KEGG   Homo sapiens (human): 3292
Entry
3292              CDS       T01001                                 
Symbol
HSD17B1, 17-beta-HSD, 20-alpha-HSD, E2DH, EDH17B2, EDHB17, HSD17, SDR28C1
Name
(RefSeq) hydroxysteroid 17-beta dehydrogenase 1
  KO
K00044  17beta-estradiol 17-dehydrogenase [EC:1.1.1.62]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa01100  Metabolic pathways
hsa04913  Ovarian steroidogenesis
Drug target
Linustedastat: D13078
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    3292 (HSD17B1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    3292 (HSD17B1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     3292 (HSD17B1)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR Epimerase GDP_Man_Dehyd DUF1776 Plexin_cytopl
Other DBs
NCBI-GeneID: 3292
NCBI-ProteinID: NP_000404
OMIM: 109684
HGNC: 5210
Ensembl: ENSG00000108786
UniProt: P14061
Structure
LinkDB
Position
17:42552923..42555214
AA seq 328 aa
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV
RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH
LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV
FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG
GAGPGAEDEAGRGAVGDPELGDPPAAPQ
NT seq 987 nt   +upstreamnt  +downstreamnt
atggcccgcaccgtggtgctcatcaccggctgttcctcgggcatcggcctgcacttggcc
gtacgtctggcttcagatccatcccagagcttcaaagtgtatgccacgttgagggacctg
aaaacacagggccggctgtgggaggcggcccgggccctggcatgccctccgggatccctg
gagacgttgcagctggacgtaagggactcaaaatccgtggccgctgcccgggaacgcgtg
actgagggccgcgtggacgtgctggtgtgtaacgcaggcctgggcctgctggggccgctg
gaggcgctgggggaggacgccgtggcctctgtgctggacgtgaatgtagtagggactgtg
cggatgctgcaggccttcctgccagacatgaagaggcgcggttcgggacgcgtgttggtg
accgggagcgtgggaggattgatggggctgcctttcaatgacgtttattgcgccagcaag
ttcgcgctcgaaggcttatgcgagagtctggcggttctgctgctgccctttggggtccac
ttgagcctgatcgagtgcggcccagtgcacaccgccttcatggagaaggtgttgggcagc
ccagaggaggtgctggaccgcacggacatccacaccttccaccgcttctaccaatacctc
gcccacagcaagcaagtctttcgcgaggcggcgcagaaccctgaggaggtggcggaggtc
ttcctcaccgctttgcgcgccccgaagccgaccctgcgctacttcaccaccgagcgcttc
ctgcccctgctgcggatgcgcctggacgaccccagcggctccaactacgtcaccgccatg
caccgggaagtgttcggcgacgttccggcaaaggccgaggctggggccgaggctgggggc
ggggccgggcctggggcagaggacgaggccgggcgcggtgcggtgggggaccctgagctc
ggcgatcctccggccgccccgcagtaa

KEGG   Homo sapiens (human): 340811
Entry
340811            CDS       T01001                                 
Symbol
AKR1C8, AKR1C8P, AKR1CL1
Name
(RefSeq) aldo-keto reductase family 1 member C8
  KO
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00590  Arachidonic acid metabolism
hsa00790  Folate biosynthesis
hsa01100  Metabolic pathways
hsa04913  Ovarian steroidogenesis
hsa05208  Chemical carcinogenesis - reactive oxygen species
Module
hsa_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
hsa_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    340811 (AKR1C8)
   00590 Arachidonic acid metabolism
    340811 (AKR1C8)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    340811 (AKR1C8)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    340811 (AKR1C8)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    340811 (AKR1C8)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     340811 (AKR1C8)
    1.1.1.188  prostaglandin-F synthase
     340811 (AKR1C8)
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     340811 (AKR1C8)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     340811 (AKR1C8)
SSDB
Motif
Pfam: Aldo_ket_red E2-E1mid DUF5376
Other DBs
NCBI-GeneID: 340811
NCBI-ProteinID: NP_001382901
HGNC: 23469
Ensembl: ENSG00000264006
UniProt: Q5T2L2
LinkDB
Position
10:complement(5115813..5185150)
AA seq 326 aa
MMTDLKQSHSVRLNDGPFMPVLGFGTYAPDHTPKSQAAEATKVAIDVGFRHIDSAYLYQN
EEEVGQAIWEKIADGTVKREEIFYTIKLWATFFRAELVHPALERSLKKLGPDYVDLFIIH
VPFAMKPGKELLPKDASGEIILETVELCDTWEALEKCKEAGLTRSIGVSNFNHKLLELIL
NKPGLKYKPTCNQVECHPYLNQSKLLEFCKSKDIVLVAYSALGSQRDPQWVDPDCPHLLE
EPILKSIAKKHSGSPGQVALRYQLQRGVVVLAKSFSQERIKENFQIFDFELTPEDMKAID
GLNRNLRYDKLQFAANHPYFPFSEEY
NT seq 981 nt   +upstreamnt  +downstreamnt
atgatgacggatctgaagcaaagccattcagtgaggctgaatgatggacccttcatgcca
gtgctgggatttggcacttatgctcctgatcatactcccaaaagccaggctgccgaggcc
accaaagtggctattgacgtaggcttccgccatattgattcagcatacttataccaaaat
gaggaggaggttggacaggccatttgggagaagatcgctgatggtaccgtcaagagagag
gaaatattctacaccatcaagctttgggctactttctttcgggcagaattggttcacccg
gccctagaaaggtcactgaagaaacttggaccggactatgtagatctcttcattattcat
gtaccatttgctatgaagcctgggaaagaattactgccaaaggatgccagtggagagatt
attttagaaactgtggagctttgtgacacttgggaggccctggagaagtgcaaagaagca
ggtttaaccaggtccattggggtgtccaatttcaatcacaagctgctggaactcatcctc
aacaagccagggctcaagtacaagcccacctgcaaccaggtggaatgtcacccttacctc
aaccagagcaaactcctggagttctgcaagtccaaggacattgttctagttgcctacagt
gccctgggatcccaaagagacccacagtgggtggatcccgactgcccacatctcttggag
gagccgatcttgaaatccattgccaagaaacacagtggaagcccaggccaggtcgccctg
cgctaccagctgcagcggggagtggtggtgctggccaagagcttctctcaggagagaatc
aaagagaacttccagatttttgactttgagttgactccagaggacatgaaagccattgat
ggcctcaacagaaatctccgatatgacaagttacaatttgctgctaatcacccttatttt
ccattttctgaagaatattga

KEGG   Homo sapiens (human): 8644
Entry
8644              CDS       T01001                                 
Symbol
AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS
Name
(RefSeq) aldo-keto reductase family 1 member C3
  KO
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00590  Arachidonic acid metabolism
hsa00790  Folate biosynthesis
hsa01100  Metabolic pathways
hsa04913  Ovarian steroidogenesis
hsa05208  Chemical carcinogenesis - reactive oxygen species
Module
hsa_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
hsa_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Network
nt06019  Steroid hormone biosynthesis
nt06226  KEAP1-NRF2 signaling (cancer)
nt06251  CYP-mediated ROS formation (cancer)
  Element
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
N01413  Metals to KEAP1-NRF2 signalig pathway
N01541  Testosterone biosynthesis
N01802  Dihydrotestosterone biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    8644 (AKR1C3)
   00590 Arachidonic acid metabolism
    8644 (AKR1C3)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    8644 (AKR1C3)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    8644 (AKR1C3)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    8644 (AKR1C3)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     8644 (AKR1C3)
    1.1.1.188  prostaglandin-F synthase
     8644 (AKR1C3)
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     8644 (AKR1C3)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     8644 (AKR1C3)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 8644
NCBI-ProteinID: NP_001240837
OMIM: 603966
HGNC: 386
Ensembl: ENSG00000196139
UniProt: P42330 A0A0A0MSS8
Structure
LinkDB
Position
10:5048781..5107686
AA seq 323 aa
MDSKHQCLKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY
NT seq 972 nt   +upstreamnt  +downstreamnt
atggattcaaaacatcagtgtttgaagctaaatgatggtcacttcatgcctgtcctggga
tttggcacctatgcacctccagaggttccgagaagtaaagctttggaggtcacaaaatta
gcaatagaagctgggttccgccatatagattctgctcatttatacaataatgaggagcag
gttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattc
tacacttcaaagctttggtccacttttcatcgaccagagttggtccgaccagccttggaa
aactcactgaagaaagctcaattggactatgttgacctctatcttattcattctccaatg
tctctaaagccaggtgaggaactttcaccaacagatgaaaatggaaaagtaatatttgac
atagtggatctctgtaccacctgggaggccatggagaagtgtaaggatgcaggattggcc
aagtccattggggtgtcaaacttcaaccgcaggcagctggagatgatcctcaacaagcca
ggactcaagtacaagcctgtctgcaaccaggtagaatgtcatccgtatttcaaccggagt
aaattgctagatttctgcaagtcgaaagatattgttctggttgcctatagtgctctggga
tctcaacgagacaaacgatgggtggacccgaactccccggtgctcttggaggacccagtc
ctttgtgccttggcaaaaaagcacaagcgaaccccagccctgattgccctgcgctaccag
ctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcgcatcagacagaac
gtgcaggtttttgagttccagttgactgcagaggacatgaaagccatagatggcctagac
agaaatctccactattttaacagtgatagttttgctagccaccctaattatccatattca
gatgaatattaa

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