Homo sapiens (human): 80746
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Entry
80746 CDS
T01001
Symbol
TSEN2, PCH2B, SEN2, SEN2L
Name
(RefSeq) tRNA splicing endonuclease subunit 2
KO
K15322
tRNA-splicing endonuclease subunit Sen2 [EC:
4.6.1.16
]
Organism
hsa
Homo sapiens (human)
Disease
H00897
Pontocerebellar hypoplasia
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03016 Transfer RNA biogenesis [BR:
hsa03016
]
80746 (TSEN2)
Enzymes [BR:
hsa01000
]
4. Lyases
4.6 Phosphorus-oxygen lyases
4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
4.6.1.16 tRNA-intron lyase
80746 (TSEN2)
Transfer RNA biogenesis [BR:
hsa03016
]
Eukaryotic type
tRNA spricing factors
tRNA splicing endonuclease complex
80746 (TSEN2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
tRNA_int_endo
tRNA_int_endo_N
Motif
Other DBs
NCBI-GeneID:
80746
NCBI-ProteinID:
NP_001138864
OMIM:
608753
HGNC:
28422
Ensembl:
ENSG00000154743
UniProt:
Q8NCE0
Structure
PDB
PDBj
LinkDB
All DBs
Position
3:12480231..12539624
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AA seq
465 aa
AA seq
DB search
MAEAVFHAPKRKRRVYETYESPLPIPFGQDHGPLKEFKIFRAEMINNNVIVRNAEDIEQL
YGKGYFGKGILSRSRPSFTISDPKLVAKWKDMKTNMPIITSKRYQHSVEWAAELMRRQGQ
DESTVRRILKDYTKPLEHPPVKRNEEAQVHDKLNSGMVSNMEGTAGGERPSVVNGDSGKS
GGVGDPREPLGCLQEGSGCHPTTESFEKSVREDASPLPHVCCCKQDALILQRGLHHEDGS
QHIGLLHPGDRGPDHEYVLVEEAECAMSEREAAPNEELVQRNRLICRRNPYRIFEYLQLS
LEEAFFLVYALGCLSIYYEKEPLTIVKLWKAFTVVQPTFRTTYMAYHYFRSKGWVPKVGL
KYGTDLLLYRKGPPFYHASYSVIIELVDDHFEGSLRRPLSWKSLAALSRVSVNVSKELML
CYLIKPSTMTDKEMESPECMKRIKVQEVILSRWVSSRERSDQDDL
NT seq
1398 nt
NT seq
+upstream
nt +downstream
nt
atggcagaagcagttttccatgccccaaagaggaaaagaagagtgtatgagacttacgag
tctccattgccaatcccttttggtcaggaccatggtcctctgaaagaattcaagatattc
cgtgctgaaatgattaacaacaatgtgattgtgaggaatgcggaggacattgagcagctc
tatgggaaaggttattttggaaaaggtattctttcaagaagccgtccaagcttcacaatt
tcagatcctaaactggttgctaaatggaaagatatgaagacaaacatgcctatcatcaca
tcaaagaggtatcagcatagtgttgagtgggcagcagagctgatgcgtagacaggggcag
gatgagagtacagtgcgcagaatcctcaaggattacacgaaaccgcttgagcatcctcct
gtgaaaaggaatgaagaggctcaagtgcatgacaagcttaactctggaatggtttccaac
atggaaggcacagcagggggagagagaccttctgtggtaaacggggactctggaaagtca
ggtggtgtgggtgatccccgtgagccattaggctgcctgcaggagggctctggctgccac
ccaacaacagagagctttgagaaaagcgtgcgagaggatgcctcacctctgccccatgtc
tgttgctgcaaacaagatgctctcatcctccagcgtggccttcatcatgaagacggcagc
cagcacatcggcctcctgcatcctggggacagagggcctgaccatgagtacgtgctggtc
gaggaagcggagtgtgccatgagcgagagggaggctgccccaaatgaggaattggtgcaa
agaaacaggttaatatgcagaagaaatccatataggatctttgagtatttgcaactcagc
ctagaagaggcctttttcttggtctatgctctgggatgtttaagtatttactatgagaag
gagcctttaacgatagtgaagctctggaaagctttcactgtagttcagcccacgttcaga
accacctacatggcctaccattactttcgaagcaagggctgggtgcccaaagtgggactc
aagtacgggacagatttactgctatatcggaaaggccctccattttaccatgcaagttat
tctgtcattatcgagctagttgatgaccattttgaaggctctctccgcaggcctctcagt
tggaagtccctggctgccttgagcagagtttccgttaatgtctctaaggaacttatgctg
tgctatttgattaaaccctctactatgactgacaaggaaatggagtcaccagaatgtatg
aaaaggattaaagttcaggaggtgattctgagtcgatgggtttcttcacgagagaggagt
gaccaagacgatctttaa
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