Homo sapiens (human): 5173 Help Entry 5173              CDS       T01001                                  Symbol PDYN, ADCA, PENKB, SCA23 Name (RefSeq) prodynorphin   KO K15840   proenkephalin B (prodynorphin) Organism hsa  Homo sapiens (human) Pathway hsa04080   Neuroactive ligand-receptor interaction hsa05017   Spinocerebellar ataxia hsa05022   Pathways of neurodegeneration - multiple diseases hsa05030   Cocaine addiction hsa05031   Amphetamine addiction hsa05034   Alcoholism Network nt06410  Calcium signaling nt06462  Spinocerebellar ataxia   Element N00971   Mutation-caused aberrant PDYN to transport of calcium Disease H00063   Spinocerebellar ataxia (SCA) Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     5173 (PDYN)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     5173 (PDYN)    05022 Pathways of neurodegeneration - multiple diseases     5173 (PDYN)   09165 Substance dependence    05030 Cocaine addiction     5173 (PDYN)    05031 Amphetamine addiction     5173 (PDYN)    05034 Alcoholism     5173 (PDYN)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    02000 Transporters [BR:hsa02000]     5173 (PDYN) Transporters [BR:hsa02000]  Other transporters   Pores ion channels [TC:1]    5173 (PDYN) BRITE hierarchyBRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Opiods_neuropep Motif Other DBs NCBI-GeneID:  5173 NCBI-ProteinID:  NP_001177821 OMIM:  131340 HGNC:  8820 Ensembl:  ENSG00000101327 Pharos:  P01213(Tbio) CPD:  C16039 C16040 C16041 C16037 C01574 C16135 UniProt:  P01213 Structure PDB LinkDB All DBs Position 20:complement(1978756..1994285) Genome browser AA seq 254 aa AA seqDB search MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWE RCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKEN TLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLR KYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRS QEDPNAYSGELFDA NT seq 765 nt NT seq  +upstreamnt  +downstreamnt atggcctggcaggggctggtcctggctgcctgcctcctcatgttcccctccaccacagcg gactgcctgtcgcggtgctccttgtgtgctgtaaagacccaggatggtcccaaacctatc aatcccctgatttgctccctgcaatgccaggctgccctgctgccctctgaggaatgggag agatgccagagctttctgtcttttttcaccccctccacccttgggctcaatgacaaggag gacttggggagcaagtcggttggggaagggccctacagtgagctggccaagctctctggg tcattcctgaaggagctggagaaaagcaagtttctcccaagtatctcaacaaaggagaac actctgagcaagagcctggaggagaagctcaggggtctctctgacgggtttagggaggga gcagagtctgagctgatgagggatgcccagctgaacgatggtgccatggagactggcaca ctctatctcgctgaggaggaccccaaggagcaggtcaaacgctatgggggctttttgcgc aaataccccaagaggagctcagaggtggctggggagggggacggggatagcatgggccat gaggacctgtacaaacgctatgggggcttcttgcggcgcattcgtcccaagctcaagtgg gacaaccagaagcgctatggcggttttctccggcgccagttcaaggtggtgactcggtct caggaagatccgaatgcttactctggagagctttttgatgcataa

Homo sapiens (human): 5179 Help Entry 5179              CDS       T01001                                  Symbol PENK, PE, PENK-A Name (RefSeq) proenkephalin   KO K18832   proenkephalin A Organism hsa  Homo sapiens (human) Pathway hsa04080   Neuroactive ligand-receptor interaction Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     5179 (PENK)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    02000 Transporters [BR:hsa02000]     5179 (PENK) Transporters [BR:hsa02000]  Other transporters   Pores ion channels [TC:1]    5179 (PENK) BRITE hierarchyBRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Opiods_neuropep SRF-TF Motif Other DBs NCBI-GeneID:  5179 NCBI-ProteinID:  NP_001129162 OMIM:  131330 HGNC:  8831 Ensembl:  ENSG00000181195 Pharos:  P01210(Tbio) CPD:  C11684 C16041 C16042 C16043 UniProt:  P01210 A0A024R7V4 Structure PDB LinkDB All DBs Position 8:complement(56440957..56446641) Genome browser AA seq 267 aa AA seqDB search MARFLTLCTWLLLLGPGLLATVRAECSQDCATCSYRLVRPADINFLACVMECEGKLPSLK IWETCKELLQLSKPELPQDGTSTLRENSKPEESHLLAKRYGGFMKRYGGFMKKMDELYPM EPEEEANGSEILAKRYGGFMKKDAEEDDSLANSSDLLKELLETGDNRERSHHQDGSDNEE EVSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEA LPSDEEGESYSKEVPEMEKRYGGFMRF NT seq 804 nt NT seq  +upstreamnt  +downstreamnt atggcgcggttcctgacactttgcacttggctgctgttgctcggccccgggctcctggcg accgtgcgggccgaatgcagccaggattgcgcgacgtgcagctaccgcctagtgcgcccg gccgacatcaacttcctggcttgcgtaatggaatgtgaaggtaaactgccttctctgaaa atttgggaaacctgcaaggagctcctgcagctgtccaaaccagagcttcctcaagatggc accagcaccctcagagaaaatagcaaaccggaagaaagccatttgctagccaaaaggtat gggggcttcatgaaaaggtatggaggcttcatgaagaaaatggatgagctttatcccatg gagccagaagaagaggccaatggaagtgagatcctcgccaagcggtatgggggcttcatg aagaaggatgcagaggaggacgactcgctggccaattcctcagacctgctaaaagagctt ctggaaacaggggacaaccgagagcgtagccaccaccaggatggcagtgataatgaggaa gaagtgagcaagagatatgggggcttcatgagaggcttaaagagaagcccccaactggaa gatgaagccaaagagctgcagaagcgatatgggggcttcatgagaagagtaggtcgccca gagtggtggatggactaccagaaacggtatggaggtttcctgaagcgctttgccgaggct ctgccctccgacgaagaaggcgaaagttactccaaagaagttcctgaaatggaaaaaaga tacggaggatttatgagattttaa

Homo sapiens (human): 5443 Help Entry 5443              CDS       T01001                                  Symbol POMC, ACTH, CLIP, LPH, MSH, NPP, OBAIRH, POC Name (RefSeq) proopiomelanocortin   KO K05228   proopiomelanocortin Organism hsa  Homo sapiens (human) Pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04915   Estrogen signaling pathway hsa04916   Melanogenesis hsa04920   Adipocytokine signaling pathway hsa04925   Aldosterone synthesis and secretion hsa04927   Cortisol synthesis and secretion hsa04934   Cushing syndrome Network nt06310  CRH-ACTH-cortisol signaling nt06360  Cushing syndrome   Element N00297   ACTH-cortisol signaling pathway N00298   CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway N00318   EGFR-ERK-ACTH signaling pathway N00319   Mutation-activated USP8 to EGFR-ERK-ACTH signaling pathway N00324   CRHR-PKA-ACTH signaling pathway N00325   Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway N00326   Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway N00327   Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway Disease H02106   Genetic obesity Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04024 cAMP signaling pathway     5443 (POMC)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     5443 (POMC)  09150 Organismal Systems   09152 Endocrine system    04920 Adipocytokine signaling pathway     5443 (POMC)    04915 Estrogen signaling pathway     5443 (POMC)    04916 Melanogenesis     5443 (POMC)    04925 Aldosterone synthesis and secretion     5443 (POMC)    04927 Cortisol synthesis and secretion     5443 (POMC)  09160 Human Diseases   09167 Endocrine and metabolic disease    04934 Cushing syndrome     5443 (POMC) BRITE hierarchyBRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  ACTH_domain NPP Op_neuropeptide ACTH_assoc Motif Other DBs NCBI-GeneID:  5443 NCBI-ProteinID:  NP_000930 OMIM:  176830 HGNC:  9201 Ensembl:  ENSG00000115138 Pharos:  P01189(Tbio) CPD:  C16019 C16020 C02758 C02017 C02210 C16134 C16136 C16137 UniProt:  P01189 Structure PDB LinkDB All DBs Position 2:complement(25160860..25168580) Genome browser AA seq 267 aa AA seqDB search MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF MTSEKSQTPLVTLFKNAIIKNAYKKGE NT seq 804 nt NT seq  +upstreamnt  +downstreamnt atgccgagatcgtgctgcagccgctcgggggccctgttgctggccttgctgcttcaggcc tccatggaagtgcgtggctggtgcctggagagcagccagtgtcaggacctcaccacggaa agcaacctgctggagtgcatccgggcctgcaagcccgacctctcggccgagactcccatg ttcccgggaaatggcgacgagcagcctctgaccgagaacccccggaagtacgtcatgggc cacttccgctgggaccgattcggccgccgcaacagcagcagcagcggcagcagcggcgca gggcagaagcgcgaggacgtctcagcgggcgaagactgcggcccgctgcctgagggcggc cccgagccccgcagcgatggtgccaagccgggcccgcgcgagggcaagcgctcctactcc atggagcacttccgctggggcaagccggtgggcaagaagcggcgcccagtgaaggtgtac cctaacggcgccgaggacgagtcggccgaggccttccccctggagttcaagagggagctg actggccagcgactccgggagggagatggccccgacggccctgccgatgacggcgcaggg gcccaggccgacctggagcacagcctgctggtggcggccgagaagaaggacgagggcccc tacaggatggagcacttccgctggggcagcccgcccaaggacaagcgctacggcggtttc atgacctccgagaagagccagacgcccctggtgacgctgttcaaaaacgccatcatcaag aacgcctacaagaagggcgagtga

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