Homo sapiens (human): 6667
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Entry
6667 CDS
T01001
Symbol
SP1
Name
(RefSeq) Sp1 transcription factor
KO
K04684
transcription factor Sp1
Organism
hsa
Homo sapiens (human)
Pathway
hsa01522
Endocrine resistance
hsa04137
Mitophagy - animal
hsa04350
TGF-beta signaling pathway
hsa04915
Estrogen signaling pathway
hsa04927
Cortisol synthesis and secretion
hsa04928
Parathyroid hormone synthesis, secretion and action
hsa04934
Cushing syndrome
hsa05016
Huntington disease
hsa05017
Spinocerebellar ataxia
hsa05163
Human cytomegalovirus infection
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05224
Breast cancer
hsa05231
Choline metabolism in cancer
hsa05415
Diabetic cardiomyopathy
Network
nt06240
Transcription (cancer)
nt06310
CRH-ACTH-cortisol signaling
nt06360
Cushing syndrome
Element
N00132
Amplified MYCN to transcriptional repression
N00297
ACTH-cortisol signaling pathway
N00298
CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00320
Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321
Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322
Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323
Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
Drug target
Terameprocol:
D09014
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04350 TGF-beta signaling pathway
6667 (SP1)
09140 Cellular Processes
09141 Transport and catabolism
04137 Mitophagy - animal
6667 (SP1)
09150 Organismal Systems
09152 Endocrine system
04915 Estrogen signaling pathway
6667 (SP1)
04928 Parathyroid hormone synthesis, secretion and action
6667 (SP1)
04927 Cortisol synthesis and secretion
6667 (SP1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
6667 (SP1)
05202 Transcriptional misregulation in cancer
6667 (SP1)
05231 Choline metabolism in cancer
6667 (SP1)
09162 Cancer: specific types
05224 Breast cancer
6667 (SP1)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
6667 (SP1)
09164 Neurodegenerative disease
05016 Huntington disease
6667 (SP1)
05017 Spinocerebellar ataxia
6667 (SP1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
6667 (SP1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
6667 (SP1)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
6667 (SP1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
6667 (SP1)
03029 Mitochondrial biogenesis [BR:
hsa03029
]
6667 (SP1)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Zinc finger
Cys2His2 SP/KLF family and related proteins
6667 (SP1)
Mitochondrial biogenesis [BR:
hsa03029
]
Mitochondrial quality control factors
Regulator of mitochondrial biogenesis
Ubiquitas transcription factors
6667 (SP1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
zf-C2H2
zf-H2C2_2
zf-C2H2_4
Zap1_zf1
zf-C2H2_6
zf-C2H2_8
Motif
Other DBs
NCBI-GeneID:
6667
NCBI-ProteinID:
NP_612482
OMIM:
189906
HGNC:
11205
Ensembl:
ENSG00000185591
UniProt:
P08047
Structure
PDB
LinkDB
All DBs
Position
12:53380176..53416446
Genome browser
AA seq
785 aa
AA seq
DB search
MSDQDHSMDEMTAVVKIEKGVGGNNGGNGNGGGAFSQARSSSTGSSSSTGGGGQESQPSP
LALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTS
KEQSGSSTNGSNGSESSKNRTVSGGQYVVAAAPNLQNQQVLTGLPGVMPNIQYQVIPQFQ
TVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQG
LANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGSQESGSQPVT
SGTTISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTTSGSSGTNSQGQTPQRVS
GLQGSDALNIQQNQTSGGSLQAGQQKEGEQNQQTQQQQILIQPQLVQGGQALQALQAAPL
SGQTFTTQAISQETLQNLQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQ
TITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTS
GIQVHPIQGLPLAIANAPGDHGAQLGLHGAGGDGIHDDTAGGEEGENSPDAQPQAGRRTR
REACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTW
SYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALS
VGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVADLQSINI
SGNGF
NT seq
2358 nt
NT seq
+upstream
nt +downstream
nt
atgagcgaccaagatcactccatggatgaaatgacagctgtggtgaaaattgaaaaagga
gttggtggcaataatgggggcaatggtaatggtggtggtgccttttcacaggctcgaagt
agcagcacaggcagtagcagcagcactggaggaggagggcaggagtcccagccatcccct
ttggctctgctggcagcaacttgcagcagaattgagtcacccaatgagaacagcaacaac
tcccagggcccgagtcagtcagggggaacaggtgagcttgacctcacagccacacaactt
tcacagggtgccaatggctggcagatcatctcttcctcctctggggctacccctacctca
aaggaacagagtggcagcagtaccaatggcagcaatggcagtgagtcttccaagaatcgc
acagtctctggtgggcagtatgttgtggctgccgctcccaacttacagaaccagcaagtt
ctgacaggactacctggagtgatgcctaatattcagtatcaagtaatcccacagttccag
accgttgatgggcaacagctgcagtttgctgccactggggcccaagtgcagcaggatggt
tctggtcaaatacagatcataccaggtgcaaaccaacagattatcacaaatcgaggaagt
ggaggcaacatcattgctgctatgccaaacctactccagcaggctgtccccctccaaggc
ctggctaataatgtactctcaggacagactcagtatgtgaccaatgtaccagtggccctg
aatgggaacatcaccttgctacctgtcaacagcgtttctgcagctaccttgactcccagc
tctcaggcagtcacgatcagcagctctgggtcccaggagagtggctcacagcctgtcacc
tcagggactaccatcagttctgccagcttggtatcatcacaagccagttccagctccttt
ttcaccaatgccaatagctactcaactactactaccaccagcaacatgggaattatgaac
tttactaccagtggatcatcagggaccaactctcaaggccagacaccccagagggtcagt
gggctacaggggtctgatgctctgaacatccagcaaaaccagacatctggaggctcattg
caagcaggccagcaaaaagaaggagagcaaaaccagcagacacagcagcaacaaattctt
atccagcctcagctagttcaagggggacaggccctccaggccctccaagcagcaccattg
tcagggcagacctttacaactcaagccatctcccaggaaaccctccagaacctccagctt
caggctgttccaaactctggtcccatcatcatccggacaccaacagtggggcccaatgga
caggtcagttggcagactctacagctgcagaacctccaagttcagaacccacaagcccaa
acaatcaccttagccccaatgcagggtgtttccttggggcagaccagcagcagcaacacc
actctcacacccattgcctcagctgcttccattcctgctggcacagtcactgtgaatgct
gctcaactctcctccatgccaggcctccagaccattaacctcagtgcattgggtacttca
ggaatccaggtgcacccaattcaaggcctgccgttggctatagcaaatgccccaggtgat
catggagctcagcttggtctccatggggctggtggtgatggaatacatgatgacacagca
ggtggagaggaaggagaaaacagcccagatgcccaaccccaagccggtcggaggacccgg
cgggaagcatgcacctgcccctactgtaaagacagtgaaggaaggggctcgggggatcct
ggcaaaaagaaacagcatatttgccacatccaaggctgtgggaaagtgtatggcaagacc
tctcacctgcgggcacacttgcgctggcatacaggcgagaggccatttatgtgtacctgg
tcatactgtgggaaacgcttcacacgttcggatgagctacagaggcacaaacgtacacac
acaggtgagaagaaatttgcctgccctgagtgtcctaagcgcttcatgaggagtgaccac
ctgtcaaaacatatcaagacccaccagaataagaagggaggcccaggtgtagctctgagt
gtgggcactttgcccctggacagtggggcaggttcagaaggcagtggcactgccactcct
tcagcccttattaccaccaatatggtagccatggaggccatctgtccagagggcattgcc
cgtcttgccaacagtggcatcaacgtcatgcaggtggcagatctgcagtccattaatatc
agtggcaatggcttctga
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