Homo sapiens (human): 8942 Help Entry 8942              CDS       T01001                                  Symbol KYNU, KYNUU, VCRL2 Name (RefSeq) kynureninase   KO K01556   kynureninase [EC:3.7.1.3] Organism hsa  Homo sapiens (human) Pathway hsa00380   Tryptophan metabolism hsa01100   Metabolic pathways hsa01240   Biosynthesis of cofactors Module hsa_M00038   Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate hsa_M00912   NAD biosynthesis, tryptophan => quinolinate => NAD Network nt06036  Lysine degradation   Element N01723   NAD biosynthesis Disease H01583   Hydroxykynureninuria H02087   Vertebral, cardiac, renal, and limb defects syndrome Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09105 Amino acid metabolism    00380 Tryptophan metabolism     8942 (KYNU) Enzymes [BR:hsa01000]  3. Hydrolases   3.7  Acting on carbon-carbon bonds    3.7.1  In ketonic substances     3.7.1.3  kynureninase      8942 (KYNU) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  KYNU_C Aminotran_5 CaKB DegT_DnrJ_EryC1 Motif Other DBs NCBI-GeneID:  8942 NCBI-ProteinID:  NP_001186170 OMIM:  605197 HGNC:  6469 Ensembl:  ENSG00000115919 UniProt:  Q16719 Structure PDBPDBj LinkDB All DBs Position 2:142877664..143055833 Genome browser AA seq 465 aa AA seqDB search MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLS LVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLM KDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHG LNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAG QAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKP ALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKK SVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEK RGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN NT seq 1398 nt NT seq  +upstreamnt  +downstreamnt atggagccttcatctcttgagctgccggctgacacagtgcagcgcattgcggctgaactc aaatgccacccaacggatgagagggtggctctccacctagatgaggaagataagctgagg cacttcagggagtgcttttatattcccaaaatacaggatctgcctccagttgatttatca ttagtgaataaagatgaaaatgccatctatttcttgggaaattctcttggccttcaacca aaaatggttaaaacatatcttgaagaagaactagataagtgggccaaaatagcagcctat ggtcatgaagtggggaagcgtccttggattacaggagatgagagtattgtaggccttatg aaggacattgtaggagccaatgagaaagaaatagccctaatgaatgctttgactgtaaat ttacatcttctaatgttatcattttttaagcctacgccaaaacgatataaaattcttcta gaagccaaagccttcccttctgatcattatgctattgagtcacaactacaacttcacgga cttaacattgaagaaagtatgcggatgataaagccaagagagggggaagaaaccttaaga atagaggatatccttgaagtaattgagaaggaaggagactcaattgcagtgatcctgttc agtggggtgcatttttacactggacagcactttaatattcctgccatcacaaaagctgga caagcgaagggttgttatgttggctttgatctagcacatgcagttggaaatgttgaactc tacttacatgactggggagttgattttgcctgctggtgttcctacaagtatttaaatgca ggagcaggaggaattgctggtgccttcattcatgaaaagcatgcccatacgattaaacct gcattagtgggatggtttggccatgaactcagcaccagatttaagatggataacaaactg cagttaatccctggggtctgtggattccgaatttcaaatcctcccattttgttggtctgt tccttgcatgctagtttagagatctttaagcaagcgacaatgaaggcattgcggaaaaaa tctgttttgctaactggctatctggaatacctgatcaagcataactatggcaaagataaa gcagcaaccaagaaaccagttgtgaacataattactccgtctcatgtagaggagcggggg tgccagctaacaataacattttctgttccaaacaaagatgttttccaagaactagaaaaa agaggagtggtttgtgacaagcggaatccaaatggcattcgagtggctccagttcctctc tataattctttccatgatgtttataaatttaccaatctgctcacttctatacttgactct gcagaaacaaaaaattag

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