KEGG   Homo sapiens (human): 7018
Entry
7018              CDS       T01001                                 
Symbol
TF, HEL-S-71p, PRO1557, PRO2086, TFQTL1
Name
(RefSeq) transferrin
  KO
K14736  transferrin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04066  HIF-1 signaling pathway
hsa04216  Ferroptosis
hsa04350  TGF-beta signaling pathway
hsa04978  Mineral absorption
Network
nt06525  Ferroptosis
  Element
N01587  Fe-TF transport
Disease
H01145  Atransferrinemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    7018 (TF)
   04066 HIF-1 signaling pathway
    7018 (TF)
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    7018 (TF)
 09150 Organismal Systems
  09154 Digestive system
   04978 Mineral absorption
    7018 (TF)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    7018 (TF)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   7018 (TF)
  Exosomal proteins of colorectal cancer cells
   7018 (TF)
SSDB
Motif
Pfam: Transferrin Phosphonate-bd
Other DBs
NCBI-GeneID: 7018
NCBI-ProteinID: NP_001054
OMIM: 190000
HGNC: 11740
Ensembl: ENSG00000091513
UniProt: P02787 A0PJA6 Q06AH7
Structure
LinkDB
Position
3:133661998..133796641
AA seq 698 aa
MRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVK
KASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVV
KKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPC
ADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRD
QYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKE
FQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTCPEAPTDECKP
VKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGK
CGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWN
IPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNKEGYYGYTGAF
RCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLAR
APNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKL
HDRNTYEKYLGEEYVKAVGNLRKCSTSSLLEACTFRRP
NT seq 2097 nt   +upstreamnt  +downstreamnt
atgaggctcgccgtgggagccctgctggtctgcgccgtcctggggctgtgtctggctgtc
cctgataaaactgtgagatggtgtgcagtgtcggagcatgaggccactaagtgccagagt
ttccgcgaccatatgaaaagcgtcattccatccgatggtcccagtgttgcttgtgtgaag
aaagcctcctaccttgattgcatcagggccattgcggcaaacgaagcggatgctgtgaca
ctggatgcaggtttggtgtatgatgcttacctggctcccaataacctgaagcctgtggtg
gcagagttctatgggtcaaaagaggatccacagactttctattatgctgttgctgtggtg
aagaaggatagtggcttccagatgaaccagcttcgaggcaagaagtcctgccacacgggt
ctaggcaggtccgctgggtggaacatccccataggcttactttactgtgacttacctgag
ccacgtaaacctcttgagaaagcagtggccaatttcttctcgggcagctgtgccccttgt
gcggatgggacggacttcccccagctgtgtcaactgtgtccagggtgtggctgctccacc
cttaaccaatacttcggctactcgggagccttcaagtgtctgaaggatggtgctggggat
gtggcctttgtcaagcactcgactatatttgagaacttggcaaacaaggctgacagggac
cagtatgagctgctttgcctggacaacacccggaagccggtagatgaatacaaggactgc
cacttggcccaggtcccttctcataccgtcgtggcccgaagtatgggcggcaaggaggac
ttgatctgggagcttctcaaccaggcccaggaacattttggcaaagacaaatcaaaagaa
ttccaactattcagctctcctcatgggaaggacctgctgtttaaggactctgcccacggg
tttttaaaagtcccccccaggatggatgccaagatgtacctgggctatgagtatgtcact
gccatccggaatctacgggaaggcacatgcccagaagccccaacagatgaatgcaagcct
gtgaagtggtgtgcgctgagccaccacgagaggctcaagtgtgatgagtggagtgttaac
agtgtagggaaaatagagtgtgtatcagcagagaccaccgaagactgcatcgccaagatc
atgaatggagaagctgatgccatgagcttggatggagggtttgtctacatagcgggcaag
tgtggtctggtgcctgtcttggcagaaaactacaataagagcgataattgtgaggataca
ccagaggcagggtattttgctatagcagtggtgaagaaatcagcttctgacctcacctgg
gacaatctgaaaggcaagaagtcctgccatacggcagttggcagaaccgctggctggaac
atccccatgggcctgctctacaataagatcaaccactgcagatttgatgaatttttcagt
gaaggttgtgcccctgggtctaagaaagactccagtctctgtaagctgtgtatgggctca
ggcctaaacctgtgtgaacccaacaacaaagagggatactacggctacacaggcgctttc
aggtgtctggttgagaagggagatgtggcctttgtgaaacaccagactgtcccacagaac
actgggggaaaaaaccctgatccatgggctaagaatctgaatgaaaaagactatgagttg
ctgtgccttgatggtaccaggaaacctgtggaggagtatgcgaactgccacctggccaga
gccccgaatcacgctgtggtcacacggaaagataaggaagcttgcgtccacaagatatta
cgtcaacagcagcacctatttggaagcaacgtaactgactgctcgggcaacttttgtttg
ttccggtcggaaaccaaggaccttctgttcagagatgacacagtatgtttggccaaactt
catgacagaaacacatatgaaaaatacttaggagaagaatatgtcaaggctgttggtaac
ctgagaaaatgctccacctcatcactcctggaagcctgcactttccgtagaccttaa

KEGG   Homo sapiens (human): 7037
Entry
7037              CDS       T01001                                 
Symbol
TFRC, CD71, IMD46, T9, TFR, TFR1, TR, TRFR, p90
Name
(RefSeq) transferrin receptor
  KO
K06503  transferrin receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04066  HIF-1 signaling pathway
hsa04144  Endocytosis
hsa04145  Phagosome
hsa04216  Ferroptosis
hsa04350  TGF-beta signaling pathway
hsa04640  Hematopoietic cell lineage
Network
nt06525  Ferroptosis
  Element
N01587  Fe-TF transport
Disease
H02526  Disorders of adaptive immunity
Drug target
Pabinafusp alfa: D11812<JP>
Tividenofusp alfa: D12806
Trontinemab: D12509
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    7037 (TFRC)
   04066 HIF-1 signaling pathway
    7037 (TFRC)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    7037 (TFRC)
   04145 Phagosome
    7037 (TFRC)
  09143 Cell growth and death
   04216 Ferroptosis
    7037 (TFRC)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    7037 (TFRC)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    7037 (TFRC)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    7037 (TFRC)
   04090 CD molecules [BR:hsa04090]
    7037 (TFRC)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M28: aminopeptidase Y family
   7037 (TFRC)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   7037 (TFRC)
  Exosomal proteins of colorectal cancer cells
   7037 (TFRC)
CD molecules [BR:hsa04090]
 Proteins
  7037 (TFRC)
SSDB
Motif
Pfam: Peptidase_M28 TFR_dimer PA DUF3855 DUF2321
Other DBs
NCBI-GeneID: 7037
NCBI-ProteinID: NP_001121620
OMIM: 190010
HGNC: 11763
Ensembl: ENSG00000072274
UniProt: P02786 Q7Z3E0
Structure
LinkDB
Position
3:complement(196049284..196082090)
AA seq 760 aa
MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPK
RCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAAR
RLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSK
VWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTK
KDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGH
AHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTD
STCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSG
VGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFT
YINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNA
AFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIK
LTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDF
GNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRK
QNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF
NT seq 2283 nt   +upstreamnt  +downstreamnt
atgatggatcaagctagatcagcattctctaacttgtttggtggagaaccattgtcatat
acccggttcagcctggctcggcaagtagatggcgataacagtcatgtggagatgaaactt
gctgtagatgaagaagaaaatgctgacaataacacaaaggccaatgtcacaaaaccaaaa
aggtgtagtggaagtatctgctatgggactattgctgtgatcgtctttttcttgattgga
tttatgattggctacttgggctattgtaaaggggtagaaccaaaaactgagtgtgagaga
ctggcaggaaccgagtctccagtgagggaggagccaggagaggacttccctgcagcacgt
cgcttatattgggatgacctgaagagaaagttgtcggagaaactggacagcacagacttc
accggcaccatcaagctgctgaatgaaaattcatatgtccctcgtgaggctggatctcaa
aaagatgaaaatcttgcgttgtatgttgaaaatcaatttcgtgaatttaaactcagcaaa
gtctggcgtgatcaacattttgttaagattcaggtcaaagacagcgctcaaaactcggtg
atcatagttgataagaacggtagacttgtttacctggtggagaatcctgggggttatgtg
gcgtatagtaaggctgcaacagttactggtaaactggtccatgctaattttggtactaaa
aaagattttgaggatttatacactcctgtgaatggatctatagtgattgtcagagcaggg
aaaatcacctttgcagaaaaggttgcaaatgctgaaagcttaaatgcaattggtgtgttg
atatacatggaccagactaaatttcccattgttaacgcagaactttcattctttggacat
gctcatctggggacaggtgacccttacacacctggattcccttccttcaatcacactcag
tttccaccatctcggtcatcaggattgcctaatatacctgtccagacaatctccagagct
gctgcagaaaagctgtttgggaatatggaaggagactgtccctctgactggaaaacagac
tctacatgtaggatggtaacctcagaaagcaagaatgtgaagctcactgtgagcaatgtg
ctgaaagagataaaaattcttaacatctttggagttattaaaggctttgtagaaccagat
cactatgttgtagttggggcccagagagatgcatggggccctggagctgcaaaatccggt
gtaggcacagctctcctattgaaacttgcccagatgttctcagatatggtcttaaaagat
gggtttcagcccagcagaagcattatctttgccagttggagtgctggagactttggatcg
gttggtgccactgaatggctagagggatacctttcgtccctgcatttaaaggctttcact
tatattaatctggataaagcggttcttggtaccagcaacttcaaggtttctgccagccca
ctgttgtatacgcttattgagaaaacaatgcaaaatgtgaagcatccggttactgggcaa
tttctatatcaggacagcaactgggccagcaaagttgagaaactcactttagacaatgct
gctttccctttccttgcatattctggaatcccagcagtttctttctgtttttgcgaggac
acagattatccttatttgggtaccaccatggacacctataaggaactgattgagaggatt
cctgagttgaacaaagtggcacgagcagctgcagaggtcgctggtcagttcgtgattaaa
ctaacccatgatgttgaattgaacctggactatgagaggtacaacagccaactgctttca
tttgtgagggatctgaaccaatacagagcagacataaaggaaatgggcctgagtttacag
tggctgtattctgctcgtggagacttcttccgtgctacttccagactaacaacagatttc
gggaatgctgagaaaacagacagatttgtcatgaagaaactcaatgatcgtgtcatgaga
gtggagtatcacttcctctctccctacgtatctccaaaagagtctcctttccgacatgtc
ttctggggctccggctctcacacgctgccagctttactggagaacttgaaactgcgtaaa
caaaataacggtgcttttaatgaaacgctgttcagaaaccagttggctctagctacttgg
actattcagggagctgcaaatgccctctctggtgacgtttgggacattgacaatgagttt
taa

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