Homo sapiens (human): 5980
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Entry
5980 CDS
T01001
Symbol
REV3L, POLZ, REV3
Name
(RefSeq) REV3 like, DNA directed polymerase zeta catalytic subunit
KO
K02350
DNA polymerase zeta [EC:
2.7.7.7
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01524
Platinum drug resistance
hsa03460
Fanconi anemia pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09124 Replication and repair
03460 Fanconi anemia pathway
5980 (REV3L)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
5980 (REV3L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03400 DNA repair and recombination proteins [BR:
hsa03400
]
5980 (REV3L)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.7 Nucleotidyltransferases
2.7.7.7 DNA-directed DNA polymerase
5980 (REV3L)
DNA repair and recombination proteins [BR:
hsa03400
]
Eukaryotic type
TLS (translesion DNA synthesis) factors
B-family DNA polymerases
5980 (REV3L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DUF4683
DNA_pol_B
DNA_pol_B_exo1
zf-C4pol
Motif
Other DBs
NCBI-GeneID:
5980
NCBI-ProteinID:
NP_002903
OMIM:
602776
HGNC:
9968
Ensembl:
ENSG00000009413
Vega:
OTTHUMG00000016318
Pharos:
O60673
(Tbio)
UniProt:
O60673
Q9UG47
Structure
PDB
LinkDB
All DBs
Position
6:complement(111299033..111483711)
Genome browser
AA seq
3130 aa
AA seq
DB search
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPY
LYVPYDGYGQQPESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKER
HFMKIYLYNPTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAV
KFRKARRKSNTLHATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDA
VAADILNRLDIEAQIGGNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKK
FQKRLQEILKQNDFSVTLSGSVDYSDGSQEFSAELTLHSEVLSPEMLQCTPANMVEVHKD
KESSKGHTRHKVEEALINEEAILNLMENSQTFQPLTQRLSESPVFMDSSPDEALVHLLAG
LESDGYRGERNRMPSPCRSFGNNKYPQNSDDEENEPQIEKEEMELSLVMSQRWDSNIEEH
CAKKRSLCRNTHRSSTEDDDSSSGEEMEWSDNSLLLASLSIPQLDGTADENSDNPLNNEN
SRTHSSVIATSKLSVKPSIFHKDAATLEPSSSAKITFQCKHTSALSSHVLNKEDLIEDLS
QTNKNTEKGLDNSVTSFTNESTYSMKYPGSLSSTVHSENSHKENSKKEILPVSSCESSIF
DYEEDIPSVTRQVPSRKYTNIRKIEKDSPFIHMHRHPNENTLGKNSFNFSDLNHSKNKVS
SEGNEKGNSTALSSLFPSSFTENCELLSCSGENRTMVHSLNSTADESGLNKLKIRYEEFQ
EHKTEKPSLSQQAAHYMFFPSVVLSNCLTRPQKLSPVTYKLQPGNKPSRLKLNKRKLAGH
QETSTKSSETGSTKDNFIQNNPCNSNPEKDNALASDLTKTTRGAFENKTPTDGFIDCHFG
DGTLETEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTHNSKISLPHPMEIGESLDGTLK
SRKRRKMSKKLPPVIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLAPL
KDFWPKVPDSPATKYPIYPLTPKKSHRRKSKHKSAKKKTGKQQRTNNENIKRTLSFRKKR
SHAILSPPSPSYNAETEDCDLNYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEIM
AAAEKEAMLFKGPNVYKKTVNSRIGKTSRARAQIKKSKAKLANPSIVTKKRNKRNQTNKL
VDDGKKKPRAKQKTNEKGTSRKHTTLKDEKIKSQSGAEVKFVLKHQNVSEFASSSGGSQL
LFKQKDMPLMGSAVDHPLSASLPTGINAQQKLSGCFSSFLESKKSVDLQTFPSSRDDLHP
SVVCNSIGPGVSKINVQRPHNQSAMFTLKESTLIQKNIFDLSNHLSQVAQNTQISSGMSS
KIEDNANNIQRNYLSSIGKLSEYRNSLESKLDQAYTPNFLHCKDSQQQIVCIAEQSKHSE
TCSPGNTASEESQMPNNCFVTSLRSPIKQIAWEQKQRGFILDMSNFKPERVKPRSLSEAI
SQTKALSQCKNRNVSTPSAFGEGQSGLAVLKELLQKRQQKAQNANTTQDPLSNKHQPNKN
ISGSLEHNKANKRTRSVTSPRKPRTPRSTKQKEKIPKLLKVDSLNLQNSSQLDNSVSDDS
PIFFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYSGSQFVPADQNLPQKFLSD
AVQDLFPGQAIEKNEFLSHDNQKCDEDKHHTTDSASWIRSGTLSPEIFEKSTIDSNENRR
HNQWKNSFHPLTTRSNSIMDSFCVQQAEDCLSEKSRLNRSSVSKEVFLSLPQPNNSDWIQ
GHTRKEMGQSLDSANTSFTAILSSPDGELVDVACEDLELYVSRNNDMLTPTPDSSPRSTS
SPSQSKNGSFTPRTANILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPR
EIGGRLLMVETRLANDLAEFEGDFSLEGLRLWKTAFSAMTQNPRPGSPLRSGQGVVNKGS
SNSPKMVEDKKIVIMPCKCAPSRQLVQVWLQAKEEYERSKKLPKTKPTGVVKSAENFSSS
VNPDDKPVVPPKMDVSPCILPTTAHTKEDVDNSQIALQAPTTGCSQTASESQMLPPVASA
SDPEKDEDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGDDRPSSPVEELPSLAFENF
LKPIKDGIQKSPCSEPQEPLVISPINTRARTGKCESLCFHSTPIIQRKLLERLPEAPGLS
PLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGFKV
SIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTEKT
ELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDPDI
LLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINIVG
RITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHY
VSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVT
PSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVENL
GKYDEFKFGCTSLRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMV
KQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETL
ERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKF
EKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFET
RDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRR
SEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFSL
IGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCDDLTQHGICSKCRSQ
PQHVAVILNQEIRELERQQEQLVKICKNCTGCFDRHIPCVSLNCPVLFKLSRVNRELSKA
PYLRQLLDQF
NT seq
9393 nt
NT seq
+upstream
nt +downstream
nt
atgttttcagtaaggatagtgactgcagactactacatggccagcccgctgcaggggctg
gatacctgccaatcccccctcacccaggcccctgtcaagaaggtgccggtggtgcgagtc
ttcggagcgaccccggcaggtcagaagacatgtcttcatctacatggcatctttccttac
ctctatgtgccatacgatggttatggacagcagccagaaagctatctttctcagatggca
ttcagtatcgacagagcacttaatgtggctttaggcaatccatcttccactgctcagcat
gtgttcaaagtgtcattagtatcaggaatgcctttttatggttatcatgagaaggaaaga
cactttatgaagatctatctttacaatcctacaatggtgaaaaggatatgtgaacttttg
caaagcggagccataatgaataaattttaccagcctcatgaagcgcatattccctacctc
ctacagctcttcattgactacaatctttatggcatgaatttaataaatctggctgctgtc
aagttccgaaaagcaagaaggaaaagtaatacattgcatgcaactggatcctgcaagaat
catttatcaggaaattctcttgctgatactttatttcggtgggaacaagatgaaatacca
agctctttaatattggaaggtgttgaaccacagagtacatgtgaattagaagtggatgct
gtagctgctgatatcttaaatcgtctggacattgaagctcaaattggtggaaaccctggt
ctacaggccatatgggaagatgaaaagcaacggcgaagaaacagaaatgaaacttctcaa
atgagccaacctgagtcacaagatcacaggtttgtgccagcaacagaaagtgaaaaaaaa
tttcagaagagacttcaggaaattctcaaacagaatgatttctctgtaacattatcagga
tctgtggactacagcgatggatcccaggagttctctgctgagttaacattgcactctgag
gttctgtctcctgaaatgcttcagtgtacaccagccaatatggtagaagttcacaaagac
aaagagtcaagcaaaggtcacactagacacaaagtggaagaagctcttattaatgaagaa
gcaattttgaaccttatggaaaatagtcagacttttcagcctttgacccaaagactgagt
gagtcacctgttttcatggacagtagtcctgatgaggctctggtacatcttcttgctggt
ttggaaagtgatggatatcggggggaaagaaataggatgccatcaccatgtcgctccttt
ggaaataataaatatccacaaaatagtgatgatgaagaaaatgaaccacagattgaaaaa
gaggaaatggagcttagtttggtgatgtcccagagatgggacagcaatattgaagaacat
tgtgccaaaaagagatcactgtgcagaaatacccacagaagttcaactgaagatgatgac
tcatcttcaggagaagaaatggaatggagtgataacagtttgcttctagccagtctttct
atacctcagttagatggaactgcagatgaaaatagtgacaatccattgaacaatgaaaat
tctagaacccactcttctgtaattgcaacaagcaagctttcagttaaaccctccatcttt
cacaaagatgctgctacattagaaccctcatcttctgctaagattacctttcagtgtaaa
cacacaagtgccctttcttcccatgttttgaacaaggaagatttaattgaagacctttca
cagacaaacaaaaatacagaaaaaggtctagataactcagtcacttcttttacaaacgaa
agcacttattctatgaaataccctggatctttaagcagtactgttcattcagaaaattct
cataaagagaatagtaagaaagagatcctcccagtatcttcctgtgaaagtagtattttt
gattatgaagaagatattccatctgttacaagacaagtaccaagtagaaaatatacaaac
attagaaaaatcgaaaaggattccccttttatacatatgcaccgtcaccctaacgagaat
acattgggcaaaaattctttcaacttttctgacttaaatcattcaaaaaataaagtatcc
tctgaaggaaatgaaaaaggaaacagcacagctctgagtagtttattcccttcatcattt
actgaaaattgtgaattactgtcatgctcaggggagaatagaactatggtgcattctctt
aatagcactgctgatgaaagtggactaaataaacttaaaattaggtatgaagaatttcaa
gaacataaaacagaaaagccaagcctcagccagcaagcagcacactatatgttttttccc
agtgttgttctttctaactgtcttactagaccacagaaactatctcctgtcacatataaa
ttacaacctggcaataaaccatcccggttaaaattgaataaaaggaaacttgcaggtcat
caggagacttctaccaaaagtagtgagactggatccacaaaagataattttatacaaaat
aatccttgtaatagtaatcctgagaaggataatgcattggctagtgatttaactaaaacc
actcgtggagcttttgaaaataaaacacccacagatggttttatagactgtcactttgga
gatggaacgttagaaactgagcagtcctttggactatatggaaataaatacacacttaga
gccaaacgcaaggtaaattatgagactgaagacagtgagtcaagttttgtaactcacaac
tcaaaaattagtctacctcatcccatggaaattggtgaaagtttagatggaactctcaaa
tcccgaaaacgaagaaaaatgtctaaaaagctgccccctgtcatcataaagtatattatt
attaatagatttagagggagaaaaaatatgcttgtgaagctaggaaaaatagactctaaa
gaaaaacaagtaatattaacagaagaaaaaatggaactatataaaaagcttgcacctttg
aaggacttttggccaaaagttcccgactcccctgcaaccaaatatcccatttatccacta
acaccaaagaaaagtcacagaagaaagtcaaaacataaatctgctaagaaaaaaactggt
aaacaacaaaggacaaataatgaaaatattaaaagaactttgtctttcaggaaaaaacgg
tcacatgctattctttctcctccctcaccatcttacaatgctgaaaccgaagattgtgac
ctgaattatagtgatgttatgtctaaactaggttttctttctgagagaagcacaagtccc
ataaattcttctccacctcgctgctggtctcccacagatccaagagctgaagaaatcatg
gctgctgcagaaaaagaggcaatgctttttaagggtcctaatgtatataagaagactgtt
aattctcgtataggaaaaactagtcgcgcaagagcacagattaagaaatcaaaagcaaag
cttgctaatccctctatagttactaagaaaaggaacaaacgaaatcagacaaataaacta
gtagatgatggaaaaaagaaaccaagagcaaaacaaaaaacaaatgagaaaggtacatcg
agaaagcatacaacacttaaggatgaaaaaataaaatctcagtctggtgctgaggttaag
tttgtactgaaacaccagaatgtgtctgaatttgcaagtagttctggaggctctcaacta
ctttttaaacagaaagatatgccactaatgggctctgctgtagatcatcccctttctgct
tccctacccactggaattaatgcacaacagaagttatctggctgcttttcttctttctta
gaaagcaagaagtctgtagatttgcagacattccccagttcacgagatgatttgcatcca
tcagttgtttgtaattctataggacctggagtctcaaaaattaatgttcaaaggcctcat
aatcaaagtgctatgtttactctaaaggaatcaacgttaattcaaaaaaatatatttgac
ctttccaatcatttatctcaggtagcacagaatacacagatatcttctggtatgtcctca
aagatagaagataatgcaaataatatacaaagaaactatttgtcatcaatcggaaagtta
agtgaatatcgcaattccctagaatcaaagctggaccaagcatatacccctaattttttg
cattgcaaagacagtcagcagcagattgtgtgcatagcggaacagtcaaagcacagtgaa
acttgttctccgggaaatacagcttcagaggaaagccaaatgcctaataattgctttgta
acttccttgagaagtccaatcaaacaaatagcatgggagcaaaagcaaaggggctttatt
ttagatatgtcaaattttaaacctgaaagagtaaaaccgaggtcgttatcagaagcaatt
tcacaaaccaaagcactttctcagtgtaaaaatcgaaatgtgtcaacaccttcagcattt
ggtgaaggacagtctggactggcagttctaaaagaattgttacaaaaaagacagcagaaa
gcacaaaatgcaaatactacacaagacccattatccaataaacatcaaccaaataaaaat
atttctggttcccttgagcataacaaagcaaataaacggacacgatcggtaacgtcccca
agaaaacctcgaactcccagaagtacaaaacaaaaagaaaaaatccccaaacttctcaaa
gtagactctttaaatttacaaaactctagccagttggataactctgtatcagatgatagt
cccatctttttttcagatccaggctttgaaagttgttactcacttgaagatagtttatct
cctgaacataattataattttgatattaacacaataggtcagactggattttgtagcttt
tattctggaagtcagtttgtcccagctgatcagaatttgcctcagaagttcctaagtgat
gctgttcaggatctttttccaggacaagctatagaaaaaaatgagtttttaagtcatgac
aaccagaaatgtgatgaagacaagcatcataccacagactcagcctcatggattagatct
ggtactttaagtcctgaaatttttgagaagtcaaccatagatagcaatgagaatcgtcgc
cacaaccagtggaaaaatagctttcatcctctaacaactcggtctaactcaataatggat
tctttctgtgttcagcaggcagaagactgtctaagtgaaaaatctagattgaataggagt
tcagtaagcaaagaagtgtttcttagcctcccacagccaaacaattcagactggattcaa
ggtcacaccagaaaagaaatgggacagtctcttgactcagccaatacctcttttactgca
atactctcctcccctgatggtgaacttgtagacgtggcctgtgaagatttagaactgtat
gtttcaagaaacaatgatatgttgacaccaactcctgatagttcaccaagatctactagc
tctccttcacaatctaaaaatggcagcttcacccctcgaactgctaacattctgaaacca
cttatgtcccccccaagtagggaagaaattatggcaactttgttggatcatgacctgtct
gagactatttaccaggaaccattttgcagtaatccttctgatgtaccagaaaagcccagg
gagattggtggacggctcctcatggtagaaactcgacttgcaaatgatctggctgagttt
gagggagacttttccttggaaggacttcgtctttggaaaacagcattctcagcaatgact
cagaatccaaggccagggtcaccccttcgcagtggccaaggagttgtcaataaagggtca
agtaatagccctaagatggttgaagataaaaaaattgtgattatgccttgcaaatgtgcc
ccaagtcgacaactggttcaagtgtggcttcaagccaaagaagaatacgaacgttccaag
aaactgcctaaaaccaagccaactggagttgtaaaatctgctgagaactttagctcttca
gttaacccagatgacaaacctgtagtgcctccaaaaatggatgtaagtccatgtatactc
cccactacagcacataccaaggaggatgttgataattctcagattgctttacaagcacca
accacgggatgtagtcaaactgcaagtgaaagtcagatgctgccaccagttgcctctgca
agtgatcccgaaaaagatgaagatgatgatgataactattacattagttatagctcccct
gattctccagtaattcccccttggcaacaaccaatatccccagattccaaagcattaaat
ggagatgatagaccctcatcaccagtagaggagctgccttcattggcttttgagaacttc
ttaaagccaataaaagatggtatacaaaaaagcccctgcagtgagcctcaagagcctcta
gtgatatctccaattaatactagggcaagaactgggaaatgtgaatcactttgctttcat
agtacaccaatcatacagagaaaacttctggaaaggcttcctgaagcacctggccttagc
ccattatcaacagaaccaaaaacacagaagttgagtaataagaaaggaagtaatactgac
actcttagaagagtactgttaacacaagcaaagaatcaatttgcagcagtaaatacccca
cagaaagaaacttctcagattgatggaccatctttaaacaatacttacggtttcaaagtc
agcatacaaaacttacaggaggcaaaagctttacatgagatacaaaatcttaccctaatc
agtgtggagttgcatgctcgaactagacgagacttagaaccggatcctgaatttgaccca
atctgtgctctgttctactgcatctcatctgacactccactgccagatacagaaaaaaca
gaactcacaggtgtaatagtgattgataaagacaagacagttttcagtcaagatatcaga
tatcagactccattacttattagatctggaattacaggactcgaagtcacctatgctgct
gatgagaaggcactttttcatgaaattgcaaatataataaagaggtatgatcctgatatt
ctgctaggatatgagattcagatgcattcctggggttacctcttacaaagggctgccgct
ttaagtattgacttatgtcggatgatctctcgggtgccagatgacaaaattgagaacaga
tttgcagctgaaagagatgagtatggatcatatacaatgagtgagataaatattgttggc
cgaattacactaaatctttggagaatcatgagaaatgaggtggctctaactaactacacc
tttgaaaatgtgagctttcatgttcttcatcagcgttttcccctctttacctttcgagtc
ttgtcagactggtttgataacaagacagatctatacagatggaaaatggttgatcattat
gttagccgtgtccgtggaaatctccaaatgttagaacagctggacctgattgggaaaacc
agtgagatggctagactttttggcattcagtttttacatgtactgacaaggggttcacag
taccgtgtggaatcaatgatgttgcgtattgctaaaccaatgaactatattcctgtgaca
cctagtgttcagcaaagatcccagatgagagccccacagtgtgttcctctaattatggag
cctgaatcccgcttctatagcaactctgttctcgttttggatttccaatcactttatcct
tctattgtgattgcatataactactgcttttccacctgccttggccatgtggagaacttg
ggaaagtatgatgagttcaaatttggctgtacctctctgagagtacctccagatttactt
taccaagttaggcatgatatcacagtgtcccccaatggagtagcttttgtcaagccttca
gtaagaaaaggtgtactaccaagaatgcttgaagaaattttgaagactagatttatggtg
aagcagtcaatgaaggcttacaagcaagacagagccctgtcacgaatgcttgatgcgcgt
cagttgggacttaagctgatagcaaatgtcacatttggctatacatctgctaatttttct
gggagaatgccatgcattgaggttggcgatagtattgttcacaaagccagagagaccttg
gaacgagctattaaactggtgaatgataccaagaaatggggggctagggttgtatatggc
gatactgacagtatgtttgtgctactgaaaggagccactaaggagcagtcttttaagatt
ggtcaggaaattgccgaagctgtaactgctaccaatcctaaaccagtgaaattgaagttt
gaaaaggtatatttgccctgtgttttacaaacaaaaaagaggtatgtgggttacatgtat
gaaacactggatcagaaggacccagtatttgatgcaaaaggaatagaaacagtcagaaga
gattcctgccctgctgtttctaagatacttgagcgttctctaaagctgctatttgaaacg
agagatataagtctaattaaacagtatgttcagcgacaatgtatgaagcttctggaagga
aaggccagcatacaagactttatctttgccaaggaatacagaggaagtttttcttataaa
ccaggagcttgtgtgccagcccttgaacttacaaggaaaatgctgacttatgaccggcgc
tctgagcctcaggttggggagcgagtgccatacgtcatcatttatgggacccccggagta
ccacttatccagcttgtaaggcgcccagtggaagtcctgcaggacccaactctgagactg
aatgctacttactatattaccaagcaaatccttccacccttggcaagaatcttctcactt
attggtattgatgtcttcagctggtatcatgaattaccaaggatccataaagctaccagc
tcctcgcgaagtgaacctgaagggcggaaaggcactatttcacaatattttactacctta
cactgtcctgtgtgtgatgacctaactcagcatggcatctgtagtaaatgtcggagccaa
cctcagcatgttgcagtcatcctcaaccaagaaatccgggagttggaacgtcaacaggag
caacttgtaaagatatgcaagaactgtacaggttgctttgatcgacacatcccatgtgtt
tctctgaactgcccagtacttttcaaactctcccgagtaaatagagaattgtccaaggca
ccatatctccggcagttattagaccagttttaa
DBGET
integrated database retrieval system
