KEGG   Homo sapiens (human): 4633
Entry
4633              CDS       T01001                                 
Symbol
MYL2, CMH10, MFM12, MLC-2, MLC-2s/v, MLC-2v, MLC2
Name
(RefSeq) myosin light chain 2
  KO
K10351  myosin regulatory light chain 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04371  Apelin signaling pathway
hsa04510  Focal adhesion
hsa04520  Adherens junction
hsa04530  Tight junction
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa04814  Motor proteins
hsa04820  Cytoskeleton in muscle cells
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05410  Hypertrophic cardiomyopathy
hsa05414  Dilated cardiomyopathy
Network
nt06181  Salmonella
nt06182  Shigella
nt06539  Cytoskeleton in muscle cells
  Element
N01074  Shigella IpaA to ITGA/B-RhoGEF-RhoA signaling pathway
N01130  Salmonella SopB to RhoA signaling pathway
N01817  Myosin thick filament
Disease
H00292  Hypertrophic cardiomyopathy
H00595  Myofibrillar myopathies
Drug target
Aficamten: D12253
Delocamten: D12949
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    4633 (MYL2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    4633 (MYL2)
   04520 Adherens junction
    4633 (MYL2)
   04530 Tight junction
    4633 (MYL2)
  09142 Cell motility
   04814 Motor proteins
    4633 (MYL2)
   04820 Cytoskeleton in muscle cells
    4633 (MYL2)
   04810 Regulation of actin cytoskeleton
    4633 (MYL2)
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    4633 (MYL2)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    4633 (MYL2)
   04261 Adrenergic signaling in cardiomyocytes
    4633 (MYL2)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    4633 (MYL2)
   05131 Shigellosis
    4633 (MYL2)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    4633 (MYL2)
   05414 Dilated cardiomyopathy
    4633 (MYL2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    4633 (MYL2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Myosins
     4633 (MYL2)
SSDB
Motif
Pfam: EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 AIF-1
Other DBs
NCBI-GeneID: 4633
NCBI-ProteinID: NP_000423
OMIM: 160781
HGNC: 7583
Ensembl: ENSG00000111245
UniProt: P10916 Q6IB42
Structure
LinkDB
Position
12:complement(110910845..110921449)
AA seq 166 aa
MAPKKAKKRAGGANSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAALGRVN
VKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGVLKADYVR
EMLTTQAERFSKEEVDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD
NT seq 501 nt   +upstreamnt  +downstreamnt
atggcacctaagaaagcaaagaagagagccgggggcgccaactccaacgtgttctccatg
ttcgaacagacccaaatccaggaatttaaggaggccttcactatcatggaccagaacagg
gatggcttcattgacaagaacgatctgagagacacctttgctgcccttgggcgagtgaac
gtgaaaaatgaagaaattgatgaaatgatcaaggaggctccgggtccaattaactttact
gtgttcctcacaatgtttggggagaaacttaagggagcggaccctgaggaaaccattctc
aacgcattcaaagtgtttgaccctgaaggcaaaggggtgctgaaggctgattacgttcgg
gaaatgctgaccacgcaggcggagaggttttccaaggaggaggttgaccagatgttcgcc
gccttcccccctgacgtgactggcaacttggactacaagaacctggtgcacatcatcacc
cacggagaagagaaggactag

KEGG   Homo sapiens (human): 4634
Entry
4634              CDS       T01001                                 
Symbol
MYL3, CMH8, MLC-lV/sb, MLC1SB, MLC1V, VLC1, VLCl
Name
(RefSeq) myosin light chain 3
  KO
K12749  myosin light chain 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04371  Apelin signaling pathway
hsa04814  Motor proteins
hsa04820  Cytoskeleton in muscle cells
hsa05410  Hypertrophic cardiomyopathy
hsa05414  Dilated cardiomyopathy
Network
nt06539  Cytoskeleton in muscle cells
  Element
N01817  Myosin thick filament
Disease
H00292  Hypertrophic cardiomyopathy
Drug target
Aficamten: D12253
Delocamten: D12949
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    4634 (MYL3)
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    4634 (MYL3)
   04820 Cytoskeleton in muscle cells
    4634 (MYL3)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    4634 (MYL3)
   04261 Adrenergic signaling in cardiomyocytes
    4634 (MYL3)
 09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    4634 (MYL3)
   05414 Dilated cardiomyopathy
    4634 (MYL3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    4634 (MYL3)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Myosins
     4634 (MYL3)
SSDB
Motif
Pfam: EF-hand_1 EF-hand_7 EF-hand_6 AIF-1 DUF2267
Other DBs
NCBI-GeneID: 4634
NCBI-ProteinID: NP_000249
OMIM: 160790
HGNC: 7584
Ensembl: ENSG00000160808
UniProt: P08590
Structure
LinkDB
Position
3:complement(46857872..46882182)
AA seq 195 aa
MAPKKPEPKKDDAKAAPKAAPAPAPPPEPERPKEVEFDASKIKIEFTPEQIEEFKEAFML
FDRTPKCEMKITYGQCGDVLRALGQNPTQAEVLRVLGKPRQEELNTKMMDFETFLPMLQH
ISKNKDTGTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGERLTEDEVEKLMAGQEDSN
GCINYEAFVKHIMSS
NT seq 588 nt   +upstreamnt  +downstreamnt
atggcccccaaaaagccagagcccaagaaggatgatgccaaggcagcccccaaggcagct
ccagctcccgcacctccccctgagcctgagcgccctaaggaggtcgagtttgatgcttcc
aagatcaagattgagttcacacctgagcagattgaagagttcaaggaagccttcatgctg
ttcgaccgcacacccaagtgtgagatgaagatcacctacgggcagtgtggggatgtcctg
cgggcgctgggccagaaccccacacaggcagaagtgctccgtgtcctggggaagccaaga
caggaagagctcaataccaagatgatggactttgaaactttcctgcctatgctccagcac
atttccaagaacaaggacacaggcacctatgaggacttcgtggaggggctgcgggtcttc
gacaaggagggcaatggcactgtcatgggtgctgagcttcgccacgtgctggccacgctg
ggtgagaggctgacagaagacgaagtggagaagttgatggctgggcaagaggactccaat
ggctgcatcaactatgaagcatttgtgaagcacatcatgtccagctaa

KEGG   Homo sapiens (human): 4635
Entry
4635              CDS       T01001                                 
Symbol
MYL4, ALC1, AMLC, GT1, PRO1957
Name
(RefSeq) myosin light chain 4
  KO
K12750  myosin light chain 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04371  Apelin signaling pathway
hsa04814  Motor proteins
hsa04820  Cytoskeleton in muscle cells
Network
nt06539  Cytoskeleton in muscle cells
  Element
N01817  Myosin thick filament
Disease
H00731  Atrial fibrillation
Drug target
Aficamten: D12253
Delocamten: D12949
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    4635 (MYL4)
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    4635 (MYL4)
   04820 Cytoskeleton in muscle cells
    4635 (MYL4)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    4635 (MYL4)
   04261 Adrenergic signaling in cardiomyocytes
    4635 (MYL4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    4635 (MYL4)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Myosins
     4635 (MYL4)
SSDB
Motif
Pfam: EF-hand_9 EF-hand_6 EF-hand_7 EF-hand_1 AIF-1
Other DBs
NCBI-GeneID: 4635
NCBI-ProteinID: NP_001002841
OMIM: 160770
HGNC: 7585
Ensembl: ENSG00000198336
UniProt: P12829
LinkDB
Position
17:47189433..47227650
AA seq 197 aa
MAPKKPEPKKEAAKPAPAPAPAPAPAPAPAPEAPKEPAFDPKSVKIDFTADQIEEFKEAF
SLFDRTPTGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPIL
QHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQED
ANGCINYEAFVKHIMSG
NT seq 594 nt   +upstreamnt  +downstreamnt
atggctcccaagaagcctgagcctaagaaggaggcagccaagccagctccagctccagct
ccagcccctgcaccagcccctgccccagctcctgaggctcccaaggaacctgcctttgac
cccaagagtgtaaagatagacttcactgccgaccagattgaagagttcaaagaggccttt
tcattgtttgaccggaccccgactggagagatgaagatcacctacggccagtgcggggat
gtactgcgggccctgggccagaaccctaccaatgccgaggtgctgcgtgtgctgggcaag
cccaagcctgaagagatgaatgtcaagatgctggactttgagacgttcttgcccatcctg
cagcacatttcccgcaacaaggagcagggcacctatgaggacttcgtggagggcctgcgt
gtctttgacaaggagagcaatggcacggtcatgggtgctgagcttcggcacgtccttgcc
accctgggagagaagatgactgaggctgaagtggagcagctgttagctgggcaagaggat
gccaatggctgcatcaattatgaagcctttgtcaagcacatcatgtcagggtga

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