Homo sapiens (human): 836
Help
Entry
836 CDS
T01001
Symbol
CASP3, CPP32, CPP32B, SCA-1
Name
(RefSeq) caspase 3
KO
K02187
caspase 3 [EC:
3.4.22.56
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01524
Platinum drug resistance
hsa04010
MAPK signaling pathway
hsa04115
p53 signaling pathway
hsa04148
Efferocytosis
hsa04210
Apoptosis
hsa04215
Apoptosis - multiple species
hsa04623
Cytosolic DNA-sensing pathway
hsa04650
Natural killer cell mediated cytotoxicity
hsa04657
IL-17 signaling pathway
hsa04668
TNF signaling pathway
hsa04726
Serotonergic synapse
hsa04932
Non-alcoholic fatty liver disease
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04936
Alcoholic liver disease
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05130
Pathogenic Escherichia coli infection
hsa05132
Salmonella infection
hsa05133
Pertussis
hsa05134
Legionellosis
hsa05145
Toxoplasmosis
hsa05146
Amoebiasis
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05200
Pathways in cancer
hsa05203
Viral carcinogenesis
hsa05205
Proteoglycans in cancer
hsa05206
MicroRNAs in cancer
hsa05210
Colorectal cancer
hsa05222
Small cell lung cancer
hsa05416
Viral myocarditis
hsa05417
Lipid and atherosclerosis
Network
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06170
Influenza A virus (IAV)
nt06231
Apoptosis (cancer)
nt06260
Colorectal cancer
nt06263
Hepatocellular carcinoma
nt06267
Small cell lung cancer
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06462
Spinocerebellar ataxia
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06465
Prion disease
nt06466
Pathways of neurodegeneration
nt06516
TNF signaling
nt06524
Apoptosis
nt06528
Calcium signaling
nt06535
Efferocytosis
Element
N00098
Intrinsic apoptotic pathway
N00100
BCL2-overexpression to intrinsic apoptotic pathway
N00101
DCC-apoptotic pathway
N00102
Loss of DCC to DCC-apoptotic pathway
N00145
Extrinsic apoptotic pathway
N00146
Crosstalk between extrinsic and intrinsic apoptotic pathways
N00165
KSHV vIAP to crosstalk between extrinsic and intrinsic apoptotic pathways
N00449
HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
N00478
EBV BARF1 to intrinsic apoptotic pathway
N00580
HSV ICP0 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00967
VGCC-Ca2+ -apoptotic pathway
N00983
Mutation-caused aberrant Htt to extrinsic apoptotic pathway
N00984
mGluR5-Ca2+ -apoptotic pathway
N00985
Mutation-caused aberrant Htt to mGluR5-Ca2+ -apoptotic pathway
N00987
Mutation-caused aberrant Htt to transport of calcium
N01002
Mutation-caused aberrant Abeta to mGluR5-Ca2+ -apoptotic pathway
N01005
Mutation-caused aberrant Abeta to crosstalk between extrinsic and intrinsic apoptotic pathways
N01007
Mutation-caused aberrant PSEN to mGluR5-Ca2+ -apoptotic pathway
N01031
Mutation-caused aberrant SNCA to VGCC-Ca2+ -apoptotic pathway
N01047
Mutation-activated LRRK2 to intrinsic apoptotic pathway
N01048
Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01049
Mutation-inactivated PRKN to intrinsic apoptotic pathway
N01050
Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01135
Mutation-caused aberrant SOD1 to intrinsic apoptotic pathway
N01199
Scrapie conformation PrPSc to mGluR5-Ca2+ -apoptotic pathway
N01200
Scrapie conformation PrPSc to transport of calcium
N01747
Find-me signal (nucleotide)
N01748
Find-me signal (LPC)
N01749
Find-me signal (CX3CL1)
N01750
Find-me signal (S1P)
N01754
Activation of XKR8
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04668 TNF signaling pathway
836 (CASP3)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
836 (CASP3)
09143 Cell growth and death
04215 Apoptosis - multiple species
836 (CASP3)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
836 (CASP3)
04657 IL-17 signaling pathway
836 (CASP3)
09156 Nervous system
04726 Serotonergic synapse
836 (CASP3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
836 (CASP3)
05206 MicroRNAs in cancer
836 (CASP3)
05205 Proteoglycans in cancer
836 (CASP3)
05203 Viral carcinogenesis
836 (CASP3)
09162 Cancer: specific types
05210 Colorectal cancer
836 (CASP3)
05222 Small cell lung cancer
836 (CASP3)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
836 (CASP3)
05161 Hepatitis B
836 (CASP3)
05160 Hepatitis C
836 (CASP3)
05164 Influenza A
836 (CASP3)
05162 Measles
836 (CASP3)
05163 Human cytomegalovirus infection
836 (CASP3)
05167 Kaposi sarcoma-associated herpesvirus infection
836 (CASP3)
05169 Epstein-Barr virus infection
836 (CASP3)
05165 Human papillomavirus infection
836 (CASP3)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
836 (CASP3)
05130 Pathogenic Escherichia coli infection
836 (CASP3)
05133 Pertussis
836 (CASP3)
05134 Legionellosis
836 (CASP3)
05152 Tuberculosis
836 (CASP3)
09174 Infectious disease: parasitic
05146 Amoebiasis
836 (CASP3)
05145 Toxoplasmosis
836 (CASP3)
09164 Neurodegenerative disease
05010 Alzheimer disease
836 (CASP3)
05012 Parkinson disease
836 (CASP3)
05014 Amyotrophic lateral sclerosis
836 (CASP3)
05016 Huntington disease
836 (CASP3)
05020 Prion disease
836 (CASP3)
05022 Pathways of neurodegeneration - multiple diseases
836 (CASP3)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
836 (CASP3)
05416 Viral myocarditis
836 (CASP3)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
836 (CASP3)
04932 Non-alcoholic fatty liver disease
836 (CASP3)
04933 AGE-RAGE signaling pathway in diabetic complications
836 (CASP3)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
836 (CASP3)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
836 (CASP3)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.22 Cysteine endopeptidases
3.4.22.56 caspase-3
836 (CASP3)
Peptidases and inhibitors [BR:
hsa01002
]
Cysteine peptidases
Family C14: caspase family
836 (CASP3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Peptidase_C14
SICA_beta
Motif
Other DBs
NCBI-GeneID:
836
NCBI-ProteinID:
NP_004337
OMIM:
600636
HGNC:
1504
Ensembl:
ENSG00000164305
UniProt:
P42574
Structure
PDB
PDBj
LinkDB
All DBs
Position
4:complement(184627696..184649447)
Genome browser
AA seq
277 aa
AA seq
DB search
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
NT seq
834 nt
NT seq
+upstream
nt +downstream
nt
atggagaacactgaaaactcagtggattcaaaatccattaaaaatttggaaccaaagatc
atacatggaagcgaatcaatggactctggaatatccctggacaacagttataaaatggat
tatcctgagatgggtttatgtataataattaataataagaattttcataaaagcactgga
atgacatctcggtctggtacagatgtcgatgcagcaaacctcagggaaacattcagaaac
ttgaaatatgaagtcaggaataaaaatgatcttacacgtgaagaaattgtggaattgatg
cgtgatgtttctaaagaagatcacagcaaaaggagcagttttgtttgtgtgcttctgagc
catggtgaagaaggaataatttttggaacaaatggacctgttgacctgaaaaaaataaca
aactttttcagaggggatcgttgtagaagtctaactggaaaacccaaacttttcattatt
caggcctgccgtggtacagaactggactgtggcattgagacagacagtggtgttgatgat
gacatggcgtgtcataaaataccagtggaggccgacttcttgtatgcatactccacagca
cctggttattattcttggcgaaattcaaaggatggctcctggttcatccagtcgctttgt
gccatgctgaaacagtatgccgacaagcttgaatttatgcacattcttacccgggttaac
cgaaaggtggcaacagaatttgagtccttttcctttgacgctacttttcatgcaaagaaa
cagattccatgtattgtttccatgctcacaaaagaactctatttttatcactaa
Homo sapiens (human): 841
Help
Entry
841 CDS
T01001
Symbol
CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5
Name
(RefSeq) caspase 8
KO
K04398
caspase 8 [EC:
3.4.22.61
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01524
Platinum drug resistance
hsa04115
p53 signaling pathway
hsa04210
Apoptosis
hsa04215
Apoptosis - multiple species
hsa04217
Necroptosis
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04623
Cytosolic DNA-sensing pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04657
IL-17 signaling pathway
hsa04668
TNF signaling pathway
hsa04932
Non-alcoholic fatty liver disease
hsa04936
Alcoholic liver disease
hsa05010
Alzheimer disease
hsa05016
Huntington disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05130
Pathogenic Escherichia coli infection
hsa05132
Salmonella infection
hsa05134
Legionellosis
hsa05142
Chagas disease
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05200
Pathways in cancer
hsa05203
Viral carcinogenesis
hsa05416
Viral myocarditis
hsa05417
Lipid and atherosclerosis
Network
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06231
Apoptosis (cancer)
nt06263
Hepatocellular carcinoma
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06466
Pathways of neurodegeneration
nt06516
TNF signaling
nt06524
Apoptosis
nt06527
Necroptosis
Element
N00145
Extrinsic apoptotic pathway
N00146
Crosstalk between extrinsic and intrinsic apoptotic pathways
N00166
KSHV vFLIP to crosstalk between extrinsic and intrinsic apoptotic pathways
N00352
HPV E6 to extrinsic apoptotic pathway
N00425
HCMV UL36 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00449
HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
N00526
HCV NS3 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00528
HCV core to extrinsic apoptotic pathway
N00579
HSV ICP6 to extrinsic apoptotic pathway
N00937
Escherichia NleF to extrinsic apoptotic pathway
N00983
Mutation-caused aberrant Htt to extrinsic apoptotic pathway
N01005
Mutation-caused aberrant Abeta to crosstalk between extrinsic and intrinsic apoptotic pathways
N01583
Regulation of extrinsic apoptotic pathway, XIAP
N01663
CASP8 regulation of RIPK1/3
Disease
H00048
Hepatocellular carcinoma
H00108
Autoimmune lymphoproliferative syndromes
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04668 TNF signaling pathway
841 (CASP8)
09140 Cellular Processes
09143 Cell growth and death
04215 Apoptosis - multiple species
841 (CASP8)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
841 (CASP8)
04657 IL-17 signaling pathway
841 (CASP8)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
841 (CASP8)
05203 Viral carcinogenesis
841 (CASP8)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
841 (CASP8)
05161 Hepatitis B
841 (CASP8)
05160 Hepatitis C
841 (CASP8)
05164 Influenza A
841 (CASP8)
05162 Measles
841 (CASP8)
05163 Human cytomegalovirus infection
841 (CASP8)
05167 Kaposi sarcoma-associated herpesvirus infection
841 (CASP8)
05169 Epstein-Barr virus infection
841 (CASP8)
05165 Human papillomavirus infection
841 (CASP8)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
841 (CASP8)
05134 Legionellosis
841 (CASP8)
05152 Tuberculosis
841 (CASP8)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
841 (CASP8)
05142 Chagas disease
841 (CASP8)
09164 Neurodegenerative disease
05010 Alzheimer disease
841 (CASP8)
05016 Huntington disease
841 (CASP8)
05022 Pathways of neurodegeneration - multiple diseases
841 (CASP8)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
841 (CASP8)
05416 Viral myocarditis
841 (CASP8)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
841 (CASP8)
04932 Non-alcoholic fatty liver disease
841 (CASP8)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
841 (CASP8)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
841 (CASP8)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.22 Cysteine endopeptidases
3.4.22.61 caspase-8
841 (CASP8)
Peptidases and inhibitors [BR:
hsa01002
]
Cysteine peptidases
Family C14: caspase family
841 (CASP8)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Peptidase_C14
DED
PYRIN
Motif
Other DBs
NCBI-GeneID:
841
NCBI-ProteinID:
NP_203519
OMIM:
601763
HGNC:
1509
Ensembl:
ENSG00000064012
UniProt:
Q14790
Structure
PDB
PDBj
LinkDB
All DBs
Position
2:201233463..201287711
Genome browser
AA seq
479 aa
AA seq
DB search
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
NT seq
1440 nt
NT seq
+upstream
nt +downstream
nt
atggacttcagcagaaatctttatgatattggggaacaactggacagtgaagatctggcc
tccctcaagttcctgagcctggactacattccgcaaaggaagcaagaacccatcaaggat
gccttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaatctgtcc
ttcctgaaggagctgctcttccgaattaatagactggatttgctgattacctacctaaac
actagaaaggaggagatggaaagggaacttcagacaccaggcagggctcaaatttctgcc
tacagggtcatgctctatcagatttcagaagaagtgagcagatcagaattgaggtctttt
aagtttcttttgcaagaggaaatctccaaatgcaaactggatgatgacatgaacctgctg
gatattttcatagagatggagaagagggtcatcctgggagaaggaaagttggacatcctg
aaaagagtctgtgcccaaatcaacaagagcctgctgaagataatcaacgactatgaagaa
ttcagcaaagagagaagcagcagccttgaaggaagtcctgatgaattttcaaatggggag
gagttgtgtggggtaatgacaatctcggactctccaagagaacaggatagtgaatcacag
actttggacaaagtttaccaaatgaaaagcaaacctcggggatactgtctgatcatcaac
aatcacaattttgcaaaagcacgggagaaagtgcccaaacttcacagcattagggacagg
aatggaacacacttggatgcaggggctttgaccacgacctttgaagagcttcattttgag
atcaagccccacgatgactgcacagtagagcaaatctatgagattttgaaaatctaccaa
ctcatggaccacagtaacatggactgcttcatctgctgtatcctctcccatggagacaag
ggcatcatctatggcactgatggacaggaggcccccatctatgagctgacatctcagttc
actggtttgaagtgcccttcccttgctggaaaacccaaagtgttttttattcaggcttgt
cagggggataactaccagaaaggtatacctgttgagactgattcagaggagcaaccctat
ttagaaatggatttatcatcacctcaaacgagatatatcccggatgaggctgactttctg
ctggggatggccactgtgaataactgtgtttcctaccgaaaccctgcagagggaacctgg
tacatccagtcactttgccagagcctgagagagcgatgtcctcgaggcgatgatattctc
accatcctgactgaagtgaactatgaagtaagcaacaaggatgacaagaaaaacatgggg
aaacagatgcctcagcctactttcacactaagaaaaaaacttgtcttcccttctgattga
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integrated database retrieval system