Homo sapiens (human): 493
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Entry
493 CDS
T01001
Symbol
ATP2B4, ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x
Name
(RefSeq) ATPase plasma membrane Ca2+ transporting 4
KO
K05850
P-type Ca2+ transporter type 2B [EC:
7.2.2.10
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04020
Calcium signaling pathway
hsa04022
cGMP-PKG signaling pathway
hsa04024
cAMP signaling pathway
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04925
Aldosterone synthesis and secretion
hsa04961
Endocrine and other factor-regulated calcium reabsorption
hsa04970
Salivary secretion
hsa04972
Pancreatic secretion
hsa04978
Mineral absorption
Network
nt06528
Calcium signaling
Element
N01429
Cytosolic Ca2+ removal, PMCA
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04020 Calcium signaling pathway
493 (ATP2B4)
04024 cAMP signaling pathway
493 (ATP2B4)
04022 cGMP-PKG signaling pathway
493 (ATP2B4)
09150 Organismal Systems
09152 Endocrine system
04925 Aldosterone synthesis and secretion
493 (ATP2B4)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
493 (ATP2B4)
09154 Digestive system
04970 Salivary secretion
493 (ATP2B4)
04972 Pancreatic secretion
493 (ATP2B4)
04978 Mineral absorption
493 (ATP2B4)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
493 (ATP2B4)
Enzymes [BR:
hsa01000
]
7. Translocases
7.2 Catalysing the translocation of inorganic cations
7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
7.2.2.10 P-type Ca2+ transporter
493 (ATP2B4)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
Cation_ATPase_C
Cation_ATPase
ATP_Ca_trans_C
E1-E2_ATPase
Cation_ATPase_N
Hydrolase
Hydrolase_3
Motif
Other DBs
NCBI-GeneID:
493
NCBI-ProteinID:
NP_001675
OMIM:
108732
HGNC:
817
Ensembl:
ENSG00000058668
UniProt:
P23634
Structure
PDB
PDBj
LinkDB
All DBs
Position
1:203626832..203744081
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AA seq
1205 aa
AA seq
DB search
MTNPSDRVLPANSMAESREGDFGCTVMELRKLMELRSRDALTQINVHYGGVQNLCSRLKT
SPVEGLSGNPADLEKRRQVFGHNVIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLS
FYRPAGEENELCGQVATTPEDENEAQAGWIEGAAILFSVIIVVLVTAFNDWSKEKQFRGL
QCRIEQEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLT
GESDHVKKSLDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIILTLLGVNEDDEGEKKKK
GKKQGVPENRNKAKTQDGVALEIQPLNSQEGIDNEEKDKKAVKVPKKEKSVLQGKLTRLA
VQIGKAGLLMSALTVFILILYFVIDNFVINRRPWLPECTPIYIQYFVKFFIIGITVLVVA
VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQA
YIGGIHYRQIPSPDVFLPKVLDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALL
GFVTDLKQDYQAVRNEVPEEKLYKVYTFNSVRKSMSTVIRNPNGGFRMYSKGASEIILRK
CNRILDRKGEAVPFKNKDRDDMVRTVIEPMACDGLRTICIAYRDFDDTEPSWDNENEILT
ELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNINTARAIATKCGILTPGDDFL
CLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTVGEHRQVV
AVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSI
SKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLL
KRRPYGRNKPLISRTMMKNILGHAFYQLIVIFILVFAGEKFFDIDSGRKAPLHSPPSQHY
TIVFNTFVLMQLFNEINSRKIHGEKNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFS
CTSLSLSQWLWCLFIGIGELLWGQFISAIPTRSLKFLKEAGHGTTKEEITKDAEGLDEID
HAEMELRRGQILWFRGLNRIQTQIKVVKAFHSSLHESIQKPYNQKSIHSFMTHPEFAIEE
ELPRTPLLDEEEEENPDKASKFGTRVLLLDGEVTPYANTNNNAVDCNQVQLPQSDSSLQS
LETSV
NT seq
3618 nt
NT seq
+upstream
nt +downstream
nt
atgacgaacccatcagaccgtgtcttgcctgccaactcgatggccgagagccgtgaaggg
gactttggctgcacagtaatggaactgaggaagctcatggagctgcgttcaagggatgca
ctgacccagattaatgtccactatggaggtgtacagaatctctgcagtagactgaaaacc
tcccctgtggaaggtctgtctgggaaccctgcagatctggagaaacgtaggcaggtgttt
ggacacaacgtgatcccccccaaaaagcccaagactttcttagaattagtgtgggaagct
cttcaagatgtcacgcttatcatcctggagattgcagccatcatctccctggtcctgtcc
ttttatcgccctgctggtgaagaaaatgaactgtgtggtcaagtcgcaactaccccagaa
gatgaaaatgaggcacaagctggctggattgagggggcagccatccttttctcagtgatc
atcgtggtgttagtgactgcctttaatgattggagcaaagagaagcaattccgggggctg
cagtgccgcattgaacaggagcaaaagttctccatcatccgaaacggtcaactcatccag
ctccctgtggctgagattgtggttggtgatattgcccaagtcaaatacggtgatctgctg
cctgcagatggaatcctgatccaagggaatgatctgaagattgatgagagctctctgaca
ggggaatctgaccatgtcaagaagtccctggacaaagaccccatgttgctctcagggacc
catgtcatggaaggttctggccggatggtggtgacagctgttggtgtcaactctcagact
ggaatcatccttactctcttgggggtcaatgaggatgacgaaggggagaaaaagaagaaa
ggtaaaaaacaaggagtccctgaaaatcgcaacaaagcaaagacccaagacggagtggcc
ctggaaatccagccactcaacagccaggagggaatcgacaatgaggaaaaggacaagaag
gcagtcaaggtgcctaaaaaggagaagtcagtgctgcagggcaagctgactcgcctggct
gttcagattgggaaagccggtctgctcatgtctgctctcacggttttcatcctgattcta
tactttgtgattgacaactttgtgataaatcgcagaccatggctccctgagtgtactccc
atctacatccagtactttgtcaagttcttcatcatcggcatcactgtactggtggtggct
gtgccagaggggctgcctctggctgtcaccatctcactggcctactctgtgaagaaaatg
atgaaagacaataacctagtacggcacttggatgcttgtgagaccatgggcaacgccacc
gccatctgctctgataagacaggcacgttgaccatgaaccgcatgactgtggtacaagct
tatattgggggcatccattaccgtcaaatcccaagccctgatgtcttcctgcccaaagtc
ctggacctcattgtcaatggcatttctatcaacagtgcttatacctccaagattctgcct
ccagagaaggagggaggcctgcctcggcaggtgggcaacaagaccgagtgtgctctgcta
ggctttgtcacagatctgaagcaggattatcaggctgtgcgtaatgaagtgcccgaggag
aagctctacaaggtgtacacctttaactcagtgcgcaagtcaatgagcaccgtcatcagg
aatcccaacggtggcttccgtatgtacagcaagggcgcctctgagatcatcttgcgcaag
tgtaatcgaatcctggaccggaaaggggaagcagtgccattcaagaataaagacagagat
gatatggtacgcactgtcatcgagcccatggcctgtgatggactccggactatctgcata
gcttaccgggacttcgatgacacagagccctcttgggacaatgagaatgagatcctcacc
gaactgacctgtatcgcggtggtgggcattgaggaccctgtgcgcccagaggtgccagat
gctattgccaaatgcaaacaagctggcattactgtcagaatggtgacaggtgacaacatc
aacacagcccgggccattgccaccaaatgtggcattctgacacctggggatgacttcctg
tgcttagaaggcaaagaattcaaccggctcatccgcaacgagaaaggcgaggtagagcaa
gaaaagctggacaagatctggcctaagcttcgggtcctggcgcgatcttctcccactgac
aagcacaccctggtgaaaggcataattgacagcactgttggggaacaccggcaggtcgtg
gctgtcactggtgatggcacaaatgacgggcctgctctgaagaaagcggatgttggtttt
gccatgggcatcgcaggcacagatgtagcaaaggaggcttcagacatcatcctaacagat
gacaacttcaccagcattgtgaaggcagtgatgtggggacgaaatgtctatgacagcatc
tccaagttcctgcagttccagctcactgtcaatgtggtggccgtgattgtagccttcact
ggagcctgtatcactcaggattccccattgaaagctgtgcagatgttgtgggttaatctg
atcatggacacttttgcttcattggccctggccacagagccccctacggaatctctgttg
aagcggcgcccctatggccgaaataagcctctgatctcacgcactatgatgaagaacatc
ttgggccatgcattctatcagctcattgtcatctttatccttgtctttgcgggtgagaaa
ttctttgatattgatagtgggaggaaggcacctctacattcaccacccagccagcactat
accattgtttttaacaccttcgtgctgatgcagctcttcaatgaaatcaactcccgaaag
atccatggagagaagaacgtcttttcaggcatctaccgcaacattatcttctgctctgta
gtcttgggcacattcatctgccagattttcatcgtggaatttgggggtaaacccttcagt
tgtacaagcctcagcctgtctcagtggctgtggtgtctcttcattgggattggagaactt
ctgtggggccagttcatctccgcaatacctacccgatccctgaagttcctgaaggaggct
gggcatggcaccaccaaagaggagatcaccaaggatgccgagggactggatgagattgac
catgctgagatggagctgcgccgaggccagatcctctggttccggggcctgaaccgtatc
cagactcagatcaaagtggtcaaagcgttccatagttccctccacgaaagcattcagaaa
ccctacaaccaaaagtccatccacagcttcatgacccaccctgaattcgccatagaggag
gagttgccacgaacaccactcctggatgaggaagaggaggaaaatcctgacaaggcttct
aagtttgggactagggtgctcctgttggatggtgaggtcactccatatgccaatacaaac
aacaatgcggtggattgcaaccaagtgcagctcccccagtcggacagctctctacagagc
ctagagacatcagtttga
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integrated database retrieval system
