcggaaggaagttatggagagaaaggtgtggagtccttcacgcag
atttccaaagaggcaggtggactctgcattgcccagtccgtgagaatcccccaggaacgc
aaagacaggaccattgactttgatagaattatcaaacagctcctggacacccccaactcc
agggccgtcgtgatttttgccaacgatgaggatataaagcagatccttgcagcagccaaa
agagctgaccaagttggccattttctttgggtgggatcagacagctggggatccaaaata
aacccactgcaccagcatgaagatatcgcagaaggggccatcaccattcagcccaagcga
gccacggtggaagggtttgatgcctactttacgtcccgtacacttgaaaacaacagaaga
aatgtatggtttgccgaatactgggaggaaaacttcaactgcaagttgacgattagtggg
tcaaaaaaagaagacacagatcgcaaatgcacaggacaggagagaattggaaaagattcc
aactatgagcaggagggtaaagtccagttcgtgattgacgcagtctatgctatggctcac
gcccttcaccacatgaacaaggatctctgtgctgactaccggggtgtctgcccagagatg
gagcaagctggaggcaagaagttgctgaagtatatacgcaatgttaatttcaatggtagt
gctggcactccagtgatgtttaacaagaacggggatgcacctgggcgttatgacatcttt
cagtaccagaccacaaacaccagcaacccgggttaccgtctgatcgggcagtggacagac
gaacttcagctcaatatagaagacatgcagtggggtaaaggagtccgagagatacccgcc
tcagtgtgcacactaccatgtaagccaggacagagaaagaagacacagaaaggaactcct
tgctgttggacctgtgagccttgcgatggttaccagtaccagtttgatgagatgacatgc
cagcattgcccctatgaccagaggcccaatgaaaatcgaaccggatgccaggatattccc
atcatcaaactggagtggcactccccctgggctgtgattcctgtcttcctggcaatgttg
gggatcattgccaccatctttgtcatggccactttcatccgctacaatgacacgcccatt
gtccgggcatctgggcgggaactcagctatgttcttttgacgggcatctttctttgctac
atcatcactttcctgatgattgccaaaccagatgtggcagtgtgttctttccggcgagtt
ttcttgggcttgggtatgtgcatcagttatgcagccctcttgacgaaaacaaatcggatt
tatcgcatatttgagcagggcaagaaatcagtaacagctcccagactcataagcccaaca
tcacaactggcaatcacttccagtttaatatcagttcagcttctaggggtgttcatttgg
tttggtgttgatccacccaacatcatcatagactatgatgaacacaagacaatgaaccct
gagcaagccagaggggttctcaagtgtgacattacagatctccaaatcatttgctccttg
ggatatagcattcttctcatggtcacatgtactgtgtatgccatcaagactcggggtgta
cccgagaattttaacgaagccaagcccattggattcactatgtacacgacatgtatagta
tggcttgccttcattccaattttttttggcaccgctcaatcagcggaaaagctctacata
caaactaccacgcttacaatctccatgaacctaagtgcatcagtggcgctggggatgcta
tacatgccgaaagtgtacatcatcattttccaccctgaactcaatgtccagaaacggaag
cgaagcttcaaggcggtagtcacagcagccaccatgtcatcgaggctgtcacacaaaccc
agtgacagacccaacggtgaggcaaagaccgagctctgtgaaaacgtagacccaaacagc
cctgctgcaaaaaagaagtatgtcagttataataacctggttatctaa

KEGG   Homo sapiens (human): 2918
Entry
2918              CDS       T01001                                 

Gene name
GRM8, GLUR8, GPRC1H, MGLUR8, mGlu8
Definition
(RefSeq) glutamate metabotropic receptor 8
  KO
K04610  metabotropic glutamate receptor 8
Organism
hsa  Homo sapiens (human)
Pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    2918 (GRM8)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2918 (GRM8)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2918 (GRM8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    2918 (GRM8)
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2918 (GRM8)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     2918 (GRM8)
G protein-coupled receptors [BR:hsa04030]
 Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   2918 (GRM8)
SSDB
Motif
Pfam: ANF_receptor 7tm_3 NCD3G Peripla_BP_6
Other DBs
NCBI-GeneID: 2918
NCBI-ProteinID: NP_000836
OMIM: 601116
HGNC: 4600
Ensembl: ENSG00000179603
Vega: OTTHUMG00000022888
Pharos: O00222(Tchem)
UniProt: O00222
LinkDB
Structure
PDB: 
6BSZ 6BT5 6E5V

Position
7q31.33
AA seq 908 aa
MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN
KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF
VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC
FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTY
ISYSNHSI
NT seq 2727 nt   +upstreamnt  +downstreamnt
atggtatgcgagggaaagcgatcagcctcttgcccttgtttcttcctcttgaccgccaag
ttctactggatcctcacaatgatgcaaagaactcacagccaggagtatgcccattccata
cgggtggatggggacattattttggggggtctcttccctgtccacgcaaagggagagaga
ggggtgccttgtggggagctgaagaaggaaaaggggattcacagactggaggccatgctt
tatgcaattgaccagattaacaaggaccctgatctcctttccaacatcactctgggtgtc
cgcatcctcgacacgtgctctagggacacctatgctttggagcagtctctaacattcgtg
caggcattaatagagaaagatgcttcggatgtgaagtgtgctaatggagatccacccatt
ttcaccaagcccgacaagatttctggcgtcataggtgctgcagcaagctccgtgtccatc
atggttgctaacattttaagactttttaagatacctcaaatcagctatgcatccacagcc
ccagagctaagtgataacaccaggtatgactttttctctcgagtggttccgcctgactcc
taccaagcccaagccatggtggacatcgtgacagcactgggatggaattatgtttcgaca
ctggcttctgaggggaactatggtgagagcggtgtggaggccttcacccagatctcgagg
gagattggtggtgtttgcattgctcagtcacagaaaatcccacgtgaaccaagacctgga
gaatttgaaaaaattatcaaacgcctgctagaaacacctaatgctcgagcagtgattatg
tttgccaatgaggatgacatcaggaggatattggaagcagcaaaaaaactaaaccaaagt
gggcattttctctggattggctcagatagttggggatccaaaatagcacctgtctatcag
caagaggagattgcagaaggggctgtgacaattttgcccaaacgagcatcaattgatgga
tttgatcgatactttagaagccgaactcttgccaataatcgaagaaatgtgtggtttgca
gaattctgggaggagaattttggctgcaagttaggatcacatgggaaaaggaacagtcat
ataaagaaatgcacagggctggagcgaattgctcgggattcatcttatgaacaggaagga
aaggtccaatttgtaattgatgctgtatattccatggcttacgccctgcacaatatgcac
aaagatctctgccctggatacattggcctttgtccacgaatgagtaccattgatgggaaa
gagctacttggttatattcgggctgtaaattttaatggcagtgctggcactcctgtcact
tttaatgaaaacggagatgctcctggacgttatgatatcttccagtatcaaataaccaac
aaaagcacagagtacaaagtcatcggccactggaccaatcagcttcatctaaaagtggaa
gacatgcagtgggctcatagagaacatactcacccggcgtctgtctgcagcctgccgtgt
aagccaggggagaggaagaaaacggtgaaaggggtcccttgctgctggcactgtgaacgc
tgtgaaggttacaactaccaggtggatgagctgtcctgtgaactttgccctctggatcag
agacccaacatgaaccgcacaggctgccagcttatccccatcatcaaattggagtggcat
tctccctgggctgtggtgcctgtgtttgttgcaatattgggaatcatcgccaccaccttt
gtgatcgtgacctttgtccgctataatgacacacctatcgtgagggcttcaggacgcgaa
cttagttacgtgctcctaacggggatttttctctgttattcaatcacgtttttaatgatt
gcagcaccagatacaatcatatgctccttccgacgggtcttcctaggacttggcatgtgt
ttcagctatgcagcccttctgaccaaaacaaaccgtatccaccgaatatttgagcagggg
aagaaatctgtcacagcgcccaagttcattagtccagcatctcagctggtgatcaccttc
agcctcatctccgtccagctccttggagtgtttgtctggtttgttgtggatcccccccac
atcatcattgactatggagagcagcggacactagatccagagaaggccaggggagtgctc
aagtgtgacatttctgatctctcactcatttgttcacttggatacagtatcctcttgatg
gtcacttgtactgtttatgccattaaaacgagaggtgtcccagagactttcaatgaagcc
aaacctattggatttaccatgtataccacctgcatcatttggttagctttcatccccatc
ttttttggtacagcccagtcagcagaaaagatgtacatccagacaacaacacttactgtc
tccatgagtttaagtgcttcagtatctctgggcatgctctatatgcccaaggtttatatt
ataatttttcatccagaacagaatgttcaaaaacgcaagaggagcttcaaggctgtggtg
acagctgccaccatgcaaagcaaactgatccaaaaaggaaatgacagaccaaatggcgag
gtgaaaagtgaactctgtgagagtcttgaaaccaacacttcctctaccaagacaacatat
atcagttacagcaatcattcaatctga

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