Homo sapiens (human): 81
Help
Entry
81 CDS
T01001
Symbol
ACTN4, ACTININ-4, FSGS, FSGS1
Name
(RefSeq) actinin alpha 4
KO
K05699
actinin alpha 1/4
Organism
hsa
Homo sapiens (human)
Pathway
hsa04510
Focal adhesion
hsa04520
Adherens junction
hsa04530
Tight junction
hsa04670
Leukocyte transendothelial migration
hsa04810
Regulation of actin cytoskeleton
hsa05131
Shigellosis
hsa05146
Amoebiasis
hsa05203
Viral carcinogenesis
hsa05322
Systemic lupus erythematosus
Network
nt06182
Shigella
Element
N01080
ITGA/B-TALIN/VINCULIN signaling pathway
N01082
Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway
Disease
H00626
Focal segmental glomerulosclerosis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
81 (ACTN4)
04520 Adherens junction
81 (ACTN4)
04530 Tight junction
81 (ACTN4)
09142 Cell motility
04810 Regulation of actin cytoskeleton
81 (ACTN4)
09150 Organismal Systems
09151 Immune system
04670 Leukocyte transendothelial migration
81 (ACTN4)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
81 (ACTN4)
09171 Infectious disease: bacterial
05131 Shigellosis
81 (ACTN4)
09174 Infectious disease: parasitic
05146 Amoebiasis
81 (ACTN4)
09163 Immune disease
05322 Systemic lupus erythematosus
81 (ACTN4)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
81 (ACTN4)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:
hsa04812
]
81 (ACTN4)
04147 Exosome [BR:
hsa04147
]
81 (ACTN4)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Small GTPases and associated proteins
Rab associated proteins
81 (ACTN4)
Cytoskeleton proteins [BR:
hsa04812
]
Eukaryotic cytoskeleton proteins
Actin filaments / Microfilaments
Actin-binding proteins
Cross-linking proteins
81 (ACTN4)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
81 (ACTN4)
Exosomal proteins of colorectal cancer cells
81 (ACTN4)
Exosomal proteins of bladder cancer cells
81 (ACTN4)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Spectrin
CH
EFhand_Ca_insen
EF-hand_1
EF-hand_6
EF-hand_7
EF-hand_8
XisI
Motif
Other DBs
NCBI-GeneID:
81
NCBI-ProteinID:
NP_004915
OMIM:
604638
HGNC:
166
Ensembl:
ENSG00000130402
UniProt:
O43707
A0A0S2Z3G9
Structure
PDB
LinkDB
All DBs
Position
19:38647649..38731589
Genome browser
AA seq
911 aa
AA seq
DB search
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWC
NSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIA
SKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKM
LDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEK
LASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQ
KASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQEL
NELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF
NNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAES
NHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANV
VGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIF
DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKD
HGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETT
DTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKS
FSTALYGESDL
NT seq
2736 nt
NT seq
+upstream
nt +downstream
nt
atggtggactaccacgcggcgaaccagtcgtaccagtacggccccagcagcgcgggcaat
ggcgctggcggcgggggcagcatgggcgactacatggcccaggaggacgactgggaccgg
gacctgctgctggacccggcctgggagaagcagcagcgcaagaccttcacggcatggtgc
aactcccacctgcggaaggcaggcacacagatcgagaacattgatgaggacttccgagac
gggctcaagctcatgctgctcctggaggtcatatcaggggagcggttacctaagccggag
cgggggaagatgagagtgcacaaaatcaacaatgtgaacaaagcgctggactttattgcc
agcaaaggcgtcaagctggtctccatcggggcagaagagattgtggacggcaacgcaaag
atgaccctgggaatgatctggaccatcatccttaggttcgccatccaggacatctccgtg
gaagagacctcggccaaggaagggctccttctctggtgccagagaaagacagccccgtat
aagaacgtcaatgtgcagaacttccacatcagctggaaggatggtcttgccttcaatgcc
ctgatccaccggcacagaccagagctgattgagtatgacaagctgaggaaggacgaccct
gtcaccaacctgaacaatgccttcgaagtggctgagaaatacctcgacatccccaagatg
ctggatgcagaggacatcgtgaacacggcccggcccgacgagaaggccataatgacctat
gtgtccagcttctaccatgccttttcaggagcgcagaaggctgaaactgccgccaaccgg
atctgtaaggtgctggctgtcaaccaagagaacgagcacctgatggaggactacgagaag
ctggccagcgacctcctggagtggatccggcgcaccatcccctggctggaggaccgtgtg
ccccaaaagactatccaggagatgcagcagaagctggaggacttccgcgactaccggcgt
gtgcacaagccgcccaaggtgcaggagaagtgccagctggagatcaacttcaacacgctg
cagaccaagctgcgcctcagcaaccggcccgccttcatgccctccgagggcaagatggtc
tcggacatcaacaatggctggcagcacttggagcaggctgagaagggctacgaggagtgg
ctgctgaatgagatccgcaggctggagcggctcgaccacctggcagagaagttccggcag
aaggcctccatccacgaggcctggactgacgggaaggaagccatgctgaagcaccgggac
tacgagacggccacactatcggacatcaaagccctcattcgcaagcacgaggccttcgag
agcgacctggctgcgcaccaggaccgcgtggagcagatcgccgccattgcccaggagctc
aacgagctggattactacgactcccacaatgtcaacacccggtgccagaagatctgtgac
cagtgggacgccctcggctctctgacacatagtcgcagggaagccctggagaaaacagag
aagcagctggaggccatcgaccagctgcacctggaatacgccaagcgcgcggcccccttc
aacaactggatggagagcgccatggaggacctccaggacatgttcatcgtccataccatc
gaggagattgagggcctgatctcagcccatgaccagttcaagtccaccctgccggacgcc
gatagggagcgcgaggccatcctggccatccacaaggaggcccagaggatcgctgagagc
aaccacatcaagctgtcgggcagcaacccctacaccaccgtcaccccgcaaatcatcaac
tccaagtgggagaaggtgcagcagctggtgccaaaacgggaccatgccctcctggaggag
cagagcaagcagcagtccaacgagcacctgcgccgccagttcgccagccaggccaatgtt
gtggggccctggatccagaccaagatggaggagatcgggcgcatctccattgagatgaac
gggaccctggaggaccagctgagccacctgaagcagtatgaacgcagcatcgtggactac
aagcccaacctggacctgctggagcagcagcaccagctcatccaggaggccctcatcttc
gacaacaagcacaccaactataccatggagcacatccgcgtgggctgggagcagctgctc
accaccattgcccgcaccatcaacgaggtggagaaccagatcctcacccgcgacgccaag
ggcatcagccaggagcagatgcaggagttccgggcgtccttcaaccacttcgacaaggat
catggcggggcgctggggcccgaggagttcaaggcctgcctcatcagcctgggctacgac
gtggagaacgaccggcagggtgaggccgagttcaaccgcatcatgagcctggtcgacccc
aaccatagcggccttgtgaccttccaagccttcatcgacttcatgtcgcgggagaccacc
gacacggacacggctgaccaggtcatcgcttccttcaaggtcttagcaggggacaagaac
ttcatcacagctgaggagctgcggagagagctgccccccgaccaggccgagtactgcatc
gcccgcatggcgccataccagggccctgacgccgtgcccggtgccctcgactacaagtcc
ttctccacggccttgtatggcgagagcgacctgtga
Homo sapiens (human): 87
Help
Entry
87 CDS
T01001
Symbol
ACTN1, BDPLT15
Name
(RefSeq) actinin alpha 1
KO
K05699
actinin alpha 1/4
Organism
hsa
Homo sapiens (human)
Pathway
hsa04510
Focal adhesion
hsa04520
Adherens junction
hsa04530
Tight junction
hsa04670
Leukocyte transendothelial migration
hsa04810
Regulation of actin cytoskeleton
hsa05131
Shigellosis
hsa05146
Amoebiasis
hsa05203
Viral carcinogenesis
hsa05322
Systemic lupus erythematosus
Network
nt06182
Shigella
Element
N01080
ITGA/B-TALIN/VINCULIN signaling pathway
N01082
Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway
Disease
H01235
Bleeding disorder platelet-type
H01740
Macrothrombocytopenia
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
87 (ACTN1)
04520 Adherens junction
87 (ACTN1)
04530 Tight junction
87 (ACTN1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
87 (ACTN1)
09150 Organismal Systems
09151 Immune system
04670 Leukocyte transendothelial migration
87 (ACTN1)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
87 (ACTN1)
09171 Infectious disease: bacterial
05131 Shigellosis
87 (ACTN1)
09174 Infectious disease: parasitic
05146 Amoebiasis
87 (ACTN1)
09163 Immune disease
05322 Systemic lupus erythematosus
87 (ACTN1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
87 (ACTN1)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:
hsa04812
]
87 (ACTN1)
04147 Exosome [BR:
hsa04147
]
87 (ACTN1)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Small GTPases and associated proteins
Rab associated proteins
87 (ACTN1)
Cytoskeleton proteins [BR:
hsa04812
]
Eukaryotic cytoskeleton proteins
Actin filaments / Microfilaments
Actin-binding proteins
Cross-linking proteins
87 (ACTN1)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
87 (ACTN1)
Exosomal proteins of colorectal cancer cells
87 (ACTN1)
Exosomal proteins of bladder cancer cells
87 (ACTN1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Spectrin
CH
EFhand_Ca_insen
EF-hand_1
EF-hand_6
EF-hand_7
EF-hand_8
EF-hand_5
XisI
Uds1
Motif
Other DBs
NCBI-GeneID:
87
NCBI-ProteinID:
NP_001093
OMIM:
102575
HGNC:
163
Ensembl:
ENSG00000072110
UniProt:
P12814
A0A024R694
Structure
PDB
LinkDB
All DBs
Position
14:complement(68874128..68979302)
Genome browser
AA seq
892 aa
AA seq
DB search
MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR
DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV
KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC
ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT
YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR
VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM
VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK
DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC
DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT
IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI
NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM
HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL
LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY
DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK
NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL
NT seq
2679 nt
NT seq
+upstream
nt +downstream
nt
atggaccattatgattctcagcaaaccaacgattacatgcagccagaagaggactgggac
cgggacctgctcctggacccggcctgggagaagcagcagagaaagacattcacggcatgg
tgtaactcccacctccggaaggcggggacacagatcgagaacatcgaagaggacttccgg
gatggcctgaagctcatgctgctgctggaggtcatctcaggtgaacgcttggccaagcca
gagcgaggcaagatgagagtgcacaagatctccaacgtcaacaaggccctggatttcata
gccagcaaaggcgtcaaactggtgtccatcggagccgaagaaatcgtggatgggaatgtg
aagatgaccctgggcatgatctggaccatcatcctgcgctttgccatccaggacatctcc
gtggaagagacttcagccaaggaagggctgctcctgtggtgtcagagaaagacagcccct
tacaaaaatgtcaacatccagaacttccacataagctggaaggatggcctcggcttctgt
gctttgatccaccgacaccggcccgagctgattgactacgggaagctgcggaaggatgat
ccactcacaaatctgaatacggcttttgacgtggcagagaagtacctggacatccccaag
atgctggatgccgaagacatcgttggaactgcccgaccggatgagaaagccatcatgact
tacgtgtctagcttctaccacgccttctctggagcccagaaggcggagacagcagccaat
cgcatctgcaaggtgttggccgtcaaccaggagaacgagcagcttatggaagactacgag
aagctggccagtgatctgttggagtggatccgccgcacaatcccgtggctggagaaccgg
gtgcccgagaacaccatgcatgccatgcaacagaagctggaggacttccgggactaccgg
cgcctgcacaagccgcccaaggtgcaggagaagtgccagctggagatcaacttcaacacg
ctgcagaccaagctgcggctcagcaaccggcctgccttcatgccctctgagggcaggatg
gtctcggacatcaacaatgcctggggctgcctggagcaggtggagaagggctatgaggag
tggttgctgaatgagatccggaggctggagcgactggaccacctggcagagaagttccgg
cagaaggcctccatccacgaggcctggactgacggcaaagaggccatgctgcgacagaag
gactatgagaccgccaccctctcggagatcaaggccctgctcaagaagcatgaggccttc
gagagtgacctggctgcccaccaggaccgtgtggagcagattgccgccatcgcacaggag
ctcaatgagctggactattatgactcacccagtgtcaacgcccgttgccaaaagatctgt
gaccagtgggacaatctgggggccctaactcagaagcgaagggaagctctggagcggacc
gagaaactgctggagaccattgaccagctgtacttggagtatgccaagcgggctgcaccc
ttcaacaactggatggagggggccatggaggacctgcaggacaccttcattgtgcacacc
attgaggagatccagggactgaccacagcccatgagcagttcaaggccaccctccctgat
gccgacaaggagcgcctggccatcctgggcatccacaatgaggtgtccaagattgtccag
acctaccacgtcaatatggcgggcaccaacccctacacaaccatcacgcctcaggagatc
aatggcaaatgggaccacgtgcggcagctggtgcctcggagggaccaagctctgacggag
gagcatgcccgacagcagcacaatgagaggctacgcaagcagtttggagcccaggccaat
gtcatcgggccctggatccagaccaagatggaggagatcgggaggatctccattgagatg
catgggaccctggaggaccagctcagccacctgcggcagtatgagaagagcatcgtcaac
tacaagccaaagattgatcagctggagggcgaccaccagctcatccaggaggcgctcatc
ttcgacaacaagcacaccaactacaccatggagcacatccgtgtgggctgggagcagctg
ctcaccaccatcgccaggaccatcaatgaggtagagaaccagatcctgacccgggatgcc
aagggcatcagccaggagcagatgaatgagttccgggcctccttcaaccactttgaccgg
gatcactccggcacactgggtcccgaggagttcaaagcctgcctcatcagcttgggttat
gatattggcaacgacccccagggagaagcagaatttgcccgcatcatgagcattgtggac
cccaaccgcctgggggtagtgacattccaggccttcattgacttcatgtcccgcgagaca
gccgacacagatacagcagaccaagtcatggcttccttcaagatcctggctggggacaag
aactacattaccatggacgagctgcgccgcgagctgccacccgaccaggctgagtactgc
atcgcgcggatggccccctacaccggccccgactccgtgccaggtgctctggactacatg
tccttctccacggcgctgtacggcgagagtgacctctaa
DBGET
integrated database retrieval system
