Homo sapiens (human): 51107
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Entry
51107 CDS
T01001
Symbol
APH1A, 6530402N02Rik, APH-1, APH-1A, CGI-78
Name
(RefSeq) aph-1 homolog A, gamma-secretase subunit
KO
K06172
gamma-secretase subunit APH-1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04330
Notch signaling pathway
hsa05010
Alzheimer disease
Network
nt06511
NOTCH signaling
Element
N01478
Notch proteolytic activation
Drug target
Avagacestat:
D09869
Begacestat:
D08869
Crenigacestat:
D11151
Nirogacestat (
DG03016
):
D10960
D11453
<US>
Osugacestat:
D12235
Semagacestat:
D09377
Tarenflurbil:
D09010
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
51107 (APH1A)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
51107 (APH1A)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Aph-1
Peptidase_M3_N
HTH_58
BRI3BP
Motif
Other DBs
NCBI-GeneID:
51107
NCBI-ProteinID:
NP_001071096
OMIM:
607629
HGNC:
29509
Ensembl:
ENSG00000117362
Pharos:
Q96BI3
(Tbio)
UniProt:
Q96BI3
Structure
PDB
PDBj
LinkDB
All DBs
Position
1:complement(150265404..150269016)
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AA seq
265 aa
AA seq
DB search
MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT
DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV
SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD
ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ
RSLLCRRQEDSRVMVYSALRIPPED
NT seq
798 nt
NT seq
+upstream
nt +downstream
nt
atgggggctgcggtgtttttcggctgcactttcgtcgcgttcggcccggccttcgcgctt
ttcttgatcactgtggctggggacccgcttcgcgttatcatcctggtcgcaggggcattt
ttctggctggtctccctgctcctggcctctgtggtctggttcatcttggtccatgtgacc
gaccggtcagatgcccggctccagtacggcctcctgatttttggtgctgctgtctctgtc
cttctacaggaggtgttccgctttgcctactacaagctgcttaagaaggcagatgagggg
ttagcatcgctgagtgaggacggaagatcacccatctccatccgccagatggcctatgtt
tctggtctctccttcggtatcatcagtggtgtcttctctgttatcaatattttggctgat
gcacttgggccaggtgtggttgggatccatggagactcaccctattacttcctgacttca
gcctttctgacagcagccattatcctgctccataccttttggggagttgtgttctttgat
gcctgtgagaggagacggtactgggctttgggcctggtggttgggagtcacctactgaca
tcgggactgacattcctgaacccctggtatgaggccagcctgctgcccatctatgcagtc
actgtttccatggggctctgggccttcatcacagctggagggtccctccgaagtattcag
cgcagcctcttgtgccgacggcaggaggacagtcgggtgatggtgtattctgccctgcgc
atcccacccgaggactga
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integrated database retrieval system