Homo sapiens (human): 51284 Help Entry 51284             CDS       T01001                                  Symbol TLR7, IMD74, SLEB17, TLR7-like Name (RefSeq) toll like receptor 7   KO K05404   toll-like receptor 7 Organism hsa  Homo sapiens (human) Pathway hsa04613   Neutrophil extracellular trap formation hsa04620   Toll-like receptor signaling pathway hsa05162   Measles hsa05164   Influenza A hsa05171   Coronavirus disease - COVID-19 Network nt06169  Measles virus (MV) nt06517  TLR signaling   Element N00690   TLR7/9-IRF7 signaling pathway N01543   TLR7/8/9-IRF5 signaling pathway Disease H00080   Systemic lupus erythematosus H00096   Defects of toll-like receptor signaling Drug target Bropirimine:  D01666 Enpatoran:  D12261 Guretolimod:  D12453 Imiquimod:  D02500<JP/US> Isatoribine:  D04619 Loxoribine:  D04787 Ruzotolimod:  D12521 Vesatolimod:  D11003 Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     51284 (TLR7)    04620 Toll-like receptor signaling pathway     51284 (TLR7)  09160 Human Diseases   09172 Infectious disease: viral    05171 Coronavirus disease - COVID-19     51284 (TLR7)    05164 Influenza A     51284 (TLR7)    05162 Measles     51284 (TLR7)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:hsa04054]     51284 (TLR7) Pattern recognition receptors [BR:hsa04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    51284 (TLR7) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  LRR_8 LRR_4 LRR_1 TIR LRR_5 LRR_9 LRR_12 TIR_2 LRR_6 Motif Other DBs NCBI-GeneID:  51284 NCBI-ProteinID:  NP_057646 OMIM:  300365 HGNC:  15631 Ensembl:  ENSG00000196664 UniProt:  Q9NYK1 B2R9N9 Structure PDB LinkDB All DBs Position X:12867072..12890361 Genome browser AA seq 1049 aa AA seqDB search MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ AHPYFWQCLKNALATDNHVAYSQVFKETV NT seq 3150 nt NT seq  +upstreamnt  +downstreamnt atggtgtttccaatgtggacactgaagagacaaattcttatcctttttaacataatccta atttccaaactccttggggctagatggtttcctaaaactctgccctgtgatgtcactctg gatgttccaaagaaccatgtgatcgtggactgcacagacaagcatttgacagaaattcct ggaggtattcccacgaacaccacgaacctcaccctcaccattaaccacataccagacatc tccccagcgtcctttcacagactggaccatctggtagagatcgatttcagatgcaactgt gtacctattccactggggtcaaaaaacaacatgtgcatcaagaggctgcagattaaaccc agaagctttagtggactcacttatttaaaatccctttacctggatggaaaccagctacta gagataccgcagggcctcccgcctagcttacagcttctcagccttgaggccaacaacatc ttttccatcagaaaagagaatctaacagaactggccaacatagaaatactctacctgggc caaaactgttattatcgaaatccttgttatgtttcatattcaatagagaaagatgccttc ctaaacttgacaaagttaaaagtgctctccctgaaagataacaatgtcacagccgtccct actgttttgccatctactttaacagaactatatctctacaacaacatgattgcaaaaatc caagaagatgattttaataacctcaaccaattacaaattcttgacctaagtggaaattgc cctcgttgttataatgccccatttccttgtgcgccgtgtaaaaataattctcccctacag atccctgtaaatgcttttgatgcgctgacagaattaaaagttttacgtctacacagtaac tctcttcagcatgtgcccccaagatggtttaagaacatcaacaaactccaggaactggat ctgtcccaaaacttcttggccaaagaaattggggatgctaaatttctgcattttctcccc agcctcatccaattggatctgtctttcaattttgaacttcaggtctatcgtgcatctatg aatctatcacaagcattttcttcactgaaaagcctgaaaattctgcggatcagaggatat gtctttaaagagttgaaaagctttaacctctcgccattacataatcttcaaaatcttgaa gttcttgatcttggcactaactttataaaaattgctaacctcagcatgtttaaacaattt aaaagactgaaagtcatagatctttcagtgaataaaatatcaccttcaggagattcaagt gaagttggcttctgctcaaatgccagaacttctgtagaaagttatgaaccccaggtcctg gaacaattacattatttcagatatgataagtatgcaaggagttgcagattcaaaaacaaa gaggcttctttcatgtctgttaatgaaagctgctacaagtatgggcagaccttggatcta agtaaaaatagtatattttttgtcaagtcctctgattttcagcatctttctttcctcaaa tgcctgaatctgtcaggaaatctcattagccaaactcttaatggcagtgaattccaacct ttagcagagctgagatatttggacttctccaacaaccggcttgatttactccattcaaca gcatttgaagagcttcacaaactggaagttctggatataagcagtaatagccattatttt caatcagaaggaattactcatatgctaaactttaccaagaacctaaaggttctgcagaaa ctgatgatgaacgacaatgacatctcttcctccaccagcaggaccatggagagtgagtct cttagaactctggaattcagaggaaatcacttagatgttttatggagagaaggtgataac agatacttacaattattcaagaatctgctaaaattagaggaattagacatctctaaaaat tccctaagtttcttgccttctggagtttttgatggtatgcctccaaatctaaagaatctc tctttggccaaaaatgggctcaaatctttcagttggaagaaactccagtgtctaaagaac ctggaaactttggacctcagccacaaccaactgaccactgtccctgagagattatccaac tgttccagaagcctcaagaatctgattcttaagaataatcaaatcaggagtctgacgaag tattttctacaagatgccttccagttgcgatatctggatctcagctcaaataaaatccag atgatccaaaagaccagcttcccagaaaatgtcctcaacaatctgaagatgttgcttttg catcataatcggtttctgtgcacctgtgatgctgtgtggtttgtctggtgggttaaccat acggaggtgactattccttacctggccacagatgtgacttgtgtggggccaggagcacac aagggccaaagtgtgatctccctggatctgtacacctgtgagttagatctgactaacctg attctgttctcactttccatatctgtatctctctttctcatggtgatgatgacagcaagt cacctctatttctgggatgtgtggtatatttaccatttctgtaaggccaagataaagggg tatcagcgtctaatatcaccagactgttgctatgatgcttttattgtgtatgacactaaa gacccagctgtgaccgagtgggttttggctgagctggtggccaaactggaagacccaaga gagaaacattttaatttatgtctcgaggaaagggactggttaccagggcagccagttctg gaaaacctttcccagagcatacagcttagcaaaaagacagtgtttgtgatgacagacaag tatgcaaagactgaaaattttaagatagcattttacttgtcccatcagaggctcatggat gaaaaagttgatgtgattatcttgatatttcttgagaagccctttcagaagtccaagttc ctccagctccggaaaaggctctgtgggagttctgtccttgagtggccaacaaacccgcaa gctcacccatacttctggcagtgtctaaagaacgccctggccacagacaatcatgtggcc tatagtcaggtgttcaaggaaacggtctag

Homo sapiens (human): 51311 Help Entry 51311             CDS       T01001                                  Symbol TLR8, CD288, IMD98, TLR-8, hTLR8 Name (RefSeq) toll like receptor 8   KO K10170   toll-like receptor 8 Organism hsa  Homo sapiens (human) Pathway hsa04613   Neutrophil extracellular trap formation hsa04620   Toll-like receptor signaling pathway hsa05171   Coronavirus disease - COVID-19 Network nt06517  TLR signaling   Element N01543   TLR7/8/9-IRF5 signaling pathway Drug target Enpatoran:  D12261 Motolimod:  D10716 Selgantolimod:  D11871 Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     51311 (TLR8)    04620 Toll-like receptor signaling pathway     51311 (TLR8)  09160 Human Diseases   09172 Infectious disease: viral    05171 Coronavirus disease - COVID-19     51311 (TLR8)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:hsa04054]     51311 (TLR8)    04090 CD molecules [BR:hsa04090]     51311 (TLR8) Pattern recognition receptors [BR:hsa04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    51311 (TLR8) CD molecules [BR:hsa04090]  Proteins   51311 (TLR8) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  LRR_8 LRR_4 TIR LRR_5 TIR_2 LRR_12 LRR_9 Motif Other DBs NCBI-GeneID:  51311 NCBI-ProteinID:  NP_619542 OMIM:  300366 HGNC:  15632 Ensembl:  ENSG00000101916 UniProt:  Q9NR97 Structure PDB LinkDB All DBs Position X:12906620..12923169 Genome browser AA seq 1041 aa AA seqDB search MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN VVLTENDSRYNNMYVDSIKQY NT seq 3126 nt NT seq  +upstreamnt  +downstreamnt atggaaaacatgttccttcagtcgtcaatgctgacctgcattttcctgctaatatctggt tcctgtgagttatgcgccgaagaaaatttttctagaagctatccttgtgatgagaaaaag caaaatgactcagttattgcagagtgcagcaatcgtcgactacaggaagttccccaaacg gtgggcaaatatgtgacagaactagacctgtctgataatttcatcacacacataacgaat gaatcatttcaagggctgcaaaatctcactaaaataaatctaaaccacaaccccaatgta cagcaccagaacggaaatcccggtatacaatcaaatggcttgaatatcacagacggggca ttcctcaacctaaaaaacctaagggagttactgcttgaagacaaccagttaccccaaata ccctctggtttgccagagtctttgacagaacttagtctaattcaaaacaatatatacaac ataactaaagagggcatttcaagacttataaacttgaaaaatctctatttggcctggaac tgctattttaacaaagtttgcgagaaaactaacatagaagatggagtatttgaaacgctg acaaatttggagttgctatcactatctttcaattctctttcacacgtgccacccaaactg ccaagctccctacgcaaactttttctgagcaacacccagatcaaatacattagtgaagaa gatttcaagggattgataaatttaacattactagatttaagcgggaactgtccgaggtgc ttcaatgccccatttccatgcgtgccttgtgatggtggtgcttcaattaatatagatcgt tttgcttttcaaaacttgacccaacttcgatacctaaacctctctagcacttccctcagg aagattaatgctgcctggtttaaaaatatgcctcatctgaaggtgctggatcttgaattc aactatttagtgggagaaatagcctctggggcatttttaacgatgctgccccgcttagaa atacttgacttgtcttttaactatataaaggggagttatccacagcatattaatatttcc agaaacttctctaaacttttgtctctacgggcattgcatttaagaggttatgtgttccag gaactcagagaagatgatttccagcccctgatgcagcttccaaacttatcgactatcaac ttgggtattaattttattaagcaaatcgatttcaaacttttccaaaatttctccaatctg gaaattatttacttgtcagaaaacagaatatcaccgttggtaaaagatacccggcagagt tatgcaaatagttcctcttttcaacgtcatatccggaaacgacgctcaacagattttgag tttgacccacattcgaacttttatcatttcacccgtcctttaataaagccacaatgtgct gcttatggaaaagccttagatttaagcctcaacagtattttcttcattgggccaaaccaa tttgaaaatcttcctgacattgcctgtttaaatctgtctgcaaatagcaatgctcaagtg ttaagtggaactgaattttcagccattcctcatgtcaaatatttggatttgacaaacaat agactagactttgataatgctagtgctcttactgaattgtccgacttggaagttctagat ctcagctataattcacactatttcagaatagcaggcgtaacacatcatctagaatttatt caaaatttcacaaatctaaaagttttaaacttgagccacaacaacatttatactttaaca gataagtataacctggaaagcaagtccctggtagaattagttttcagtggcaatcgcctt gacattttgtggaatgatgatgacaacaggtatatctccattttcaaaggtctcaagaat ctgacacgtctggatttatcccttaataggctgaagcacatcccaaatgaagcattcctt aatttgccagcgagtctcactgaactacatataaatgataatatgttaaagttttttaac tggacattactccagcagtttcctcgtctcgagttgcttgacttacgtggaaacaaacta ctctttttaactgatagcctatctgactttacatcttcccttcggacactgctgctgagt cataacaggatttcccacctaccctctggctttctttctgaagtcagtagtctgaagcac ctcgatttaagttccaatctgctaaaaacaatcaacaaatccgcacttgaaactaagacc accaccaaattatctatgttggaactacacggaaacccctttgaatgcacctgtgacatt ggagatttccgaagatggatggatgaacatctgaatgtcaaaattcccagactggtagat gtcatttgtgccagtcctggggatcaaagagggaagagtattgtgagtctggagctaaca acttgtgtttcagatgtcactgcagtgatattatttttcttcacgttctttatcaccacc atggttatgttggctgccctggctcaccatttgttttactgggatgtttggtttatatat aatgtgtgtttagctaaggtaaaaggctacaggtctctttccacatcccaaactttctat gatgcttacatttcttatgacaccaaagatgcctctgttactgactgggtgataaatgag ctgcgctaccaccttgaagagagccgagacaaaaacgttctcctttgtctagaggagagg gattgggacccgggattggccatcatcgacaacctcatgcagagcatcaaccaaagcaag aaaacagtatttgttttaaccaaaaaatatgcaaaaagctggaactttaaaacagctttt tacttggctttgcagaggctaatggatgagaacatggatgtgattatatttatcctgctg gagccagtgttacagcattctcagtatttgaggctacggcagcggatctgtaagagctcc atcctccagtggcctgacaacccgaaggcagaaggcttgttttggcaaactctgagaaat gtggtcttgactgaaaatgattcacggtataacaatatgtatgtcgattccattaagcaa tactaa

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