Homo sapiens (human): 2977
Help
Entry
2977 CDS
T01001
Symbol
GUCY1A2, GC-SA2, GUC1A2
Name
(RefSeq) guanylate cyclase 1 soluble subunit alpha 2
KO
K12318
guanylate cyclase soluble subunit alpha [EC:
4.6.1.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa04022
cGMP-PKG signaling pathway
hsa04270
Vascular smooth muscle contraction
hsa04540
Gap junction
hsa04611
Platelet activation
hsa04713
Circadian entrainment
hsa04730
Long-term depression
hsa04921
Oxytocin signaling pathway
hsa04924
Renin secretion
hsa04970
Salivary secretion
Drug target
Amyl nitrite:
D00517
<JP>
Cinaciguat:
D07577
Nicorandil:
D01810
<JP>
Olinciguat:
D11475
Praliciguat:
D11274
Riociguat:
D09572
<JP/US>
Vericiguat:
D11051
<JP/US>
Zagociguat:
D12516
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
2977 (GUCY1A2)
09130 Environmental Information Processing
09132 Signal transduction
04022 cGMP-PKG signaling pathway
2977 (GUCY1A2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
2977 (GUCY1A2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
2977 (GUCY1A2)
09152 Endocrine system
04921 Oxytocin signaling pathway
2977 (GUCY1A2)
04924 Renin secretion
2977 (GUCY1A2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
2977 (GUCY1A2)
09154 Digestive system
04970 Salivary secretion
2977 (GUCY1A2)
09156 Nervous system
04730 Long-term depression
2977 (GUCY1A2)
09159 Environmental adaptation
04713 Circadian entrainment
2977 (GUCY1A2)
Enzymes [BR:
hsa01000
]
4. Lyases
4.6 Phosphorus-oxygen lyases
4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
4.6.1.2 guanylate cyclase
2977 (GUCY1A2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Guanylate_cyc
HNOBA
HNOB
Rx_N
Motif
Other DBs
NCBI-GeneID:
2977
NCBI-ProteinID:
NP_000846
OMIM:
601244
HGNC:
4684
Ensembl:
ENSG00000152402
UniProt:
P33402
LinkDB
All DBs
Position
11:complement(106674019..107018476)
Genome browser
AA seq
732 aa
AA seq
DB search
MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPA
PTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQV
IGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNI
CFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYF
HPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKLCSDVSNPGNCSCLTFLIKECENTN
IMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKF
EDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSIL
FLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTH
QALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPM
QVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELS
EEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSP
TTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSY
NIGTMFLRETSL
NT seq
2199 nt
NT seq
+upstream
nt +downstream
nt
atgtctcgaaggaagatttcgtccgagtccttcagctccctgggctccgactacctggag
accagcccggaggaggagggggagtgccccctgtctaggctctgctggaatggcagccgg
agcccgcccgggccgctggagcccagcccggccgcagctgccgctgccgccgccccggcc
ccgaccccggctgcttctgccgccgccgccgctgccactgccggggccaggagggtgcag
cgccggaggcgggtcaacctggactcgctgggcgagagcatcagccgcctgacggcgccc
tcgcctcagacgatacagcagactctcaagaggacactgcagtattatgaacatcaagtt
attggttacagggatgcagaaaagaatttccacaatatctctaacagatgctcctatgca
gaccactccaacaaagaagaaattgaagatgtctcaggaattcttcagtgtactgctaat
atactcggtttgaagtttgaggaaattcaaaaaagatttggtgaagagttctttaatata
tgctttcatgagaatgagagagtccttcgagctgtaggtggcactttgcaggactttttt
aacggctttgatgctttgttggaacacattagaacttcttttggaaaacaggccactctg
gagtcaccatctttcctatgcaaagagctccctgaaggtactctcatgctccactacttc
caccctcaccatattgtggggtttgcaatgctggggatgattaaggctgcaggaaagaag
atctatcggctggatgtggaagtggaacaggttgcaaatgagaagctatgctctgatgtt
tcaaacccaggcaattgtagctgtcttactttccttatcaaagaatgtgaaaatactaat
atcatgaagaaccttccacagggaacctcccaagttcctgcggacctcagaattagcatc
aacaccttctgtagagccttccctttccacttgatgtttgatcccagcatgtcagtcctt
cagttgggggaaggtctaaggaagcagcttcgatgtgacactcacaaagtgctcaagttt
gaggactgcttcgagattgtatctccaaaggttaatgccacctttgaaagggtcctgctg
cgactgtctaccccgtttgtgattagaaccaagcctgaggcttctggctctgaaaataaa
gacaaggtgatggaagtcaaaggacaaatgatccatgttccagaatcaaattccatttta
tttttgggctctccatgtgtggacaagttggatgaactcatgggccgagggctacatctc
tcagacatccctatccatgatgccacccgagatgtcattttggttggtgagcaggcaaag
gcccaagatgggttgaagaaaaggatggataaattaaaggcaactttagaaagaactcac
caggccctggaagaagagaaaaagaagacagtggatcttctatattctattttccctggt
gatgtagcccagcaattatggcaagggcagcaagtacaggccagaaagtttgatgatgtc
accatgctcttttcagacattgttggcttcacagccatatgtgcccagtgtactcccatg
caagtaatcagcatgctgaatgaactgtacaccagatttgaccaccagtgtggatttttg
gatatttataaggtggaaacaataggtgatgcctactgtgttgcagcagggctccacaga
aaaagcctctgccatgctaaacccattgctctgatggccttgaagatgatggaactttca
gaagaggtgctgacacctgatggaagaccgattcagatgaggataggaattcactcaggc
tccgtgctggctggagttgttggggtgcgaatgccacgttattgcctgtttggaaataat
gtcacactggcaagcaaattcgagtcgggaagtcaccctcggcgcatcaatgtcagccca
accacttaccaattattaaaacgagaagaaagtttcacattcattccgcggtctcgtgaa
gagcttccagacaactttccaaaggaaattcctgggatctgctatttcctggaggtaagg
actggtccaaagccaccaaagccttctctttcttcgtcgagaataaaaaaggtttcctac
aacatcggcaccatgttcctccgggagacaagcctctga
Homo sapiens (human): 2982
Help
Entry
2982 CDS
T01001
Symbol
GUCY1A1, GC-S-alpha-1, GC-SA3, GCS-alpha-3, GUC1A3, GUCA3, GUCSA3, GUCY1A3, MYMY6
Name
(RefSeq) guanylate cyclase 1 soluble subunit alpha 1
KO
K12318
guanylate cyclase soluble subunit alpha [EC:
4.6.1.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa04022
cGMP-PKG signaling pathway
hsa04270
Vascular smooth muscle contraction
hsa04540
Gap junction
hsa04611
Platelet activation
hsa04713
Circadian entrainment
hsa04730
Long-term depression
hsa04921
Oxytocin signaling pathway
hsa04924
Renin secretion
hsa04970
Salivary secretion
Disease
H01396
Moyamoya disease
Drug target
Amyl nitrite:
D00517
<JP>
Cinaciguat:
D07577
Nicorandil:
D01810
<JP>
Olinciguat:
D11475
Praliciguat:
D11274
Riociguat:
D09572
<JP/US>
Vericiguat:
D11051
<JP/US>
Zagociguat:
D12516
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
2982 (GUCY1A1)
09130 Environmental Information Processing
09132 Signal transduction
04022 cGMP-PKG signaling pathway
2982 (GUCY1A1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
2982 (GUCY1A1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
2982 (GUCY1A1)
09152 Endocrine system
04921 Oxytocin signaling pathway
2982 (GUCY1A1)
04924 Renin secretion
2982 (GUCY1A1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
2982 (GUCY1A1)
09154 Digestive system
04970 Salivary secretion
2982 (GUCY1A1)
09156 Nervous system
04730 Long-term depression
2982 (GUCY1A1)
09159 Environmental adaptation
04713 Circadian entrainment
2982 (GUCY1A1)
Enzymes [BR:
hsa01000
]
4. Lyases
4.6 Phosphorus-oxygen lyases
4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
4.6.1.2 guanylate cyclase
2982 (GUCY1A1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Guanylate_cyc
HNOBA
HNOB
Motif
Other DBs
NCBI-GeneID:
2982
NCBI-ProteinID:
NP_000847
OMIM:
139396
HGNC:
4685
Ensembl:
ENSG00000164116
UniProt:
Q02108
Structure
PDB
LinkDB
All DBs
Position
4:155666848..155737059
Genome browser
AA seq
690 aa
AA seq
DB search
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
QQGTNSKPCFQKKDVEDGNANFLGKASGID
NT seq
2073 nt
NT seq
+upstream
nt +downstream
nt
atgttctgcacgaagctcaaggatctcaagatcacaggagagtgtcctttctccttactg
gcaccaggtcaagttcctaacgagtcttcagaggaggcagcaggaagctcagagagctgc
aaagcaaccgtgcccatctgtcaagacattcctgagaagaacatacaagaaagtcttcct
caaagaaaaaccagtcggagccgagtctatcttcacactttggcagagagtatttgcaaa
ctgattttcccagagtttgaacggctgaatgttgcacttcagagaacattggcaaagcac
aaaataaaagaaagcaggaaatctttggaaagagaagactttgaaaaaacaattgcagag
caagcagttgcagcaggagttccagtggaggttatcaaagaatctcttggtgaagaggtt
tttaaaatatgttacgaggaagatgaaaacatccttggggtggttggaggcacccttaaa
gattttttaaacagcttcagtacccttctgaaacagagcagccattgccaagaagcagga
aaaaggggcaggcttgaggacgcctccattctatgcctggataaggaggatgattttcta
catgtttactacttcttccctaagagaaccacctccctgattcttcccggcatcataaag
gcagctgctcacgtattatatgaaacggaagtggaagtgtcgttaatgcctccctgcttc
cataatgattgcagcgagtttgtgaatcagccctacttgttgtactccgttcacatgaaa
agcaccaagccatccctgtcccccagcaaaccccagtcctcgctggtgattcccacatcg
ctattctgcaagacatttccattccatttcatgtttgacaaagatatgacaattctgcaa
tttggcaatggcatcagaaggctgatgaacaggagagactttcaaggaaagcctaatttt
gaagaatactttgaaattctgactccaaaaatcaaccagacgtttagcgggatcatgact
atgttgaatatgcagtttgttgtacgagtgaggagatgggacaactctgtgaaaaaatct
tcaagggttatggacctcaaaggccaaatgatctacattgttgaatccagtgcaatcttg
tttttggggtcaccctgtgtggacagattagaagattttacaggacgagggctctacctc
tcagacatcccaattcacaatgcactgagggatgtggtcttaataggggaacaagcccga
gctcaagatggcctgaagaagaggctggggaagctgaaggctacccttgagcaagcccac
caagccctggaggaggagaagaaaaagacagtagaccttctgtgctccatatttccctgt
gaggttgctcagcagctgtggcaagggcaagttgtgcaagccaagaagttcagtaatgtc
accatgctcttctcagacatcgttgggttcactgccatctgctcccagtgctcaccgctg
caggtcatcaccatgctcaatgcactgtacactcgcttcgaccagcagtgtggagagctg
gatgtctacaaggtggagaccattggcgatgcctattgtgtagctgggggattacacaaa
gagagtgatactcatgctgttcagatagcgctgatggccctgaagatgatggagctctct
gatgaagttatgtctccccatggagaacctatcaagatgcgaattggactgcactctgga
tcagtttttgctggcgtcgttggagttaaaatgccccgttactgtctttttggaaacaat
gtcactctggctaacaaatttgagtcctgcagtgtaccacgaaaaatcaatgtcagccca
acaacttacagattactcaaagactgtcctggtttcgtgtttacccctcgatcaagggag
gaacttccaccaaacttccctagtgaaatccccggaatctgccattttctggatgcttac
caacaaggaacaaactcaaaaccatgcttccaaaagaaagatgtggaagatggcaatgcc
aattttttaggcaaagcatcaggaatagattag
Homo sapiens (human): 2983
Help
Entry
2983 CDS
T01001
Symbol
GUCY1B1, GC-S-beta-1, GC-SB3, GUC1B3, GUCB3, GUCSB3, GUCY1B3
Name
(RefSeq) guanylate cyclase 1 soluble subunit beta 1
KO
K12319
guanylate cyclase soluble subunit beta [EC:
4.6.1.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa04022
cGMP-PKG signaling pathway
hsa04270
Vascular smooth muscle contraction
hsa04540
Gap junction
hsa04611
Platelet activation
hsa04713
Circadian entrainment
hsa04730
Long-term depression
hsa04921
Oxytocin signaling pathway
hsa04924
Renin secretion
hsa04970
Salivary secretion
Drug target
Amyl nitrite:
D00517
<JP>
Cinaciguat:
D07577
Nicorandil:
D01810
<JP>
Olinciguat:
D11475
Praliciguat:
D11274
Riociguat:
D09572
<JP/US>
Vericiguat:
D11051
<JP/US>
Zagociguat:
D12516
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
2983 (GUCY1B1)
09130 Environmental Information Processing
09132 Signal transduction
04022 cGMP-PKG signaling pathway
2983 (GUCY1B1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
2983 (GUCY1B1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
2983 (GUCY1B1)
09152 Endocrine system
04921 Oxytocin signaling pathway
2983 (GUCY1B1)
04924 Renin secretion
2983 (GUCY1B1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
2983 (GUCY1B1)
09154 Digestive system
04970 Salivary secretion
2983 (GUCY1B1)
09156 Nervous system
04730 Long-term depression
2983 (GUCY1B1)
09159 Environmental adaptation
04713 Circadian entrainment
2983 (GUCY1B1)
Enzymes [BR:
hsa01000
]
4. Lyases
4.6 Phosphorus-oxygen lyases
4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
4.6.1.2 guanylate cyclase
2983 (GUCY1B1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Guanylate_cyc
HNOBA
HNOB
Motif
Other DBs
NCBI-GeneID:
2983
NCBI-ProteinID:
NP_000848
OMIM:
139397
HGNC:
4687
Ensembl:
ENSG00000061918
UniProt:
Q02153
Structure
PDB
LinkDB
All DBs
Position
4:155759021..155807811
Genome browser
AA seq
619 aa
AA seq
DB search
MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
VWFLSRKNTGTEETKQDDD
NT seq
1860 nt
NT seq
+upstream
nt +downstream
nt
atgtacggatttgtgaatcacgccctggagttgctggtgatccgcaattacggccccgag
gtgtgggaagacatcaaaaaagaggcacagttagatgaagaaggacagtttcttgtcaga
ataatatatgatgactccaaaacttatgatttggttgctgctgcaagcaaagtcctcaat
ctcaatgctggagaaatcctccaaatgtttgggaagatgtttttcgtcttttgccaagaa
tctggttatgatacaatcttgcgtgtcctgggctctaatgtcagagaatttctacagaac
cttgatgctctgcacgaccaccttgctaccatctacccaggaatgcgtgcaccttccttt
aggtgcactgatgcagaaaagggcaaaggactcattttgcactactactcagagagagaa
ggacttcaggatattgtcattggaatcatcaaaacagtggcacaacaaatccatggcact
gaaatagacatgaaggttattcagcaaagaaatgaagaatgtgatcatactcaattttta
attgaagaaaaagagtcaaaagaagaggatttttatgaagatcttgacagatttgaagaa
aatggtacccaggaatcacgcatcagcccatatacattctgcaaagcttttccttttcat
ataatatttgaccgggacctagtggtcactcagtgtggcaatgctatatacagagttctc
ccccagctccagcctgggaattgcagccttctgtctgtcttctcgctggttcgtcctcat
attgatattagtttccatgggatcctttctcacatcaatactgtttttgtattgagaagc
aaggaaggattgttggatgtggagaaattagaatgtgaggatgaactgactgggactgag
atcagctgcttacgtctcaagggtcaaatgatctacttacctgaagcagatagcatactt
tttctatgttcaccaagtgtcatgaacctggacgatttgacaaggagagggctgtatcta
agtgacatccctctgcatgatgccacgcgcgatcttgttcttttgggagaacaatttaga
gaggaatacaaactcacccaagaactggaaatcctcactgacaggctacagctcacgtta
agagccctggaagatgaaaagaaaaagacagacacattgctgtattctgtccttcctccg
tctgttgccaatgagctgcggcacaagcgtccagtgcctgccaaaagatatgacaatgtg
accatcctctttagtggcattgtgggcttcaatgctttctgtagcaagcatgcatctgga
gaaggagccatgaagatcgtcaacctcctcaacgacctctacaccagatttgacacactg
actgattcccggaaaaacccatttgtttataaggtggagactgttggtgacaagtatatg
acagtgagtggtttaccagagccatgcattcaccatgcacgatccatctgccacctggcc
ttggacatgatggaaattgctggccaggttcaagtagatggtgaatctgttcagataaca
atagggatacacactggagaggtagttacaggtgtcataggacagcggatgcctcgatac
tgtctttttgggaatactgtcaacctcacaagccgaacagaaaccacaggagaaaaggga
aaaataaatgtgtctgaatatacatacagatgtcttatgtctccagaaaattcagatcca
caattccacttggagcacagaggcccagtgtccatgaagggcaaaaaagaaccaatgcaa
gtttggtttctatccagaaaaaatacaggaacagaggaaacaaagcaggatgatgactga
DBGET
integrated database retrieval system
