KEGG   Homo sapiens (human): 7067
Entry
7067              CDS       T01001                                 
Symbol
THRA, AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, THRalpha, THRalpha1, THRalpha2, TRalpha, TRalpha1, TRalpha2, c-ERBA-1, c-erbA
Name
(RefSeq) thyroid hormone receptor alpha
  KO
K05547  thyroid hormone receptor alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04919  Thyroid hormone signaling pathway
Network
nt06322  TRH-TSH-TH signaling
  Element
N00798  Thyroid hormone signaling pathway
Disease
H00250  Congenital nongoitrous hypothyroidism (CHNG)
Drug target
Dextrothyroxine: D03750
Levothyroxine (DG00510): D08125
Levothyroxine sodium: D01010<JP/US> D11113<US>
Liothyronine (DG01372): D08128 D08129
Liothyronine sodium: D01011<JP/US>
Thyroid (DG01993): D01012 D06482
Tiratricol: D07214
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    7067 (THRA)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    7067 (THRA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    7067 (THRA)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    7067 (THRA)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    7067 (THRA)
Nuclear receptors [BR:hsa03310]
 1. Thyroid hormone like
  1A. Thyroid hormone receptor (THR)
   7067 (THRA)
SSDB
Motif
Pfam: zf-C4 Hormone_recep
Other DBs
NCBI-GeneID: 7067
NCBI-ProteinID: NP_001177848
OMIM: 190120
HGNC: 11796
Ensembl: ENSG00000126351
UniProt: P10827
Structure
LinkDB
Position
17:40062193..40093867
AA seq 490 aa
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
EDLAGNAASP
NT seq 1473 nt   +upstreamnt  +downstreamnt
atggaacagaagccaagcaaggtggagtgtgggtcagacccagaggagaacagtgccagg
tcaccagatggaaagcgaaaaagaaagaacggccaatgttccctgaaaaccagcatgtca
gggtatatccctagttacctggacaaagacgagcagtgtgtcgtgtgtggggacaaggca
actggttatcactaccgctgtatcacttgtgagggctgcaagggcttctttcgccgcaca
atccagaagaacctccatcccacctattcctgcaaatatgacagctgctgtgtcattgac
aagatcacccgcaatcagtgccagctgtgccgcttcaagaagtgcatcgccgtgggcatg
gccatggacttggttctagatgactcgaagcgggtggccaagcgtaagctgattgagcag
aaccgggagcggcggcggaaggaggagatgatccgatcactgcagcagcgaccagagccc
actcctgaagagtgggatctgatccacattgccacagaggcccatcgcagcaccaatgcc
cagggcagccattggaaacagaggcggaaattcctgcccgatgacattggccagtcaccc
attgtctccatgccggacggagacaaggtggacctggaagccttcagcgagtttaccaag
atcatcaccccggccatcacccgtgtggtggactttgccaaaaaactgcccatgttctcc
gagctgccttgcgaagaccagatcatcctcctgaaggggtgctgcatggagatcatgtcc
ctgcgggcggctgtccgctacgaccctgagagcgacaccctgacgctgagtggggagatg
gctgtcaagcgggagcagctcaagaatggcggcctgggcgtagtctccgacgccatcttt
gaactgggcaagtcactctctgcctttaacctggatgacacggaagtggctctgctgcag
gctgtgctgctaatgtcaacagaccgctcgggcctgctgtgtgtggacaagatcgagaag
agtcaggaggcgtacctgctggcgttcgagcactacgtcaaccaccgcaaacacaacatt
ccgcacttctggcccaagctgctgatgaaggagagagaagtgcagagttcgattctgtac
aagggggcagcggcagaaggccggccgggcgggtcactgggcgtccacccggaaggacag
cagcttctcggaatgcatgttgttcagggtccgcaggtccggcagcttgagcagcagctt
ggtgaagcgggaagtctccaagggccggttcttcagcaccagagcccgaagagcccgcag
cagcgtctcctggagctgctccaccgaagcggaattctccatgcccgagcggtctgtggg
gaagacgacagcagtgaggcggactccccgagctcctctgaggaggaaccggaggtctgc
gaggacctggcaggcaatgcagcctctccctga

KEGG   Homo sapiens (human): 7068
Entry
7068              CDS       T01001                                 
Symbol
THRB, C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, THRbeta, THRbeta1, TRb, TRbeta, TRbeta1, Thrbeta2
Name
(RefSeq) thyroid hormone receptor beta
  KO
K08362  thyroid hormone receptor beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04919  Thyroid hormone signaling pathway
Network
nt06322  TRH-TSH-TH signaling
  Element
N00798  Thyroid hormone signaling pathway
Disease
H00249  Thyroid hormone resistance syndrome
Drug target
Dextrothyroxine: D03750
Levothyroxine (DG00510): D08125
Levothyroxine sodium: D01010<JP/US> D11113<US>
Liothyronine (DG01372): D08128 D08129
Liothyronine sodium: D01011<JP/US>
Resmetirom: D11602<US>
Sobetirome: D09381
Thyroid (DG01993): D01012 D06482
Tiratricol: D07214
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    7068 (THRB)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    7068 (THRB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    7068 (THRB)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    7068 (THRB)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    7068 (THRB)
Nuclear receptors [BR:hsa03310]
 1. Thyroid hormone like
  1A. Thyroid hormone receptor (THR)
   7068 (THRB)
SSDB
Motif
Pfam: zf-C4 Hormone_recep
Other DBs
NCBI-GeneID: 7068
NCBI-ProteinID: NP_000452
OMIM: 190160
HGNC: 11799
Ensembl: ENSG00000151090
UniProt: P10828 A0A024R2I8
Structure
LinkDB
Position
3:complement(24117153..24495708)
AA seq 461 aa
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
NT seq 1386 nt   +upstreamnt  +downstreamnt
atgactcccaacagtatgacagaaaatggccttacagcctgggacaaaccgaagcactgt
ccagaccgagaacacgactggaagctagtaggaatgtctgaagcctgcctacataggaag
agccattcagagaggcgcagcacgttgaaaaatgaacagtcgtcgccacatctcatccag
accacttggactagctcaatattccatctggaccatgatgatgtgaacgaccagagtgtc
tcaagtgcccagaccttccaaacggaggagaagaaatgtaaagggtacatccccagttac
ttagacaaggacgagctctgtgtagtgtgtggtgacaaagccaccgggtatcactaccgc
tgtatcacgtgtgaaggctgcaagggtttctttagaagaaccattcagaaaaatctccat
ccatcctattcctgtaaatatgaaggaaaatgtgtcatagacaaagtcacgcgaaatcag
tgccaggaatgtcgctttaagaaatgcatctatgttggcatggcaacagatttggtgctg
gatgacagcaagaggctggccaagaggaagctgatagaggagaaccgggagaaaagacgg
cgggaagagctgcagaagtccatcgggcacaagccagagcccacagacgaggaatgggag
ctcatcaaaactgtcaccgaagcccatgtggcgaccaacgcccaaggcagccactggaag
caaaaacggaaattcctgccagaagacattggacaagcaccaatagtcaatgccccagaa
ggtggaaaggttgacttggaagccttcagccattttacaaaaatcatcacaccagcaatt
accagagtggtggattttgccaaaaagttgcctatgttttgtgagctgccatgtgaagac
cagatcatcctcctcaaaggctgctgcatggagatcatgtcccttcgcgctgctgtgcgc
tatgacccagaaagtgagactttaaccttgaatggggaaatggcagtgacacggggccag
ctgaaaaatgggggtcttggggtggtgtcagacgccatctttgacctgggcatgtctctg
tcttctttcaacctggatgacactgaagtagccctccttcaggccgtcctgctgatgtct
tcagatcgcccggggcttgcctgtgttgagagaatagaaaagtaccaagatagtttcctg
ctggcctttgaacactatatcaattaccgaaaacaccacgtgacacacttttggccaaaa
ctcctgatgaaggtgacagatctgcggatgataggagcctgccatgccagccgcttcctg
cacatgaaggtggaatgccccacagaactcttcccccctttgttcttggaagtgttcgag
gattag

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