Homo sapiens (human): 3702 Help Entry 3702              CDS       T01001                                  Symbol ITK, EMT, LPFS1, LYK, PSCTK2 Name (RefSeq) IL2 inducible T cell kinase   KO K07363   IL2-inducible T-cell kinase [EC:2.7.10.2] Organism hsa  Homo sapiens (human) Pathway hsa04062   Chemokine signaling pathway hsa04660   T cell receptor signaling pathway hsa04670   Leukocyte transendothelial migration Disease H00107   Other well-defined immunodeficiency syndromes H01970   Lymphoproliferative syndrome Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09151 Immune system    04660 T cell receptor signaling pathway     3702 (ITK)    04670 Leukocyte transendothelial migration     3702 (ITK)    04062 Chemokine signaling pathway     3702 (ITK)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     3702 (ITK) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      3702 (ITK) Protein kinases [BR:hsa01001]  Non-receptor tyrosine kinases   TEC family    3702 (ITK) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase SH2 PH SH3_1 BTK SH3_9 SH3_10 SH3_2 SH3_3 PH_8 ABC1 SH3_4 Motif Other DBs NCBI-GeneID:  3702 NCBI-ProteinID:  NP_005537 OMIM:  186973 HGNC:  6171 Ensembl:  ENSG00000113263 UniProt:  Q08881 Structure PDB LinkDB All DBs Position 5:157180840..157255185 Genome browser AA seq 620 aa AA seqDB search MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE DRPAFSRLLRQLAEIAESGL NT seq 1863 nt NT seq  +upstreamnt  +downstreamnt atgaacaactttatcctcctggaagaacagctcatcaagaaatcccaacaaaagagaaga acttctccctcgaactttaaagtccgcttctttgtgttaaccaaagccagcctggcatac tttgaagatcgtcatgggaagaagcgcacgctgaaggggtccattgagctctcccgaatc aaatgtgttgagattgtgaaaagtgacatcagcatcccatgccactataaatacccgttt caggtggtgcatgacaactacctcctatatgtgtttgctccagatcgtgagagccggcag cgctgggtgctggcccttaaagaagaaacgaggaataataacagtttggtgcctaaatat catcctaatttctggatggatgggaagtggaggtgctgttctcagctggagaagcttgca acaggctgtgcccaatatgatccaaccaagaatgcttcaaagaagcctcttcctcctact cctgaagacaacaggcgaccactttgggaacctgaagaaactgtggtcattgccttatat gactaccaaaccaatgatcctcaggaactcgcactgcggcgcaacgaagagtactgcctg ctggacagttctgagattcactggtggagagtccaggacaggaatgggcatgaaggatat gtaccaagcagttatctggtggaaaaatctccaaataatctggaaacctatgagtggtac aataagagtatcagccgagacaaagctgaaaaacttcttttggacacaggcaaagaagga gccttcatggtaagggattccaggactgcaggaacatacaccgtgtctgttttcaccaag gctgttgtaagtgagaacaatccctgtataaagcattatcacatcaaggaaacaaatgac aatcctaagcgatactatgtggctgaaaagtatgtgttcgattccatccctcttctcatc aactatcaccaacataatggaggaggcctggtgactcgactccggtatccagtttgtttt gggaggcagaaagccccagttacagcagggctgagatacgggaaatgggtgatcgacccc tcagagctcacttttgtgcaagagattggcagtgggcaatttgggttggtgcatctgggc tactggctcaacaaggacaaggtggctatcaaaaccattcgggaaggggctatgtcagaa gaggacttcatagaggaggctgaagtaatgatgaaactctctcatcccaaactggtgcag ctgtatggggtgtgcctggagcaggcccccatctgcctggtgtttgagttcatggagcac ggctgcctgtcagattatctacgcacccagcggggactttttgctgcagagaccctgctg ggcatgtgtctggatgtgtgtgagggcatggcctacctggaagaggcatgtgtcatccac agagacttggctgccagaaattgtttggtgggagaaaaccaagtcatcaaggtgtctgac tttgggatgacaaggttcgttctggatgatcagtacaccagttccacaggcaccaaattc ccggtgaagtgggcatccccagaggttttctctttcagtcgctatagcagcaagtccgat gtgtggtcatttggtgtgctgatgtgggaagttttcagtgaaggcaaaatcccgtatgaa aaccgaagcaactcagaggtggtggaagacatcagtaccggatttcggttgtacaagccc cggctggcctccacacacgtctaccagattatgaatcactgctggaaagagagaccagaa gatcggccagccttctccagactgctgcgtcaactggctgaaattgcagaatcaggactt tag

Homo sapiens (human): 7006 Help Entry 7006              CDS       T01001                                  Symbol TEC, PSCTK4 Name (RefSeq) tec protein tyrosine kinase   KO K07364   tyrosine-protein kinase Tec [EC:2.7.10.2] Organism hsa  Homo sapiens (human) Pathway hsa04380   Osteoclast differentiation hsa04660   T cell receptor signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09151 Immune system    04660 T cell receptor signaling pathway     7006 (TEC)   09158 Development and regeneration    04380 Osteoclast differentiation     7006 (TEC)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     7006 (TEC) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      7006 (TEC) Protein kinases [BR:hsa01001]  Non-receptor tyrosine kinases   TEC family    7006 (TEC) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase SH2 PH SH3_1 BTK SH3_2 SH3_9 SH3_10 ABC1 PH_3 SH3_3 Kinase-like Motif Other DBs NCBI-GeneID:  7006 NCBI-ProteinID:  NP_003206 OMIM:  600583 HGNC:  11719 Ensembl:  ENSG00000135605 UniProt:  P42680 Structure PDB LinkDB All DBs Position 4:complement(48135783..48269838) Genome browser AA seq 631 aa AA seqDB search MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIK CVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKY HPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNS EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSN NLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHY HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR CWQEKPEGRPSFEDLLRTIDELVECEETFGR NT seq 1896 nt NT seq  +upstreamnt  +downstreamnt atgaattttaacactattttggaggagattcttattaaaaggtcacagcagaaaaagaag acatcgcccttaaactacaaagagagactttttgtacttacaaagtccatgctaacctac tatgagggtcgagcagagaagaaatacagaaaggggtttattgatgtttcaaaaatcaag tgtgtggaaatagtgaagaatgatgatggtgtcattccctgtcaaaataagtatccattt caggttgttcatgatgctaacacactttacatttttgcacctagtccacaaagcagggac ctgtgggtgaagaagttaaaagaagaaataaagaacaacaataatattatgattaaatat catcctaaattctggacagatggaagttatcagtgttgtagacaaactgaaaaattagca cccggatgtgaaaaatacaatctttttgagagcagtataagaaaagcactacctccagca ccagaaacaaagaagcgaaggcctcccccaccaattccactagaagaagaagataatagt gaagaaatcgttgtagccatgtatgatttccaagcagcagaaggacatgatctcagatta gagagaggccaagagtatctcattttagaaaagaatgatgttcattggtggagagcaaga gataaatatgggaatgaaggatatatcccaagtaattacgtaacgggaaagaaatcaaac aacttagatcaatatgaatggtattgcagaaatatgaatagaagcaaggcagagcaactc ctccgcagtgaagataaagaaggtggttttatggtaagggattccagtcaaccaggcttg tacacagtctccctttataccaagtttggaggagaaggttcatcgggttttaggcattat catataaaggaaacaacaacatctccaaagaagtattacctagctgaaaaacatgctttt ggctccattcctgagattattgaatatcataagcacaatgcagcaggacttgtcaccagg cttcggtacccagttagtgtgaaagggaagaatgcacccaccactgcaggattcagctat gagaaatgggagattaacccttcagaactgacctttatgagggaattgggaagtggactg tttggagtggtgaggcttggcaaatggcgagcccagtacaaagtcgcaatcaaagctatt cgggaaggtgcaatgtgcgaggaggactttatagaagaagctaaagtgatgatgaaactg acacacccgaagttagtgcagctttatggtgtgtgcacccagcagaaaccaatatacatt gttactgagttcatggaaaggggctgccttctgaatttcctccgacagagacaaggtcat ttcagtagagacgtactgctgagcatgtgtcaggatgtgtgtgaagggatggagtatctg gagagaaacagcttcatccacagagatctggctgccagaaattgtctagtaagtgaggcg ggagttgtaaaagtatctgattttggaatggccaggtatgttctggatgatcagtacaca agttcttctggtgctaagtttcctgtgaagtggtgtccacctgaagtgtttaattacagc cgcttcagcagcaaatcagatgtctggtcatttggtgttttaatgtgggaagtattcacg gaaggcagaatgccttttgaaaaatacaccaattatgaagtggtaaccatggttactcga ggccaccgactctaccagccgaagttggcgtccaactatgtgtatgaggtgatgctgaga tgttggcaggagaaaccagagggaaggccttctttcgaagatctgctgcgcacaatagat gaactagttgaatgtgaagaaacttttggaagataa

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