KEGG T01001: 55584

Homo sapiens (human): 55584

Entry

55584             CDS       T01001

Symbol

CHRNA9, HSA243342, NACHRA9

Name

(RefSeq) cholinergic receptor nicotinic alpha 9 subunit

K04810

nicotinic acetylcholine receptor alpha-9

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa05207

Chemical carcinogenesis - receptor activation

Network

nt06210 ERK signaling (cancer)
nt06214 PI3K signaling (cancer)

Element

N01350

NNK/NNN to PI3K signaling pathway

N01353

E2 to RAS-ERK signaling pathway

Drug target

Acetylcholine (DG01133):

D00999<JP/US>

Atracurium (DG00771):

D00758<US>

Cisatracurium:

D00759<US>

Cytisinicline:

D07770

Dimethyltubocurarine:

D07272

Doxacurium chloride:

D00760

Fazadinium bromide:

D07273

Hexamethonium bromide:

D02204

Lobeline (DG01287):

D02202 D02364 D08138

Mecamylamine (DG00252):

D00611<US>

Mivacurium chloride:

D00763

Nicotine (DG00994):

D03365<JP/US> D05156 D05157

Pancuronium (DG00769):

D00492

Pipecuronium bromide:

D00764

Rocuronium bromide:

D00765<JP/US>

Tubocurarine (DG00767):

D02207 D08655

Vecuronium (DG00770):

D00767<US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    55584 (CHRNA9)
09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    55584 (CHRNA9)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    55584 (CHRNA9)
Ion channels [BR:hsa04040]
Ligand-gated channels
  Acetylcholine (nicotinic)
   55584 (CHRNA9)

SSDB

Motif

Pfam:

Neur_chan_LBD Neur_chan_memb DUF5665 Ubiq_cyt_C_chap

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

4:40335333..40355217

AA seq 479 aa
MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTL
QITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLY
NKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNG
NQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFY
IVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIG
KYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLS
PHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQ
YKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD

NT seq 1440 nt +upstreamnt +downstreamnt
atgaactggtcccattcctgcatctccttttgctggatctactttgctgcttccagactg
agagctgcagagacggcagatggaaaatatgctcagaagttgtttaatgacctttttgaa
gattattctaatgctcttcgtccagtggaagatacagataaagtcctgaatgtgaccctg
cagattacgctctctcagattaaggatatggatgaaagaaaccaaattctgactgcttat
ttgtggatccgccaaatctggcacgatgcctatctcacgtgggaccgagatcagtacgat
ggcctagactccatcaggatccccagtgacctcgtgtggaggccagacatcgtcttatat
aacaaggctgatgatgaatcttcagagcctgtgaacaccaatgtggtcctgcggtatgat
gggctgatcacctgggatgcaccggccatcaccaaaagctcctgtgtggtggatgtcacc
tacttcccttttgacaaccagcagtgcaacctgacttttggttcctggacctacaatggc
aatcaggtggacatattcaacgccttggacagcggagatctctctgacttcattgaagat
gtggaatgggaggtccatggcatgcccgctgtgaagaatgtgatctcctatggctgctgc
tctgagccttacccggatgtcacattcaccctccttctgaagaggaggtcctcgttctat
atcgtcaacctcctcatcccatgcgtcctcatatcttttctggctcctctgagtttttat
ctcccagcagcctccggagaaaaggtctccctgggagtgaccatcctgttggccatgact
gtatttcagctaatggtggcagaaatcatgccggcctcagaaaatgtgcccctgataggt
aaatactacatagccacgatggccctgatcacagcctccactgcgttgaccatcatggtg
atgaatatccacttctgtggggccgaggcccggccggtgccacactgggccagggtggtc
atcctgaaatacatgtccagggtcttgtttgtctatgatgtgggtgaaagctgcctcagc
ccgcaccacagtagagagcgggaccacctcacgaaagtttatagcaaactcccagagtct
aacctgaaagcagccaggaacaaagacctttccagaaagaaggacatgaacaaacgctta
aagaacgacctgggctgccagggtaagaaccctcaggaggccgagagttactgtgcacag
tacaaagtgctgacgaggaatattgagtacatcgccaagtgcctcaaagaccacaaggcc
accaattccaaggggagtgaatggaagaaggtggcgaaagtcatagaccgattcttcatg
tggatttttttcattatggtgtttgtgatgactattttgatcatagcaagagcggattag

Homo sapiens (human): 896

Entry

896               CDS       T01001

Symbol

CCND3

Name

(RefSeq) cyclin D3

K10152

G1/S-specific cyclin-D3

Organism

hsa Homo sapiens (human)

Pathway

hsa04110

Cell cycle

hsa04115

p53 signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04218

Cellular senescence

hsa04310

Wnt signaling pathway

hsa04390

Hippo signaling pathway

hsa04510

Focal adhesion

hsa04630

JAK-STAT signaling pathway

hsa05162

Measles

hsa05164

Influenza A

hsa05165

Human papillomavirus infection

hsa05166

Human T-cell leukemia virus 1 infection

hsa05169

Epstein-Barr virus infection

hsa05200

Pathways in cancer

hsa05203

Viral carcinogenesis

hsa05207

Chemical carcinogenesis - receptor activation

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06214  PI3K signaling (cancer)
nt06230  Cell cycle (cancer)
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06273  Glioma
nt06276  Chronic myeloid leukemia

Element

N00066

MDM2-p21-Cell cycle G1/S

N00067

Deleted p14(ARF) to p21-cell cycle G1/S

N00068

Amplified MDM2 to p21-cell cycle G1/S

N00069

p16-Cell cycle G1/S

N00070

Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S

N00071

Deleted p16(INK4a) to p16-cell cycle G1/S

N00072

Amplified CDK4 to cell cycle G1/S

N00073

Mutation-activated CDK4 to cell cycle G1/S

N00076

Mutation-inactivated p14(ARF) to p21-cell cycle G1/S

N00088

Amplified MYC to p15-cell cycle G1/S

N00089

Amplified MYC to cell cycle G1/S

N00090

p15-Cell cycle G1/S

N00347

p300-p21-Cell cycle G1/S

N00483

EBV EBNA3C to cell cycle G1/S

N00741

IAV M2 to cell cycle G1/S

N01350

NNK/NNN to PI3K signaling pathway

Disease

H00010

Multiple myeloma

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    896 (CCND3)
   04390 Hippo signaling pathway
    896 (CCND3)
   04630 JAK-STAT signaling pathway
    896 (CCND3)
   04151 PI3K-Akt signaling pathway
    896 (CCND3)
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    896 (CCND3)
   04115 p53 signaling pathway
    896 (CCND3)
   04218 Cellular senescence
    896 (CCND3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    896 (CCND3)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    896 (CCND3)
   05207 Chemical carcinogenesis - receptor activation
    896 (CCND3)
   05203 Viral carcinogenesis
    896 (CCND3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    896 (CCND3)
   05164 Influenza A
    896 (CCND3)
   05162 Measles
    896 (CCND3)
   05169 Epstein-Barr virus infection
    896 (CCND3)
   05165 Human papillomavirus infection
    896 (CCND3)

SSDB

Motif

Pfam:

Cyclin_N Cyclin_C K-cyclin_vir_C

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

6:complement(41934933..42050035)

AA seq 292 aa
MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL

NT seq 879 nt +upstreamnt +downstreamnt
atggagctgctgtgttgcgaaggcacccggcacgcgccccgggccgggccggacccgcgg
ctgctgggggaccagcgtgtcctgcagagcctgctccgcctggaggagcgctacgtaccc
cgcgcctcctacttccagtgcgtgcagcgggagatcaagccgcacatgcggaagatgctg
gcttactggatgctggaggtatgtgaggagcagcgctgtgaggaggaagtcttccccctg
gccatgaactacctggatcgctacctgtcttgcgtccccacccgaaaggcgcagttgcag
ctcctgggtgcggtctgcatgctgctggcctccaagctgcgcgagaccacgcccctgacc
atcgaaaaactgtgcatctacaccgaccacgctgtctctccccgccagttgcgggactgg
gaggtgctggtcctagggaagctcaagtgggacctggctgctgtgattgcacatgatttc
ctggccttcattctgcaccggctctctctgccccgtgaccgacaggccttggtcaaaaag
catgcccagacctttttggccctctgtgctacagattatacctttgccatgtacccgcca
tccatgatcgccacgggcagcattggggctgcagtgcaaggcctgggtgcctgctccatg
tccggggatgagctcacagagctgctggcagggatcactggcactgaagtggactgcctg
cgggcctgtcaggagcagatcgaagctgcactcagggagagcctcagggaagcctctcag
accagctccagcccagcgcccaaagccccccggggctccagcagccaagggcccagccag
accagcactcctacagatgtcacagccatacacctgtag

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