Homo sapiens (human): 83464
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Entry
83464 CDS
T01001
Symbol
APH1B, APH-1B, PRO1328, PSFL, TAAV688, aph-1beta
Name
(RefSeq) aph-1 homolog B, gamma-secretase subunit
KO
K06172
gamma-secretase subunit APH-1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04330
Notch signaling pathway
hsa05010
Alzheimer disease
Network
nt06511
NOTCH signaling
Element
N01478
Notch proteolytic activation
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
83464 (APH1B)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
83464 (APH1B)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Aph-1
Motif
Other DBs
NCBI-GeneID:
83464
NCBI-ProteinID:
NP_112591
OMIM:
607630
HGNC:
24080
Ensembl:
ENSG00000138613
Pharos:
Q8WW43
(Tbio)
UniProt:
Q8WW43
Structure
PDB
PDBj
LinkDB
All DBs
Position
15:63277605..63309126
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AA seq
257 aa
AA seq
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MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS
GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG
CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
CLLCQDKNFLLYNQRSR
NT seq
774 nt
NT seq
+upstream
nt +downstream
nt
atgactgcggccgtgttcttcggctgcgccttcattgccttcgggcctgcgctcgccctt
tatgtcttcaccatcgccaccgagccgttgcgtatcatcttcctcatcgccggagctttc
ttctggttggtgtctctactgatttcgtcccttgtttggttcatggcaagagtcattatt
gacaacaaagatggaccaacacagaaatatctgctgatctttggagcgtttgtctctgtc
tatatccaagaaatgttccgatttgcatattataaactcttaaaaaaagccagtgaaggt
ttgaagagtataaacccaggtgagacagcaccctctatgcgactgctggcctatgtttct
ggcttgggctttggaatcatgagtggagtattttcctttgtgaataccctatctgactcc
ttggggccaggcacagtgggcattcatggagattctcctcaattcttcctttattcagct
ttcatgacgctggtcattatcttgctgcatgtattctggggcattgtattttttgatggc
tgtgagaagaaaaagtggggcatcctccttatcgttctcctgacccacctgctggtgtca
gcccagaccttcataagttcttattatggaataaacctggcgtcagcatttataatcctg
gtgctcatgggcacctgggcattcttagctgcgggaggcagctgccgaagcctgaaactc
tgcctgctctgccaagacaagaactttcttctttacaaccagcgctccagataa
DBGET
integrated database retrieval system
