Entry |
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Symbol |
MASP1, 3MC1, CRARF, CRARF1, MAP-1, MAP1, MASP, MASP-3, MASP3, MAp44, PRSS5, RaRF
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Name |
(RefSeq) MBL associated serine protease 1
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KO |
K03992 | mannan-binding lectin serine protease 1 [EC:3.4.21.-] |
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Organism |
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Pathway |
hsa04610 | Complement and coagulation cascades |
hsa05150 | Staphylococcus aureus infection |
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Network |
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Element |
N01312 | SARS-CoV-2 S to lectin pathway of complement cascade |
N01491 | Lectin pathway of complement cascade, C4/C2 to C3 convertase formation |
N01502 | Lectin pathway of coagulation cascade, fibrinogen to fibrin |
N01520 | Regulation of fibrinolytic system, C1INH |
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Disease |
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Drug target |
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Brite |
KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
09151 Immune system
04610 Complement and coagulation cascades
5648 (MASP1)
09160 Human Diseases
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
5648 (MASP1)
09171 Infectious disease: bacterial
05150 Staphylococcus aureus infection
5648 (MASP1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:hsa01002]
5648 (MASP1)
Peptidases and inhibitors [BR:hsa01002]
Serine peptidases
Family S1: chymotrypsin family
5648 (MASP1)
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SSDB |
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Motif |
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Other DBs |
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Structure |
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LinkDB |
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Position |
3:complement(187217282..187291737)
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AA seq |
699 aa
MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL
YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS
DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT
CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV
PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE
CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP
TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW
MNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLL
GSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTL
HPQYDPNTFENDVALVELLESPVLNAFVMPICLPEGPQQEGAMVIVSGWGKQFLQRFPET
LMEIEIPIVDHSTCQKAYAPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQW
YLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQRVTGVRN |
NT seq |
2100 nt +upstreamnt +downstreamnt
atgaggtggctgcttctctattatgctctgtgcttctccctgtcaaaggcttcagcccac
accgtggagctaaacaatatgtttggccagatccagtcgcctggttatccagactcctat
cccagtgattcagaggtgacttggaatatcactgtcccagatgggtttcggatcaagctt
tacttcatgcacttcaacttggaatcctcctacctttgtgaatatgactatgtgaaggta
gaaactgaggaccaggtgctggcaaccttctgtggcagggagaccacagacacagagcag
actcccggccaggaggtggtcctctcccctggctccttcatgtccatcactttccggtca
gatttctccaatgaggagcgtttcacaggctttgatgcccactacatggctgtggatgtg
gacgagtgcaaggagagggaggacgaggagctgtcctgtgaccactactgccacaactac
attggcggctactactgctcctgccgcttcggctacatcctccacacagacaacaggacc
tgccgagtggagtgcagtgacaacctcttcactcaaaggactggggtgatcaccagccct
gacttcccaaacccttaccccaagagctctgaatgcctgtataccatcgagctggaggag
ggtttcatggtcaacctgcagtttgaggacatatttgacattgaggaccatcctgaggtg
ccctgcccctatgactacatcaagatcaaagttggtccaaaagttttggggcctttctgt
ggagagaaagccccagaacccatcagcacccagagccacagtgtcctgatcctgttccat
agtgacaactcgggagagaaccggggctggaggctctcatacagggctgcaggaaatgag
tgcccagagctacagcctcctgtccatgggaaaatcgagccctcccaagccaagtatttc
ttcaaagaccaagtgctcgtcagctgtgacacaggctacaaagtgctgaaggataatgtg
gagatggacacattccagattgagtgtctgaaggatgggacgtggagtaacaagattccc
acctgtaaaattgtagactgtagagccccaggagagctggaacacgggctgatcaccttc
tctacaaggaacaacctcaccacatacaagtctgagatcaaatactcctgtcaggagccc
tattacaagatgctcaacaataacacaggtatatatacctgttctgcccaaggagtctgg
atgaataaagtattggggagaagcctacccacctgccttccagtgtgtgggctccccaag
ttctcccggaagctgatggccaggatcttcaatggacgcccagcccagaaaggcaccact
ccctggattgccatgctgtcacacctgaatgggcagcccttctgcggaggctcccttcta
ggctccagctggatcgtgaccgccgcacactgcctccaccagtcactcgatccggaagat
ccgaccctacgtgattcagacttgctcagcccttctgacttcaaaatcatcctgggcaag
cattggaggctccggtcagatgaaaatgaacagcatctcggcgtcaaacacaccactctc
cacccccagtatgatcccaacacattcgagaatgacgtggctctggtggagctgttggag
agcccagtgctgaatgccttcgtgatgcccatctgtctgcctgagggaccccagcaggaa
ggagccatggtcatcgtcagcggctgggggaagcagttcttgcaaaggttcccagagacc
ctgatggagattgaaatcccgattgttgaccacagcacctgccagaaggcttatgccccg
ctgaagaagaaagtgaccagggacatgatctgtgctggggagaaggaagggggaaaggac
gcctgtgcgggtgactctggaggccccatggtgaccctgaatagagaaagaggccagtgg
tacctggtgggcactgtgtcctggggtgatgactgtgggaagaaggaccgctacggagta
tactcttacatccaccacaacaaggactggatccagagggtcaccggagtgaggaactga |