KEGG   Homo sapiens (human): 55584
Entry
55584             CDS       T01001                                 
Symbol
CHRNA9, HSA243342, NACHRA9
Name
(RefSeq) cholinergic receptor nicotinic alpha 9 subunit
  KO
K04810  nicotinic acetylcholine receptor alpha-9
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa05207  Chemical carcinogenesis - receptor activation
Network
nt06210  ERK signaling
nt06214  PI3K signaling
  Element
N01350  NNK/NNN to PI3K signaling pathway
N01353  E2 to RAS-ERK signaling pathway
Drug target
Acetylcholine (DG01133): D00999<JP/US>
Atracurium (DG00771): D00758<US>
Cisatracurium: D00759<US>
Cytisinicline: D07770
Dimethyltubocurarine: D07272
Doxacurium chloride: D00760
Fazadinium bromide: D07273
Hexamethonium bromide: D02204
Lobeline (DG01287): D02202 D02364 D08138
Mecamylamine (DG00252): D00611<US>
Mivacurium chloride: D00763
Nicotine (DG00994): D03365<JP/US> D05156 D05157
Pancuronium (DG00769): D00492<US>
Pipecuronium bromide: D00764
Rocuronium bromide: D00765<JP/US>
Tubocurarine (DG00767): D02207 D08655
Vecuronium (DG00770): D00767<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    55584 (CHRNA9)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    55584 (CHRNA9)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    55584 (CHRNA9)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Acetylcholine (nicotinic)
   55584 (CHRNA9)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb DUF5665
Other DBs
NCBI-GeneID: 55584
NCBI-ProteinID: NP_060051
OMIM: 605116
HGNC: 14079
Ensembl: ENSG00000174343
Pharos: Q9UGM1(Tbio)
UniProt: Q9UGM1
Structure
LinkDB
Position
4:40335333..40355217
AA seq 479 aa
MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTL
QITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLY
NKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNG
NQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFY
IVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIG
KYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLS
PHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQ
YKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD
NT seq 1440 nt   +upstreamnt  +downstreamnt
atgaactggtcccattcctgcatctccttttgctggatctactttgctgcttccagactg
agagctgcagagacggcagatggaaaatatgctcagaagttgtttaatgacctttttgaa
gattattctaatgctcttcgtccagtggaagatacagataaagtcctgaatgtgaccctg
cagattacgctctctcagattaaggatatggatgaaagaaaccaaattctgactgcttat
ttgtggatccgccaaatctggcacgatgcctatctcacgtgggaccgagatcagtacgat
ggcctagactccatcaggatccccagtgacctcgtgtggaggccagacatcgtcttatat
aacaaggctgatgatgaatcttcagagcctgtgaacaccaatgtggtcctgcggtatgat
gggctgatcacctgggatgcaccggccatcaccaaaagctcctgtgtggtggatgtcacc
tacttcccttttgacaaccagcagtgcaacctgacttttggttcctggacctacaatggc
aatcaggtggacatattcaacgccttggacagcggagatctctctgacttcattgaagat
gtggaatgggaggtccatggcatgcccgctgtgaagaatgtgatctcctatggctgctgc
tctgagccttacccggatgtcacattcaccctccttctgaagaggaggtcctcgttctat
atcgtcaacctcctcatcccatgcgtcctcatatcttttctggctcctctgagtttttat
ctcccagcagcctccggagaaaaggtctccctgggagtgaccatcctgttggccatgact
gtatttcagctaatggtggcagaaatcatgccggcctcagaaaatgtgcccctgataggt
aaatactacatagccacgatggccctgatcacagcctccactgcgttgaccatcatggtg
atgaatatccacttctgtggggccgaggcccggccggtgccacactgggccagggtggtc
atcctgaaatacatgtccagggtcttgtttgtctatgatgtgggtgaaagctgcctcagc
ccgcaccacagtagagagcgggaccacctcacgaaagtttatagcaaactcccagagtct
aacctgaaagcagccaggaacaaagacctttccagaaagaaggacatgaacaaacgctta
aagaacgacctgggctgccagggtaagaaccctcaggaggccgagagttactgtgcacag
tacaaagtgctgacgaggaatattgagtacatcgccaagtgcctcaaagaccacaaggcc
accaattccaaggggagtgaatggaagaaggtggcgaaagtcatagaccgattcttcatg
tggatttttttcattatggtgtttgtgatgactattttgatcatagcaagagcggattag

KEGG   Homo sapiens (human): 896
Entry
896               CDS       T01001                                 
Symbol
CCND3
Name
(RefSeq) cyclin D3
  KO
K10152  G1/S-specific cyclin-D3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa04115  p53 signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04218  Cellular senescence
hsa04310  Wnt signaling pathway
hsa04390  Hippo signaling pathway
hsa04510  Focal adhesion
hsa04630  JAK-STAT signaling pathway
hsa05162  Measles
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
Network
nt06130  Cell cycle (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06214  PI3K signaling
nt06230  Cell cycle
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06273  Glioma
nt06276  Chronic myeloid leukemia
  Element
N00066  MDM2-p21-Cell cycle G1/S
N00067  Deleted p14(ARF) to p21-cell cycle G1/S
N00068  Amplified MDM2 to p21-cell cycle G1/S
N00069  p16-Cell cycle G1/S
N00070  Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
N00071  Deleted p16(INK4a) to p16-cell cycle G1/S
N00072  Amplified CDK4 to cell cycle G1/S
N00073  Mutation-activated CDK4 to cell cycle G1/S
N00076  Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
N00088  Amplified MYC to p15-cell cycle G1/S
N00089  Amplified MYC to cell cycle G1/S
N00090  p15-Cell cycle G1/S
N00347  p300-p21-Cell cycle G1/S
N00483  EBV EBNA3C to cell cycle G1/S
N00741  IAV M2 to cell cycle G1/S
N01350  NNK/NNN to PI3K signaling pathway
Disease
H00010  Multiple myeloma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    896 (CCND3)
   04390 Hippo signaling pathway
    896 (CCND3)
   04630 JAK-STAT signaling pathway
    896 (CCND3)
   04151 PI3K-Akt signaling pathway
    896 (CCND3)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    896 (CCND3)
   04115 p53 signaling pathway
    896 (CCND3)
   04218 Cellular senescence
    896 (CCND3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    896 (CCND3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    896 (CCND3)
   05207 Chemical carcinogenesis - receptor activation
    896 (CCND3)
   05203 Viral carcinogenesis
    896 (CCND3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    896 (CCND3)
   05164 Influenza A
    896 (CCND3)
   05162 Measles
    896 (CCND3)
   05169 Epstein-Barr virus infection
    896 (CCND3)
   05165 Human papillomavirus infection
    896 (CCND3)
SSDB
Motif
Pfam: Cyclin_N Cyclin_C K-cyclin_vir_C
Other DBs
NCBI-GeneID: 896
NCBI-ProteinID: NP_001751
OMIM: 123834
HGNC: 1585
Ensembl: ENSG00000112576
Pharos: P30281(Tchem)
UniProt: P30281
Structure
LinkDB
Position
6:complement(41934933..42048894)
AA seq 292 aa
MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
NT seq 879 nt   +upstreamnt  +downstreamnt
atggagctgctgtgttgcgaaggcacccggcacgcgccccgggccgggccggacccgcgg
ctgctgggggaccagcgtgtcctgcagagcctgctccgcctggaggagcgctacgtaccc
cgcgcctcctacttccagtgcgtgcagcgggagatcaagccgcacatgcggaagatgctg
gcttactggatgctggaggtatgtgaggagcagcgctgtgaggaggaagtcttccccctg
gccatgaactacctggatcgctacctgtcttgcgtccccacccgaaaggcgcagttgcag
ctcctgggtgcggtctgcatgctgctggcctccaagctgcgcgagaccacgcccctgacc
atcgaaaaactgtgcatctacaccgaccacgctgtctctccccgccagttgcgggactgg
gaggtgctggtcctagggaagctcaagtgggacctggctgctgtgattgcacatgatttc
ctggccttcattctgcaccggctctctctgccccgtgaccgacaggccttggtcaaaaag
catgcccagacctttttggccctctgtgctacagattatacctttgccatgtacccgcca
tccatgatcgccacgggcagcattggggctgcagtgcaaggcctgggtgcctgctccatg
tccggggatgagctcacagagctgctggcagggatcactggcactgaagtggactgcctg
cgggcctgtcaggagcagatcgaagctgcactcagggagagcctcagggaagcctctcag
accagctccagcccagcgcccaaagccccccggggctccagcagccaagggcccagccag
accagcactcctacagatgtcacagccatacacctgtag

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