KEGG   Homo sapiens (human): 5173
Entry
5173              CDS       T01001                                 
Symbol
PDYN, ADCA, PENKB, SCA23
Name
(RefSeq) prodynorphin
  KO
K15840  proenkephalin B (prodynorphin)
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04082  Neuroactive ligand signaling
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
Network
nt06462  Spinocerebellar ataxia
nt06466  Pathways of neurodegeneration
nt06544  Neuroactive ligand signaling
  Element
N00971  Mutation-caused aberrant PDYN to transport of calcium
N01917  Preprohormone cleavage, PDYN
Disease
H00063  Spinocerebellar ataxia (SCA)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5173 (PDYN)
   04082 Neuroactive ligand signaling
    5173 (PDYN)
   04081 Hormone signaling
    5173 (PDYN)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    5173 (PDYN)
   05022 Pathways of neurodegeneration - multiple diseases
    5173 (PDYN)
  09165 Substance dependence
   05030 Cocaine addiction
    5173 (PDYN)
   05031 Amphetamine addiction
    5173 (PDYN)
   05034 Alcoholism
    5173 (PDYN)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    5173 (PDYN)
   04052 Cytokines and neuropeptides [BR:hsa04052]
    5173 (PDYN)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   5173 (PDYN)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  GPCR binding
   5173 (PDYN)
SSDB
Motif
Pfam: Opiods_neuropep
Other DBs
NCBI-GeneID: 5173
NCBI-ProteinID: NP_001177821
OMIM: 131340
HGNC: 8820
Ensembl: ENSG00000101327
CPD: C16039 C16040 C16041 C16037 C01574 C16135
UniProt: P01213
Structure
LinkDB
Position
20:complement(1978756..1994285)
AA seq 254 aa
MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWE
RCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKEN
TLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLR
KYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRS
QEDPNAYSGELFDA
NT seq 765 nt   +upstreamnt  +downstreamnt
atggcctggcaggggctggtcctggctgcctgcctcctcatgttcccctccaccacagcg
gactgcctgtcgcggtgctccttgtgtgctgtaaagacccaggatggtcccaaacctatc
aatcccctgatttgctccctgcaatgccaggctgccctgctgccctctgaggaatgggag
agatgccagagctttctgtcttttttcaccccctccacccttgggctcaatgacaaggag
gacttggggagcaagtcggttggggaagggccctacagtgagctggccaagctctctggg
tcattcctgaaggagctggagaaaagcaagtttctcccaagtatctcaacaaaggagaac
actctgagcaagagcctggaggagaagctcaggggtctctctgacgggtttagggaggga
gcagagtctgagctgatgagggatgcccagctgaacgatggtgccatggagactggcaca
ctctatctcgctgaggaggaccccaaggagcaggtcaaacgctatgggggctttttgcgc
aaataccccaagaggagctcagaggtggctggggagggggacggggatagcatgggccat
gaggacctgtacaaacgctatgggggcttcttgcggcgcattcgtcccaagctcaagtgg
gacaaccagaagcgctatggcggttttctccggcgccagttcaaggtggtgactcggtct
caggaagatccgaatgcttactctggagagctttttgatgcataa

KEGG   Homo sapiens (human): 5179
Entry
5179              CDS       T01001                                 
Symbol
PENK, PE, PENK-A
Name
(RefSeq) proenkephalin
  KO
K18832  proenkephalin A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04082  Neuroactive ligand signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5179 (PENK)
   04082 Neuroactive ligand signaling
    5179 (PENK)
   04081 Hormone signaling
    5179 (PENK)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    5179 (PENK)
   04052 Cytokines and neuropeptides [BR:hsa04052]
    5179 (PENK)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   5179 (PENK)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  GPCR binding
   5179 (PENK)
SSDB
Motif
Pfam: Opiods_neuropep CENPH
Other DBs
NCBI-GeneID: 5179
NCBI-ProteinID: NP_001129162
OMIM: 131330
HGNC: 8831
Ensembl: ENSG00000181195
CPD: C11684 C16041 C16042 C16043
UniProt: P01210
Structure
LinkDB
Position
8:complement(56440957..56446641)
AA seq 267 aa
MARFLTLCTWLLLLGPGLLATVRAECSQDCATCSYRLVRPADINFLACVMECEGKLPSLK
IWETCKELLQLSKPELPQDGTSTLRENSKPEESHLLAKRYGGFMKRYGGFMKKMDELYPM
EPEEEANGSEILAKRYGGFMKKDAEEDDSLANSSDLLKELLETGDNRERSHHQDGSDNEE
EVSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEA
LPSDEEGESYSKEVPEMEKRYGGFMRF
NT seq 804 nt   +upstreamnt  +downstreamnt
atggcgcggttcctgacactttgcacttggctgctgttgctcggccccgggctcctggcg
accgtgcgggccgaatgcagccaggattgcgcgacgtgcagctaccgcctagtgcgcccg
gccgacatcaacttcctggcttgcgtaatggaatgtgaaggtaaactgccttctctgaaa
atttgggaaacctgcaaggagctcctgcagctgtccaaaccagagcttcctcaagatggc
accagcaccctcagagaaaatagcaaaccggaagaaagccatttgctagccaaaaggtat
gggggcttcatgaaaaggtatggaggcttcatgaagaaaatggatgagctttatcccatg
gagccagaagaagaggccaatggaagtgagatcctcgccaagcggtatgggggcttcatg
aagaaggatgcagaggaggacgactcgctggccaattcctcagacctgctaaaagagctt
ctggaaacaggggacaaccgagagcgtagccaccaccaggatggcagtgataatgaggaa
gaagtgagcaagagatatgggggcttcatgagaggcttaaagagaagcccccaactggaa
gatgaagccaaagagctgcagaagcgatatgggggcttcatgagaagagtaggtcgccca
gagtggtggatggactaccagaaacggtatggaggtttcctgaagcgctttgccgaggct
ctgccctccgacgaagaaggcgaaagttactccaaagaagttcctgaaatggaaaaaaga
tacggaggatttatgagattttaa

KEGG   Homo sapiens (human): 5368
Entry
5368              CDS       T01001                                 
Symbol
PNOC, N/OFQ, NOP, OFQ, PPNOC, ppN/OFQ
Name
(RefSeq) prepronociceptin
  KO
K25696  prepronociceptin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04082  Neuroactive ligand signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5368 (PNOC)
   04082 Neuroactive ligand signaling
    5368 (PNOC)
   04081 Hormone signaling
    5368 (PNOC)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    5368 (PNOC)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  GPCR binding
   5368 (PNOC)
SSDB
Motif
Pfam: Opiods_neuropep Nociceptin
Other DBs
NCBI-GeneID: 5368
NCBI-ProteinID: NP_006219
OMIM: 601459
HGNC: 9163
Ensembl: ENSG00000168081
CPD: C16044 C15871
UniProt: Q13519
Structure
LinkDB
Position
8:28316988..28343351
AA seq 176 aa
MKVLLCDLLLLSLFSSVFSSCQRDCLTCQEKLHPALDSFDLEVCILECEEKVFPSPLWTP
CTKVMARSSWQLSPAAPEHVAAALYQPRASEMQHLRRMPRVRSLFQEQEEPEPGMEEAGE
MEQKQLQKRFGGFTGARKSARKLANQKRFSEFMRQYLVLSMQSSQRRRTLHQNGNV
NT seq 531 nt   +upstreamnt  +downstreamnt
atgaaagtcctgctttgtgacctgctgctgctcagtctcttctccagtgtgttcagcagt
tgtcagagggactgtctcacatgccaggagaagctccacccagccctggacagcttcgac
ctggaggtgtgcatcctcgagtgtgaagagaaggtcttccccagccccctctggactcca
tgcaccaaggtcatggccaggagctcttggcagctcagccctgccgccccagagcatgtg
gcggctgctctctaccagccgagagcttcggagatgcagcatctgcggcgaatgccccga
gtccggagcttgttccaggagcaggaagagcccgagcctggcatggaggaggctggtgag
atggagcagaagcagctgcagaagagatttgggggcttcaccggggcccggaagtcggcc
aggaagttggccaatcagaagcggttcagtgagtttatgaggcaatacttggtcctgagc
atgcagtccagccagcgccggcgcaccctgcaccagaatggtaatgtgtag

KEGG   Homo sapiens (human): 5443
Entry
5443              CDS       T01001                                 
Symbol
POMC, ACTH, CLIP, LPH, MSH, NPP, OBAIRH, POC
Name
(RefSeq) proopiomelanocortin
  KO
K05228  proopiomelanocortin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04082  Neuroactive ligand signaling
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04920  Adipocytokine signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04927  Cortisol synthesis and secretion
hsa04934  Cushing syndrome
Network
nt06310  CRH-ACTH-cortisol signaling
nt06360  Cushing syndrome
nt06544  Neuroactive ligand signaling
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00318  EGFR-ERK-ACTH signaling pathway
N00319  Mutation-activated USP8 to EGFR-ERK-ACTH signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N01913  Melanocortin receptor signaling, MSH
N01916  Preprohormone cleavage, POMC
Disease
H02106  Genetic obesity
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    5443 (POMC)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5443 (POMC)
   04082 Neuroactive ligand signaling
    5443 (POMC)
   04081 Hormone signaling
    5443 (POMC)
 09150 Organismal Systems
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    5443 (POMC)
   04915 Estrogen signaling pathway
    5443 (POMC)
   04916 Melanogenesis
    5443 (POMC)
   04925 Aldosterone synthesis and secretion
    5443 (POMC)
   04927 Cortisol synthesis and secretion
    5443 (POMC)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    5443 (POMC)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    5443 (POMC)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  GPCR binding
   5443 (POMC)
SSDB
Motif
Pfam: ACTH_domain NPP Op_neuropeptide
Other DBs
NCBI-GeneID: 5443
NCBI-ProteinID: NP_000930
OMIM: 176830
HGNC: 9201
Ensembl: ENSG00000115138
CPD: C16019 C16020 C02758 C02017 C02210 C16134 C16136 C16137
UniProt: P01189
Structure
LinkDB
Position
2:complement(25160860..25168580)
AA seq 267 aa
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE
NT seq 804 nt   +upstreamnt  +downstreamnt
atgccgagatcgtgctgcagccgctcgggggccctgttgctggccttgctgcttcaggcc
tccatggaagtgcgtggctggtgcctggagagcagccagtgtcaggacctcaccacggaa
agcaacctgctggagtgcatccgggcctgcaagcccgacctctcggccgagactcccatg
ttcccgggaaatggcgacgagcagcctctgaccgagaacccccggaagtacgtcatgggc
cacttccgctgggaccgattcggccgccgcaacagcagcagcagcggcagcagcggcgca
gggcagaagcgcgaggacgtctcagcgggcgaagactgcggcccgctgcctgagggcggc
cccgagccccgcagcgatggtgccaagccgggcccgcgcgagggcaagcgctcctactcc
atggagcacttccgctggggcaagccggtgggcaagaagcggcgcccagtgaaggtgtac
cctaacggcgccgaggacgagtcggccgaggccttccccctggagttcaagagggagctg
actggccagcgactccgggagggagatggccccgacggccctgccgatgacggcgcaggg
gcccaggccgacctggagcacagcctgctggtggcggccgagaagaaggacgagggcccc
tacaggatggagcacttccgctggggcagcccgcccaaggacaagcgctacggcggtttc
atgacctccgagaagagccagacgcccctggtgacgctgttcaaaaacgccatcatcaag
aacgcctacaagaagggcgagtga

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