Homo sapiens (human): 5164 Help Entry 5164              CDS       T01001                                  Symbol PDK2, PDHK2, PDKII Name (RefSeq) pyruvate dehydrogenase kinase 2   KO K00898   pyruvate dehydrogenase kinase 2/3/4 [EC:2.7.11.2] Organism hsa  Homo sapiens (human) Pathway hsa05415   Diabetic cardiomyopathy Drug target Sodium dichloroacetate:  D05857 Brite KEGG Orthology (KO) [BR:hsa00001]  09160 Human Diseases   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     5164 (PDK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     5164 (PDK2) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.2  [pyruvate dehydrogenase (acetyl-transferring)] kinase      5164 (PDK2) Protein kinases [BR:hsa01001]  Serine/threonine kinases: Other   PDHK family [OT]    5164 (PDK2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  BCDHK_Adom3 HATPase_c HATPase_c_3 Motif Other DBs NCBI-GeneID:  5164 NCBI-ProteinID:  NP_002602 OMIM:  602525 HGNC:  8810 Ensembl:  ENSG00000005882 Vega:  OTTHUMG00000161948 Pharos:  Q15119(Tbio) UniProt:  Q15119 Structure PDB LinkDB All DBs Position 17:50094737..50112152 Genome browser AA seq 407 aa AA seqDB search MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVR LANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIR NRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVY VPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKI ERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL KALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS NT seq 1224 nt NT seq  +upstreamnt  +downstreamnt atgcgctgggtgtgggcgctgctgaagaatgcgtccctggcaggggcgcccaagtacata gagcacttcagcaagttctccccgtccccgctgtccatgaagcagtttctggacttcgga tccagcaatgcctgtgagaaaacctccttcaccttcctcaggcaggagctgcctgtgcgc ctggccaacatcatgaaagagatcaacctgcttcccgaccgagtgctgagcacaccctcc gtgcagctggtgcagagctggtatgtccagagcctcctggacatcatggagttcctggac aaggatcccgaggaccatcgcaccctgagccagttcactgacgccctggtcaccatccgg aaccggcacaacgacgtggtgcccaccatggcacaaggcgtgcttgagtacaaggacacc tacggcgatgaccccgtctccaaccagaacatccagtacttcctggaccgcttctacctc agccgcatctccatccgcatgctcatcaaccagcacaccctcatctttgatggcagcacc aacccagcccatcccaaacacatcggcagcatcgaccccaactgcaacgtctctgaggtg gtcaaagatgcctacgacatggctaagctcctgtgtgacaagtattacatggcctcacct gacctggagatccaggagatcaatgcagccaactccaaacagccgattcacatggtctac gtcccctcccacctctaccacatgctctttgagctcttcaagaatgccatgagggcgact gtggaaagccatgagtccagcctcattctcccacccatcaaggtcatggtggccttgggt gaggaagatctgtccatcaagatgagtgaccgaggtgggggtgttcccttgaggaagatt gagcgactcttcagctacatgtactccacagcacccaccccccagcctggcaccggggga acgccgctggctggctttggttatgggctccccatttcccgcctctacgccaagtacttc cagggagacctgcagctcttctccatggaaggctttgggaccgatgctgtcatctatctc aaggccctgtccacggactcggtggagcgcctgcctgtctacaacaagtcagcctggcgc cactaccagaccatccaggaggccggcgactggtgtgtgcccagcacggagcccaagaac acgtccacgtaccgcgtcagctaa

Homo sapiens (human): 5165 Help Entry 5165              CDS       T01001                                  Symbol PDK3, CMTX6, GS1-358P8.4 Name (RefSeq) pyruvate dehydrogenase kinase 3   KO K00898   pyruvate dehydrogenase kinase 2/3/4 [EC:2.7.11.2] Organism hsa  Homo sapiens (human) Pathway hsa05415   Diabetic cardiomyopathy Disease H00264   Charcot-Marie-Tooth disease Drug target Sodium dichloroacetate:  D05857 Brite KEGG Orthology (KO) [BR:hsa00001]  09160 Human Diseases   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     5165 (PDK3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     5165 (PDK3) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.2  [pyruvate dehydrogenase (acetyl-transferring)] kinase      5165 (PDK3) Protein kinases [BR:hsa01001]  Serine/threonine kinases: Other   PDHK family [OT]    5165 (PDK3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  BCDHK_Adom3 HATPase_c HATPase_c_3 Motif Other DBs NCBI-GeneID:  5165 NCBI-ProteinID:  NP_005382 OMIM:  300906 HGNC:  8811 Ensembl:  ENSG00000067992 Vega:  OTTHUMG00000021269 Pharos:  Q15120(Tbio) UniProt:  Q15120 Structure PDB LinkDB All DBs Position X:24465286..24550466 Genome browser AA seq 406 aa AA seqDB search MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANT MREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNRHN DVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVH PKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSH LFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRL FNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKA LSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQ NT seq 1221 nt NT seq  +upstreamnt  +downstreamnt atgcggctgttccggtggctgctgaagcagccggtgcccaagcagatcgagcgctactcg cgcttttcgccgtcgccgctctccatcaaacaattcctggacttcgggagagataatgca tgtgagaaaacttcatatatgtttctacgaaaggaacttcctgtgcggctggctaacaca atgagagaagttaatcttctgccggataatttacttaaccgcccttcagtgggattggtt cagagttggtatatgcagagttttcttgaacttttagaatatgaaaataagagccctgag gatccacaggtcttggataactttctacaagttctgattaaagtcagaaatagacacaat gatgtggttcctacaatggcacaaggagtgattgaatacaaggagaagtttgggtttgat cctttcattagcactaacatccaatattttctggatcggttttataccaaccgcatctct ttccgcatgcttattaatcagcacacacttctgtttgggggtgacactaatcctgttcat cctaaacacataggaagtatcgatcccacctgtaacgtggcggatgtggtgaaagatgca tatgaaacagccaagatgctgtgtgaacagtattacctggtagctccagagctggaagtt gaagaattcaatgccaaagcgccagacaaacctattcaggtggtttatgtgccctcacat ctgtttcatatgctatttgagttgttcaagaactcaatgagagcgacagttgaactctat gaagacagaaaagagggctaccctgctgttaaaaccctcgttactttgggtaaagaagac ttatccattaagatcagtgacctaggtggtggtgtcccacttcgaaaaatagatcgtctt tttaactacatgtattctactgctcctagacccagcctggagcctaccagagctgcccct ttggctggatttggttatggtttgccaatttcccgtctgtatgctagatattttcaagga gatctgaaactgtattccatggaaggagtgggtactgatgctgtcatttatttgaaggct ctttcaagtgagtcatttgagagacttccagtttttaataagtccgcatggcgccattac aagaccacgcctgaagccgatgattggagcaatcccagcagtgaacccagggatgcttca aaatacaaagcaaaacagtaa

Homo sapiens (human): 5166 Help Entry 5166              CDS       T01001                                  Symbol PDK4 Name (RefSeq) pyruvate dehydrogenase kinase 4   KO K00898   pyruvate dehydrogenase kinase 2/3/4 [EC:2.7.11.2] Organism hsa  Homo sapiens (human) Pathway hsa05415   Diabetic cardiomyopathy Drug target Sodium dichloroacetate:  D05857 Brite KEGG Orthology (KO) [BR:hsa00001]  09160 Human Diseases   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     5166 (PDK4)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     5166 (PDK4) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.2  [pyruvate dehydrogenase (acetyl-transferring)] kinase      5166 (PDK4) Protein kinases [BR:hsa01001]  Serine/threonine kinases: Other   PDHK family [OT]    5166 (PDK4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  BCDHK_Adom3 HATPase_c Adaptin_N CheB_methylest Motif Other DBs NCBI-GeneID:  5166 NCBI-ProteinID:  NP_002603 OMIM:  602527 HGNC:  8812 Ensembl:  ENSG00000004799 Vega:  OTTHUMG00000153977 Pharos:  Q16654(Tbio) UniProt:  Q16654 A4D1H4 Structure PDB LinkDB All DBs Position 7:complement(95583499..95596516) Genome browser AA seq 411 aa AA seqDB search MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQE LPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTL IKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIF SDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPIH IVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPL RIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDA IIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM NT seq 1236 nt NT seq  +upstreamnt  +downstreamnt atgaaggcggcccgcttcgtgctgcgcagcgctggctcgctcaacggcgccggcctggtg ccccgagaggtggagcatttctcgcgctacagcccgtccccgctgtccatgaagcagcta ctggactttggttcagaaaatgcatgtgaaagaacttcttttgcatttttgcgacaagaa ttgcctgtgagactcgccaacattctgaaggaaattgatatcctcccgacccaattagta aatacctcttcagtgcaattggttaaaagctggtatatacagagcctgatggatttggtg gaattccatgagaaaagcccagatgaccagaaagcattatcagactttgtagatacactc atcaaagttcgaaatagacaccataatgtagtccctacaatggcacaaggaatcatagag tataaagatgcctgtacagttgacccagtcaccaatcaaaatcttcaatatttcttggat cgattttacatgaaccgtatttctactcggatgctgatgaaccagcacattcttatattt agtgactcacagacaggaaacccaagccacattggaagcattgatcctaactgtgatgtg gtagcagtggtccaagatgcctttgagtgttcaaggatgctctgtgatcagtattattta tcatctccagaattaaagcttacacaagtgaatggaaaatttccagaccaaccaattcac atcgtgtatgttccttctcacctccatcatatgctctttgaactatttaagaatgcaatg cgggcaacagttgaacaccaggaaaatcagccttcccttacaccaatagaggttattgtt gtcttgggaaaagaagaccttaccattaagatttcagacagaggaggtggtgttcccctg agaattattgaccgcctctttagttatacatactccactgcaccaacgcctgtgatggat aattcccggaatgctcctttggctggttttggttacggcttgccaatttctcgtctgtat gcaaagtactttcaaggagatctgaatctctactctttatcaggatatggaacagatgct atcatctacttaaaggctttgtcttctgagtctatagaaaaacttccagtttttaacaag tcagccttcaaacattatcagatgagctctgaggctgatgactggtgtatcccaagcagg gaaccaaagaacctggcaaaagaagtggccatgtga

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