KEGG   Homo sapiens (human): 8650
Entry
8650              CDS       T01001                                 
Symbol
NUMB, C14orf41, S171, c14_5527
Name
(RefSeq) NUMB endocytic adaptor protein
  KO
K06057  numb
Organism
hsa  Homo sapiens (human)
Pathway
hsa04330  Notch signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    8650 (NUMB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    8650 (NUMB)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   LDLR adaptor proteins
    8650 (NUMB)
SSDB
Motif
Pfam: PID NumbF PTB PID_2
Other DBs
NCBI-GeneID: 8650
NCBI-ProteinID: NP_001005743
OMIM: 603728
HGNC: 8060
Ensembl: ENSG00000133961
UniProt: P49757
Structure
LinkDB
Position
14:complement(73275216..73458546)
AA seq 651 aa
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICED
AVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPD
RNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTA
TFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPS
SPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINE
LPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQ
SPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQS
SGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPAS
PFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFG
TAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASA
DRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL
NT seq 1956 nt   +upstreamnt  +downstreamnt
atgaacaaattacggcaaagttttaggagaaagaaggatgtttatgttccagaggccagt
cgtccacatcagtggcagacagatgaagaaggcgttcgcaccggaaaatgtagcttcccg
gttaagtaccttggccatgtagaagttgatgaatcaagaggaatgcacatctgtgaagat
gctgtaaaaagattgaaagctgaaaggaagttcttcaaaggcttctttggaaaaactgga
aagaaagcagttaaagcagttctgtgggtctcagcagatggactcagagttgtggatgaa
aaaactaaggacctcatagttgaccagacgatagagaaagtttctttctgtgccccagac
aggaactttgatagagccttttcttacatatgccgtgatggcaccactcgtcgctggatc
tgtcactgcttcatggctgtcaaggacacaggtgaaaggttgagccatgcagtaggctgt
gcttttgcagcctgtttagagcgcaagcagaagcgggagaaggaatgtggagtgactgct
acttttgatgctagtcggaccacttttacaagagaaggatcattccgtgtcacaacagcc
actgaacaagcagaaagagaggagatcatgaaacaaatgcaagatgccaagaaagctgaa
acagataagatagtcgttggttcatcagttgcccctggcaacactgccccatccccatcc
tctcccacctctcctacttctgatgccacgacctctctggagatgaacaatcctcatgcc
atcccacgccggcatgctccaattgaacagcttgctcgccaaggctctttccgaggtttt
cctgctcttagccagaagatgtcaccctttaaacgccaactatccctacgcatcaatgag
ttgccttccactatgcagaggaagactgatttccccattaaaaatgcagtgccagaagta
gaaggggaggcagagagcatcagctccctgtgctcacagatcaccaatgccttcagcaca
cctgaggaccccttctcatctgctccgatgaccaaaccagtgacagtggtggcaccacaa
tctcctaccttccaagctaatggcactgactcagccttccatgtgcttgctaagccagcc
catactgctctagcacccgtagcaatgcctgtgcgtgaaaccaacccttgggcccatgcc
cctgatgctgctaacaaggaaattgcagccacatgttcggggaccgagtggggtcaatct
tctggtgctgcctctccaggtctcttccaggccggtcatagacgtactccctctgaggcc
gaccgatggttagaagaggtgtctaagagcgtccgggctcagcagccccaggcctcagct
gctcctctgcagccagttctccagcctcctccacccactgccatctcccagccagcatca
cctttccaagggaatgcattcctcacctctcagcctgtgccagtgggtgtggtcccagcc
ctgcaaccagcctttgtccctgcccagtcctatcctgtggccaatggaatgccctatcca
gcccctaatgtgcctgtggtgggcatcactccctcccagatggtggccaacgtatttggc
actgcaggccaccctcaggctgcccatccccatcagtcacccagcctggtcaggcagcag
acattccctcactacgaggcaagcagtgctaccaccagtcccttctttaagcctcctgct
cagcacctcaacggttctgcagctttcaatggtgtagatgatggcaggttggcctcagca
gacaggcatacagaggttcctacaggcacctgcccagtggatccttttgaagcccagtgg
gctgcattagaaaataagtccaagcagcgtactaatccctcccctaccaaccctttctcc
agtgacttacagaagacgtttgaaattgaactttaa

KEGG   Homo sapiens (human): 9253
Entry
9253              CDS       T01001                                 
Symbol
NUMBL, CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23
Name
(RefSeq) NUMB like endocytic adaptor protein
  KO
K06057  numb
Organism
hsa  Homo sapiens (human)
Pathway
hsa04330  Notch signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    9253 (NUMBL)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    9253 (NUMBL)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   LDLR adaptor proteins
    9253 (NUMBL)
SSDB
Motif
Pfam: NumbF PID PTB PID_2 DUF1932 Spt20_SEP TFIIA
Other DBs
NCBI-GeneID: 9253
NCBI-ProteinID: NP_004747
OMIM: 604018
HGNC: 8061
Ensembl: ENSG00000105245
UniProt: Q9Y6R0 A8K033
Structure
LinkDB
Position
19:complement(40665905..40690651)
AA seq 609 aa
MSRSAAASGGPRRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEA
SRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWV
SADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDS
GERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPD
KKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQL
VRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSI
NALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEV
SQVAKAQQQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVF
LPPPHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAF
PPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGD
LQKTFEIEL
NT seq 1830 nt   +upstreamnt  +downstreamnt
atgtcccgcagcgcggcggccagcggcggaccccggaggcctgagcggcacctgccccca
gccccctgtggggccccggggcccccagaaacctgcaggacggagccagacggggcgggc
accatgaacaagttacggcagagcctgcggcggaggaagccagcctacgtgcccgaggcg
tcgcgcccgcaccagtggcaggcagacgaggacgcggtgcggaagggcacgtgcagcttc
ccggtcaggtacctgggtcacgtggaggtagaggagtcccggggaatgcacgtgtgtgaa
gatgcggtgaagaagctgaaggcgatgggccgaaagtccgtgaagtctgtcctgtgggtg
tcagccgatgggctccgagtggtggacgacaaaaccaaggatcttctggtcgaccagacc
atcgaaaaggtctccttttgtgctcctgaccgcaacctggacaaggctttctcctatatc
tgtcgtgacgggactacccgccgctggatctgccactgttttctggcactgaaggactcc
ggcgagaggctgagccacgctgtgggctgtgcttttgccgcctgcctggagcgaaaacag
cgacgggagaaggaatgtggggtcacggccgccttcgatgccagccgcaccagcttcgcc
cgcgagggctccttccgcctgtctgggggtgggcggcctgctgagcgagaggccccggac
aagaagaaagcagaggcagcagctgcccccactgtggctcctggccctgcccagcctggg
cacgtgtccccgacaccagccaccacatcccctggtgagaagggtgaggcaggcacccct
gtggctgcaggcaccactgcggccgccatcccccggcgccatgcacccctggagcagctg
gttcgccagggctccttccgtgggttcccagcactcagccagaagaactcgcctttcaaa
cggcagctgagcctacggctgaatgagctgccatccacgctgcagcgccgcactgacttc
caggtgaagggcacagtgcctgagatggagcctcctggtgccggcgacagtgacagcatc
aacgctctgtgcacacagatcagttcatcttttgccagtgctggagcgccagcaccaggg
ccaccacctgccacaacagggacttctgcctggggtgagccctccgtgccccctgcagct
gccttccagcctgggcacaagcggacaccttcagaggctgagcgatggctggaggaggtg
tcacaggtggccaaggcccagcagcagcagcagcagcaacagcaacagcagcagcagcag
cagcagcaacagcagcaagcagcctcagtggccccagtgcccaccatgcctcctgccctg
cagcctttccccgcccccgtggggccctttgacgctgcacctgcccaagtggccgtgttc
ctgccacccccacacatgcagcccccttttgtgcccgcctacccgggcttgggctaccca
ccgatgccccgggtgcccgtggtgggcatcacaccctcacagatggtggcaaacgccttc
tgctcagccgcccagctccagcctcagcctgccactctgcttgggaaagctggggccttc
ccgccccctgccatacccagtgcccctgggagccaggcccgccctcgccccaatggggcc
ccctggccccctgagccagcgcctgccccagctccagagttggacccctttgaggcccag
tgggcggcattagaaggcaaagccactgtagagaaaccctccaaccccttttctggcgac
ctgcaaaagacattcgagattgaactgtag

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