Homo sapiens (human): 640
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Entry
640 CDS
T01001
Symbol
BLK, MODY11
Name
(RefSeq) BLK proto-oncogene, Src family tyrosine kinase
KO
K08890
B lymphoid tyrosine kinase [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04662
B cell receptor signaling pathway
Disease
H00410
Maturity onset diabetes of the young (MODY)
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04662 B cell receptor signaling pathway
640 (BLK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
640 (BLK)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
640 (BLK)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
SRC family
640 (BLK)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
SH3_1
SH3_9
SH3_2
SH3_3
SH3_16
Haspin_kinase
ABC1
Motif
Other DBs
NCBI-GeneID:
640
NCBI-ProteinID:
NP_001706
OMIM:
191305
HGNC:
1057
Ensembl:
ENSG00000136573
Pharos:
P51451
(Tchem)
UniProt:
P51451
Q05D26
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All DBs
Position
8:11494387..11564599
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AA seq
505 aa
AA seq
DB search
MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK
HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE
MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR
CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS
LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY
AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD
LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS
FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER
PTFEFLQSVLEDFYTATERQYELQP
NT seq
1518 nt
NT seq
+upstream
nt +downstream
nt
atggggctggtaagtagcaaaaagccggacaaggaaaagccgatcaaagagaaggacaag
ggccaatggagccccctgaaggtcagcgcccaagacaaggacgccccgccactgccgccc
ctggttgtcttcaaccaccttactcctccaccgcccgatgaacacctggatgaagacaag
catttcgtggtggctctgtatgactacaccgctatgaatgatcgggacctgcagatgctg
aagggggagaagctacaggtcctgaagggaactggagactggtggctggccaggtcactc
gtcacaggaagagaaggctatgtgcccagtaactttgtggcccgagtggagagcctggaa
atggaaaggtggttctttagatcacagggtcggaaggaggctgagaggcagcttcttgct
ccaatcaacaaggccggctcctttcttatcagagagagtgaaaccaacaaaggtgccttc
tccctgtctgtgaaggatgtcaccacccagggggagctgatcaagcactataagatccgc
tgcctggatgaagggggctactacatctccccccggatcaccttcccctcgctccaggcc
ctggtgcagcactattctaagaagggggatggtctatgccagaggctgaccctgccctgt
gtgcgcccggccccgcagaatccctgggcccaggatgaatgggagatcccccggcagtct
ctcaggctggtcaggaaactcgggtctggacaattcggcgaagtctggatgggttactac
aaaaacaacatgaaggtggccattaagacgctgaaggagggaaccatgtctccagaagcc
tttctgggtgaggccaacgtgatgaaggctctgcagcacgagcggctggtccgactctac
gcagtggtcaccaaggagcccatctacattgtcaccgagtacatggccagaggatgcctg
ctggatttcctgaagacagatgaagggagcagattgtcactcccaaggctgattgacatg
tcggcgcagattgctgaagggatggcatacattgagcgcatgaattccatccaccgcgac
ctgcgggcggccaacatcctggtgtctgaggccttgtgctgcaaaattgctgattttggc
ttggctcgaatcatcgacagtgaatacacggcccaagagggggccaagttccccatcaag
tggacagccccggaagccatccacttcggggtcttcaccatcaaagcagacgtgtggtcg
tttggagtcctcctgatggaagttgtcacttatgggcgggtgccatacccagggatgagc
aaccccgaggtcatccgcaacctggagcgcggctaccgcatgccgcgccccgacacctgc
ccgcccgagctgtaccgcggcgtcatcgccgagtgctggcgcagccggcccgaggagcgg
cccaccttcgagttcctgcagtcggtgctggaggacttctacacggccaccgagcggcag
tacgagctgcagccctag
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