Entry |
|
Symbol |
TGFBR2, AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TBR-ii, TBRII, TGFR-2, TGFbeta-RII, tbetaR-II
|
Name |
(RefSeq) transforming growth factor beta receptor 2
|
KO |
|
Organism |
|
Pathway |
hsa04060 | Cytokine-cytokine receptor interaction |
hsa04933 | AGE-RAGE signaling pathway in diabetic complications |
hsa05166 | Human T-cell leukemia virus 1 infection |
hsa05202 | Transcriptional misregulation in cancer |
|
Network |
|
Element |
N00063 | TGF-beta signaling pathway |
N00064 | Mutation-inactivated TGFBR2 to TGF-beta signaling pathway |
N00065 | Mutation-inactivated SMAD2 to TGF-beta signaling pathway |
N00134 | EWSR1-FLI1 fusion to transcriptional repression |
N00241 | TGFBR2-reduced expression to TGF-beta signaling pathway |
N00256 | TGFBR1-reduced expression to TGF-beta signaling pathway |
N00531 | HBV HBx to TGF-beta signaling pathway |
|
Disease |
H00048 | Hepatocellular carcinoma |
H00801 | Familial thoracic aortic aneurysm and dissection |
H02565 | Hereditary nonpolyposis colorectal cancer |
|
Drug target |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04350 TGF-beta signaling pathway
7048 (TGFBR2)
04390 Hippo signaling pathway
7048 (TGFBR2)
04068 FoxO signaling pathway
7048 (TGFBR2)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
7048 (TGFBR2)
09150 Organismal Systems
09151 Immune system
04659 Th17 cell differentiation
7048 (TGFBR2)
09152 Endocrine system
04926 Relaxin signaling pathway
7048 (TGFBR2)
09158 Development and regeneration
04380 Osteoclast differentiation
7048 (TGFBR2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
7048 (TGFBR2)
05202 Transcriptional misregulation in cancer
7048 (TGFBR2)
09162 Cancer: specific types
05210 Colorectal cancer
7048 (TGFBR2)
05212 Pancreatic cancer
7048 (TGFBR2)
05225 Hepatocellular carcinoma
7048 (TGFBR2)
05226 Gastric cancer
7048 (TGFBR2)
05220 Chronic myeloid leukemia
7048 (TGFBR2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
7048 (TGFBR2)
05161 Hepatitis B
7048 (TGFBR2)
09174 Infectious disease: parasitic
05142 Chagas disease
7048 (TGFBR2)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
7048 (TGFBR2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
7048 (TGFBR2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
7048 (TGFBR2)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.30 receptor protein serine/threonine kinase
7048 (TGFBR2)
Protein kinases [BR:hsa01001]
Receptor serine/threonine kinases (RSTK): TKL group
TGFBR2 family [OT]
7048 (TGFBR2)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
LinkDB |
|
Position |
3:30606356..30694142
|
AA seq |
567 aa
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFST
CDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPK
CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI
SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTE
LLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLK
HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH
LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG
TARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVRE
HPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSE
LEHLDRLSGRSCSEEKIPEDGSLNTTK |
NT seq |
1704 nt +upstreamnt +downstreamnt
atgggtcgggggctgctcaggggcctgtggccgctgcacatcgtcctgtggacgcgtatc
gccagcacgatcccaccgcacgttcagaagtcggttaataacgacatgatagtcactgac
aacaacggtgcagtcaagtttccacaactgtgtaaattttgtgatgtgagattttccacc
tgtgacaaccagaaatcctgcatgagcaactgcagcatcacctccatctgtgagaagcca
caggaagtctgtgtggctgtatggagaaagaatgacgagaacataacactagagacagtt
tgccatgaccccaagctcccctaccatgactttattctggaagatgctgcttctccaaag
tgcattatgaaggaaaaaaaaaagcctggtgagactttcttcatgtgttcctgtagctct
gatgagtgcaatgacaacatcatcttctcagaagaatataacaccagcaatcctgacttg
ttgctagtcatatttcaagtgacaggcatcagcctcctgccaccactgggagttgccata
tctgtcatcatcatcttctactgctaccgcgttaaccggcagcagaagctgagttcaacc
tgggaaaccggcaagacgcggaagctcatggagttcagcgagcactgtgccatcatcctg
gaagatgaccgctctgacatcagctccacgtgtgccaacaacatcaaccacaacacagag
ctgctgcccattgagctggacaccctggtggggaaaggtcgctttgctgaggtctataag
gccaagctgaagcagaacacttcagagcagtttgagacagtggcagtcaagatctttccc
tatgaggagtatgcctcttggaagacagagaaggacatcttctcagacatcaatctgaag
catgagaacatactccagttcctgacggctgaggagcggaagacggagttggggaaacaa
tactggctgatcaccgccttccacgccaagggcaacctacaggagtacctgacgcggcat
gtcatcagctgggaggacctgcgcaagctgggcagctccctcgcccgggggattgctcac
ctccacagtgatcacactccatgtgggaggcccaagatgcccatcgtgcacagggacctc
aagagctccaatatcctcgtgaagaacgacctaacctgctgcctgtgtgactttgggctt
tccctgcgtctggaccctactctgtctgtggatgacctggctaacagtgggcaggtggga
actgcaagatacatggctccagaagtcctagaatccaggatgaatttggagaatgttgag
tccttcaagcagaccgatgtctactccatggctctggtgctctgggaaatgacatctcgc
tgtaatgcagtgggagaagtaaaagattatgagcctccatttggttccaaggtgcgggag
cacccctgtgtcgaaagcatgaaggacaacgtgttgagagatcgagggcgaccagaaatt
cccagcttctggctcaaccaccagggcatccagatggtgtgtgagacgttgactgagtgc
tgggaccacgacccagaggcccgtctcacagcccagtgtgtggcagaacgcttcagtgag
ctggagcatctggacaggctctcggggaggagctgctcggaggagaagattcctgaagac
ggctccctaaacactaccaaatag |