KEGG   Homo sapiens (human): 4891
Entry
4891              CDS       T01001                                 
Symbol
SLC11A2, AHMIO1, DCT1, DMT1, NRAMP2
Name
(RefSeq) solute carrier family 11 member 2
  KO
K21398  natural resistance-associated macrophage protein 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome
hsa04216  Ferroptosis
hsa04978  Mineral absorption
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
Network
nt06525  Ferroptosis
  Element
N01587  Fe-TF transport
Disease
H01196  Hypochromic microcytic anemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    4891 (SLC11A2)
  09143 Cell growth and death
   04216 Ferroptosis
    4891 (SLC11A2)
 09150 Organismal Systems
  09154 Digestive system
   04978 Mineral absorption
    4891 (SLC11A2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4891 (SLC11A2)
   05012 Parkinson disease
    4891 (SLC11A2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    4891 (SLC11A2)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC11: Proton-coupled metal ion transporter
   4891 (SLC11A2)
SSDB
Motif
Pfam: Nramp
Other DBs
NCBI-GeneID: 4891
NCBI-ProteinID: NP_001167597
OMIM: 600523
HGNC: 10908
Ensembl: ENSG00000110911
UniProt: P49281 A0A0X8GKR4
Structure
LinkDB
Position
12:complement(50952263..51028886)
AA seq 568 aa
MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEE
EYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQR
LAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRI
PLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGM
FVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIES
CIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGG
VVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAI
IPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAG
GILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDC
GHTCHLGLTAQPELYLLNTMDADSLVSR
NT seq 1707 nt   +upstreamnt  +downstreamnt
atggtgctgggtcctgaacagaagatgtcagatgacagtgtttctggagatcatggggag
tctgccagtcttggtaacatcaaccctgcctatagtaatccctctctttcacagtcccct
ggggactcagaggagtacttcgccacttactttaatgagaagatctccattcctgaggag
gagtactcttgttttagctttcgtaaactctgggctttcaccggaccaggttttcttatg
agcattgcctacctggatccaggaaatattgaatccgatttgcagtctggagcagtggct
ggatttaagttgctctggatccttctgttggccacccttgtggggctgctgctccagcgg
cttgcagctagactgggagtggttactgggctgcatcttgctgaagtatgtcaccgtcag
tatcccaaggtcccacgagtcatcctgtggctgatggtggagttggctatcatcggctca
gacatgcaagaagtcattggctcagccattgctatcaatcttctgtctgtaggaagaatt
cctctgtggggtggcgttctcatcaccattgcagatacttttgtatttctcttcttggac
aaatatggcttgcggaagctagaagcattttttggctttctcatcactattatggccctc
acatttggatatgagtatgttacagtgaaacccagccagagccaggtactcaagggcatg
ttcgtaccatcctgttcaggctgtcgcactccacagattgaacaggctgtgggcatcgtg
ggagctgtcatcatgccacacaacatgtacctgcattctgccttagtcaagtctagacag
gtaaaccggaacaataagcaggaagttcgagaagccaataagtactttttcattgaatcc
tgcattgcactctttgtttccttcatcatcaatgtctttgttgtctcagtctttgctgaa
gcattttttgggaaaaccaacgagcaggtggttgaagtctgtacaaataccagcagtcct
catgctggcctctttcctaaagataactcgacactggctgtggacatctacaaagggggt
gttgtgctgggatgttactttgggcctgctgcactctacatttgggcagtggggatcctg
gctgcaggacagagctccaccatgacaggaacctattctggccagtttgtcatggaggga
ttcctgaacctaaagtggtcacgctttgcccgagtggttctgactcgctctattgccatc
atccccactctgcttgttgctgtcttccaagatgtagagcatctaacagggatgaatgac
tttctgaatgttctacagagcttacagcttccctttgctctcatacccatcctcacattt
acgagcttgcggccagtaatgagtgactttgccaatggactaggctggcggattgcagga
ggaatcttggtccttatcatctgttccatcaatatgtactttgtagtggtttatgtccgg
gacctagggcatgtggcattatatgtggtggctgctgtggtcagcgtggcttatctgggc
tttgtgttctacttgggttggcaatgtttgattgcactgggcatgtccttcctggactgt
gggcatacgtgccatctgggattgacagctcagcctgaactctatcttctgaacaccatg
gacgctgactcacttgtgtctagatga

KEGG   Homo sapiens (human): 23516
Entry
23516             CDS       T01001                                 
Symbol
SLC39A14, HCIN, HMNDYT2, LZT-Hs4, NET34, ZIP14, cig19
Name
(RefSeq) solute carrier family 39 member 14
  KO
K14720  solute carrier family 39 (zinc transporter), member 14
Organism
hsa  Homo sapiens (human)
Pathway
hsa04216  Ferroptosis
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
Network
nt06525  Ferroptosis
  Element
N01587  Fe-TF transport
Disease
H01938  Hypermanganesemia with dystonia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    23516 (SLC39A14)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    23516 (SLC39A14)
   05012 Parkinson disease
    23516 (SLC39A14)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    23516 (SLC39A14)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC39: Metal ion transporter
   23516 (SLC39A14)
SSDB
Motif
Pfam: Zip
Other DBs
NCBI-GeneID: 23516
NCBI-ProteinID: NP_001121903
OMIM: 608736
HGNC: 20858
Ensembl: ENSG00000104635
UniProt: Q15043
LinkDB
Position
8:22367278..22434129
AA seq 492 aa
MKLLLLHPAFQSCLLLTLLGLWRTTPEAHASSLGAPAISAASFLQDLIHRYGEGDSLTLQ
QLKALLNHLDVGVGRGNVTQHVQGHRNLSTCFSSGDLFTAHNFSEQSRIGSSELQEFCPT
ILQQLDSRACTSENQENEENEQTEEGRPSAVEVWGYGLLCVTVISLCSLLGASVVPFMKK
TFYKRLLLYFIALAIGTLYSNALFQLIPEAFGFNPLEDYYVSKSAVVFGGFYLFFFTEKI
LKILLKQKNEHHHGHSHYASESLPSKKDQEEGVMEKLQNGDLDHMIPQHCSSELDGKAPM
VDEKVIVGSLSVQDLQASQSACYWLKGVRYSDIGTLAWMITLSDGLHNFIDGLAIGASFT
VSVFQGISTSVAILCEEFPHELGDFVILLNAGMSIQQALFFNFLSACCCYLGLAFGILAG
SHFSANWIFALAGGMFLYISLADMFPEMNEVCQEDERKGSILIPFIIQNLGLLTGFTIMV
VLTMYSGQIQIG
NT seq 1479 nt   +upstreamnt  +downstreamnt
atgaagctgctgctgctgcacccggccttccagagctgcctcctgctgaccctgcttggc
ttatggagaaccacccctgaggctcacgcttcatccctgggtgcaccagctatcagcgct
gcctccttcctgcaggatctaatacatcggtatggcgagggtgacagcctcactctgcag
cagctgaaggccctactcaaccacctggatgtgggagtgggccggggtaatgtcacccag
cacgtgcaaggacacaggaacctctccacgtgctttagttctggagacctcttcactgcc
cacaatttcagcgagcagtcgcggattgggagcagcgagctccaggagttctgccccacc
atcctccagcagctggattcccgggcctgcacctcggagaaccaggaaaacgaggagaat
gagcagacggaggaggggcggccaagcgctgttgaagtgtggggatacggtctcctctgt
gtgaccgtcatctccctctgctccctcctgggggccagcgtggtgcccttcatgaagaag
accttttacaagaggctgctgctctacttcatagctctggcgattggaaccctctactcc
aacgccctcttccagctcatcccggaggcatttggtttcaaccctctggaagattattat
gtctccaagtctgcagtggtgtttgggggcttttatcttttctttttcacagagaagatc
ttgaagattcttcttaagcagaaaaatgagcatcatcatggacacagccattatgcctct
gagtcgcttccctccaagaaggaccaggaggagggggtgatggagaagctgcagaacggg
gacctggaccacatgattcctcagcactgcagcagtgagctggacggcaaggcgcccatg
gtggacgagaaggtcattgtgggctcgctctctgtgcaggacctgcaggcttcccagagt
gcttgctactggctgaaaggtgtccgctactctgatatcggcactctggcctggatgatc
actctgagcgacggcctccataatttcatcgatggcctggccatcggtgcttccttcact
gtgtcagttttccaaggcatcagcacctcggtggccatcctctgtgaggagttcccacat
gagctaggagactttgtcatcctgctcaacgctgggatgagcatccaacaagctctcttc
ttcaacttcctttctgcctgctgctgctacctgggtctggcctttggcatcctggccggc
agccacttctctgccaactggatttttgcgctagctggaggaatgttcttgtatatttct
ctggctgatatgttccctgagatgaatgaggtctgtcaagaggatgaaaggaagggcagc
atcttgattccatttatcatccagaacctgggcctcctgactggattcaccatcatggtg
gtcctcaccatgtattcaggacagatccagattgggtag

KEGG   Homo sapiens (human): 64116
Entry
64116             CDS       T01001                                 
Symbol
SLC39A8, BIGM103, CDG2N, LZT-Hs6, PP3105, ZIP8
Name
(RefSeq) solute carrier family 39 member 8
  KO
K14714  solute carrier family 39 (zinc transporter), member 8
Organism
hsa  Homo sapiens (human)
Pathway
hsa04216  Ferroptosis
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
Network
nt06525  Ferroptosis
  Element
N01587  Fe-TF transport
Disease
H00119  Congenital disorders of glycosylation type II
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    64116 (SLC39A8)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    64116 (SLC39A8)
   05012 Parkinson disease
    64116 (SLC39A8)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    64116 (SLC39A8)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC39: Metal ion transporter
   64116 (SLC39A8)
SSDB
Motif
Pfam: Zip EF-hand_Zip DUF4271
Other DBs
NCBI-GeneID: 64116
NCBI-ProteinID: NP_001128618
OMIM: 608732
HGNC: 20862
Ensembl: ENSG00000138821
UniProt: Q9C0K1
LinkDB
Position
4:complement(102251041..102345482)
AA seq 460 aa
MAPGRAVAGLLLLAAAGLGGVAEGPGLAFSEDVLSVFGANLSLSAAQLQHLLEQMGAASR
VGVPEPGQLHFNQCLTAEEIFSLHGFSNATQITSSKFSVICPAVLQQLNFHPCEDRPKHK
TRPSHSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPKILTFFVGLAIGTLFSNAIFQ
LIPEAFGFDPKVDSYVEKAVAVFGGFYLLFFFERMLKMLLKTYGQNGHTHFGNDNFGPQE
KTHQPKALPAINGVTCYANPAVTEANGHIHFDNVSVVSLQDGKKEPSSCTCLKGPKLSEI
GTIAWMITLCDALHNFIDGLAIGASCTLSLLQGLSTSIAILCEEFPHELGDFVILLNAGM
STRQALLFNFLSACSCYVGLAFGILVGNNFAPNIIFALAGGMFLYISLADMFPEMNDMLR
EKVTGRKTDFTFFMIQNAGMLTGFTAILLITLYAGEIELE
NT seq 1383 nt   +upstreamnt  +downstreamnt
atggccccgggtcgcgcggtggccgggctcctgttgctggcggccgccggcctcggagga
gtggcggaggggccagggctagccttcagcgaggatgtgctgagcgtgttcggcgcgaat
ctgagcctgtcggcggcgcagctccagcacttgctggagcagatgggagccgcctcccgc
gtgggcgtcccggagcctggccagctgcacttcaaccagtgtttaactgctgaagagatc
ttttcccttcatggcttttcaaatgctacccaaataaccagctccaaattctctgtcatc
tgtccagcagtcttacagcaattgaactttcacccatgtgaggatcggcccaagcacaaa
acaagaccaagtcattcagaagtttggggatatggattcctgtcagtgacgattattaat
ctggcatctctcctcggattgattttgactccactgataaagaaatcttatttcccaaag
attttgaccttttttgtggggctggctattgggactcttttttcaaatgcaattttccaa
cttattccagaggcatttggatttgatcccaaagtcgacagttatgttgagaaggcagtt
gctgtgtttggtggattttacctacttttcttttttgaaagaatgctaaagatgttatta
aagacatatggtcagaatggtcatacccactttggaaatgataactttggtcctcaagaa
aaaactcatcaacctaaagcattacctgccatcaatggtgtgacatgctatgcaaatcct
gctgtcacagaagctaatggacatatccattttgataatgtcagtgtggtatctctacag
gatggaaaaaaagagccaagttcatgtacctgtttgaaggggcccaaactgtcagaaata
gggacgattgcctggatgataacgctctgcgatgccctccacaatttcatcgatggcctg
gcgattggggcttcctgcaccttgtctctccttcagggactcagtacttccatagcaatc
ctatgtgaggagtttccccacgagttaggagactttgtgatcctactcaatgcagggatg
agcactcgacaagccttgctattcaacttcctttctgcatgttcctgctatgttgggcta
gcttttggcattttggtgggcaacaatttcgctccaaatattatatttgcacttgctgga
ggcatgttcctctatatttctctggcagatatgtttccagagatgaatgatatgctgaga
gaaaaggtaactggaagaaaaaccgatttcaccttcttcatgattcagaatgctggaatg
ttaactggattcacagccattctactcattaccttgtatgcaggagaaatcgaattggag
taa

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